| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Krishna L Bharani, Aurélie Ledreux, Anah Gilmore, Steven L Carroll, Ann-Charlotte Granhol. Serum pro-BDNF levels correlate with phospho-tau staining in Alzheimer's disease. Neurobiology of aging. vol 87. 2020-09-14. PMID:31882186. |
disruption of brain-derived neurotrophic factor (bdnf) biosynthesis and/or signaling has been implicated in the pathogenesis of alzheimer's disease (ad). |
2020-09-14 |
2023-08-13 |
Not clear |
| Meysam Amidfar, Jade de Oliveira, Ewa Kucharska, Josiane Budni, Yong-Ku Ki. The role of CREB and BDNF in neurobiology and treatment of Alzheimer's disease. Life sciences. vol 257. 2020-09-11. PMID:32603820. |
the role of creb and bdnf in neurobiology and treatment of alzheimer's disease. |
2020-09-11 |
2023-08-13 |
Not clear |
| Olivia Belbin, Kevin Morgan, Chris Medway, Donald Warden, Mario Cortina-Borja, Cornelia M van Duijn, Hieab H H Adams, Ana Frank-Garcia, Keeley Brookes, Pascual Sánchez-Juan, Victoria Alvarez, Reinhard Heun, Heike Kölsch, Eliecer Coto, Patrick G Kehoe, Eloy Rodriguez-Rodriguez, Maria J Bullido, M Arfan Ikram, A David Smith, Donald J Lehman. The Epistasis Project: A Multi-Cohort Study of the Effects of BDNF, DBH, and SORT1 Epistasis on Alzheimer's Disease Risk. Journal of Alzheimer's disease : JAD. vol 68. issue 4. 2020-08-17. PMID:30909233. |
the epistasis project: a multi-cohort study of the effects of bdnf, dbh, and sort1 epistasis on alzheimer's disease risk. |
2020-08-17 |
2023-08-13 |
Not clear |
| Olivia Belbin, Kevin Morgan, Chris Medway, Donald Warden, Mario Cortina-Borja, Cornelia M van Duijn, Hieab H H Adams, Ana Frank-Garcia, Keeley Brookes, Pascual Sánchez-Juan, Victoria Alvarez, Reinhard Heun, Heike Kölsch, Eliecer Coto, Patrick G Kehoe, Eloy Rodriguez-Rodriguez, Maria J Bullido, M Arfan Ikram, A David Smith, Donald J Lehman. The Epistasis Project: A Multi-Cohort Study of the Effects of BDNF, DBH, and SORT1 Epistasis on Alzheimer's Disease Risk. Journal of Alzheimer's disease : JAD. vol 68. issue 4. 2020-08-17. PMID:30909233. |
pre-synaptic secretion of brain-derived neurotrophic factor (bdnf) from noradrenergic neurons may protect the alzheimer's disease (ad) brain from amyloid pathology. |
2020-08-17 |
2023-08-13 |
Not clear |
| Stephen D Ginsberg, Michael H Malek-Ahmadi, Melissa J Alldred, Yinghua Chen, Kewei Chen, Moses V Chao, Scott E Counts, Elliott J Mufso. Brain-derived neurotrophic factor (BDNF) and TrkB hippocampal gene expression are putative predictors of neuritic plaque and neurofibrillary tangle pathology. Neurobiology of disease. vol 132. 2020-07-27. PMID:31349032. |
downregulation of brain-derived neurotrophic factor (bdnf) and its cognate neurotrophin receptor, trkb, were observed during the progression of dementia, but whether the alzheimer's disease (ad) pathological lesions diffuse plaques, (dps), neuritic plaques (nps), and neurofibrillary tangles (nfts) are related to this alteration remains to be clarified. |
2020-07-27 |
2023-08-13 |
Not clear |
| Hui Xia, Min Wang, Jie-Qiong Li, Chen-Chen Tan, Xi-Peng Cao, Lan Tan, Jin-Tai Y. The Influence of BDNF Val66Met Polymorphism on Cognition, Cerebrospinal Fluid, and Neuroimaging Markers in Non-Demented Elderly. Journal of Alzheimer's disease : JAD. vol 68. issue 1. 2020-06-22. PMID:30775992. |
the brain-derived neurotrophic factor (bdnf) val66met polymorphism emerged as a risk factor for alzheimer's disease (ad). |
2020-06-22 |
2023-08-13 |
Not clear |
| Durany, Michel, Kurt, Cruz-Sánchez, Cervós-Navarro, Riedere. Brain-derived neurotrophic factor and neurotrophin-3 levels in Alzheimer's disease brains. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 18. issue 8. 2020-06-01. PMID:11154850. |
in the present study, we investigated the levels of brain-derived neurotrophic factor (bdnf) and neurotrophin-3 (nt-3) in post-mortem brain tissue of alzheimer's disease (ad) patients, and we observed a significant increase of bdnf concentration in hippocampus and parietal cortex of ad patients, as well as a negative correlation between nt-3 levels and age in hippocampus and putamen of control subjects, and for bdnf in frontal cortex. |
2020-06-01 |
2023-08-12 |
human |
| Jie Xiang, Zhi-Hao Wang, Eun Hee Ahn, Xia Liu, Shan-Ping Yu, Fredric P Manfredsson, Ivette M Sandoval, Gong Ju, Shengxi Wu, Keqiang Y. Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer's disease pathologies. Proceedings of the National Academy of Sciences of the United States of America. vol 116. issue 18. 2020-03-25. PMID:31004063. |
bdnf, an essential trophic factor implicated in synaptic plasticity and neuronal survival, is reduced in alzheimer's disease (ad). |
2020-03-25 |
2023-08-13 |
Not clear |
| Benoit de Pins, Carmen Cifuentes-Díaz, Amel Thamila Farah, Laura López-Molina, Enrica Montalban, Anna Sancho-Balsells, Ana López, Silvia Ginés, José María Delgado-García, Jordi Alberch, Agnès Gruart, Jean-Antoine Girault, Albert Giral. Conditional BDNF Delivery from Astrocytes Rescues Memory Deficits, Spine Density, and Synaptic Properties in the 5xFAD Mouse Model of Alzheimer Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 13. 2020-03-18. PMID:30700530. |
conditional bdnf delivery from astrocytes rescues memory deficits, spine density, and synaptic properties in the 5xfad mouse model of alzheimer disease. |
2020-03-18 |
2023-08-13 |
mouse |
| Benoit de Pins, Carmen Cifuentes-Díaz, Amel Thamila Farah, Laura López-Molina, Enrica Montalban, Anna Sancho-Balsells, Ana López, Silvia Ginés, José María Delgado-García, Jordi Alberch, Agnès Gruart, Jean-Antoine Girault, Albert Giral. Conditional BDNF Delivery from Astrocytes Rescues Memory Deficits, Spine Density, and Synaptic Properties in the 5xFAD Mouse Model of Alzheimer Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 13. 2020-03-18. PMID:30700530. |
it has been well documented that neurotrophins, including brain-derived neurotrophic factor (bdnf), are severely affected in alzheimer's disease (ad), but their administration faces a myriad of technical challenges. |
2020-03-18 |
2023-08-13 |
mouse |
| Yufeng Chen, Fan Xue, Guobin Xia, Zhenlei Zhao, Chun Chen, Yunhong Li, Ying Zhan. Transepithelial transport mechanisms of 7,8-dihydroxyflavone, a small molecular TrkB receptor agonist, in human intestinal Caco-2 cells. Food & function. vol 10. issue 8. 2020-02-05. PMID:31384856. |
7,8-dihydroxyflavone (7,8-dhf), as a high-affinity trkb receptor agonist, has been extensively explored in many human disorders involving brain-derived neurotrophic factor (bdnf) such as alzheimer's disease, parkinson's disease, depression, and obesity. |
2020-02-05 |
2023-08-13 |
human |
| X Anton Alvarez, Irene Alvarez, Olalla Iglesias, Ignacio Crespo, Jesus Figueroa, Manuel Aleixandre, Carlos Linares, Elias Granizo, Manuel Garcia-Fantini, Jose Marey, Eliezer Masliah, Stefan Winter, Dafin Muresanu, Herbert Moessle. Synergistic Increase of Serum BDNF in Alzheimer Patients Treated with Cerebrolysin and Donepezil: Association with Cognitive Improvement in ApoE4 Cases. The international journal of neuropsychopharmacology. vol 19. issue 6. 2020-01-23. PMID:27207906. |
synergistic increase of serum bdnf in alzheimer patients treated with cerebrolysin and donepezil: association with cognitive improvement in apoe4 cases. |
2020-01-23 |
2023-08-13 |
Not clear |
| Atsushi Sawamoto, Satoshi Okuyama, Mitsunari Nakajima, Yoshiko Furukaw. Citrus flavonoid 3,5,6,7,8,3',4'-heptamethoxyflavone induces BDNF via cAMP/ERK/CREB signaling and reduces phosphodiesterase activity in C6 cells. Pharmacological reports : PR. vol 71. issue 4. 2020-01-16. PMID:31195342. |
brain-derived neurotrophic factor (bdnf) is associated with onset of several central nervous system disorders, e.g., parkinson's disease, alzheimer's disease, depression, epilepsy, and chronic pain. |
2020-01-16 |
2023-08-13 |
mouse |
| Elisa Conti, Denise Grana, Giovanni Stefanoni, Alberto Corsini, Margherita Botta, Paolo Magni, Angelo Aliprandi, Christian Lunetta, Ildebrando Appollonio, Carlo Ferrarese, Lucio Tremolizz. Irisin and BDNF serum levels and behavioral disturbances in Alzheimer's disease. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 40. issue 6. 2019-12-02. PMID:30810826. |
irisin and bdnf serum levels and behavioral disturbances in alzheimer's disease. |
2019-12-02 |
2023-08-13 |
Not clear |
| Ekaterina Eremenko, Kritika Mittal, Omer Berner, Nikita Kamenetsky, Anna Nemirovsky, Yehezqel Elyahu, Alon Monsoneg. BDNF-producing, amyloid β-specific CD4 T cells as targeted drug-delivery vehicles in Alzheimer's disease. EBioMedicine. vol 43. 2019-11-25. PMID:31085101. |
as brain-derived neurotrophic factor (bdnf) is reduced in the brain of people with alzheimer's disease (ad) and its administration has shown promising therapeutic effects in mouse model of the disease, we generated a novel platform for t cell-based bdnf delivery into the brain parenchyma. |
2019-11-25 |
2023-08-13 |
mouse |
| Ekaterina Rogaeva, Gerold Schmitt-Ulm. Does BDNF Val66Met contribute to preclinical Alzheimer's disease? Brain : a journal of neurology. vol 139. issue Pt 10. 2019-11-20. PMID:27671028. |
does bdnf val66met contribute to preclinical alzheimer's disease? |
2019-11-20 |
2023-08-13 |
Not clear |
| Sergio M G Solinas, Elke Edelmann, Volkmar Leßmann, Michele Miglior. A kinetic model for Brain-Derived Neurotrophic Factor mediated spike timing-dependent LTP. PLoS computational biology. vol 15. issue 4. 2019-11-12. PMID:31017891. |
accordingly, bdnf signaling dysfunctions are associated with many neurological and neurodegenerative conditions including alzheimer's and huntington's disease. |
2019-11-12 |
2023-08-13 |
mouse |
| Minh Bao Huynh, Mohand Ouidir Ouidja, Sandrine Chantepie, Gilles Carpentier, Auriane Maïza, Ganlin Zhang, Joao Vilares, Rita Raisman-Vozari, Dulce Papy-Garci. Glycosaminoglycans from Alzheimer's disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau. PloS one. vol 14. issue 1. 2019-11-04. PMID:30608949. |
here, we show that total sulfated gags from hippocampus of alzheimer's disease have altered capacities to bind and potentiate the activities of growth factors including fgf-2, vegf, and bdnf while their capacity to bind to tau is remarkable increased. |
2019-11-04 |
2023-08-13 |
Not clear |
| Maria Laura Giuffrida, Agata Copani, Enrico Rizzarell. A promising connection between BDNF and Alzheimer's disease. Aging. vol 10. issue 8. 2019-10-04. PMID:30082505. |
a promising connection between bdnf and alzheimer's disease. |
2019-10-04 |
2023-08-13 |
Not clear |
| Yen Ying Lim, Jason Hassenstab, Alison Goate, Anne M Fagan, Tammie L S Benzinger, Carlos Cruchaga, Eric McDade, Jasmeer Chhatwal, Johannes Levin, Martin R Farlow, Neill R Graff-Radford, Christoph Laske, Colin L Masters, Stephen Salloway, Peter Schofield, John C Morris, Paul Maruff, Randall J Batema. Effect of BDNFVal66Met on disease markers in dominantly inherited Alzheimer's disease. Annals of neurology. vol 84. issue 3. 2019-08-22. PMID:30014553. |
previous studies suggest that the brain-derived neurotrophic factor (bdnf) val66met (rs6265) polymorphism may influence symptom onset in alzheimer's disease (ad). |
2019-08-22 |
2023-08-13 |
Not clear |