| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' I Ferrer, C Mar\\xc3\\xadn, M J Rey, T Ribalta, E Goutan, R Blanco, E Tolosa, E Mart\\xc3\\xa. BDNF and full-length and truncated TrkB expression in Alzheimer disease. Implications in therapeutic strategies. Journal of neuropathology and experimental neurology. vol 58. issue 7. 1999-07-27. PMID:10411343.' |
bdnf and full-length and truncated trkb expression in alzheimer disease. |
1999-07-27 |
2023-08-12 |
human |
| b' I Ferrer, C Mar\\xc3\\xadn, M J Rey, T Ribalta, E Goutan, R Blanco, E Tolosa, E Mart\\xc3\\xa. BDNF and full-length and truncated TrkB expression in Alzheimer disease. Implications in therapeutic strategies. Journal of neuropathology and experimental neurology. vol 58. issue 7. 1999-07-27. PMID:10411343.' |
brain-derived neurotrophic factor (bdnf), and full-length and truncated tyrosin kinase b receptor (trkb) protein expression were examined by western blotting and immunohistochemistry in the frontal cortex and hippocampus of individuals affected by long-lasting severe alzheimer disease (ad) and age-matched controls. |
1999-07-27 |
2023-08-12 |
human |
| S D Croll, N Y Ip, R M Lindsay, S J Wiegan. Expression of BDNF and trkB as a function of age and cognitive performance. Brain research. vol 812. issue 1-2. 1999-02-10. PMID:9813325. |
the expression of the neurotrophic factor bdnf increases during learning-related events and is decreased in the hippocampus of alzheimer's disease patients, suggesting that it plays a role in learning, memory, and/or age-related memory deficits. |
1999-02-10 |
2023-08-12 |
rat |
| E Bednarski, J C Lauterborn, C M Gall, G Lync. Lysosomal dysfunction reduces brain-derived neurotrophic factor expression. Experimental neurology. vol 150. issue 1. 1998-04-14. PMID:9514826. |
brain-derived neurotrophic factor (bdnf) expression in hippocampus and cortex is considerably reduced in alzheimer's disease. |
1998-04-14 |
2023-08-12 |
Not clear |
| B Connor, D Young, Q Yan, R L Faull, B Synek, M Draguno. Brain-derived neurotrophic factor is reduced in Alzheimer's disease. Brain research. Molecular brain research. vol 49. issue 1-2. 1998-02-11. PMID:9387865. |
consistent with this hypothesis, a reduction in bdnf mrna expression has been observed in human post-mortem alzheimer's disease hippocampi. |
1998-02-11 |
2023-08-12 |
human |
| B Connor, D Young, Q Yan, R L Faull, B Synek, M Draguno. Brain-derived neurotrophic factor is reduced in Alzheimer's disease. Brain research. Molecular brain research. vol 49. issue 1-2. 1998-02-11. PMID:9387865. |
to further investigate this observation, we examined whether the alteration in bdnf expression also occurred at the protein level in human post-mortem alzheimer's disease hippocampi and temporal cortices using immunohistochemical techniques. |
1998-02-11 |
2023-08-12 |
human |
| B Connor, D Young, Q Yan, R L Faull, B Synek, M Draguno. Brain-derived neurotrophic factor is reduced in Alzheimer's disease. Brain research. Molecular brain research. vol 49. issue 1-2. 1998-02-11. PMID:9387865. |
these results support and extend previous findings that bdnf mrna is reduced in the human alzheimer's disease hippocampus and temporal cortex, and suggest that a loss of bdnf may contribute to the progressive atrophy of neurons in alzheimer's disease. |
1998-02-11 |
2023-08-12 |
human |
| M Dragunow, P Hughes, S E Mason-Parker, P Lawlor, W C Abraha. TrkB expression in dentate granule cells is associated with a late phase of long-term potentiation. Brain research. Molecular brain research. vol 46. issue 1-2. 1997-08-05. PMID:9191102. |
thus, both bdnf and its receptor trkb are induced in granule cells by stimulation that produces durable ltp, suggesting that this neurotrophin and its receptor play an important role in memory formation and may be suitable targets for the development of cognitive-enhancing drugs in the treatment of diseases, such as alzheimer's. |
1997-08-05 |
2023-08-12 |
Not clear |
| W M Purcell, C Westgate, C K Atterwil. Rat brain mast cells: an in vitro paradigm for assessing the toxic effects of neurotropic therapeutics. Neurotoxicology. vol 17. issue 3-4. 1997-06-23. PMID:9086508. |
neurotrophic factors (ntfs) such as nerve growth factor (ngf), brain-derived neurotrophic factor (bdnf) and ciliary neurotrophic factor (cntf) are currently being explored as novel therapeutics in a range of neurodegenerative disorders such as amyotrophic lateral sclerosis (als) and alzheimer's disease. |
1997-06-23 |
2023-08-12 |
rat |
| M Narisawa-Saito, K Wakabayashi, S Tsuji, H Takahashi, H Naw. Regional specificity of alterations in NGF, BDNF and NT-3 levels in Alzheimer's disease. Neuroreport. vol 7. issue 18. 1997-04-18. PMID:9116211. |
regional specificity of alterations in ngf, bdnf and nt-3 levels in alzheimer's disease. |
1997-04-18 |
2023-08-12 |
Not clear |
| M Narisawa-Saito, K Wakabayashi, S Tsuji, H Takahashi, H Naw. Regional specificity of alterations in NGF, BDNF and NT-3 levels in Alzheimer's disease. Neuroreport. vol 7. issue 18. 1997-04-18. PMID:9116211. |
using two-site enzyme immunoassays (eias), we measured the levels of neurotrophins, nerve growth factor (ngf), brain-derived neurotrophic factor (bdnf) and neurotrophin-3 (nt-3) simultaneously in three brain regions (motor cortex, dentate gyrus and entorhinal cortex) of patients with alzheimer's disease (ad) and control individuals. |
1997-04-18 |
2023-08-12 |
Not clear |
| F Boissière, B Faucheux, Y Agid, E C Hirsc. Expression of catalytic trkB gene in the striatum and the basal forebrain of patients with Alzheimer's disease: an in situ hybridization study. Neuroscience letters. vol 221. issue 2-3. 1997-04-18. PMID:9121684. |
the expression of catalytic trkb gene, encoding for the high affinity brain-derived neurotrophic factor (bdnf) and neurotrophin-4/5 (nt-4/5) receptor, was studied post mortem in the striatum and the nucleus basalis of meynert of patients with alzheimer's disease (ad) and control subjects, using in situ hybridization coupled with choline acetyltransferase immunohistochemistry. |
1997-04-18 |
2023-08-12 |
human |
| M Narisawa-Saito, H Naw. Differential regulation of hippocampal neurotrophins during aging in rats. Journal of neurochemistry. vol 67. issue 3. 1996-10-02. PMID:8752119. |
changes in the expression of bdnf mrna and ngf protein were opposite to those reported to occur in alzheimer's disease. |
1996-10-02 |
2023-08-12 |
rat |
| W J Friedman, I B Black, H Persson, C F Ibáñe. Synergistic trophic actions on rat basal forebrain neurons revealed by a synthetic NGF/BDNF chimaeric molecule. The European journal of neuroscience. vol 7. issue 4. 1995-08-30. PMID:7620616. |
basal forebrain cholinergic neurons, which degenerate in alzheimer's disease, respond to multiple trophic factors, including the neurotrophins, nerve growth factor (ngf) and brain-derived neurotrophic factor (bdnf). |
1995-08-30 |
2023-08-12 |
rat |
| R M Lindsa. Neurotrophic growth factors and neurodegenerative diseases: therapeutic potential of the neurotrophins and ciliary neurotrophic factor. Neurobiology of aging. vol 15. issue 2. 1995-02-27. PMID:7838303. |
initial animal studies with bdnf indicate efficacy of bdnf in models of alzheimer's and parkinson's disease and small fiber sensory neuropathy. |
1995-02-27 |
2023-08-12 |
Not clear |
| H Thoenen, F Zafra, B Hengerer, D Lindhol. The synthesis of nerve growth factor and brain-derived neurotrophic factor in hippocampal and cortical neurons is regulated by specific transmitter systems. Annals of the New York Academy of Sciences. vol 640. 1992-02-28. PMID:1776765. |
the regulation of ngf and bdnf synthesis via specific transmitter systems is discussed in the context of the refined tuning of synaptic functions, the potential implications for memory functions, and the possible therapeutic consequences for the treatment of alzheimer's disease. |
1992-02-28 |
2023-08-11 |
Not clear |
| H S Phillips, J M Hains, M Armanini, G R Laramee, S A Johnson, J W Winslo. BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease. Neuron. vol 7. issue 5. 1992-01-14. PMID:1742020. |
bdnf mrna is decreased in the hippocampus of individuals with alzheimer's disease. |
1992-01-14 |
2023-08-11 |
Not clear |