| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Saila Vepsäläinen, Eero Castren, Seppo Helisalmi, Susan Iivonen, Arto Mannermaa, Maarit Lehtovirta, Tuomo Hänninen, Hilkka Soininen, Mikko Hiltune. Genetic analysis of BDNF and TrkB gene polymorphisms in Alzheimer's disease. Journal of neurology. vol 252. issue 4. 2005-12-15. PMID:15726264. |
according to previous biochemical and genetic findings, brain-derived neurotrophic factor (bdnf), via activation of its tyrosine kinase receptor b (trkb), is considered as a plausible candidate for contributing to alzheimer's disease (ad). |
2005-12-15 |
2023-08-12 |
human |
| Y Li, C Rowland, K Tacey, J Catanese, J Sninsky, J Hardy, J Powell, S Lovestone, J C Morris, L Thal, A Goate, M Owen, J Williams, A Grup. The BDNF Val66Met polymorphism is not associated with late onset Alzheimer's disease in three case-control samples. Molecular psychiatry. vol 10. issue 9. 2005-11-08. PMID:15970929. |
the bdnf val66met polymorphism is not associated with late onset alzheimer's disease in three case-control samples. |
2005-11-08 |
2023-08-12 |
Not clear |
| Masataka Nishimura, Sadako Kuno, Ryuji Kaji, Hideshi Kawakam. Brain-derived neurotrophic factor gene polymorphisms in Japanese patients with sporadic Alzheimer's disease, Parkinson's disease, and multiple system atrophy. Movement disorders : official journal of the Movement Disorder Society. vol 20. issue 8. 2005-10-19. PMID:15838855. |
we studied two genetic polymorphisms (240c/t and 480g/a) of the brain-derived neurotrophic factor (bdnf) gene in japanese patients with alzheimer's disease (ad, n = 172), parkinson's disease (pd, n = 327), and multiple system atrophy (msa, n = 122), as well as controls (n = 275). |
2005-10-19 |
2023-08-12 |
Not clear |
| Jian-Tao Bian, Jun-Wu Zhang, Zhen-Xin Zhang, Hua-Lu Zha. Association analysis of brain-derived neurotrophic factor (BDNF) gene 196 A/G polymorphism with Alzheimer's disease (AD) in mainland Chinese. Neuroscience letters. vol 387. issue 1. 2005-10-13. PMID:16054753. |
association analysis of brain-derived neurotrophic factor (bdnf) gene 196 a/g polymorphism with alzheimer's disease (ad) in mainland chinese. |
2005-10-13 |
2023-08-12 |
Not clear |
| Jian-Tao Bian, Jun-Wu Zhang, Zhen-Xin Zhang, Hua-Lu Zha. Association analysis of brain-derived neurotrophic factor (BDNF) gene 196 A/G polymorphism with Alzheimer's disease (AD) in mainland Chinese. Neuroscience letters. vol 387. issue 1. 2005-10-13. PMID:16054753. |
a functional polymorphism in the coding region of brain-derived neurotrophic factor (bdnf) gene (196 a/g, met66val) has recently been reported to be associated with alzheimer's disease (ad) and with an overrepresentation of g allele in ad patients, but different results have also been presented. |
2005-10-13 |
2023-08-12 |
Not clear |
| Sophie Pezet, Marzia Malcangi. Brain-derived neurotrophic factor as a drug target for CNS disorders. Expert opinion on therapeutic targets. vol 8. issue 5. 2005-08-22. PMID:15469390. |
this review aims to correlate the features of some cns disorders (parkinson's disease, alzheimer's disease, depression, epilepsy and chronic pain) to changes in bdnf expression in the brain. |
2005-08-22 |
2023-08-12 |
Not clear |
| Shiyong Peng, Joanne Wuu, Elliott J Mufson, Margaret Fahnestoc. Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease. Journal of neurochemistry. vol 93. issue 6. 2005-08-02. PMID:15935057. |
brain-derived neurotrophic factor (bdnf) is critical for the function and survival of neurons that degenerate in the late stage of alzheimer's disease (ad). |
2005-08-02 |
2023-08-12 |
human |
| Diane Olin, James MacMurray, David E Coming. Risk of late-onset Alzheimer's disease associated with BDNF C270T polymorphism. Neuroscience letters. vol 381. issue 3. 2005-07-26. PMID:15896483. |
risk of late-onset alzheimer's disease associated with bdnf c270t polymorphism. |
2005-07-26 |
2023-08-12 |
human |
| Diane Olin, James MacMurray, David E Coming. Risk of late-onset Alzheimer's disease associated with BDNF C270T polymorphism. Neuroscience letters. vol 381. issue 3. 2005-07-26. PMID:15896483. |
our objective was to determine if there is an association between the bdnf gene and alzheimer's disease (ad) in a us population. |
2005-07-26 |
2023-08-12 |
human |
| Jung Lee, Hiroaki Fukumoto, Jennifer Orne, Jochen Klucken, Susan Raju, Charles R Vanderburg, Michael C Irizarry, Bradley T Hyman, Martin Ingelsso. Decreased levels of BDNF protein in Alzheimer temporal cortex are independent of BDNF polymorphisms. Experimental neurology. vol 194. issue 1. 2005-07-15. PMID:15899246. |
decreased levels of bdnf protein in alzheimer temporal cortex are independent of bdnf polymorphisms. |
2005-07-15 |
2023-08-12 |
human |
| Jung Lee, Hiroaki Fukumoto, Jennifer Orne, Jochen Klucken, Susan Raju, Charles R Vanderburg, Michael C Irizarry, Bradley T Hyman, Martin Ingelsso. Decreased levels of BDNF protein in Alzheimer temporal cortex are independent of BDNF polymorphisms. Experimental neurology. vol 194. issue 1. 2005-07-15. PMID:15899246. |
levels of brain-derived neurotrophic factor (bdnf) are reduced in specific brain regions in alzheimer's disease (ad) and bdnf gene polymorphisms have been suggested to influence ad risk, hippocampal function, and memory. |
2005-07-15 |
2023-08-12 |
human |
| Purnima Desai, Robert Nebes, Steven T DeKosky, M Ilyas Kambo. Investigation of the effect of brain-derived neurotrophic factor (BDNF) polymorphisms on the risk of late-onset Alzheimer's disease (AD) and quantitative measures of AD progression. Neuroscience letters. vol 379. issue 3. 2005-06-24. PMID:15843069. |
investigation of the effect of brain-derived neurotrophic factor (bdnf) polymorphisms on the risk of late-onset alzheimer's disease (ad) and quantitative measures of ad progression. |
2005-06-24 |
2023-08-12 |
human |
| Helen E Scharfman, Neil J Maclusk. Similarities between actions of estrogen and BDNF in the hippocampus: coincidence or clue? Trends in neurosciences. vol 28. issue 2. 2005-04-25. PMID:15667930. |
furthermore, disruption of the relationship between estrogen and bdnf could contribute to neurological and psychiatric disorders that have been associated with the hippocampus, such as alzheimer's disease, depression and epilepsy. |
2005-04-25 |
2023-08-12 |
Not clear |
| Benedetta Nacmias, Carolina Piccini, Silvia Bagnoli, Andrea Tedde, Elena Cellini, Laura Bracco, Sandro Sorb. Brain-derived neurotrophic factor, apolipoprotein E genetic variants and cognitive performance in Alzheimer's disease. Neuroscience letters. vol 367. issue 3. 2004-12-17. PMID:15337270. |
to investigate the effect of bdnf and apoe polymorphisms on the cognitive profile of mild-moderate alzheimer's disease (ad) cases, ad patients, genotyped for apoe and bdnf polymorphisms, underwent extensive neuropsychological investigation. |
2004-12-17 |
2023-08-12 |
Not clear |
| Mark P Mattson, Stuart Maudsley, Bronwen Marti. BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends in neurosciences. vol 27. issue 10. 2004-11-30. PMID:15374669. |
impaired 5-ht and bdnf signaling is central to depression and anxiety disorders, but could also play important roles in the pathogenesis of several age-related disorders, including insulin resistance syndrome, alzheimer's disease and huntington's disease. |
2004-11-30 |
2023-08-12 |
Not clear |
| Motoharu Hayash. [Molecular mechanisms for the development and aging of the primate central nervous system]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 24. issue 4. 2004-11-30. PMID:15484819. |
similar reductions of gene expressions of srif and bdnf in the brains of the patients with alzheimer's disease, suggest that aged monkeys are good model animals for these neuro-degenerative diseases. |
2004-11-30 |
2023-08-12 |
monkey |
| Guido J Burbach, Rainer Hellweg, Carola A Haas, Domenico Del Turco, Uwe Deicke, Dorothee Abramowski, Mathias Jucker, Matthias Staufenbiel, Thomas Delle. Induction of brain-derived neurotrophic factor in plaque-associated glial cells of aged APP23 transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 10. 2004-05-28. PMID:15014117. |
changes in bdnf expression have also been reported during the course of several neurological disorders, including alzheimer's disease (ad). |
2004-05-28 |
2023-08-12 |
mouse |
| Shih-Jen Tsai, Chen-Jee Hong, Hsiu-Chih Liu, Tsung-Yun Liu, Li-En Hsu, Ching-Hua Li. Association analysis of brain-derived neurotrophic factor Val66Met polymorphisms with Alzheimer's disease and age of onset. Neuropsychobiology. vol 49. issue 1. 2004-03-08. PMID:14730194. |
because of a decrease in central brain-derived neurotrophic factor (bdnf) levels in alzheimer's disease (ad) and the important role of bdnf in neuronal survival, bdnf may represent a candidate gene conferring susceptibility to ad. |
2004-03-08 |
2023-08-12 |
Not clear |
| Bernadeta Michalski, Margaret Fahnestoc. Pro-brain-derived neurotrophic factor is decreased in parietal cortex in Alzheimer's disease. Brain research. Molecular brain research. vol 111. issue 1-2. 2003-07-16. PMID:12654514. |
brain-derived neurotrophic factor (bdnf) promotes the function and survival of the major neuronal types affected in alzheimer disease, such as hippocampal, cortical and basal forebrain cholinergic neurons. |
2003-07-16 |
2023-08-12 |
human |
| Bernadeta Michalski, Margaret Fahnestoc. Pro-brain-derived neurotrophic factor is decreased in parietal cortex in Alzheimer's disease. Brain research. Molecular brain research. vol 111. issue 1-2. 2003-07-16. PMID:12654514. |
we and others have demonstrated a reduction in bdnf mrna expression in alzheimer's disease hippocampus and cortex, which may help to explain the selective vulnerability of these neurons. |
2003-07-16 |
2023-08-12 |
human |