| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pirjo Komulainen, Maria Pedersen, Tuomo Hänninen, Helle Bruunsgaard, Timo A Lakka, Miia Kivipelto, Maija Hassinen, Tuomas H Rauramaa, Bente K Pedersen, Rainer Raurama. BDNF is a novel marker of cognitive function in ageing women: the DR's EXTRA Study. Neurobiology of learning and memory. vol 90. issue 4. 2009-02-13. PMID:18707012. |
while low circulating levels of bdnf have been suggested to predispose to alzheimer's disease, very little data are available on its association with cognitive function in general population. |
2009-02-13 |
2023-08-12 |
human |
| Arianna Cozza, Erika Melissari, Paola Iacopetti, Veronica Mariotti, Andrea Tedde, Benedetta Nacmias, Angela Conte, Sandro Sorbi, Silvia Pellegrin. SNPs in neurotrophin system genes and Alzheimer's disease in an Italian population. Journal of Alzheimer's disease : JAD. vol 15. issue 1. 2008-11-18. PMID:18780967. |
increasing evidence suggests a role for nerve growth factor (ngfb), brain-derived neurotrophic factor (bdnf), and their receptors, nerve growth factor receptor (ngfr), and neurotrophin tyrosine kinase receptors 1 and 2 (ntrk1 and ntrk2), in alzheimer's disease (ad). |
2008-11-18 |
2023-08-12 |
Not clear |
| A G Xuan, D H Long, H G Gu, D D Yang, L P Hong, S L Len. BDNF improves the effects of neural stem cells on the rat model of Alzheimer's disease with unilateral lesion of fimbria-fornix. Neuroscience letters. vol 440. issue 3. 2008-11-05. PMID:18579298. |
bdnf improves the effects of neural stem cells on the rat model of alzheimer's disease with unilateral lesion of fimbria-fornix. |
2008-11-05 |
2023-08-12 |
rat |
| Hui Yu, Zhijun Zhang, Yongmei Shi, Feng Bai, Chunming Xie, Yun Qian, Yonggui Yuan, Linglong Den. Association study of the decreased serum BDNF concentrations in amnestic mild cognitive impairment and the Val66Met polymorphism in Chinese Han. The Journal of clinical psychiatry. vol 69. issue 7. 2008-09-09. PMID:18505307. |
experimental and clinical data suggested that brain-derived neurotrophic factor (bdnf) plays an important role in the pathogenesis of alzheimer's disease (ad). |
2008-09-09 |
2023-08-12 |
Not clear |
| Zhaohui Liu, Dongliang Ma, Gaifeng Feng, Yanbing Ma, Haitao H. Recombinant AAV-mediated expression of human BDNF protects neurons against cell apoptosis in Abeta-induced neuronal damage model. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 27. issue 3. 2008-07-02. PMID:17641830. |
the viral vector-mediated gene expression of bdnf may pave the way of a novel therapeutic strategy for the treatment of neurodegenerative diseases such as alzheimer's disease. |
2008-07-02 |
2023-08-12 |
human |
| Italo Mocchetti, Milton Brow. Targeting neurotrophin receptors in the central nervous system. CNS & neurological disorders drug targets. vol 7. issue 1. 2008-07-02. PMID:18289034. |
the ability of small molecules to mimic bdnf has a potential therapeutic importance in preventing neuronal damage in several chronic neurodegenerative diseases including parkinson's disease, alzheimer's disease, and aids dementia. |
2008-07-02 |
2023-08-12 |
Not clear |
| T Leyhe, Elke Stransky, G W Eschweiler, G Buchkremer, C Lask. Increase of BDNF serum concentration during donepezil treatment of patients with early Alzheimer's disease. European archives of psychiatry and clinical neuroscience. vol 258. issue 2. 2008-05-15. PMID:17990049. |
increase of bdnf serum concentration during donepezil treatment of patients with early alzheimer's disease. |
2008-05-15 |
2023-08-12 |
Not clear |
| Yinghui Hu, Shelley J Russe. BDNF and the diseased nervous system: a delicate balance between adaptive and pathological processes of gene regulation. Journal of neurochemistry. vol 105. issue 1. 2008-04-28. PMID:18208542. |
bdnf has emerged as one of the most important signaling molecules for the developing nervous system as well as the impaired nervous system, and multiple diseases, such as alzheimer's, parkinson's, huntington's, epilepsy, rett's syndrome, and psychiatric depression, are linked by their association with potential dysregulation of bdnf-driven signal transduction programs. |
2008-04-28 |
2023-08-12 |
Not clear |
| Frank M Longo, Tao Yang, Juliet K Knowles, Youmei Xie, Laura A Moore, Stephen M Mass. Small molecule neurotrophin receptor ligands: novel strategies for targeting Alzheimer's disease mechanisms. Current Alzheimer research. vol 4. issue 5. 2008-03-21. PMID:18220511. |
a number of factors limit the therapeutic application of neurotrophin proteins, such as nerve growth factor (ngf) and brain-derived growth factor (bdnf), for alzheimer's and other neurodegenerative diseases. |
2008-03-21 |
2023-08-12 |
Not clear |
| Clive R Bramha. Control of synaptic consolidation in the dentate gyrus: mechanisms, functions, and therapeutic implications. Progress in brain research. vol 163. 2008-03-14. PMID:17765733. |
dysregulation of bdnf synthesis and arc function, specifically within the dentate gyrus, is linked to behavioral symptoms and cognitive deficits in animal models of depression and alzheimer's disease. |
2008-03-14 |
2023-08-12 |
rat |
| Megan E Kozisek, David Middlemas, David B Bylun. Brain-derived neurotrophic factor and its receptor tropomyosin-related kinase B in the mechanism of action of antidepressant therapies. Pharmacology & therapeutics. vol 117. issue 1. 2008-03-11. PMID:17949819. |
clinical studies demonstrate an association between bdnf levels and several disorders, including depression, epilepsy, bipolar disorder, parkinson's and alzheimer's diseases. |
2008-03-11 |
2023-08-12 |
Not clear |
| Xiao-ming He, Zhen-xin Zhang, Jun-wu Zhang, Yong-tao Zhou, Mou-ni Tang, Cheng-bin Wu, Zhen Hon. Lack of association between the BDNF gene Val66Met polymorphism and Alzheimer disease in a Chinese Han population. Neuropsychobiology. vol 55. issue 3-4. 2007-12-03. PMID:17657167. |
lack of association between the bdnf gene val66met polymorphism and alzheimer disease in a chinese han population. |
2007-12-03 |
2023-08-12 |
Not clear |
| Fabrice Guillemot, Italina Cerutti, Charles Auffray, Marie-Dominique Devigne. A transgenic mouse model engineered to investigate human brain-derived neurotrophic factor in vivo. Transgenic research. vol 16. issue 2. 2007-10-03. PMID:17225071. |
brain-derived neurotrophic factor (bdnf) is an attractive component for the treatment of various neurodegenerative diseases such as alzheimer's or parkinson's disease. |
2007-10-03 |
2023-08-12 |
mouse |
| K S Krabbe, A R Nielsen, R Krogh-Madsen, P Plomgaard, P Rasmussen, C Erikstrup, C P Fischer, B Lindegaard, A M W Petersen, S Taudorf, N H Secher, H Pilegaard, H Bruunsgaard, B K Pederse. Brain-derived neurotrophic factor (BDNF) and type 2 diabetes. Diabetologia. vol 50. issue 2. 2007-09-26. PMID:17151862. |
decreased levels of brain-derived neurotrophic factor (bdnf) have been implicated in the pathogenesis of alzheimer's disease and depression. |
2007-09-26 |
2023-08-12 |
human |
| J Garcia de Yebenes, J Yebenes, M A Men. Neurotrophic factors in neurodegenerative disorders: model of Parkinson's disease. Neurotoxicity research. vol 2. issue 2-3. 2007-07-09. PMID:16787836. |
those compounds have been used in humans for several neurological disorders including amyotrophic lateral sclerosis--ciliary derived neurotrophic factor (cntf) and brain derived neurotrophic factor (bdnf), alzheimer's disease and peripheral neuropathy--nerve growth factor (ngf) and parkinson's disease (pd)--glial derived neurotrophic factor (gdnf). |
2007-07-09 |
2023-08-12 |
human |
| Chiara Zuccato, Elena Cattane. Role of brain-derived neurotrophic factor in Huntington's disease. Progress in neurobiology. vol 81. issue 5-6. 2007-07-06. PMID:17379385. |
bdnf is a small dimeric protein that is widely expressed in adult mammalian brain and has been shown to promote the survival of all major neuronal types affected in alzheimer's disease (ad) and parkinson's disease (pd). |
2007-07-06 |
2023-08-12 |
mouse |
| Shih-Jen Tsa. Statins may enhance the proteolytic cleavage of proBDNF: implications for the treatment of depression. Medical hypotheses. vol 68. issue 6. 2007-07-03. PMID:17097821. |
furthermore, bdnf dysfunction has also been implicated in several other neuropsychiatric diseases, such as alzheimer's disease, attention-deficit hyperactivity disorder and rett syndrome. |
2007-07-03 |
2023-08-12 |
Not clear |
| C Laske, E Stransky, T Leyhe, G W Eschweiler, A Wittorf, E Richartz, M Bartels, G Buchkremer, K Schot. Stage-dependent BDNF serum concentrations in Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 9. 2007-05-02. PMID:16362629. |
stage-dependent bdnf serum concentrations in alzheimer's disease. |
2007-05-02 |
2023-08-12 |
Not clear |
| C Laske, E Stransky, T Leyhe, G W Eschweiler, A Wittorf, E Richartz, M Bartels, G Buchkremer, K Schot. Stage-dependent BDNF serum concentrations in Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 9. 2007-05-02. PMID:16362629. |
levels of bdnf were below the detection limit of the assay in unconcentrated csf samples of ad patients and non-demendet controls.in summary, bdnf serum values are increased in early stages of alzheimer's disease, which may reflect a compensatory repair mechanism in early neurodegeneration and could also contribute to increased degradation of beta-amyloid (abeta). |
2007-05-02 |
2023-08-12 |
Not clear |
| C Laske, E Stransky, T Leyhe, G W Eschweiler, A Wittorf, E Richartz, M Bartels, G Buchkremer, K Schot. Stage-dependent BDNF serum concentrations in Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 9. 2007-05-02. PMID:16362629. |
bdnf should be further evaluated as a candidate marker for clinical diagnosis and therapeutic monitoring in alzheimer's disease. |
2007-05-02 |
2023-08-12 |
Not clear |