| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Filippo Caraci, Agata Copani, Ferdinando Nicoletti, Filippo Drag. Depression and Alzheimer's disease: neurobiological links and common pharmacological targets. European journal of pharmacology. vol 626. issue 1. 2010-03-26. PMID:19837057. |
in particular, a specific impairment in the signaling of some neurotrophins such as transforming-growth-factor beta1 (tgf-beta1) and brain-derived neurotrophic factor (bdnf) has been observed both in depression and alzheimer's disease. |
2010-03-26 |
2023-08-12 |
Not clear |
| Noriko Fukumoto, Takashi Fujii, Onofre Combarros, M Ilyas Kamboh, Shin-Jen Tsai, Sachio Matsushita, Benedetta Nacmias, David E Comings, Humberto Arboleda, Martin Ingelsson, Bradley T Hyman, Hiroyasu Akatsu, Andrew Grupe, Agnes Lumi Nishimura, Mayana Zatz, Kari M Mattila, Juha Rinne, Yu-ichi Goto, Takashi Asada, Shun Nakamura, Hiroshi Kunug. Sexually dimorphic effect of the Val66Met polymorphism of BDNF on susceptibility to Alzheimer's disease: New data and meta-analysis. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 153B. issue 1. 2010-03-23. PMID:19504537. |
sexually dimorphic effect of the val66met polymorphism of bdnf on susceptibility to alzheimer's disease: new data and meta-analysis. |
2010-03-23 |
2023-08-12 |
Not clear |
| Noriko Fukumoto, Takashi Fujii, Onofre Combarros, M Ilyas Kamboh, Shin-Jen Tsai, Sachio Matsushita, Benedetta Nacmias, David E Comings, Humberto Arboleda, Martin Ingelsson, Bradley T Hyman, Hiroyasu Akatsu, Andrew Grupe, Agnes Lumi Nishimura, Mayana Zatz, Kari M Mattila, Juha Rinne, Yu-ichi Goto, Takashi Asada, Shun Nakamura, Hiroshi Kunug. Sexually dimorphic effect of the Val66Met polymorphism of BDNF on susceptibility to Alzheimer's disease: New data and meta-analysis. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 153B. issue 1. 2010-03-23. PMID:19504537. |
conflicting results have been reported as to whether genetic variations (val66met and c270t) of the brain-derived neurotrophic factor gene (bdnf) confer susceptibility to alzheimer's disease (ad). |
2010-03-23 |
2023-08-12 |
Not clear |
| Bente K Pedersen, Maria Pedersen, Karen S Krabbe, Helle Bruunsgaard, Vance B Matthews, Mark A Febbrai. Role of exercise-induced brain-derived neurotrophic factor production in the regulation of energy homeostasis in mammals. Experimental physiology. vol 94. issue 12. 2010-01-18. PMID:19748969. |
low levels of bdnf are found in patients with neurodegenerative diseases, including alzheimer's disease and major depression. |
2010-01-18 |
2023-08-12 |
Not clear |
| Agnes Fehér, Anna Juhász, Agnes Rimanóczy, János Kálmán, Zoltán Jank. Association between BDNF Val66Met polymorphism and Alzheimer disease, dementia with Lewy bodies, and Pick disease. Alzheimer disease and associated disorders. vol 23. issue 3. 2010-01-08. PMID:19812463. |
association between bdnf val66met polymorphism and alzheimer disease, dementia with lewy bodies, and pick disease. |
2010-01-08 |
2023-08-12 |
Not clear |
| Tamara Aid-Pavlidis, Pavlos Pavlidis, Tõnis Timmus. Meta-coexpression conservation analysis of microarray data: a "subset" approach provides insight into brain-derived neurotrophic factor regulation. BMC genomics. vol 10. 2009-10-30. PMID:19737418. |
alterations in brain-derived neurotrophic factor (bdnf) gene expression contribute to serious pathologies such as depression, epilepsy, cancer, alzheimer's, huntington and parkinson's disease. |
2009-10-30 |
2023-08-12 |
Not clear |
| B Borroni, S Archetti, C Costanzi, M Grassi, M Ferrari, A Radeghieri, L Caimi, C Caltagirone, M Di Luca, A Padovan. Role of BDNF Val66Met functional polymorphism in Alzheimer's disease-related depression. Neurobiology of aging. vol 30. issue 9. 2009-10-09. PMID:18179845. |
role of bdnf val66met functional polymorphism in alzheimer's disease-related depression. |
2009-10-09 |
2023-08-12 |
Not clear |
| B Borroni, S Archetti, C Costanzi, M Grassi, M Ferrari, A Radeghieri, L Caimi, C Caltagirone, M Di Luca, A Padovan. Role of BDNF Val66Met functional polymorphism in Alzheimer's disease-related depression. Neurobiology of aging. vol 30. issue 9. 2009-10-09. PMID:18179845. |
no study has investigated the role of bdnf genetic variation and depressive symptoms in alzheimer's disease (ad). |
2009-10-09 |
2023-08-12 |
Not clear |
| Mathew Blurton-Jones, Masashi Kitazawa, Hilda Martinez-Coria, Nicholas A Castello, Franz-Josef Müller, Jeanne F Loring, Tritia R Yamasaki, Wayne W Poon, Kim N Green, Frank M LaFerl. Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 32. 2009-09-21. PMID:19633196. |
neural stem cells improve cognition via bdnf in a transgenic model of alzheimer disease. |
2009-09-21 |
2023-08-12 |
mouse |
| Mathew Blurton-Jones, Masashi Kitazawa, Hilda Martinez-Coria, Nicholas A Castello, Franz-Josef Müller, Jeanne F Loring, Tritia R Yamasaki, Wayne W Poon, Kim N Green, Frank M LaFerl. Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 32. 2009-09-21. PMID:19633196. |
taken together, our findings demonstrate that neural stem cells can ameliorate complex behavioral deficits associated with widespread alzheimer disease pathology via bdnf. |
2009-09-21 |
2023-08-12 |
mouse |
| Chiara Zuccato, Elena Cattane. Brain-derived neurotrophic factor in neurodegenerative diseases. Nature reviews. Neurology. vol 5. issue 6. 2009-08-18. PMID:19498435. |
changes in the levels and activities of neurotrophic factors, such as brain-derived neurotrophic factor (bdnf), have been described in a number of neurodegenerative disorders, including huntington disease, alzheimer disease and parkinson disease. |
2009-08-18 |
2023-08-12 |
human |
| Shiyong Peng, Diego J Garzon, Monica Marchese, William Klein, Stephen D Ginsberg, Beverly M Francis, Howard T J Mount, Elliott J Mufson, Ahmad Salehi, Margaret Fahnestoc. Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 29. 2009-08-10. PMID:19625522. |
downregulation of brain-derived neurotrophic factor (bdnf) in the cortex occurs early in the progression of alzheimer's disease (ad). |
2009-08-10 |
2023-08-12 |
mouse |
| Thomas Leyhe, Gerhard W Eschweiler, Elke Stransky, Thomas Gasser, Peter Annas, Hans Basun, Christoph Lask. Increase of BDNF serum concentration in lithium treated patients with early Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 16. issue 3. 2009-05-18. PMID:19276559. |
increase of bdnf serum concentration in lithium treated patients with early alzheimer's disease. |
2009-05-18 |
2023-08-12 |
Not clear |
| Gemma Molinaro, Giuseppe Battaglia, Barbara Riozzi, Luisa Di Menna, Liborio Rampello, Valeria Bruno, Ferdinando Nicolett. Memantine treatment reduces the expression of the K(+)/Cl(-) cotransporter KCC2 in the hippocampus and cerebral cortex, and attenuates behavioural responses mediated by GABA(A) receptor activation in mice. Brain research. vol 1265. 2009-05-13. PMID:19236854. |
), a drug that is currently prescribed for the treatment of alzheimer's disease, increased the levels of brain-derived neurotrophic factor (bdnf) and reduced the expression of the neuron-specific k(+)/cl(-) co-transporter, kcc2, in the hippocampus and cerebral cortex of mice. |
2009-05-13 |
2023-08-12 |
mouse |
| Lucia Tapia-Arancibia, Esteban Aliaga, Michelle Silhol, Sandor Arancibi. New insights into brain BDNF function in normal aging and Alzheimer disease. Brain research reviews. vol 59. issue 1. 2009-04-09. PMID:18708092. |
new insights into brain bdnf function in normal aging and alzheimer disease. |
2009-04-09 |
2023-08-12 |
Not clear |
| Lucia Tapia-Arancibia, Esteban Aliaga, Michelle Silhol, Sandor Arancibi. New insights into brain BDNF function in normal aging and Alzheimer disease. Brain research reviews. vol 59. issue 1. 2009-04-09. PMID:18708092. |
modification of bdnf and/or the expression of its receptors (trkb.fl, trkb.t1 and trkb.t2) have been described during normal aging and alzheimer disease. |
2009-04-09 |
2023-08-12 |
Not clear |
| Alan H Nagahara, David A Merrill, Giovanni Coppola, Shingo Tsukada, Brock E Schroeder, Gideon M Shaked, Ling Wang, Armin Blesch, Albert Kim, James M Conner, Edward Rockenstein, Moses V Chao, Edward H Koo, Daniel Geschwind, Eliezer Masliah, Andrea A Chiba, Mark H Tuszynsk. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nature medicine. vol 15. issue 3. 2009-03-30. PMID:19198615. |
here we show broad neuroprotective effects of entorhinal brain-derived neurotrophic factor (bdnf) administration in several animal models of alzheimer's disease, with extension of therapeutic benefits into the degenerating hippocampus. |
2009-03-30 |
2023-08-12 |
mouse |
| Alan H Nagahara, David A Merrill, Giovanni Coppola, Shingo Tsukada, Brock E Schroeder, Gideon M Shaked, Ling Wang, Armin Blesch, Albert Kim, James M Conner, Edward Rockenstein, Moses V Chao, Edward H Koo, Daniel Geschwind, Eliezer Masliah, Andrea A Chiba, Mark H Tuszynsk. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nature medicine. vol 15. issue 3. 2009-03-30. PMID:19198615. |
collectively, these findings indicate that bdnf exerts substantial protective effects on crucial neuronal circuitry involved in alzheimer's disease, acting through amyloid-independent mechanisms. |
2009-03-30 |
2023-08-12 |
mouse |
| Alan H Nagahara, David A Merrill, Giovanni Coppola, Shingo Tsukada, Brock E Schroeder, Gideon M Shaked, Ling Wang, Armin Blesch, Albert Kim, James M Conner, Edward Rockenstein, Moses V Chao, Edward H Koo, Daniel Geschwind, Eliezer Masliah, Andrea A Chiba, Mark H Tuszynsk. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nature medicine. vol 15. issue 3. 2009-03-30. PMID:19198615. |
bdnf therapeutic delivery merits exploration as a potential therapy for alzheimer's disease. |
2009-03-30 |
2023-08-12 |
mouse |
| O Schulte-Herbrüggen, S Eckart, U Deicke, A Kühl, U Otten, H Danker-Hopfe, D Abramowski, M Staufenbiel, R Hellwe. Age-dependent time course of cerebral brain-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 in APP23 transgenic mice. Journal of neuroscience research. vol 86. issue 12. 2009-03-16. PMID:18438945. |
neurotrophins, including brain-derived neurotrophic factor (bdnf), nerve growth factor (ngf), and neurotrophin-3 (nt-3), have repeatedly been shown to be involved in the pathophysiology of alzheimer's disease (ad). |
2009-03-16 |
2023-08-12 |
mouse |