| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria del Carmen Cardenas-Aguayo, Syed Faraz Kazim, Inge Grundke-Iqbal, Khalid Iqba. Neurogenic and neurotrophic effects of BDNF peptides in mouse hippocampal primary neuronal cell cultures. PloS one. vol 8. issue 1. 2013-08-15. PMID:23320097. |
the level of brain-derived neurotrophic factor (bdnf), a member of the neurotrophin family, is down regulated in alzheimer's disease (ad), parkinson's disease (pd), depression, stress, and anxiety; conversely the level of this neurotrophin is increased in autism spectrum disorders. |
2013-08-15 |
2023-08-12 |
mouse |
| Chiara Boiocchi, Elisa Maggioli, Michele Zorzetto, Elena Sinforiani, Cristina Cereda, Giovanni Ricevuti, Mariaclara Cucci. Brain-derived neurotrophic factor gene variants and Alzheimer disease: an association study in an Alzheimer disease Italian population. Rejuvenation research. vol 16. issue 1. 2013-08-01. PMID:23215636. |
changes in production of bdnf have been reported in differing neurodegenerative pathologies and, in particular, in alzheimer disease (ad). |
2013-08-01 |
2023-08-12 |
human |
| Allam Appa Ra. Views and opinion on BDNF as a target for diabetic cognitive dysfunction. Bioinformation. vol 9. issue 11. 2013-07-26. PMID:23888094. |
bdnf is recognized as a metabotrophic factor, a molecule that is involved in alzheimer's disease (ad) as well as in other neurological disorders. |
2013-07-26 |
2023-08-12 |
Not clear |
| Bai Lu, Guhan Nagappan, Xiaoming Guan, Pradeep J Nathan, Paul Wre. BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases. Nature reviews. Neuroscience. vol 14. issue 6. 2013-07-16. PMID:23674053. |
understanding the role of brain-derived neurotrophic factor (bdnf) in synaptic plasticity and synaptogenesis, the impact of the bdnf val66met polymorphism in alzheimer's disease-relevant endophenotypes - including episodic memory and hippocampal volume - and the technological progress in measuring synaptic changes in humans all pave the way for a 'synaptic repair' therapy for neurodegenerative diseases that targets pathophysiology rather than pathogenesis. |
2013-07-16 |
2023-08-12 |
Not clear |
| T Hochstrasser, D Ehrlich, B Sperner-Unterweger, C Humpe. Antidepressants and anti-inflammatory drugs differentially reduce the release of NGF and BDNF from rat platelets. Pharmacopsychiatry. vol 46. issue 1. 2013-06-28. PMID:22699957. |
platelets store serotonin and brain-derived neurotrophic factor (bdnf) as well as amyloid precursor protein and nerve growth factor (ngf), thus platelets are of special interest in depression and alzheimer's disease, respectively. |
2013-06-28 |
2023-08-12 |
rat |
| Wakako Maruyama, Makoto Nao. ''70th Birthday Professor Riederer'' induction of glial cell line-derived and brain-derived neurotrophic factors by rasagiline and (-)deprenyl: a way to a disease-modifying therapy? Journal of neural transmission (Vienna, Austria : 1996). vol 120. issue 1. 2013-06-14. PMID:22892822. |
gdnf and bdnf have been reported to reduce parkinson and alzheimer's diseases, respectively. |
2013-06-14 |
2023-08-12 |
Not clear |
| Barbara Borroni, Marta Bianchi, Enrico Premi, Antonella Alberici, Silvana Archetti, Barbara Paghera, Carlo Cerini, Alice Papetti, Alessandro Padovan. The brain-derived neurotrophic factor Val66Met polymorphism is associated with reduced hippocampus perfusion in frontotemporal lobar degeneration. Journal of Alzheimer's disease : JAD. vol 31. issue 2. 2013-06-04. PMID:22596272. |
a larger group of ftld patients (n = 194) and controls (n = 396; 162 healthy subjects and 234 alzheimer's disease (ad) patients) underwent genetic analyses, considering bdnf polymorphisms (val66met, rs2049045 c/g, g11757c). |
2013-06-04 |
2023-08-12 |
human |
| Alessio Travaglia, Diego La Mendola, Antonio Magrì, Vincenzo Giuseppe Nicoletti, Adriana Pietropaolo, Enrico Rizzarell. Copper, BDNF and Its N-terminal domain: inorganic features and biological perspectives. Chemistry (Weinheim an der Bergstrasse, Germany). vol 18. issue 49. 2013-05-23. PMID:23135810. |
altered bdnf signaling is involved in several neurodegenerative disorders including alzheimer's disease. |
2013-05-23 |
2023-08-12 |
human |
| Nicholas A Castello, Kim N Green, Frank M LaFerl. Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter Aβ or tau pathology. PloS one. vol 7. issue 8. 2013-02-19. PMID:22870188. |
bdnf has recently garnered significant attention as a potential therapeutic target for neurodegenerative diseases such as alzheimer disease (ad), but emerging evidence suggests that bdnf may also be mechanistically involved in the pathogenesis of ad. |
2013-02-19 |
2023-08-12 |
mouse |
| János Kállmán, Magdolna Pákáski, Szabina Szucs, Sára Kálmán, Orsike Fazekas, Petra Santha, Gyula Szabó, Zoltán Janka, János Kálmá. [The role of immobilization stress and sertindole on the expression of APP, MAPK-1 and beta-actin genes in rat brain]. Ideggyogyaszati szemle. vol 65. issue 11-12. 2013-01-25. PMID:23289174. |
as one of its multiple effects, elevated blood cortisol levels decrease the synthesis of the neuroprotective bdnf, thus leading to hippocampal atrophy and synapse loss, and rendering it a possible cause for the alzheimer's disease (ad) related neuropathological and cognitive changes. |
2013-01-25 |
2023-08-12 |
rat |
| Susanna Kemppainen, Tomi Rantamäki, André Jerónimo-Santos, Gregoire Lavasseur, Henri Autio, Nina Karpova, Elisa Kärkkäinen, Saara Stavén, Hugo Vicente Miranda, Tiago F Outeiro, Maria J Diógenes, Serge Laroche, Sabrina Davis, Ana M Sebastião, Eero Castrén, Heikki Tanil. Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice. Neurobiology of aging. vol 33. issue 6. 2013-01-24. PMID:22209410. |
levels of bdnf and its main receptor trkb (trkb.tk) have been reported to be decreased while the levels of the truncated trkb (trkb.t1) are increased in alzheimer's disease. |
2013-01-24 |
2023-08-12 |
mouse |
| Susanna Kemppainen, Tomi Rantamäki, André Jerónimo-Santos, Gregoire Lavasseur, Henri Autio, Nina Karpova, Elisa Kärkkäinen, Saara Stavén, Hugo Vicente Miranda, Tiago F Outeiro, Maria J Diógenes, Serge Laroche, Sabrina Davis, Ana M Sebastião, Eero Castrén, Heikki Tanil. Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice. Neurobiology of aging. vol 33. issue 6. 2013-01-24. PMID:22209410. |
these data suggest that amyloid-β changes the ratio between trkb isoforms in favor of the dominant-negative trkb.t1 isoform both in vitro and in vivo and supports the role of bdnf signaling through trkb in the pathophysiology and cognitive deficits of alzheimer's disease. |
2013-01-24 |
2023-08-12 |
mouse |
| Xuan Ye, Wenjiao Tai, Dan Zhan. The early events of Alzheimer's disease pathology: from mitochondrial dysfunction to BDNF axonal transport deficits. Neurobiology of aging. vol 33. issue 6. 2013-01-24. PMID:22212405. |
the early events of alzheimer's disease pathology: from mitochondrial dysfunction to bdnf axonal transport deficits. |
2013-01-24 |
2023-08-12 |
Not clear |
| Tomoyuki Nagata, Shunichiro Shinagawa, Kazutaka Nukariya, Hisashi Yamada, Kazuhiko Nakayam. Association between BDNF polymorphism (Val66Met) and executive function in patients with amnestic mild cognitive impairment or mild Alzheimer disease. Dementia and geriatric cognitive disorders. vol 33. issue 4. 2012-11-29. PMID:22699449. |
association between bdnf polymorphism (val66met) and executive function in patients with amnestic mild cognitive impairment or mild alzheimer disease. |
2012-11-29 |
2023-08-12 |
Not clear |
| Tomoyuki Nagata, Shunichiro Shinagawa, Kazutaka Nukariya, Hisashi Yamada, Kazuhiko Nakayam. Association between BDNF polymorphism (Val66Met) and executive function in patients with amnestic mild cognitive impairment or mild Alzheimer disease. Dementia and geriatric cognitive disorders. vol 33. issue 4. 2012-11-29. PMID:22699449. |
in the present study, we examined whether brain-derived neurotrophic factor (bdnf) polymorphism (val66met) influenced the changeable executive dysfunction of patients with two separate disease stages: amnestic mild cognitive impairment (a-mci) or mild alzheimer disease (ad), which are comparatively similar demented conditions. |
2012-11-29 |
2023-08-12 |
Not clear |
| Soon-Tae Lee, Kon Chu, Keun-Hwa Jung, Jin Hee Kim, Ji-Young Huh, Hyejin Yoon, Dong-Kyu Park, Ji-Yeon Lim, Jeong-Min Kim, Daejong Jeon, Hoon Ryu, Sang Kun Lee, Manho Kim, Jae-Kyu Ro. miR-206 regulates brain-derived neurotrophic factor in Alzheimer disease model. Annals of neurology. vol 72. issue 2. 2012-11-01. PMID:22926857. |
alzheimer disease (ad) brains are deficient in brain-derived neurotrophic factor (bdnf), which regulates synaptic plasticity and memory. |
2012-11-01 |
2023-08-12 |
mouse |
| Chang Su, Rebecca L Cunningham, Nataliya Rybalchenko, Meharvan Sing. Progesterone increases the release of brain-derived neurotrophic factor from glia via progesterone receptor membrane component 1 (Pgrmc1)-dependent ERK5 signaling. Endocrinology. vol 153. issue 9. 2012-10-29. PMID:22778217. |
collectively, our data describe that p4 elicits an increase in bdnf release from glia via a pgrmc1-induced erk5 signaling mechanism and identify pgrmc1 as a potential therapeutic target for future hormone-based drug development for the treatment of such degenerative diseases as alzheimer's disease as well as other diseases wherein neurotrophin dysregulation is noted. |
2012-10-29 |
2023-08-12 |
Not clear |
| Thierry Burnouf, Ya-Po Kuo, David Blum, Sylvie Burnouf, Chen-Yao S. Human platelet concentrates: a source of solvent/detergent-treated highly enriched brain-derived neurotrophic factor. Transfusion. vol 52. issue 8. 2012-10-25. PMID:22211513. |
alterations in bdnf homeostasis are associated with aging and are found in several neurodegenerative conditions such as alzheimer's, huntington's, and parkinson's diseases and multiple sclerosis. |
2012-10-25 |
2023-08-12 |
human |
| Zhongling Feng, Feng Ga. Stem cell challenges in the treatment of neurodegenerative disease. CNS neuroscience & therapeutics. vol 18. issue 2. 2012-09-25. PMID:22070610. |
in addition, neural stem cells (nscs), via brain-derived neurotrophic factor (bdnf), have been shown to ameliorate complex behavioral deficits associated with widespread alzheimer's disease (ad) pathology in a transgenic mouse model of ad. |
2012-09-25 |
2023-08-12 |
mouse |
| J Wong, M Higgins, G Halliday, B Garne. Amyloid beta selectively modulates neuronal TrkB alternative transcript expression with implications for Alzheimer's disease. Neuroscience. vol 210. 2012-09-21. PMID:22426239. |
dysregulation in brain-derived neurotrophic factor (bdnf)/full-length trkb (trkb-tk+) signaling is implicated in promoting neurodegeneration in alzheimer's disease (ad). |
2012-09-21 |
2023-08-12 |
Not clear |