| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patricia F Kao, Meredith G Banigan, Charles R Vanderburg, Ann C McKee, Peter R Polgar, Sudha Seshadri, Ivana Delall. Increased expression of TrkB and Capzb2 accompanies preserved cognitive status in early Alzheimer disease pathology. Journal of neuropathology and experimental neurology. vol 71. issue 7. 2012-09-04. PMID:22710966. |
here, we explore whether a specifically vulnerable population of human neurons shows a compensatory response to the neuropathological changes of alzheimer disease (ad) and whether that response depends on an upregulation of the bdnf pathway. |
2012-09-04 |
2023-08-12 |
human |
| Shelley J Allen, Judy J Watson, David Dawbar. The neurotrophins and their role in Alzheimer's disease. Current neuropharmacology. vol 9. issue 4. 2012-08-23. PMID:22654716. |
in particular there have been a number of studies on the involvement of nerve growth factor (ngf) and brain derived neurotrophic factor (bdnf) in the development of alzheimer's disease. |
2012-08-23 |
2023-08-12 |
Not clear |
| Shelley J Allen, Judy J Watson, David Dawbar. The neurotrophins and their role in Alzheimer's disease. Current neuropharmacology. vol 9. issue 4. 2012-08-23. PMID:22654716. |
this review briefly describes the pathology, symptoms and molecular processes associated with alzheimer's disease; it discusses the involvement of the neurotrophins, particularly ngf and bdnf, and their receptors, with changes in bdnf considered particularly in the light of its importance in synaptic plasticity. |
2012-08-23 |
2023-08-12 |
Not clear |
| Ira Driscoll, Bronwen Martin, Yang An, Stuart Maudsley, Luigi Ferrucci, Mark P Mattson, Susan M Resnic. Plasma BDNF is associated with age-related white matter atrophy but not with cognitive function in older, non-demented adults. PloS one. vol 7. issue 4. 2012-08-03. PMID:22523577. |
bdnf plasma and serum levels have been associated with depression, alzheimer's disease, and other psychiatric and neurodegenerative disorders. |
2012-08-03 |
2023-08-12 |
Not clear |
| Yuki Iwasaki, Takayuki Negishi, Makoto Inoue, Tomoko Tashiro, Takeshi Tabira, Nobuyuki Kimur. Sendai virus vector-mediated brain-derived neurotrophic factor expression ameliorates memory deficits and synaptic degeneration in a transgenic mouse model of Alzheimer's disease. Journal of neuroscience research. vol 90. issue 5. 2012-07-16. PMID:22252710. |
growing evidence suggests that decreased brain-derived neurotrophic factor (bdnf) levels are associated with alzheimer's disease (ad) pathogenesis. |
2012-07-16 |
2023-08-12 |
mouse |
| Monika Karczewska-Kupczewska, Irina Kowalska, Agnieszka Nikołajuk, Agnieszka Adamska, Magdalena Zielińska, Natalia Kamińska, Elżbieta Otziomek, Maria Górska, Marek Strączkowsk. Circulating brain-derived neurotrophic factor concentration is downregulated by intralipid/heparin infusion or high-fat meal in young healthy male subjects. Diabetes care. vol 35. issue 2. 2012-06-12. PMID:22210566. |
brain-derived neurotrophic factor (bdnf) regulates neuronal differentiation and synaptic plasticity, and its decreased levels are supposed to play a role in the pathogenesis of alzheimer's disease and other disorders. |
2012-06-12 |
2023-08-12 |
human |
| Chang Su, Wendy Underwood, Nataliya Rybalchenko, Meharvan Sing. ERK1/2 and ERK5 have distinct roles in the regulation of brain-derived neurotrophic factor expression. Journal of neuroscience research. vol 89. issue 10. 2012-06-04. PMID:21647938. |
dysregulation of brain-derived neurotrophic factor (bdnf) has been implicated in deficits of long-term potentiation and cognition and may contribute to the development of alzheimer's disease (ad). |
2012-06-04 |
2023-08-12 |
Not clear |
| Yoko Ozawa, Mariko Sasaki, Noriko Takahashi, Mamoru Kamoshita, Seiji Miyake, Kazuo Tsubot. Neuroprotective effects of lutein in the retina. Current pharmaceutical design. vol 18. issue 1. 2012-05-31. PMID:22211688. |
furthermore, degradation of the functional proteins, rhodopsin (a visual substance) and synaptophysin (a synaptic vesicle protein also influenced in other neurodegenerative diseases such as alzheimer's disease and parkinson's disease), the depletion of brain-derived neurotrophic factor (bdnf), and dna damage are prevented by lutein, which preserves visual function. |
2012-05-31 |
2023-08-12 |
mouse |
| Emmanuelle Cousin, Sandrine Macé, Corinne Rocher, Colette Dib, Gaëlle Muzard, Didier Hannequin, Laurent Pradier, Jean-François Deleuze, Emmanuelle Génin, Alexis Brice, Dominique Campio. No replication of genetic association between candidate polymorphisms and Alzheimer's disease. Neurobiology of aging. vol 32. issue 8. 2012-05-14. PMID:19889475. |
we selected 16 candidate genes involved in biological pathways closely related to the pathology, and for which a genetic association with alzheimer's disease was previously detected: ace, bace1, bdnf, ece1, hspg2, ide, il1a, il6, il10, mapt, plau, prnp, psen1, sorl1, tfcp2 and tgfb1. |
2012-05-14 |
2023-08-12 |
Not clear |
| Latha Devi, Masuo Ohn. 7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 2. 2012-04-17. PMID:21900882. |
increasing evidence suggests that reductions in brain-derived neurotrophic factor (bdnf) and its receptor tyrosine receptor kinase b (trkb) may have a role in the pathogenesis of alzheimer's disease (ad). |
2012-04-17 |
2023-08-12 |
mouse |
| Breno Satler Diniz, Antonio Lucio Teixeir. Brain-derived neurotrophic factor and Alzheimer's disease: physiopathology and beyond. Neuromolecular medicine. vol 13. issue 4. 2012-03-26. PMID:21898045. |
serum or plasma, of patients with alzheimer's disease (ad), and low bdnf levels in the csf as predictor of future cognitive decline in healthy older subjects. |
2012-03-26 |
2023-08-12 |
human |
| Tomoyuki Nagata, Shunichiro Shinagawa, Kazutaka Nukariya, Yusuke Ochiai, Satoshi Kawamura, Miyuki Agawa-Ohta, Hiroo Kasahara, Kazuhiko Nakayama, Hisashi Yamad. Association between brain-derived neurotrophic factor (BDNF) gene polymorphisms and executive function in Japanese patients with Alzheimer's disease. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society. vol 11. issue 3. 2012-03-06. PMID:21951954. |
association between brain-derived neurotrophic factor (bdnf) gene polymorphisms and executive function in japanese patients with alzheimer's disease. |
2012-03-06 |
2023-08-12 |
Not clear |
| Tomoyuki Nagata, Shunichiro Shinagawa, Kazutaka Nukariya, Yusuke Ochiai, Satoshi Kawamura, Miyuki Agawa-Ohta, Hiroo Kasahara, Kazuhiko Nakayama, Hisashi Yamad. Association between brain-derived neurotrophic factor (BDNF) gene polymorphisms and executive function in Japanese patients with Alzheimer's disease. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society. vol 11. issue 3. 2012-03-06. PMID:21951954. |
to address the functional roles of genetic polymorphisms of brain-derived neurotrophic factor (bdnf) in alzheimer's disease (ad) from a neuropsychological aspect, we used a cross-sectional study design to investigate the association between novel single nucleotide polymorphisms (snps) of the bdnf gene (val66met (g196a) and c270t) and the frontal assessment battery (fab) score, which reflects executive function as a non-memory cognitive impairment. |
2012-03-06 |
2023-08-12 |
Not clear |
| Kunihiro Sakuma, Akihiko Yamaguch. The recent understanding of the neurotrophin's role in skeletal muscle adaptation. Journal of biomedicine & biotechnology. vol 2011. 2012-01-31. PMID:21960735. |
muscle contractions (e.g., exercise) produce bdnf mrna and protein in skeletal muscle, and the bdnf seems to play a role in enhancing glucose metabolism and may act for myokine to improve various brain disorders (e.g., alzheimer's disease and major depression). |
2012-01-31 |
2023-08-12 |
human |
| Lu Zhang, Yu Fang, Zhaoshu Zeng, Yajun Lian, Jianke Wei, Hongcan Zhu, Yanjie Jia, Xinyu Zhao, Yuming X. BDNF gene polymorphisms are associated with Alzheimer's disease-related depression and antidepressant response. Journal of Alzheimer's disease : JAD. vol 26. issue 3. 2012-01-11. PMID:21677379. |
bdnf gene polymorphisms are associated with alzheimer's disease-related depression and antidepressant response. |
2012-01-11 |
2023-08-12 |
human |
| Lu Zhang, Yu Fang, Zhaoshu Zeng, Yajun Lian, Jianke Wei, Hongcan Zhu, Yanjie Jia, Xinyu Zhao, Yuming X. BDNF gene polymorphisms are associated with Alzheimer's disease-related depression and antidepressant response. Journal of Alzheimer's disease : JAD. vol 26. issue 3. 2012-01-11. PMID:21677379. |
the current study examined potential association between single nucleotide polymorphisms (snps) of the bdnf gene (g11757 c, c270t, g196a, g-712a) and alzheimer's disease-related depression (ad-d). |
2012-01-11 |
2023-08-12 |
human |
| Farah D Lubi. Epigenetic gene regulation in the adult mammalian brain: multiple roles in memory formation. Neurobiology of learning and memory. vol 96. issue 1. 2011-10-28. PMID:21419233. |
this review will also highlight evidence for the role of epigenetics in aberrant bdnf gene regulation in the pathogenesis of cognitive dysfunction associated with seizure disorders, rett syndrome, schizophrenia, and alzheimer's disease. |
2011-10-28 |
2023-08-12 |
Not clear |
| Francesco Angelucci, Francesca Gelfo, Paola De Bartolo, Carlo Caltagirone, Laura Petrosin. BDNF concentrations are decreased in serum and parietal cortex in immunotoxin 192 IgG-Saporin rat model of cholinergic degeneration. Neurochemistry international. vol 59. issue 1. 2011-10-27. PMID:21672569. |
the neurotrophin brain-derived neurotrophic factor (bdnf) has been extensively studied because of its role in survival, differentiation and function of neurons undergoing degeneration in pathological conditions such as cholinergic neurons in alzheimer's disease (ad). |
2011-10-27 |
2023-08-12 |
rat |
| Christoph Laske, Konstantinos Stellos, Nadine Hoffmann, Elke Stransky, Guido Straten, Gerhard W Eschweiler, Thomas Leyh. Higher BDNF serum levels predict slower cognitive decline in Alzheimer's disease patients. The international journal of neuropsychopharmacology. vol 14. issue 3. 2011-09-19. PMID:20860877. |
higher bdnf serum levels predict slower cognitive decline in alzheimer's disease patients. |
2011-09-19 |
2023-08-12 |
Not clear |
| Christoph Laske, Konstantinos Stellos, Nadine Hoffmann, Elke Stransky, Guido Straten, Gerhard W Eschweiler, Thomas Leyh. Higher BDNF serum levels predict slower cognitive decline in Alzheimer's disease patients. The international journal of neuropsychopharmacology. vol 14. issue 3. 2011-09-19. PMID:20860877. |
several recent studies have demonstrated altered bdnf serum levels in alzheimer's disease (ad) patients. |
2011-09-19 |
2023-08-12 |
Not clear |