| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tomi Rantamäki, Susanna Kemppainen, Henri Autio, Saara Stavén, Hennariikka Koivisto, Masami Kojima, Hanna Antila, Pasi O Miettinen, Elisa Kärkkäinen, Nina Karpova, Liisa Vesa, Lothar Lindemann, Marius C Hoener, Heikki Tanila, Eero Castré. The impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer's disease. PloS one. vol 8. issue 7. 2014-02-07. PMID:23844236. |
reduced bdnf levels have been detected in the brains of alzheimer's disease (ad) patients but the exact role of bdnf in the pathophysiology of the disorder remains obscure. |
2014-02-07 |
2023-08-12 |
mouse |
| b' Antonio Ciaramella, Francesca Salani, Federica Bizzoni, Maria Donata Orfei, Roberto Langella, Francesco Angelucci, Gianfranco Spalletta, Anna Rita Taddei, Carlo Caltagirone, Paola Boss\\xc3\\xb. The stimulation of dendritic cells by amyloid beta 1-42 reduces BDNF production in Alzheimer\'s disease patients. Brain, behavior, and immunity. vol 32. 2014-01-27. PMID:23578995.' |
the stimulation of dendritic cells by amyloid beta 1-42 reduces bdnf production in alzheimer's disease patients. |
2014-01-27 |
2023-08-12 |
human |
| Wei Zhang, Pei-jun Wang, Ming-hua Li, Guo-liang Wang, Ping Li, Xiao-long Ga. 1H-MRS assessment of the therapeutic effect of bilateral intraventricular BDNF infusion into APP/PS1 double transgenic mice. Journal of molecular neuroscience : MN. vol 50. issue 3. 2014-01-10. PMID:23315172. |
in the present study, 1h-mrs was used to evaluate the therapeutic effects of bilateral intraventricular bdnf infusion into alzheimer's disease app/ps1 double transgenic mice. |
2014-01-10 |
2023-08-12 |
mouse |
| Davide Carlino, Maurizio De Vanna, Enrico Tongiorg. Is altered BDNF biosynthesis a general feature in patients with cognitive dysfunctions? The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 19. issue 4. 2013-12-31. PMID:23242909. |
significantly, an altered expression of bdnf forms was found in postmortem brains and serum from patients with schizophrenia, alzheimer's disease and mood disorders. |
2013-12-31 |
2023-08-12 |
Not clear |
| Alan H Nagahara, Michael Mateling, Imre Kovacs, Ling Wang, Simone Eggert, Edward Rockenstein, Edward H Koo, Eliezer Masliah, Mark H Tuszynsk. Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 39. 2013-11-25. PMID:24068826. |
brain-derived neurotrophic factor (bdnf) improves molecular, cellular, and behavioral measures of neural dysfunction in genetic models of alzheimer's disease (blurton-jones et al., 2009; nagahara et al., 2009). |
2013-11-25 |
2023-08-12 |
mouse |
| Alan H Nagahara, Michael Mateling, Imre Kovacs, Ling Wang, Simone Eggert, Edward Rockenstein, Edward H Koo, Eliezer Masliah, Mark H Tuszynsk. Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 39. 2013-11-25. PMID:24068826. |
we now report prevention of neuronal loss with early life bdnf treatment in mutant mice expressing two amyloid precursor protein (app) mutations associated with early-onset familial alzheimer's disease. |
2013-11-25 |
2023-08-12 |
mouse |
| Alan H Nagahara, Michael Mateling, Imre Kovacs, Ling Wang, Simone Eggert, Edward Rockenstein, Edward H Koo, Eliezer Masliah, Mark H Tuszynsk. Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 39. 2013-11-25. PMID:24068826. |
notably, bdnf did not affect amyloid plaque numbers, indicating that direct amyloid reduction is not necessary to achieve significant neuroprotective benefits in mutant amyloid models of alzheimer's disease. |
2013-11-25 |
2023-08-12 |
mouse |
| Katarzyna Adamczuk, An-Sofie De Weer, Natalie Nelissen, Kewei Chen, Kristel Sleegers, Karolien Bettens, Christine Van Broeckhoven, Mathieu Vandenbulcke, Pradeep Thiyyagura, Patrick Dupont, Koen Van Laere, Eric M Reiman, Rik Vandenbergh. Polymorphism of brain derived neurotrophic factor influences β amyloid load in cognitively intact apolipoprotein E ε4 carriers. NeuroImage. Clinical. vol 2. 2013-11-01. PMID:24179803. |
brain derived neurotrophic factor (bdnf) modulates neural plasticity, which has been implicated in alzheimer's disease. |
2013-11-01 |
2023-08-12 |
human |
| Virginia Plá, Sonia Paco, Gregory Ghezali, Victor Ciria, Esther Pozas, Isidro Ferrer, Fernando Aguad. Secretory sorting receptors carboxypeptidase E and secretogranin III in amyloid β-associated neural degeneration in Alzheimer's disease. Brain pathology (Zurich, Switzerland). vol 23. issue 3. 2013-10-28. PMID:22998035. |
in alzheimer's disease (ad), the wide range of changes includes impaired function of key secretory peptidic cargos such as brain-derived neurotrophic factor (bdnf) and neuropeptides. |
2013-10-28 |
2023-08-12 |
mouse |
| Chengbo Meng, Zhiyong He, Da Xin. Low-level laser therapy rescues dendrite atrophy via upregulating BDNF expression: implications for Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 33. 2013-10-23. PMID:23946409. |
low-level laser therapy rescues dendrite atrophy via upregulating bdnf expression: implications for alzheimer's disease. |
2013-10-23 |
2023-08-12 |
mouse |
| Chengbo Meng, Zhiyong He, Da Xin. Low-level laser therapy rescues dendrite atrophy via upregulating BDNF expression: implications for Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 33. 2013-10-23. PMID:23946409. |
downregulation of brain-derived neurotrophic factor (bdnf) in the hippocampus occurs early in the progression of alzheimer's disease (ad). |
2013-10-23 |
2023-08-12 |
mouse |
| Michael P Walker, Frank M LaFerla, Salvador S Oddo, Gregory J Brewe. Reversible epigenetic histone modifications and Bdnf expression in neurons with aging and from a mouse model of Alzheimer's disease. Age (Dordrecht, Netherlands). vol 35. issue 3. 2013-10-17. PMID:22237558. |
reversible epigenetic histone modifications and bdnf expression in neurons with aging and from a mouse model of alzheimer's disease. |
2013-10-17 |
2023-08-12 |
mouse |
| S M Rothman, M P Mattso. Activity-dependent, stress-responsive BDNF signaling and the quest for optimal brain health and resilience throughout the lifespan. Neuroscience. vol 239. 2013-10-17. PMID:23079624. |
insufficient exposure to such challenges, genetic factors may conspire to impair bdnf production and/or signaling resulting in the vulnerability of the brain to injury and neurodegenerative disorders including alzheimer's, parkinson's and huntington's diseases. |
2013-10-17 |
2023-08-12 |
human |
| L C Harte-Hargrove, N J Maclusky, H E Scharfma. Brain-derived neurotrophic factor-estrogen interactions in the hippocampal mossy fiber pathway: implications for normal brain function and disease. Neuroscience. vol 239. 2013-10-17. PMID:23276673. |
we suggest that the interactions between bdnf and 17β-estradiol in the mfs are potentially important in the normal function of the hippocampus, and have implications for sex differences in functions that depend on the mfs and in diseases where mf plasticity has been suggested to play an important role, alzheimer's disease, epilepsy and addiction. |
2013-10-17 |
2023-08-12 |
Not clear |
| Nicoletta Croce, Francesca Gelfo, Maria Teresa Ciotti, Giorgio Federici, Carlo Caltagirone, Sergio Bernardini, Francesco Angelucc. NPY modulates miR-30a-5p and BDNF in opposite direction in an in vitro model of Alzheimer disease: a possible role in neuroprotection? Molecular and cellular biochemistry. vol 376. issue 1-2. 2013-10-17. PMID:23358924. |
npy modulates mir-30a-5p and bdnf in opposite direction in an in vitro model of alzheimer disease: a possible role in neuroprotection? |
2013-10-17 |
2023-08-12 |
rat |
| Nicoletta Croce, Francesca Gelfo, Maria Teresa Ciotti, Giorgio Federici, Carlo Caltagirone, Sergio Bernardini, Francesco Angelucc. NPY modulates miR-30a-5p and BDNF in opposite direction in an in vitro model of Alzheimer disease: a possible role in neuroprotection? Molecular and cellular biochemistry. vol 376. issue 1-2. 2013-10-17. PMID:23358924. |
using in vitro models of alzheimer's disease (ad), we found that the toxic effects of amyloid beta 25-35 (aβ(25-35)) on the neurotrophin brain-derived neurotrophic factor (bdnf) were counteracted by pre-incubation with neuropeptide y (npy), a neuropeptide expressed within the central nervous system. |
2013-10-17 |
2023-08-12 |
rat |
| N Pluchino, M Russo, A N Santoro, P Litta, V Cela, A R Genazzan. Steroid hormones and BDNF. Neuroscience. vol 239. 2013-10-17. PMID:23380505. |
several studies have shown an altered bdnf production and secretion in a variety of neurodegenerative diseases like alzheimer's and parkinson's diseases but also in mood disorders like depression, eating disorders and schizophrenia. |
2013-10-17 |
2023-08-12 |
Not clear |
| Dildar Konukoglu, Gülnur Andican, Sinem Fırtına, Gökhan Erkol, Asuman Kur. Serum brain-derived neurotrophic factor, nerve growth factor and neurotrophin-3 levels in dementia. Acta neurologica Belgica. vol 112. issue 3. 2013-09-19. PMID:22740022. |
brain-derived neurotrophic factor (bdnf), nerve growth factor (ngf), and neurotrophin-3 (nt-3) were determined in alzheimer's dementia patients without medication (ad; n: 22), alzheimer's dementia patients receiving cholinesterase inhibitor (cei) treatment (ad + cei; n: 32) and vascular dementia patients receiving cei treatment (vad + cei; n: 27) and the age-matched control group (n: 20). |
2013-09-19 |
2023-08-12 |
Not clear |
| Dildar Konukoglu, Gülnur Andican, Sinem Fırtına, Gökhan Erkol, Asuman Kur. Serum brain-derived neurotrophic factor, nerve growth factor and neurotrophin-3 levels in dementia. Acta neurologica Belgica. vol 112. issue 3. 2013-09-19. PMID:22740022. |
in conclusion, our results suggest that while serum ngf levels are associated with the presence of dementia, serum bdnf levels may be associated with the severity of alzheimer's dementia. |
2013-09-19 |
2023-08-12 |
Not clear |
| Josh D Woolley, Eric V Strobl, Wendy B Shelly, Anna M Karydas, R N Robin Ketelle, Owen M Wolkowitz, Bruce L Miller, Katherine P Ranki. BDNF serum concentrations show no relationship with diagnostic group or medication status in neurodegenerative disease. Current Alzheimer research. vol 9. issue 7. 2013-08-16. PMID:21605064. |
studies have reported altered bdnf serum concentrations in patients with alzheimer's disease (ad). |
2013-08-16 |
2023-08-12 |
human |