| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bernadeta Michalski, Margaret Fahnestoc. Pro-brain-derived neurotrophic factor is decreased in parietal cortex in Alzheimer's disease. Brain research. Molecular brain research. vol 111. issue 1-2. 2003-07-16. PMID:12654514. |
several studies have also shown decreased bdnf protein in alzheimer's disease. |
2003-07-16 |
2023-08-12 |
human |
| M Riemenschneider, S Schwarz, S Wagenpfeil, J Diehl, U Müller, H Förstl, A Kur. A polymorphism of the brain-derived neurotrophic factor (BDNF) is associated with Alzheimer's disease in patients lacking the Apolipoprotein E epsilon4 allele. Molecular psychiatry. vol 7. issue 7. 2003-02-25. PMID:12192623. |
a polymorphism of the brain-derived neurotrophic factor (bdnf) is associated with alzheimer's disease in patients lacking the apolipoprotein e epsilon4 allele. |
2003-02-25 |
2023-08-12 |
Not clear |
| M Riemenschneider, S Schwarz, S Wagenpfeil, J Diehl, U Müller, H Förstl, A Kur. A polymorphism of the brain-derived neurotrophic factor (BDNF) is associated with Alzheimer's disease in patients lacking the Apolipoprotein E epsilon4 allele. Molecular psychiatry. vol 7. issue 7. 2003-02-25. PMID:12192623. |
because of its implication in neuroprotection, formation of long lasting memories and a disturbed function in alzheimer's disease (ad), brain-derived neurotrophic factor (bdnf) may represent an appropriate candidate gene conferring risk to ad. |
2003-02-25 |
2023-08-12 |
Not clear |
| M Fahnestock, D Garzon, R M D Holsinger, B Michalsk. Neurotrophic factors and Alzheimer's disease: are we focusing on the wrong molecule? Journal of neural transmission. Supplementum. issue 62. 2003-01-10. PMID:12456067. |
in alzheimer's disease, bdnf mrna and protein are decreased in basal forebrain cholinergic neuron target tissues such as cortex and hippocampus. |
2003-01-10 |
2023-08-12 |
human |
| M Fahnestock, D Garzon, R M D Holsinger, B Michalsk. Neurotrophic factors and Alzheimer's disease: are we focusing on the wrong molecule? Journal of neural transmission. Supplementum. issue 62. 2003-01-10. PMID:12456067. |
bdnf mrna levels are decreased 50% in nucleus basalis of alzheimer disease patients compared to controls. |
2003-01-10 |
2023-08-12 |
human |
| M Fahnestock, D Garzon, R M D Holsinger, B Michalsk. Neurotrophic factors and Alzheimer's disease: are we focusing on the wrong molecule? Journal of neural transmission. Supplementum. issue 62. 2003-01-10. PMID:12456067. |
thus, reduced bdnf mrna and protein levels in alzheimer's disease suggests that bdnf administration may be an effective therapeutic strategy for this disorder. |
2003-01-10 |
2023-08-12 |
human |
| Z Liu, J Che. [The research advance of brain derived neurotrophic factor]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 17. issue 4. 2002-10-25. PMID:11211839. |
bdnf plays an important role in the growth, development, differentiation, maintenance and regeneration of various types of neurons in the cns and has potential application to the treatment of brain injury and neurodegenerative diseases such as alzheimer's disease, parkinson's syndrome, huntington's chorea and amyotrophic lateral sclerosis. |
2002-10-25 |
2023-08-12 |
Not clear |
| Diego Garzon, Guanhua Yu, Margaret Fahnestoc. A new brain-derived neurotrophic factor transcript and decrease in brain-derived neurotrophic factor transcripts 1, 2 and 3 in Alzheimer's disease parietal cortex. Journal of neurochemistry. vol 82. issue 5. 2002-10-18. PMID:12358753. |
brain-derived neurotrophic factor (bdnf) supports hippocampal, cortical and basal forebrain cholinergic neurons, which lose function in alzheimer's disease. |
2002-10-18 |
2023-08-12 |
human |
| Diego Garzon, Guanhua Yu, Margaret Fahnestoc. A new brain-derived neurotrophic factor transcript and decrease in brain-derived neurotrophic factor transcripts 1, 2 and 3 in Alzheimer's disease parietal cortex. Journal of neurochemistry. vol 82. issue 5. 2002-10-18. PMID:12358753. |
however, the molecular mechanism of the down-regulation of bdnf in alzheimer's disease is unknown. |
2002-10-18 |
2023-08-12 |
human |
| M Ventriglia, L Bocchio Chiavetto, L Benussi, G Binetti, O Zanetti, M A Riva, M Gennarell. Association between the BDNF 196 A/G polymorphism and sporadic Alzheimer's disease. Molecular psychiatry. vol 7. issue 2. 2002-05-14. PMID:11840305. |
association between the bdnf 196 a/g polymorphism and sporadic alzheimer's disease. |
2002-05-14 |
2023-08-12 |
Not clear |
| J Satoh, Y Kurod. Nicastrin, a key regulator of presenilin function, is expressed constitutively in human neural cell lines. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 21. issue 2. 2001-10-25. PMID:11396676. |
both tnf-alpha and il-1, aberrantly produced by activated microglia and astrocytes, play a role in amyloidogenesis and neurodegeneration in the brains of alzheimer's disease (ad) patients, while bdnf synthesized chiefly by neurons has been found to be substantially reduced in ad brains. |
2001-10-25 |
2023-08-12 |
human |
| L Tong, P L Thornton, R Balazs, C W Cotma. Beta -amyloid-(1-42) impairs activity-dependent cAMP-response element-binding protein signaling in neurons at concentrations in which cell survival Is not compromised. The Journal of biological chemistry. vol 276. issue 20. 2001-07-05. PMID:11278679. |
in view of the critical role of creb and bdnf in neuronal plasticity, including learning and memory, the observations indicate a novel pathway through which abeta may interfere with neuronal functions and contribute to cognitive deficit in alzheimer's disease before the stage of massive neuronal degeneration. |
2001-07-05 |
2023-08-12 |
Not clear |
| H Kunugi, A Ueki, M Otsuka, K Isse, H Hirasawa, N Kato, T Nabika, S Kobayashi, S Nank. A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease. Molecular psychiatry. vol 6. issue 1. 2001-05-10. PMID:11244490. |
a novel polymorphism of the brain-derived neurotrophic factor (bdnf) gene associated with late-onset alzheimer's disease. |
2001-05-10 |
2023-08-12 |
Not clear |
| H Kunugi, A Ueki, M Otsuka, K Isse, H Hirasawa, N Kato, T Nabika, S Kobayashi, S Nank. A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease. Molecular psychiatry. vol 6. issue 1. 2001-05-10. PMID:11244490. |
several lines of evidence have suggested altered functions of the brain-derived neurotrophic factor (bdnf) in the pathogenesis of neurodegenerative diseases including alzheimer's disease (ad). |
2001-05-10 |
2023-08-12 |
Not clear |
| N Durany, T Michel, J Kurt, F F Cruz-Sánchez, J Cervás-Navarro, P Riedere. Brain-derived neurotrophic factor and neurotrophin-3 levels in Alzheimer's disease brains. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 18. issue 8. 2001-03-22. PMID:11156744. |
in the present study, we investigated the levels of brain-derived neurotrophic factor (bdnf) and neurotrophin-3 (nt-3) in post-mortem brain tissue of alzheimer's disease (ad) patients, and we observed a significant increase of bdnf concentration in hippocampus and parietal cortex of ad patients, as well as a negative correlation between nt-3 levels and age in hippocampus and putamen of control subjects, and for bdnf in frontal cortex. |
2001-03-22 |
2023-08-12 |
human |
| M G Murer, Q Yan, R Raisman-Vozar. Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease. Progress in neurobiology. vol 63. issue 1. 2000-12-07. PMID:11040419. |
bdnf has been found to promote survival of all major neuronal types affected in alzheimer's disease and parkinson's disease, like hippocampal and neocortical neurons, cholinergic septal and basal forebrain neurons, and nigral dopaminergic neurons. |
2000-12-07 |
2023-08-12 |
human |
| M G Murer, Q Yan, R Raisman-Vozar. Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease. Progress in neurobiology. vol 63. issue 1. 2000-12-07. PMID:11040419. |
but our primary aim is to review the literature regarding bdnf distribution in the human brain, and the modifications of bdnf expression which occur in the brain of individuals with alzheimer's disease and parkinson's disease. |
2000-12-07 |
2023-08-12 |
human |
| C Hock, K Heese, C Hulette, C Rosenberg, U Otte. Region-specific neurotrophin imbalances in Alzheimer disease: decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas. Archives of neurology. vol 57. issue 6. 2000-07-13. PMID:10867782. |
nerve growth factor (ngf), brain-derived neurotrophic factor (bdnf), neurotrophin 3 (nt-3), and neurotrophin 4/5 (nt-4/5) are members of the neurotrophin gene family that support the survival of specific neuronal populations, including those that are affected by neurodegeneration in alzheimer disease (ad). |
2000-07-13 |
2023-08-12 |
Not clear |
| R M Holsinger, J Schnarr, P Henry, V T Castelo, M Fahnestoc. Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in Alzheimer's disease. Brain research. Molecular brain research. vol 76. issue 2. 2000-06-05. PMID:10762711. |
quantitation of bdnf mrna in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in alzheimer's disease. |
2000-06-05 |
2023-08-12 |
human |
| I Ferrer, C Marín, M J Rey, T Ribalt. Brain-derived neurotrophic factor in patients with frontotemporal dementia. Neuroscience letters. vol 279. issue 1. 2000-03-07. PMID:10670781. |
bdnf expression is reduced in alzheimer disease, but little is known about bdnf expression in other types of dementia. |
2000-03-07 |
2023-08-12 |
Not clear |