| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuto Kashiwagi, Takemi Rokugawa, Tomomi Yamada, Atsushi Obata, Hiroshi Watabe, Yoshichika Yoshioka, Kohji Ab. Pharmacological MRI response to a selective dopamine transporter inhibitor, GBR12909, in awake and anesthetized rats. Synapse (New York, N.Y.). vol 69. issue 4. 2015-12-04. PMID:25612063. |
in this study we investigated the phmri responses to a selective dopamine transporter (dat) inhibitor, gbr12909, and a dopamine (da) releaser, d-amphetamine (amph), in the isoflurane anesthetized and awake rats using a relative cerebral blood volume (rcbv) method. |
2015-12-04 |
2023-08-13 |
rat |
| Manuel Delgado-Alvarado, Patricia de la Riva, Haritz Jiménez-Urbieta, Belén Gago, Alazne Gabilondo, Belén Bornstein, María Cruz Rodríguez-Oro. Parkinsonism, cognitive deficit and behavioural disturbance caused by a novel mutation in the polymerase gamma gene. Journal of the neurological sciences. vol 350. issue 1-2. 2015-12-04. PMID:25724872. |
a comprehensive study showed striatal dopamine deficiency on dat scan and ragged red fibres as evidenced by gomori staining in a biopsy of the biceps brachii. |
2015-12-04 |
2023-08-13 |
Not clear |
| Hongyan Gou, Di Wen, Chunling Ma, Ming Li, Yingmin Li, Wenfang Zhang, Li Liu, Bin Con. Protective effects of cholecystokinin-8 on methamphetamine-induced behavioral changes and dopaminergic neurodegeneration in mice. Behavioural brain research. vol 283. 2015-12-02. PMID:25629941. |
cck-8 pretreatment attenuated meth (10mg/kg)-induced hyperthermia, the decrease of tyrosine hydroxylase (th) and dopamine transporter (dat) in the striatum, and th in the substantia nigra. |
2015-12-02 |
2023-08-13 |
mouse |
| Rashed Harun, Christine M Grassi, Miranda J Munoz, Gonzalo E Torres, Amy K Wagne. Neurobiological model of stimulated dopamine neurotransmission to interpret fast-scan cyclic voltammetry data. Brain research. vol 1599. 2015-12-01. PMID:25527399. |
the current, widely implemented interpretive framework for doing so is the michaelis-menten (m-m) model, which is grounded on two assumptions- (1) da release rate is constant during stimulation, and (2) da reuptake occurs through dopamine transporters (dat) in a manner consistent with m-m enzyme kinetics. |
2015-12-01 |
2023-08-13 |
Not clear |
| Mahesh Darna, Joshua S Beckmann, Cassandra D Gipson, Michael T Bardo, Linda P Dwoski. Effect of environmental enrichment on dopamine and serotonin transporters and glutamate neurotransmission in medial prefrontal and orbitofrontal cortex. Brain research. vol 1599. 2015-12-01. PMID:25536304. |
recent studies have reported that rats raised in an enriched condition (ec) have decreased dopamine transporter (dat) function and expression in medial prefrontal cortex (mpfc), as well as increased d-amphetamine-induced glutamate release in nucleus accumbens compared to rats raised in an isolated condition (ic). |
2015-12-01 |
2023-08-13 |
rat |
| Eline R Zaaijer, Kora de Bruin, Susanne E la Fleur, Anna E Goudriaan, Wim van den Brink, Jan Booi. Subchronic administration of short-acting naltrexone has no effect on striatal dopamine transporter availability, food intake or body weight gain in rats. Journal of psychopharmacology (Oxford, England). vol 29. issue 3. 2015-12-01. PMID:25586403. |
however, questions have been raised about possible anhedonic side effects, because the opioid system is directly involved in hedonic responses to natural rewarding activities, possibly due to its indirect effects on the striatal dopamine transporter (dat). |
2015-12-01 |
2023-08-13 |
rat |
| Inga Y Rauschenbach, Evgenia K Karpova, Natalya V Adonyeva, Olga V Andreenkova, Natalya V Faddeeva, Elena V Burdina, Alexander A Alekseev, Petr N Menshanov, Nataly E Gruntenk. Disruption of insulin signalling affects the neuroendocrine stress reaction in Drosophila females. The Journal of experimental biology. vol 217. issue Pt 20. 2015-11-20. PMID:25214494. |
we show that suppression of the insulin-like receptor (inr) in the corpus allatum, a specialised endocrine gland that synthesises jh, causes an increase in dopamine level and jh-hydrolysing activity and alters the activities of enzymes that produce as well as those that degrade dopamine [alkaline phosphatase (alp), tyrosine hydroxylase (th) and dopamine-dependent arylalkylamine n-acetyltransferase (dat)]. |
2015-11-20 |
2023-08-13 |
drosophila_melanogaster |
| Jan Kunzler, Katharina Braun, Joerg Boc. Early life stress and sex-specific sensitivity of the catecholaminergic systems in prefrontal and limbic regions of Octodon degus. Brain structure & function. vol 220. issue 2. 2015-11-16. PMID:24343570. |
the aim of this study was to test the hypothesis that catecholaminergic fibers and dopamine transporters (dat) are differentially vulnerable towards els-induced neuronal changes in male and female brains. |
2015-11-16 |
2023-08-12 |
Not clear |
| Katja Kerstin Schneider, Andrea B Schote, Jobst Meyer, Christian Fring. Genes of the dopaminergic system selectively modulate top-down but not bottom-up attention. Cognitive, affective & behavioral neuroscience. vol 15. issue 1. 2015-11-13. PMID:25253063. |
both the catechol o-methyltransferase (comt) protein and the dopamine transporter (dat) protein are crucial for the degradation and inactivation of da. |
2015-11-13 |
2023-08-13 |
human |
| Narasimha M Midde, Yaxia Yuan, Pamela M Quizon, Wei-Lun Sun, Xiaoqin Huang, Chang-Guo Zhan, Jun Zh. Mutations at tyrosine 88, lysine 92 and tyrosine 470 of human dopamine transporter result in an attenuation of HIV-1 Tat-induced inhibition of dopamine transport. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 10. issue 1. 2015-11-12. PMID:25604666. |
hiv-1 transactivator of transcription (tat) protein disrupts the dopamine (da) neurotransmission by inhibiting da transporter (dat) function, leading to increased neurocognitive impairment in hiv-1 infected individuals. |
2015-11-12 |
2023-08-13 |
human |
| Kristal R Tucker, Ethan R Block, Edwin S Levita. Action potentials and amphetamine release antipsychotic drug from dopamine neuron synaptic VMAT vesicles. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 32. 2015-11-10. PMID:26216995. |
striatal cyam overlapped with the dopamine transporter (dat). |
2015-11-10 |
2023-08-13 |
human |
| Panojot Bifsha, Jianqi Yang, Rory A Fisher, Jacques Droui. Rgs6 is required for adult maintenance of dopaminergic neurons in the ventral substantia nigra. PLoS genetics. vol 10. issue 12. 2015-11-06. PMID:25501001. |
these low th neurons also express markers of increased dopamine signaling, namely increased dat and phospho-erk1/2 expression. |
2015-11-06 |
2023-08-13 |
mouse |
| Matej Markota, Jessica Sin, Harry Pantazopoulos, Rebecca Jonilionis, Sabina Berrett. Reduced dopamine transporter expression in the amygdala of subjects diagnosed with schizophrenia. Schizophrenia bulletin. vol 40. issue 5. 2015-11-03. PMID:24936023. |
we tested the hypothesis that the expression of the dopamine transporter (dat) is decreased in the amygdala of subjects with schizophrenia. |
2015-11-03 |
2023-08-13 |
human |
| Matej Markota, Jessica Sin, Harry Pantazopoulos, Rebecca Jonilionis, Sabina Berrett. Reduced dopamine transporter expression in the amygdala of subjects diagnosed with schizophrenia. Schizophrenia bulletin. vol 40. issue 5. 2015-11-03. PMID:24936023. |
this dat decrease may disrupt dopamine uptake, leading to increased dopaminergic synaptic transmission and spillage into the extracellular space with activation of extrasynaptic dopamine receptors. |
2015-11-03 |
2023-08-13 |
human |
| E Bowton, C Saunders, I A Reddy, N G Campbell, P J Hamilton, L K Henry, H Coon, D Sakrikar, J M Veenstra-VanderWeele, R D Blakely, J Sutcliffe, H J G Matthies, K Erreger, A Gall. SLC6A3 coding variant Ala559Val found in two autism probands alters dopamine transporter function and trafficking. Translational psychiatry. vol 4. 2015-11-02. PMID:25313507. |
emerging evidence associates dysfunction in the dopamine (da) transporter (dat) with the pathophysiology of autism spectrum disorder (asd). |
2015-11-02 |
2023-08-13 |
human |
| Rong Xu, Sarah A Lord, Ryan M Peterson, Emily A Fergason-Cantrell, John R Lever, Susan Z Leve. Ether modifications to 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine (SA4503): effects on binding affinity and selectivity for sigma receptors and monoamine transporters. Bioorganic & medicinal chemistry. vol 23. issue 1. 2015-10-22. PMID:25468036. |
sa4503 and a subset of ether analogs were also evaluated for dopamine transporter (dat) and serotonin transporter (sert) affinity. |
2015-10-22 |
2023-08-13 |
Not clear |
| Kelly Rose Tavares Neves, Hélio Vitoriano Nobre, Luzia Kalyne A M Leal, Geanne Matos de Andrade, Gerly Anne de Castro Brito, Glauce Socorro de Barros Vian. Pentoxifylline Neuroprotective Effects Are Possibly Related to Its Anti-Inflammatory and TNF-Alpha Inhibitory Properties, in the 6-OHDA Model of Parkinson's Disease. Parkinson's disease. vol 2015. 2015-10-22. PMID:26491600. |
in addition, decreases in immunostaining for th and dopamine transporter (dat) were reversed. |
2015-10-22 |
2023-08-13 |
rat |
| Shuyong Zhu, Chengjiang Zhao, Yingying Wu, Qiaoqiao Yang, Aiyun Shao, Tiepeng Wang, Jianfu Wu, Yanqing Yin, Yandong Li, Jincan Hou, Xinhua Zhang, Guomin Zhou, Xiaosong Gu, Xiaomin Wang, Xosé R Bustelo, Jiawei Zho. Identification of a Vav2-dependent mechanism for GDNF/Ret control of mesolimbic DAT trafficking. Nature neuroscience. vol 18. issue 8. 2015-10-21. PMID:26147533. |
dopamine transporter (dat)-mediated da reuptake is one of the most critical mechanisms for normal da homeostasis. |
2015-10-21 |
2023-08-13 |
mouse |
| J Sun, N J Cairns, J S Perlmutter, R H Mach, J X. Regulation of dopamine D₃ receptor in the striatal regions and substantia nigra in diffuse Lewy body disease. Neuroscience. vol 248. 2015-10-20. PMID:23732230. |
the densities of the dopamine d₁ receptor, vesicular monoamine transporter 2 (vmat2), and dopamine transporter (dat) were also measured by quantitative autoradiography using [(3)h]sch23390, [(3)h]dihydrotetrabenazine, and [(3)h]win35428, respectively. |
2015-10-20 |
2023-08-12 |
Not clear |
| Ole V Mortensen, Sandhya Kortager. Designing modulators of monoamine transporters using virtual screening techniques. Frontiers in pharmacology. vol 6. 2015-10-20. PMID:26483692. |
the plasma-membrane monoamine transporters (mats), including the serotonin (sert), norepinephrine (net) and dopamine (dat) transporters, serve a pivotal role in limiting monoamine-mediated neurotransmission through the reuptake of their respective monoamine neurotransmitters. |
2015-10-20 |
2023-08-13 |
drosophila_melanogaster |