| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karin Nordenankar, Casey J A Smith-Anttila, Nadine Schweizer, Thomas Viereckel, Carolina Birgner, Jana Mejia-Toiber, Marisela Morales, Richardson N Leao, Åsa Wallén-Mackenzi. Increased hippocampal excitability and impaired spatial memory function in mice lacking VGLUT2 selectively in neurons defined by tyrosine hydroxylase promoter activity. Brain structure & function. vol 220. issue 4. 2016-03-18. PMID:24802380. |
three populations of neurons expressing the vesicular glutamate transporter 2 (vglut2) were recently described in the a10 area of the mouse midbrain, of which two populations were shown to express the gene encoding, the rate-limiting enzyme for catecholamine synthesis, tyrosine hydroxylase (th).one of these populations ("th-vglut2 class1") also expressed the dopamine transporter (dat) gene while one did not ("th-vglut2 class2"), and the remaining population did not express th at all ("vglut2-only"). |
2016-03-18 |
2023-08-13 |
mouse |
| Anna-Maria Kasparbauer, Dan Rujescu, Michael Riedel, Oliver Pogarell, Anna Costa, Thomas Meindl, Christian la Fougère, Ulrich Ettinge. Methylphenidate effects on brain activity as a function of SLC6A3 genotype and striatal dopamine transporter availability. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 3. 2016-03-15. PMID:25220215. |
we pharmacologically challenged catecholamine reuptake, using methylphenidate, to investigate its effects on brain activity during a motor response inhibition task as a function of the 3'-utr variable number of tandem repeats (vntr) polymorphism of the dopamine transporter (dat) gene (slc6a3) and the availability of dats in the striatum. |
2016-03-15 |
2023-08-13 |
human |
| Joanna S Fowler, Jean Logan, Nora D Volkow, Elena Shumay, Fred McCall-Perez, Millard Jayne, Gene-Jack Wang, David L Alexoff, Karen Apelskog-Torres, Barbara Hubbard, Pauline Carter, Payton King, Stanley Fahn, Michelle Gilmor, Frank Telang, Colleen Shea, Youwen Xu, Lisa Muenc. Evidence that formulations of the selective MAO-B inhibitor, selegiline, which bypass first-pass metabolism, also inhibit MAO-A in the human brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 3. 2016-03-15. PMID:25249059. |
we also measured dopamine transporter (dat) availability in three subjects from the 10 mg group. |
2016-03-15 |
2023-08-13 |
human |
| Mark J Ferris, Erin S Calipari, Jamie H Rose, Cody A Siciliano, Haiguo Sun, Rong Chen, Sara R Jone. A Single Amphetamine Infusion Reverses Deficits in Dopamine Nerve-Terminal Function Caused by a History of Cocaine Self-Administration. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 8. 2016-03-08. PMID:25689882. |
following cocaine self-administration, dopamine release, maximal rate of uptake (vmax), and membrane-associated dopamine transporter (dat) levels were reduced, and the dat was less sensitive to cocaine. |
2016-03-08 |
2023-08-13 |
Not clear |
| Mark J Ferris, Erin S Calipari, Jamie H Rose, Cody A Siciliano, Haiguo Sun, Rong Chen, Sara R Jone. A Single Amphetamine Infusion Reverses Deficits in Dopamine Nerve-Terminal Function Caused by a History of Cocaine Self-Administration. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 8. 2016-03-08. PMID:25689882. |
a single amphetamine infusion reduced vmax and membrane dat levels in cocaine-naive animals, but fully restored all aspects of dopamine terminal function in cocaine self-administering animals. |
2016-03-08 |
2023-08-13 |
Not clear |
| R Kolanos, J S Partilla, M H Baumann, B A Hutsell, M L Banks, S S Negus, R A Glenno. Stereoselective Actions of Methylenedioxypyrovalerone (MDPV) To Inhibit Dopamine and Norepinephrine Transporters and Facilitate Intracranial Self-Stimulation in Rats. ACS chemical neuroscience. vol 6. issue 5. 2016-03-07. PMID:25688761. |
the designer stimulant methylenedioxypyrovalerone (mdpv) is a potent reuptake inhibitor at transporters for dopamine (dat) and norepinephrine (net) that produces a constellation of abuse-related behavioral effects. |
2016-03-07 |
2023-08-13 |
rat |
| Yogesh D Aher, Saraswathi Subramaniyan, Bharanidharan Shanmugasundaram, Ajinkya Sase, Sivaprakasam R Saroja, Marion Holy, Harald Höger, Tetyana Beryozkina, Harald H Sitte, Johann J Leban, Gert Lube. A Novel Heterocyclic Compound CE-104 Enhances Spatial Working Memory in the Radial Arm Maze in Rats and Modulates the Dopaminergic System. Frontiers in behavioral neuroscience. vol 10. 2016-03-04. PMID:26941626. |
the efficacy of ce-104 in blocking mat [dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter] was determined using in vitro neurotransmitter uptake assay. |
2016-03-04 |
2023-08-13 |
human |
| Di Wang, Wei Wang, Yulin Zhou, Juan Wang, Dongxu Jia, Hei Kiu Wong, Zhang-Jin Zhan. Studies on the regulatory effect of Peony-Glycyrrhiza Decoction on prolactin hyperactivity and underlying mechanism in hyperprolactinemia rat model. Neuroscience letters. vol 606. 2016-03-01. PMID:26297122. |
in previous experiment, pgd suppressed prolactin (prl) level in mmq cells, involving modulating the expression of d2 receptor (drd2) and dopamine transporter (dat). |
2016-03-01 |
2023-08-13 |
rat |
| S Sarkar, B Gough, J Raymick, M A Beaudoin, S F Ali, A Virmani, Z K Biniend. Histopathological and electrophysiological indices of rotenone-evoked dopaminergic toxicity: Neuroprotective effects of acetyl-L-carnitine. Neuroscience letters. vol 606. 2016-03-01. PMID:26321151. |
rats were perfused immediately after testing with 4% paraformaldehyde and immunohistochemical analysis of dopamine transporter (dat), tyrosine hydroxylase (th), glial fibrillary acidic protein (gfap), and microglial cd11b marker was performed in the caudate-putamen (cpu) and the substantia nigra pars compacta (snc) in order to estimate dopaminergic neuronal and transporter damage. |
2016-03-01 |
2023-08-13 |
rat |
| Giovanni Camardese, Luisa De Risio, Marco Di Nicola, Lorella Pucci, Fabrizio Cocciolillo, Pietro Bria, Alessandro Giordano, Luigi Janiri, Daniela Di Giud. Changes of dopamine transporter availability in depressed patients with and without anhedonia: a 123I-N-ω-fluoropropyl-carbomethoxy-3β- (4-Iodophenyl)tropane SPECT study. Neuropsychobiology. vol 70. issue 4. 2016-02-29. PMID:25613182. |
dopamine transporters (dat) may play a crucial role in the pathophysiology of dopaminergic transmission. |
2016-02-29 |
2023-08-13 |
Not clear |
| M D Sconce, M J Churchill, R E Greene, C K Meshu. Intervention with exercise restores motor deficits but not nigrostriatal loss in a progressive MPTP mouse model of Parkinson's disease. Neuroscience. vol 299. 2016-02-29. PMID:25943481. |
mice treated with 4 weeks of mptp showed a 41% loss of vesicular monoamine transporter ii (vmat2), a 71% increase in the ratio of glycosylated/non-glycosylated dopamine transporter (dat), and significant increases in glutamate transporters including vglut1, glt-1, and excitatory amino acid carrier 1. |
2016-02-29 |
2023-08-13 |
mouse |
| Andrzej Dekundy, Flora Mela, Martine Hofmann, Wojciech Danys. Effects of dopamine uptake inhibitor MRZ-9547 in animal models of Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 6. 2016-02-22. PMID:25319446. |
mrz-9547 (d-(2-(2-oxo-4(r)-phenylpyrrolidin-1-yl)-acetamide) is a drug acting at the dopamine transporter (dat). |
2016-02-22 |
2023-08-13 |
rat |
| Kai Liu, Huamin Xu, Hengwei Xiang, Peng Sun, Junxia Xi. Protective effects of Ndfip1 on MPP(+)-induced apoptosis in MES23.5 cells and its underlying mechanisms. Experimental neurology. vol 273. 2016-02-18. PMID:26300475. |
in addition, we found that ndfip1 overexpression could decrease the protein level of dopamine transporter (dat). |
2016-02-18 |
2023-08-13 |
Not clear |
| Eve Privman, B Jill Vento. Comparison of dopamine kinetics in the larval Drosophila ventral nerve cord and protocerebrum with improved optogenetic stimulation. Journal of neurochemistry. vol 135. issue 4. 2016-02-16. PMID:26296526. |
when the competitive dopamine transporter (dat) inhibitor nisoxetine was applied, the km increased significantly in both regions while vmax stayed the same. |
2016-02-16 |
2023-08-13 |
drosophila_melanogaster |
| Antonio Augimeri, Andrea Cherubini, Giuseppe Lucio Cascini, Domenico Galea, Maria Eugenia Caligiuri, Gaetano Barbagallo, Gennarina Arabia, Aldo Quattron. CADA-computer-aided DaTSCAN analysis. EJNMMI physics. vol 3. issue 1. 2016-02-16. PMID:26879864. |
dopamine transporter (dat) imaging (datscan) is useful for the differential diagnosis of parkinsonian syndromes. |
2016-02-16 |
2023-08-13 |
Not clear |
| Y Takamatsu, Y Hagino, A Sato, T Takahashi, S Y Nagasawa, Y Kubo, M Mizuguchi, G R Uhl, I Sora, K Iked. Improvement of learning and increase in dopamine level in the frontal cortex by methylphenidate in mice lacking dopamine transporter. Current molecular medicine. vol 15. issue 3. 2016-02-12. PMID:25817856. |
recent studies have drawn attention to altered dopamine-mediated neurotransmission in adhd, particularly reuptake by the dopamine transporter (dat). |
2016-02-12 |
2023-08-13 |
mouse |
| Y Kasahara, Y Arime, F S Hall, G R Uhl, I Sor. Region-specific dendritic spine loss of pyramidal neurons in dopamine transporter knockout mice. Current molecular medicine. vol 15. issue 3. 2016-02-12. PMID:25817859. |
dopamine transporter (dat) knockout (ko) mice show numerous behavioral alterations, including hyperlocomotion, cognitive deficits, impulsivity and impairment of prepulse inhibition of the startle reflex (ppi), phenotypes that may be relevant to frontostriatal disorders such as schizophrenia. |
2016-02-12 |
2023-08-13 |
mouse |
| Aida Niñerola-Baizán, Santiago Rojas, Núria Roé-Vellvé, Francisco Lomeña, Domènec Ros, Javier Paví. Dopamine transporter imaging in the aged rat: a [¹²³I]FP-CIT SPECT study. Nuclear medicine and biology. vol 42. issue 4. 2016-02-09. PMID:25624150. |
one of the results of this susceptibility is a decline in striatal dopamine transporter (dat) availability. |
2016-02-09 |
2023-08-13 |
rat |
| Christian Pifl, Harald Reither, Oleh Hornykiewic. The profile of mephedrone on human monoamine transporters differs from 3,4-methylenedioxymethamphetamine primarily by lower potency at the vesicular monoamine transporter. European journal of pharmacology. vol 755. 2016-02-09. PMID:25771452. |
we therefore compared their effects on the human monoamine transporters using human cell lines stably expressing the human noradrenaline, dopamine and serotonin transporter (net, dat and sert); preparations of synaptic vesicles from human striatum in uptake experiments; and a superfusion system where releasing effects can be reliably measured. |
2016-02-09 |
2023-08-13 |
human |
| Yasir H Ahmed-Braimah, Andrea L Sweigar. A single gene causes an interspecific difference in pigmentation in Drosophila. Genetics. vol 200. issue 1. 2016-02-08. PMID:25769982. |
the mapped interval includes only the first exon and regulatory region(s) of the dopamine n-acetyltransferase gene (dat). |
2016-02-08 |
2023-08-13 |
drosophila_melanogaster |