| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David S Wheeler, Suzanne M Underhill, Donna B Stolz, Geoffrey H Murdoch, Edda Thiels, Guillermo Romero, Susan G Amar. Amphetamine activates Rho GTPase signaling to mediate dopamine transporter internalization and acute behavioral effects of amphetamine. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 51. 2016-06-07. PMID:26553986. |
consistent with this model, the activation of d1/d5 receptors that couple to pka in dopamine neurons antagonizes rhoa activation, dat internalization, and hyperlocomotion observed in mice after amph treatment. |
2016-06-07 |
2023-08-13 |
mouse |
| Ben D Richardson, Kaustuv Saha, Danielle Krout, Elizabeth Cabrera, Bruce Felts, L Keith Henry, Jarod Swant, Mu-Fa Zou, Amy Hauck Newman, Habibeh Khoshboue. Membrane potential shapes regulation of dopamine transporter trafficking at the plasma membrane. Nature communications. vol 7. 2016-06-07. PMID:26804245. |
in addition to da release and availability of synaptic da receptors, timing and magnitude of da neurotransmission depend on extracellular da-level regulation by the dopamine transporter (dat), the membrane expression and trafficking of which are highly dynamic. |
2016-06-07 |
2023-08-13 |
Not clear |
| Anmol Kumar, Jaakko Kopra, Kärt Varendi, Lauriina L Porokuokka, Anne Panhelainen, Satu Kuure, Pepin Marshall, Nina Karalija, Mari-Anne Härma, Carolina Vilenius, Kersti Lilleväli, Triin Tekko, Jelena Mijatovic, Nita Pulkkinen, Madis Jakobson, Maili Jakobson, Roxana Ola, Erik Palm, Maria Lindahl, Ingrid Strömberg, Vootele Võikar, T Petteri Piepponen, Mart Saarma, Jaan-Olle Andresso. GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function. PLoS genetics. vol 11. issue 12. 2016-06-01. PMID:26681446. |
enhanced gdnf levels up-regulated striatal dopamine transporter activity by at least five fold resulting in enhanced susceptibility to 6-ohda, a toxin transported into dopamine neurons by dat. |
2016-06-01 |
2023-08-13 |
mouse |
| P Borghammer, K Knudsen, K Østergaard, E H Danielsen, N Pavese, A Arveschoug, H Bluhme, M Bode, A Morsin. Combined DaT imaging and olfactory testing for differentiating parkinsonian disorders. International journal of clinical practice. vol 68. issue 11. 2016-05-27. PMID:24754902. |
dopamine transporter (dat) imaging with single photon emission computed tomography (spect) detects loss of striatal dopaminergic innervation with very high sensitivity. |
2016-05-27 |
2023-08-13 |
Not clear |
| J S Bonano, M L Banks, R Kolanos, F Sakloth, M L Barnier, R A Glennon, N V Cozzi, J S Partilla, M H Baumann, S S Negu. Quantitative structure-activity relationship analysis of the pharmacology of para-substituted methcathinone analogues. British journal of pharmacology. vol 172. issue 10. 2016-05-24. PMID:25438806. |
this study examined quantitative structure-activity relationships (qsar) for mcat and six para-substituted mcat analogues on (a) in vitro potency to promote monoamine release via dopamine and serotonin transporters (dat and sert, respectively), and (b) in vivo modulation of intracranial self-stimulation (icss), a behavioural procedure used to evaluate abuse potential. |
2016-05-24 |
2023-08-13 |
Not clear |
| Xiangjun Xu, Emily J Jaehne, Zarina Greenberg, Peter McCarthy, Eiman Saleh, Clare L Parish, Daria Camera, Julian Heng, Matilda Haas, Bernhard T Baune, Udani Ratnayake, Maarten van den Buuse, Angel F Lopez, Hayley S Ramshaw, Quenten Schwar. 14-3-3ζ deficient mice in the BALB/c background display behavioural and anatomical defects associated with neurodevelopmental disorders. Scientific reports. vol 5. 2016-05-24. PMID:26207352. |
in contrast to our previous analyses, 14-3-3ζ(-/-) balb/c mice lacked locomotor hyperactivity that was underscored by normal levels of the dopamine transporter (dat) and dopamine signalling. |
2016-05-24 |
2023-08-13 |
mouse |
| Florence F Roussotte, Boris A Gutman, Derrek P Hibar, Sarah K Madsen, Katherine L Narr, Paul M Thompso. Carriers of a common variant in the dopamine transporter gene have greater dementia risk, cognitive decline, and faster ventricular expansion. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 11. issue 10. 2016-05-23. PMID:25496873. |
genetic variants in dat1, the gene encoding the dopamine transporter (dat) protein, have been implicated in many brain disorders. |
2016-05-23 |
2023-08-13 |
Not clear |
| Beryl Luk, Mohinuddin Mohammed, Fang Liu, Frank J S Le. A Physical Interaction between the Dopamine Transporter and DJ-1 Facilitates Increased Dopamine Reuptake. PloS one. vol 10. issue 8. 2016-05-11. PMID:26305376. |
the regulation of the dopamine transporter (dat) impacts extracellular dopamine levels after release from dopaminergic neurons. |
2016-05-11 |
2023-08-13 |
Not clear |
| Beryl Luk, Mohinuddin Mohammed, Fang Liu, Frank J S Le. A Physical Interaction between the Dopamine Transporter and DJ-1 Facilitates Increased Dopamine Reuptake. PloS one. vol 10. issue 8. 2016-05-11. PMID:26305376. |
co-expression of dat and dj-1 in hek-293t cells leads to an increase in [3h] dopamine uptake that does not appear to be mediated by increased total dat expression but rather through an increase in dat cell surface localization. |
2016-05-11 |
2023-08-13 |
Not clear |
| Beryl Luk, Mohinuddin Mohammed, Fang Liu, Frank J S Le. A Physical Interaction between the Dopamine Transporter and DJ-1 Facilitates Increased Dopamine Reuptake. PloS one. vol 10. issue 8. 2016-05-11. PMID:26305376. |
our study suggests that dj-1 may also play a role in regulating dopamine levels by modifying dat activity. |
2016-05-11 |
2023-08-13 |
Not clear |
| Jeffrey S Stehouwer, Mark M Goodma. Fluorine-18 Radiolabeled PET Tracers for Imaging Monoamine Transporters: Dopamine, Serotonin, and Norepinephrine. PET clinics. vol 4. issue 1. 2016-05-10. PMID:20216936. |
this review focuses on the development of fluorine-18 radiolabeled pet tracers for imaging the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net). |
2016-05-10 |
2023-08-12 |
Not clear |
| Stefanie Geisler, Nicola Beindorff, Markus Cremer, Kerstin Hoffmann, Winfried Brenner, Paul Cumming, Philipp T Meyer, Karl-Josef Langen, Eberhard Fuchs, Ralph Bucher. Characterization of [123I]FP-CIT binding to the dopamine transporter in the striatum of tree shrews by quantitative in vitro autoradiography. Synapse (New York, N.Y.). vol 69. issue 10. 2016-05-10. PMID:26126942. |
despite its wide clinical use, the saturation binding parameters of [(123) i]fp-cit for the dopamine transporter (dat) have not yet been determined in any mammalian brain. |
2016-05-10 |
2023-08-13 |
Not clear |
| Sijia Wu, Karl D Bellve, Kevin E Fogarty, Haley E Melikia. Ack1 is a dopamine transporter endocytic brake that rescues a trafficking-dysregulated ADHD coding variant. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 50. 2016-05-09. PMID:26621748. |
the dopamine (da) transporter (dat) facilitates high-affinity presynaptic da reuptake that temporally and spatially constrains da neurotransmission. |
2016-05-09 |
2023-08-13 |
Not clear |
| Maria A de Souza Silva, Claudia Mattern, Cvetana Decheva, Joseph P Huston, Adolfo G Sadile, Markus Beu, H-W Müller, Susanne Nikolau. Intranasal Dopamine Reduces In Vivo [(123)I]FP-CIT Binding to Striatal Dopamine Transporter: Correlation with Behavioral Changes and Evidence for Pavlovian Conditioned Dopamine Response. Frontiers in behavioral neuroscience. vol 10. 2016-05-05. PMID:27148001. |
we here examined whether in-da application influences dopamine transporter (dat) binding in the dorsal striatum and assessed the extent of binding in relation to motor and exploratory behaviors. |
2016-05-05 |
2023-08-13 |
Not clear |
| Gavin McLaughlin, Noreen Morris, Pierce V Kavanagh, John D Power, Brendan Twamley, John O'Brien, Brian Talbot, Geraldine Dowling, Olivia Mahony, Simon D Brandt, Julian Patrick, Roland P Archer, John S Partilla, Michael H Bauman. Synthesis, characterization, and monoamine transporter activity of the new psychoactive substance 3',4'-methylenedioxy-4-methylaminorex (MDMAR). Drug testing and analysis. vol 7. issue 7. 2016-05-04. PMID:25331619. |
cis-mdmar, trans-mdmar, cis-4,4'-dmar and trans-4,4'-dmar were more potent than mdma in their ability to function as efficacious substrate-type releasers at the dopamine (dat) and norepinephrine (net) transporters in rat brain tissue. |
2016-05-04 |
2023-08-13 |
rat |
| Patrick C McHugh, David A Buckle. The structure and function of the dopamine transporter and its role in CNS diseases. Vitamins and hormones. vol 98. 2016-05-02. PMID:25817874. |
in this chapter, we explore the basic science of the dopamine transporter (dat), an integral component of a system that regulates dopamine homeostasis. |
2016-05-02 |
2023-08-13 |
Not clear |
| Yohei Mukai, Miho Murat. [Scans without Evidence of Dopamine Deficit (SWEDDs)]. Brain and nerve = Shinkei kenkyu no shinpo. vol 68. issue 1. 2016-05-02. PMID:26764301. |
dopamine transporter (dat) single-photon emission computed tomography (spect) and [18f]fluoro-l-dopa ([18f]dopa) positron emission tomography (pet) facilitate the investigation of dopaminergic hypofunction in neurodegenerative diseases. |
2016-05-02 |
2023-08-13 |
human |
| Е V Konovalova, Е G Ivashkin, А V Lopachev, О М Lopacheva, А А Komissarov, I А Grivennikov, Е V Novosadova, E B Dashynimaev, Е Yu Fedotova, S N Illarioshki. [Functional properties of dopaminergic neurons obtained from fibroblasts of a patient with PARK2 form of Parkinson's disease]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 115. issue 12. 2016-04-28. PMID:26978505. |
to carry out a functional analysis of dopamine transporter (dat) in autosomal recessive parkinson's disease caused by mutations in the park2 gene. |
2016-04-28 |
2023-08-13 |
Not clear |
| Daniele Tomassoni, Enea Traini, Manuele Mancini, Vincenzo Bramanti, Syed Sarosh Mahdi, Francesco Ament. Dopamine, vesicular transporters, and dopamine receptor expression in rat major salivary glands. American journal of physiology. Regulatory, integrative and comparative physiology. vol 309. issue 5. 2016-04-26. PMID:26136535. |
the localization of dopamine stores and the expression and localization of dopamine (dat) and vesicular monoamine transporters (vmat) type-1 and -2 and of dopamine d1-like and d2-like receptor subtypes were investigated in rat submandibular, sublingual, and parotid salivary glands by hplc with electrochemical detection, as well as immunochemical and immunohistochemical techniques. |
2016-04-26 |
2023-08-13 |
rat |
| Daniele Tomassoni, Enea Traini, Manuele Mancini, Vincenzo Bramanti, Syed Sarosh Mahdi, Francesco Ament. Dopamine, vesicular transporters, and dopamine receptor expression in rat major salivary glands. American journal of physiology. Regulatory, integrative and comparative physiology. vol 309. issue 5. 2016-04-26. PMID:26136535. |
western blot analysis revealed dat, vmat-1, vmat-2, and dopamine receptors immunoreactivity in membrane preparations obtained from the three glands investigated. |
2016-04-26 |
2023-08-13 |
rat |