| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Evgeniya V Efimova, Raul R Gainetdinov, Evgeny A Budygin, Tatyana D Sotnikov. Dopamine transporter mutant animals: a translational perspective. Journal of neurogenetics. vol 30. issue 1. 2017-12-20. PMID:27276191. |
the dopamine transporter (dat) plays an important homeostatic role in the control of both the extracellular and intraneuronal concentrations of dopamine, thereby providing effective control over activity of dopaminergic transmission. |
2017-12-20 |
2023-08-13 |
mouse |
| Evgeniya V Efimova, Raul R Gainetdinov, Evgeny A Budygin, Tatyana D Sotnikov. Dopamine transporter mutant animals: a translational perspective. Journal of neurogenetics. vol 30. issue 1. 2017-12-20. PMID:27276191. |
since brain dopamine is known to be involved in numerous neuropsychiatric disorders, investigations using mice with genetically altered dat function and thus intensity of dopamine-mediated signaling have provided numerous insights into the pathology of these disorders and novel pathological mechanisms that could be targeted to provide new therapeutic approaches for these disorders. |
2017-12-20 |
2023-08-13 |
mouse |
| Lisa S Robison, Mala Ananth, Michael Hadjiargyrou, David E Komatsu, Panayotis K Thano. Chronic oral methylphenidate treatment reversibly increases striatal dopamine transporter and dopamine type 1 receptor binding in rats. Journal of neural transmission (Vienna, Austria : 1996). vol 124. issue 5. 2017-12-20. PMID:28116523. |
in vitro receptor autoradiography was performed to quantify binding levels of dopamine transporter (dat), dopamine type 1 (d1r)-like receptors, and dopamine type 2 (d2r)-like receptors using [ |
2017-12-20 |
2023-08-13 |
rat |
| Inés Reynoso-Moreno, Israel Najar-Guerrero, Noé Escareño, Mario Eduardo Flores-Soto, Jürg Gertsch, Juan Manuel Viveros-Parede. An Endocannabinoid Uptake Inhibitor from Black Pepper Exerts Pronounced Anti-Inflammatory Effects in Mice. Journal of agricultural and food chemistry. vol 65. issue 43. 2017-12-20. PMID:28942644. |
a subsequent screen of 45 cns-related receptors, ion channels, and transporters revealed apparent interactions of guineensine with the dopamine transporter dat, 5ht2a, and sigma receptors, uncovering its prospective polypharmacology. |
2017-12-20 |
2023-08-13 |
mouse |
| Sivaprakasam R Saroja, Yogesh D Aher, Predrag Kalaba, Nilima Y Aher, Martin Zehl, Volker Korz, Saraswathi Subramaniyan, Andras G Miklosi, Lisa Zanon, Winfried Neuhaus, Harald Höger, Thierry Langer, Ernst Urban, Johann Leban, Gert Lube. A novel heterocyclic compound targeting the dopamine transporter improves performance in the radial arm maze and modulates dopamine receptors D1-D3. Behavioural brain research. vol 312. 2017-12-19. PMID:27288589. |
a series of compounds targeting the dopamine transporter (dat) has been shown to improve memory performance most probably by re-uptake inhibition. |
2017-12-19 |
2023-08-13 |
rat |
| Sivaprakasam R Saroja, Yogesh D Aher, Predrag Kalaba, Nilima Y Aher, Martin Zehl, Volker Korz, Saraswathi Subramaniyan, Andras G Miklosi, Lisa Zanon, Winfried Neuhaus, Harald Höger, Thierry Langer, Ernst Urban, Johann Leban, Gert Lube. A novel heterocyclic compound targeting the dopamine transporter improves performance in the radial arm maze and modulates dopamine receptors D1-D3. Behavioural brain research. vol 312. 2017-12-19. PMID:27288589. |
although specific dat inhibitors are available, there is limited information about specificity, mechanism and in particular the effect on dopamine receptors. |
2017-12-19 |
2023-08-13 |
rat |
| Maggie C Evans, Greg M Anderso. Dopamine Neuron-Restricted Leptin Receptor Signaling Reduces Some Aspects of Food Reward but Exacerbates the Obesity of Leptin Receptor-Deficient Male Mice. Endocrinology. vol 158. issue 12. 2017-12-18. PMID:28938472. |
to further explore the role of direct lepr-dopamine neuron signaling in the control of feeding behavior and energy homeostasis, we generated mice in which leprs were expressed exclusively in dopamine transporter (dat)-expressing neurons (leprdat). |
2017-12-18 |
2023-08-13 |
mouse |
| A Chiavaroli, L Recinella, C Ferrante, S Martinotti, M Vacca, L Brunetti, G Orlando, S Leon. Effects of central fibroblast growth factor 21 and irisin in anxiety-like behavior. Journal of biological regulators and homeostatic agents. vol 31. issue 3. 2017-12-14. PMID:28890831. |
prefrontal cortex levels of norepinephrine (ne), dopamine (da) and serotonin (5-hydroxytryptamine, 5-ht) and the gene expression of catechol-o-methyltransferase (comt), dopamine transport (dat) and tyrosine hydroxylase (th), were measured by high performance liquid chromatography (hplc) analysis and real-time reverse transcription polymerase chain reaction (rt-pcr). |
2017-12-14 |
2023-08-13 |
rat |
| Shasha Xu, Ying Liu, Yu Li, Yangping Deng, Jie Yuan, Rongbin Lv, Yuankai Wang, Guangming Zhang, Zhirui Guo, Daxu Fu, Hui Zeng, Mei Han, Xingdang Li. Availability of dopamine transporters in heroin-dependent subjects: A Psychiatry research. Neuroimaging. vol 263. 2017-12-13. PMID:28376406. |
availability of dopamine transporters in heroin-dependent subjects: a this study was to reconfirm the reduced dopamine transporter (dat) availability in heroin-dependent subjects and validate the use of 2β-carbomethoxy-3β-(4-chlorophenyl)-8-(2-fluoroethyl)-nortropane ( |
2017-12-13 |
2023-08-13 |
human |
| Ahmed M Hussein, Yogesh D Aher, Predrag Kalaba, Nilima Y Aher, Vladimir Dragačević, Bojana Radoman, Marija Ilić, Johann Leban, Tetyana Beryozkina, Abdel Baset M A Ahmed, Ernst Urban, Thierry Langer, Gert Lube. A novel heterocyclic compound improves working memory in the radial arm maze and modulates the dopamine receptor D1R in frontal cortex of the Sprague-Dawley rat. Behavioural brain research. vol 332. 2017-12-12. PMID:28629964. |
specific and effective dopamine re-uptake inhibition dat (ic50=4,1±0,8μm) made us test this compound in a radial arm maze (ram) in the rat. |
2017-12-12 |
2023-08-13 |
rat |
| Ahmed M Hussein, Yogesh D Aher, Predrag Kalaba, Nilima Y Aher, Vladimir Dragačević, Bojana Radoman, Marija Ilić, Johann Leban, Tetyana Beryozkina, Abdel Baset M A Ahmed, Ernst Urban, Thierry Langer, Gert Lube. A novel heterocyclic compound improves working memory in the radial arm maze and modulates the dopamine receptor D1R in frontal cortex of the Sprague-Dawley rat. Behavioural brain research. vol 332. 2017-12-12. PMID:28629964. |
ce-125 (4-((benzhydrylsulfinyl)methyl)-2-cyclopropylthiazole), was tested for dopamine (dat), serotonin and norepinephrine re-uptake inhibition by a well-established system. |
2017-12-12 |
2023-08-13 |
rat |
| Ahmed M Hussein, Yogesh D Aher, Predrag Kalaba, Nilima Y Aher, Vladimir Dragačević, Bojana Radoman, Marija Ilić, Johann Leban, Tetyana Beryozkina, Abdel Baset M A Ahmed, Ernst Urban, Thierry Langer, Gert Lube. A novel heterocyclic compound improves working memory in the radial arm maze and modulates the dopamine receptor D1R in frontal cortex of the Sprague-Dawley rat. Behavioural brain research. vol 332. 2017-12-12. PMID:28629964. |
frontal cortex was taken at the last day of the ram test and dopamine receptors d1r and d2r, dat and phosphorylated dat protein levels were determined. |
2017-12-12 |
2023-08-13 |
rat |
| Egle Janenaite, Valentina Vengeliene, Anton Bespalov, Berthold Beh. Potential role of tyrosine hydroxylase in the loss of psychostimulant effect of amphetamine under conditions of impaired dopamine transporter activity. Behavioural brain research. vol 334. 2017-12-11. PMID:28750831. |
amphetamine and methylphenidate are known to have stimulatory effect in healthy subjects but not in humans with attention deficit hyperactivity disorder and in rodents with impaired dopamine transporter (dat) function. |
2017-12-11 |
2023-08-13 |
human |
| Mehrak Javadi-Paydar, Robert F Roscoe, Adam R Denton, Charles F Mactutus, Rosemarie M Booz. HIV-1 and cocaine disrupt dopamine reuptake and medium spiny neurons in female rat striatum. PloS one. vol 12. issue 11. 2017-12-11. PMID:29176843. |
taken together, the current study provides evidence for dysfunction of the dopamine transporter (dat) in mediating da reuptake in hiv-1 tg rats and limited responses to acute coc exposure. |
2017-12-11 |
2023-08-13 |
rat |
| Mariana G Fronza, Lucimar M Pinto Brod, Angela Maria Casaril, Manoela Sacramento, Diego Alves, Lucielli Savegnag. Computational and biological evidences on the serotonergic involvement of SeTACN antidepressant-like effect in mice. PloS one. vol 12. issue 11. 2017-12-05. PMID:29091968. |
a series of phenylselanyl-1h-1,2,3-triazole-4-carbonitriles with different substituents were screened for their binding affinity with serotonin transporter (sert) and dopamine transporter (dat) by docking molecular. |
2017-12-05 |
2023-08-13 |
mouse |
| Valentina Vengeliene, Anton Bespalov, Martin Roßmanith, Sandra Horschitz, Stefan Berger, Ana L Relo, Hamid R Noori, Peggy Schneider, Thomas Enkel, Dusan Bartsch, Miriam Schneider, Berthold Behl, Anita C Hansson, Patrick Schloss, Rainer Spanage. Towards trans-diagnostic mechanisms in psychiatry: neurobehavioral profile of rats with a loss-of-function point mutation in the dopamine transporter gene. Disease models & mechanisms. vol 10. issue 4. 2017-12-04. PMID:28167616. |
here, we used a new genetic rat model with a loss-of-function point mutation in the dopamine transporter (dat) gene ( |
2017-12-04 |
2023-08-13 |
rat |
| Shyamsunder R Joolakanti, Justin R Nickell, Venumadhav Janganati, Guangrong Zheng, Linda P Dwoskin, Peter A Crook. Lobelane analogues containing 4-hydroxy and 4-(2-fluoroethoxy) aromatic substituents: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2. Bioorganic & medicinal chemistry letters. vol 26. issue 10. 2017-11-22. PMID:27080180. |
a series of lobelane and gz-793a analogues that incorporate aromatic 4-hydroxy and 4-(2-fluoroethoxy) substituents were synthesized and evaluated for inhibition of [(3)h]dopamine (da) uptake at the vesicular monoamine transporter-2 (vmat2) and the dopamine transporter (dat), and [(3)h]serotonin uptake at the serotonin transporter (sert). |
2017-11-22 |
2023-08-13 |
Not clear |
| Arthur S C França, Larissa Muratori, George Carlos Nascimento, Catia Mendes Pereira, Sidarta Ribeiro, Bruno Lobão-Soare. Object recognition impairment and rescue by a dopamine D2 antagonist in hyperdopaminergic mice. Behavioural brain research. vol 308. 2017-11-21. PMID:27059337. |
genetically-modified mice without the dopamine transporter (dat) are hyperdopaminergic, and serve as models for studies of addiction, mania and hyperactive disorders. |
2017-11-21 |
2023-08-13 |
mouse |
| Stephanie M Greer, Andrea N Goldstein, Brian Knutson, Matthew P Walke. A Genetic Polymorphism of the Human Dopamine Transporter Determines the Impact of Sleep Deprivation on Brain Responses to Rewards and Punishments. Journal of cognitive neuroscience. vol 28. issue 6. 2017-11-16. PMID:26918589. |
combining fmri with an established incentive paradigm and individual genotyping, here, we test the hypothesis that trait differences in the human dopamine transporter (dat) gene-associated with altered synaptic dopamine signalling-govern the impact of sleep deprivation on neural sensitivity to impending monetary gains and losses. |
2017-11-16 |
2023-08-13 |
human |
| Stephanie M Greer, Andrea N Goldstein, Brian Knutson, Matthew P Walke. A Genetic Polymorphism of the Human Dopamine Transporter Determines the Impact of Sleep Deprivation on Brain Responses to Rewards and Punishments. Journal of cognitive neuroscience. vol 28. issue 6. 2017-11-16. PMID:26918589. |
only participants carrying a copy of the nine-repeat dat allele-linked to higher phasic dopamine activity-expressed amplified striatal response during anticipation of monetary gain following sleep deprivation. |
2017-11-16 |
2023-08-13 |
human |