| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mert Gur, Mary Hongying Cheng, Elia Zomot, Ivet Baha. Effect of Dimerization on the Dynamics of Neurotransmitter:Sodium Symporters. The journal of physical chemistry. B. vol 121. issue 15. 2018-05-07. PMID:28118712. |
in this study, we examined the collective dynamics of two members of the family, leucine transporter (leut) and dopamine transporter (dat), to assess the significance of dimerization in modulating the functional motions of the monomers. |
2018-05-07 |
2023-08-13 |
Not clear |
| Yasmina Martí, Friederike Matthaeus, Thorsten Lau, Patrick Schlos. Methyl-4-phenylpyridinium (MPP+) differentially affects monoamine release and re-uptake in murine embryonic stem cell-derived dopaminergic and serotonergic neurons. Molecular and cellular neurosciences. vol 83. 2018-05-03. PMID:28673772. |
mpp+ is taken up by the dopamine transporter (dat) into da neurons where it exerts its neurotoxic action on mitochondria by affecting complex i of the respiratory chain. |
2018-05-03 |
2023-08-13 |
mouse |
| Bernandie Jean, Christopher K Surratt, Jeffry D Madur. Molecular dynamics of conformation-specific dopamine transporter-inhibitor complexes. Journal of molecular graphics & modelling. vol 76. 2018-05-02. PMID:28734204. |
cocaine binds to and stabilizes the outward- (extracellular-) facing conformation of the dopamine transporter (dat) protein, while the low abuse potential dat inhibitor benztropine prefers the inward- (cytoplasmic-) facing conformation. |
2018-05-02 |
2023-08-13 |
Not clear |
| Ernesto Solis, Julie A Suyama, Matthew F Lazenka, Louis J DeFelice, S Stevens Negus, Bruce E Blough, Matthew L Bank. Dissociable effects of the prodrug phendimetrazine and its metabolite phenmetrazine at dopamine transporters. Scientific reports. vol 6. 2018-05-01. PMID:27514281. |
pdm blocked the endogenous basal hdat (human dopamine transporter) current in voltage-clamped (-60 mv) oocytes consistent with a dat inhibitor profile, whereas its metabolite pm induced an inward hdat current consistent with a dat substrate profile. |
2018-05-01 |
2023-08-13 |
human |
| Ernesto Solis, Julie A Suyama, Matthew F Lazenka, Louis J DeFelice, S Stevens Negus, Bruce E Blough, Matthew L Bank. Dissociable effects of the prodrug phendimetrazine and its metabolite phenmetrazine at dopamine transporters. Scientific reports. vol 6. 2018-05-01. PMID:27514281. |
overall, these results suggest a novel mechanism for pdm therapeutic effects via initial pdm dat inhibition followed by pm dat substrate-induced dopamine release. |
2018-05-01 |
2023-08-13 |
human |
| Abdelrahman R Shalabi, Donna Walther, Michael H Baumann, Richard A Glenno. Deconstructed Analogues of Bupropion Reveal Structural Requirements for Transporter Inhibition versus Substrate-Induced Neurotransmitter Release. ACS chemical neuroscience. vol 8. issue 6. 2018-05-01. PMID:28220701. |
bupropion (1), an α-aminophenone uptake inhibitor at plasma membrane transporters for dopamine (dat) and norepinephrine (net), is a widely prescribed antidepressant and smoking cessation aid. |
2018-05-01 |
2023-08-13 |
Not clear |
| Panpan Wang, Xiaoyu Zhang, Tingting Fu, Shuang Li, Bo Li, Weiwei Xue, Xiaojun Yao, Yuzong Chen, Feng Zh. Differentiating Physicochemical Properties between Addictive and Nonaddictive ADHD Drugs Revealed by Molecular Dynamics Simulation Studies. ACS chemical neuroscience. vol 8. issue 6. 2018-05-01. PMID:28557437. |
it is known that psychostimulants' addictiveness is largely attributed to their interaction with dopamine transporter (dat) and their binding modes in dat can thus facilitate the understanding of the mechanism underlining drugs' addictiveness. |
2018-05-01 |
2023-08-13 |
Not clear |
| M J Churchill, L Pflibsen, M D Sconce, C Moore, K Kim, C K Meshu. Exercise in an animal model of Parkinson's disease: Motor recovery but not restoration of the nigrostriatal pathway. Neuroscience. vol 359. 2018-04-30. PMID:28754312. |
the mptp group had a significant 170% increase in the glycosylated/non-glycosylated dopamine transporter (dat) and a 200% increase in microglial marker, iba-1, in the striatum. |
2018-04-30 |
2023-08-13 |
mouse |
| Ernesto Solis, John S Partilla, Farhana Sakloth, Iwona Ruchala, Kathryn L Schwienteck, Louis J De Felice, Jose M Eltit, Richard A Glennon, S Stevens Negus, Michael H Bauman. N-Alkylated Analogs of 4-Methylamphetamine (4-MA) Differentially Affect Monoamine Transporters and Abuse Liability. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 10. 2018-04-24. PMID:28530234. |
clandestine chemists synthesize novel stimulant drugs by exploiting structural templates known to target monoamine transporters for dopamine, norepinephrine, and serotonin (dat, net, and sert, respectively). |
2018-04-24 |
2023-08-13 |
rat |
| Motoyasu Honma, Yuki Murai, Shuhei Shima, Yuko Yotsumoto, Takeshi Kuroda, Akinori Futamura, Azusa Shiromaru, Ikuya Murakami, Mitsuru Kawamur. Spatial distortion related to time compression during spatiotemporal production in Parkinson's disease. Neuropsychologia. vol 102. 2018-04-17. PMID:28601527. |
results were analyzed in relation to deficiency of presynaptic dopamine transporter (dat) in the striatum. |
2018-04-17 |
2023-08-13 |
human |
| Alicia J Avelar, Jianjing Cao, Amy Hauck Newman, Michael J Beckstea. Atypical dopamine transporter inhibitors R-modafinil and JHW 007 differentially affect D2 autoreceptor neurotransmission and the firing rate of midbrain dopamine neurons. Neuropharmacology. vol 123. 2018-04-17. PMID:28625719. |
abuse of psychostimulants like cocaine that inhibit dopamine (da) reuptake through the dopamine transporter (dat) represents a major public health issue, however fda-approved pharmacotherapies have yet to be developed. |
2018-04-17 |
2023-08-13 |
mouse |
| Ana Isabelle G de Queiroz, Adriano José Maia Chaves Filho, Tatiane da Silva Araújo, Camila Nayane Carvalho Lima, Michel de Jesus Souza Machado, André F Carvalho, Silvania Maria Mendes Vasconcelos, David Freitas de Lucena, João Quevedo, Danielle Maced. Antimanic activity of minocycline in a GBR12909-induced model of mania in mice: Possible role of antioxidant and neurotrophic mechanisms. Journal of affective disorders. vol 225. 2018-04-11. PMID:28783519. |
recently, single administration of the dopamine transporter (dat) inhibitor, gbr12909, was related to mania-like alterations. |
2018-04-11 |
2023-08-13 |
mouse |
| Federico Rodriguez-Porcel, Sheheryar Jamali, Andrew P Duker, Alberto J Espa. Dopamine transporter scanning in the evaluation of patients with suspected Parkinsonism: a case-based user's guide. Expert review of neurotherapeutics. vol 16. issue 1. 2018-04-10. PMID:26564057. |
dopamine transporter (dat) single photon emission computed tomography (spect) (datscan), an imaging technique that probes the integrity of the presynaptic nigrostriatal system, can be useful in the evaluation of clinically complex parkinsonian disorders in the appropriate context and when adequately interpreted. |
2018-04-10 |
2023-08-13 |
Not clear |
| Suraj Adhikary, Daniel J Deredge, Anu Nagarajan, Lucy R Forrest, Patrick L Wintrode, Satinder K Sing. Conformational dynamics of a neurotransmitter:sodium symporter in a lipid bilayer. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 10. 2018-04-10. PMID:28223522. |
the symporters for the biogenic amines serotonin (sert), dopamine (dat), and norepinephrine (net) are targets of multiple psychoactive agents, and their dysfunction has been implicated in numerous neuropsychiatric ailments. |
2018-04-10 |
2023-08-13 |
Not clear |
| Yanhui Chen, Xiaolan Zheng, Linqi Xie, Liang Huang, Zhongling Ke, Jie Zheng, Hongzhu Lu, Jun H. Glucocorticoids/glucocorticoid receptors effect on dopaminergic neurotransmitters in ADHD rats. Brain research bulletin. vol 131. 2018-04-09. PMID:28458039. |
the levels of dopamine, norepinephrine, and dopamine transporter (dat) in the prefrontal cortex and striatum were also tested. |
2018-04-09 |
2023-08-13 |
rat |
| Anita Cybulska-Klosowicz, Julia Dabrowska, Sebastian Niedzielec, Renata Zakrzewska, Aleksandra Rozyck. Potential role of dopamine transporter in behavioral flexibility. Acta neurobiologiae experimentalis. vol 77. issue 2. 2018-04-03. PMID:28691722. |
the regulatory control in maintaining da homeostasis and function is provided by the dopamine transporter (dat), which therefore likely plays a significant role in controlling the influence of da on cognitive processes. |
2018-04-03 |
2023-08-13 |
mouse |
| Rathan M Subramaniam, Kirk A Frey, Christopher H Hunt, Gustavo A Mercier, Lilja B Solnes, Patrick M Colletti, Yang Lu, Bital Savir-Baruch, Hadyn T William. ACR-ACNM Practice Parameter for the Performance of Dopamine Transporter (DaT) Single Photon Emission Computed Tomography (SPECT) Imaging for Movement Disorders. Clinical nuclear medicine. vol 42. issue 11. 2018-04-02. PMID:28922189. |
acr-acnm practice parameter for the performance of dopamine transporter (dat) single photon emission computed tomography (spect) imaging for movement disorders. |
2018-04-02 |
2023-08-13 |
Not clear |
| Yukari Suda, Naoko Kuzumaki, Michiko Narita, Yusuke Hamada, Masahiro Shibasaki, Kenichi Tanaka, Hideki Tamura, Takashi Kawamura, Takashige Kondo, Akihiro Yamanaka, Minoru Narit. Effect of ghrelin on the motor deficit caused by the ablation of nigrostriatal dopaminergic cells or the inhibition of striatal dopamine receptors. Biochemical and biophysical research communications. vol 496. issue 4. 2018-03-22. PMID:29378186. |
in the present study, we further investigated the role of the sn-ghrelin system in motor function under the stereotaxic injection of aav-cmv-flex-diphtheria toxin a (dta) into the sn of dopamine transporter (dat)-cre (dat |
2018-03-22 |
2023-08-13 |
Not clear |
| Yixin Li, Baijuan Xia, Rongrong Li, Dan Yin, Wenmei Lian. Changes in Expression of Dopamine, Its Receptor, and Transporter in Nucleus Accumbens of Heroin-Addicted Rats with Brain-Derived Neurotrophic Factor (BDNF) Overexpression. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-03-19. PMID:28598964. |
material and methods we established a rat model of heroin addiction and observed changes in the expression of bdnf, da, dopamine receptor (drd), dopamine transporter (dat), and other relevant pathways in nac. |
2018-03-19 |
2023-08-13 |
rat |
| Matthew F Lazenka, S Stevens Negu. Oral modafinil facilitates intracranial self-stimulation in rats: comparison with methylphenidate. Behavioural pharmacology. vol 28. issue 4. 2018-03-06. PMID:28125506. |
modafinil is a low-potency inhibitor of dopamine transporters (dat) approved clinically to promote wakefulness. |
2018-03-06 |
2023-08-13 |
rat |