| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giovanni Addolorato, Mariangela Antonelli, Fabrizio Cocciolillo, Gabriele A Vassallo, Claudia Tarli, Luisa Sestito, Antonio Mirijello, Anna Ferrulli, Daniele A Pizzuto, Giovanni Camardese, Antonio Miceli, Marco Diana, Alessandro Giordano, Antonio Gasbarrini, Daniela Di Giud. Deep Transcranial Magnetic Stimulation of the Dorsolateral Prefrontal Cortex in Alcohol Use Disorder Patients: Effects on Dopamine Transporter Availability and Alcohol Intake. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 27. issue 5. 2018-03-06. PMID:28390775. |
we investigated alcohol intake and dopamine transporter (dat) availability by single photon emission computed tomography (spect) in the striatum of aud patients before and after deep rtms. |
2018-03-06 |
2023-08-13 |
human |
| Motoyasu Honma, Takeshi Kuroda, Akinori Futamura, Azusa Shiromaru, Mitsuru Kawamur. Dysfunctional counting of mental time in Parkinson's disease. Scientific reports. vol 6. 2018-02-21. PMID:27146904. |
the current study examined time underestimation and counting in patients with pd, in relation to dopamine transporter (dat) located on presynaptic nerve endings in the striatum. |
2018-02-21 |
2023-08-13 |
Not clear |
| Anne Horn, C Scheller, S du Plessis, R Burger, G Arendt, J Joska, S Sopper, C M Maschke, M Obermann, I W Husstedt, J Hain, P Riederer, E Koutsilier. The dopamine-related polymorphisms BDNF, COMT, DRD2, DRD3, and DRD4 are not linked with changes in CSF dopamine levels and frequency of HIV infection. Journal of neural transmission (Vienna, Austria : 1996). vol 124. issue 4. 2018-02-21. PMID:27909828. |
we showed previously that higher levels in csf dopamine in hiv patients are associated with the presence of the dopamine transporter (dat) 10/10-repeat allele which was also detected more frequently in hiv-infected individuals compared to uninfected subjects. |
2018-02-21 |
2023-08-13 |
human |
| Jie Yuan, Xing Dang Liu, Mei Han, Rong Bin Lv, Yuan Kai Wang, Guang Ming Zhang, Yu L. Comparison of striatal dopamine transporter levels in chronic heroin-dependent and methamphetamine-dependent subjects. Addiction biology. vol 22. issue 1. 2018-02-13. PMID:26040446. |
to compare the effects of heroin and methamphetamine (meth) addiction on dopamine transporters (dats) in the same dose and duration, we assessed dat levels in the striatum by |
2018-02-13 |
2023-08-13 |
human |
| Placido Illiano, Ambra Lanzo, Damiana Leo, Maria Paglione, Giuseppina Zampi, Raul R Gainetdinov, Elia Di Schiav. A Caenorhabditis elegans model to study dopamine transporter deficiency syndrome. The European journal of neuroscience. vol 45. issue 1. 2018-02-01. PMID:27519790. |
dopamine transporter deficiency syndrome (dtds) is a novel autosomal recessive disorder caused by mutations in the dopamine transporter (dat), which leads to the partial or total loss of function of the protein. |
2018-02-01 |
2023-08-13 |
human |
| Placido Illiano, Ambra Lanzo, Damiana Leo, Maria Paglione, Giuseppina Zampi, Raul R Gainetdinov, Elia Di Schiav. A Caenorhabditis elegans model to study dopamine transporter deficiency syndrome. The European journal of neuroscience. vol 45. issue 1. 2018-02-01. PMID:27519790. |
in c. elegans transgenic animals expressing the human wild-type form, we observed a rescue of the knockout phenotype, as assessed using two well-established paradigms, known to be regulated by the endogenous uptake of dopamine or 6-hydroxydopamine (6-ohda) by dat. |
2018-02-01 |
2023-08-13 |
human |
| Kelly M Lohr, Shababa T Masoud, Ali Salahpour, Gary W Mille. Membrane transporters as mediators of synaptic dopamine dynamics: implications for disease. The European journal of neuroscience. vol 45. issue 1. 2018-02-01. PMID:27520881. |
the dopamine transporter (dat; slc6a3) and the vesicular monoamine transporter 2 (vmat2; slc18a2) are regulators of dopamine homeostasis in the presynaptic neuron. |
2018-02-01 |
2023-08-13 |
mouse |
| Kelly M Lohr, Shababa T Masoud, Ali Salahpour, Gary W Mille. Membrane transporters as mediators of synaptic dopamine dynamics: implications for disease. The European journal of neuroscience. vol 45. issue 1. 2018-02-01. PMID:27520881. |
dat transports dopamine from the extracellular space into the cytosol of the presynaptic terminal. |
2018-02-01 |
2023-08-13 |
mouse |
| Kelly M Lohr, Shababa T Masoud, Ali Salahpour, Gary W Mille. Membrane transporters as mediators of synaptic dopamine dynamics: implications for disease. The European journal of neuroscience. vol 45. issue 1. 2018-02-01. PMID:27520881. |
here, we review the importance of dat and vmat2 function in the delicate balance of neuronal dopamine. |
2018-02-01 |
2023-08-13 |
mouse |
| Maddalena Mereu, Lauren E Chun, Thomas E Prisinzano, Amy H Newman, Jonathan L Katz, Gianluigi Tand. The unique psychostimulant profile of (±)-modafinil: investigation of behavioral and neurochemical effects in mice. The European journal of neuroscience. vol 45. issue 1. 2018-02-01. PMID:27545285. |
blockade of dopamine (da) reuptake via the dopamine transporter (dat) is a primary mechanism identified as underlying the therapeutic actions of (±)-modafinil (modafinil) and its r-enantiomer, armodafinil. |
2018-02-01 |
2023-08-13 |
mouse |
| Qin Wu, Wei Yan, Houcheng Cheng, Chunsheng Liu, Tien-Chieh Hung, Xiaochun Guo, Guangyu L. Parental transfer of microcystin-LR induced transgenerational effects of developmental neurotoxicity in zebrafish offspring. Environmental pollution (Barking, Essex : 1987). vol 231. issue Pt 1. 2018-02-01. PMID:28837927. |
in addition, the acetylcholinesterase (ache) activity was remarkably decreased in mclr parental exposure groups, while the expression levels of manf, bdnf, ache, htr1ab, htr1b, htr2a, htr1aa, htr5a, dat, th1 and th2 genes coincided with the decreased content of neurotransmitters (dopamine, dopac and serotonin) and the activity of ache. |
2018-02-01 |
2023-08-13 |
zebrafish |
| Hongliang Yi, Xiaohang Bao, Xiaotong Tang, Xiaotang Fan, Haiwei X. Estrogen modulation of calretinin and BDNF expression in midbrain dopaminergic neurons of ovariectomised mice. Journal of chemical neuroanatomy. vol 77. 2018-01-31. PMID:27211874. |
dopamine transporter (dat) mrna and bdnf mrna levels in the midbrain were also significantly increased by estrogen treatment (p<0.05). |
2018-01-31 |
2023-08-13 |
mouse |
| Mauro Ceccanti, Roberto Coccurello, Valentina Carito, Stefania Ciafrè, Giampiero Ferraguti, Giacomo Giacovazzo, Rosanna Mancinelli, Paola Tirassa, George N Chaldakov, Esterina Pascale, Marco Ceccanti, Claudia Codazzo, Marco Fior. Paternal alcohol exposure in mice alters brain NGF and BDNF and increases ethanol-elicited preference in male offspring. Addiction biology. vol 21. issue 4. 2018-01-29. PMID:25940002. |
ngf and bdnf, their receptors (p75(ntr) , trka and trkb), dopamine active transporter (dat), dopamine receptors d1 and d2, pro-ngf and pro-bdnf were also evaluated in brain areas. |
2018-01-29 |
2023-08-13 |
mouse |
| R López-Arnau, M A Luján, L Duart-Castells, D Pubill, J Camarasa, O Valverde, E Escubed. Exposure of adolescent mice to 3,4-methylenedioxypyrovalerone increases the psychostimulant, rewarding and reinforcing effects of cocaine in adulthood. British journal of pharmacology. vol 174. issue 10. 2018-01-29. PMID:28262947. |
it selectively inhibits the dopamine transporter (dat) and is 10-50-fold more potent as a dat blocker than cocaine, suggesting a high abuse liability. |
2018-01-29 |
2023-08-13 |
mouse |
| Troels Rahbek-Clemmensen, Matthew D Lycas, Simon Erlendsson, Jacob Eriksen, Mia Apuschkin, Frederik Vilhardt, Trine N Jørgensen, Freja H Hansen, Ulrik Gethe. Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains. Nature communications. vol 8. issue 1. 2018-01-26. PMID:28963530. |
the molecular organization of the dopamine transporter in nanodomains is reversibly reduced by short-term activation of nmda-type ionotropic glutamate receptors, implicating dopamine transporter nanodomain distribution as a potential mechanism to modulate dopaminergic neurotransmission in response to excitatory input.the dopamine transporter (dat) has a crucial role in the regulation of neurotransmission. |
2018-01-26 |
2023-08-13 |
Not clear |
| Brenna K Brown, Jill Murrell, Harish Karne, Amit Anan. The effects of DAT1 genotype on fMRI activation in an emotional go/no-go task. Brain imaging and behavior. vol 11. issue 1. 2018-01-25. PMID:26843006. |
the dopamine transporter (dat) modulates dopamine reuptake. |
2018-01-25 |
2023-08-13 |
human |
| Brenna K Brown, Jill Murrell, Harish Karne, Amit Anan. The effects of DAT1 genotype on fMRI activation in an emotional go/no-go task. Brain imaging and behavior. vol 11. issue 1. 2018-01-25. PMID:26843006. |
a variable number tandem repeat (vntr) in the dopamine transporter gene (dat1) affects dat expression. |
2018-01-25 |
2023-08-13 |
human |
| Jun Zhu, Yaxia Yuan, Narasimha M Midde, Adrian M Gomez, Wei-Lun Sun, Pamela M Quizon, Chang-Guo Zha. HIV-1 transgenic rats display an increase in [(3)H]dopamine uptake in the prefrontal cortex and striatum. Journal of neurovirology. vol 22. issue 3. 2018-01-24. PMID:26501780. |
dopamine transporter (dat)-mediated dopamine transport is critical for normal dopamine homeostasis. |
2018-01-24 |
2023-08-13 |
rat |
| Jun Zhu, Yaxia Yuan, Narasimha M Midde, Adrian M Gomez, Wei-Lun Sun, Pamela M Quizon, Chang-Guo Zha. HIV-1 transgenic rats display an increase in [(3)H]dopamine uptake in the prefrontal cortex and striatum. Journal of neurovirology. vol 22. issue 3. 2018-01-24. PMID:26501780. |
our published work has demonstrated that transactivator of transcription (tat)-induced inhibition of dat is mediated by allosteric binding site(s) on dat, not the interaction with the dopamine uptake site. |
2018-01-24 |
2023-08-13 |
rat |
| Predrag Kalaba, Nilima Y Aher, Marija Ilić, Vladimir Dragačević, Marcus Wieder, Andras G Miklosi, Martin Zehl, Judith Wackerlig, Alexander Roller, Tetyana Beryozkina, Bojana Radoman, Sivaprakasam R Saroja, Wolfgang Lindner, Eduardo Perez Gonzalez, Vasiliy Bakulev, Johann Jakob Leban, Harald H Sitte, Ernst Urban, Thierry Langer, Gert Lube. Heterocyclic Analogues of Modafinil as Novel, Atypical Dopamine Transporter Inhibitors. Journal of medicinal chemistry. vol 60. issue 22. 2018-01-23. PMID:29091428. |
it is targeting the dopamine transporter (dat) with moderate selectivity, thereby leading to reuptake inhibition and increased dopamine levels in the synaptic cleft. |
2018-01-23 |
2023-08-13 |
Not clear |