| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Megan L Fitzgerald, Suham A Kassir, Mark D Underwood, Mihran J Bakalian, J John Mann, Victoria Arang. Dysregulation of Striatal Dopamine Receptor Binding in Suicide. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 4. 2018-01-19. PMID:27402414. |
to determine whether there are alterations in the striatal dopamine system in suicide, we conducted a quantitative autoradiographic survey of dopamine transporter (dat; [ |
2018-01-19 |
2023-08-13 |
Not clear |
| Elina Mäkinen, Juho Joutsa, Jarkko Johansson, Maija Mäki, Marko Seppänen, Valtteri Kaasine. Visual versus automated analysis of [I-123]FP-CIT SPECT scans in parkinsonism. Journal of neural transmission (Vienna, Austria : 1996). vol 123. issue 11. 2018-01-18. PMID:27324804. |
the clinical evaluation of dopamine transporter (dat) spect scans typically relies on visual analysis in combination with an automated semi-quantitative method. |
2018-01-18 |
2023-08-13 |
Not clear |
| Zheng-Xiong Xi, Rui Song, Xia Li, Guan-Yi Lu, Xiao-Qing Peng, Yi He, Guo-Hua Bi, Siyuan Peter Sheng, Hong-Ju Yang, Haiying Zhang, Jin Li, Mark Froimowitz, Eliot L Gardne. CTDP-32476: A Promising Agonist Therapy for Treatment of Cocaine Addiction. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 3. 2018-01-16. PMID:27534265. |
we report here an atypical dopamine (da) transporter (dat) inhibitor, ctdp-32476, that may have translational potential for treating cocaine addiction. |
2018-01-16 |
2023-08-13 |
rat |
| Xuefang Liang, Christopher L Souders, Jiliang Zhang, Christopher J Martyniu. Tributyltin induces premature hatching and reduces locomotor activity in zebrafish (Danio rerio) embryos/larvae at environmentally relevant levels. Chemosphere. vol 189. 2018-01-15. PMID:28961535. |
to address mechanisms related to changes in behavioral activity, we measured transcripts associated with muscle function (myf6, myod, and myog) and dopamine signaling (th, dat, dopamine receptors) as dopamine regulates behavior. |
2018-01-15 |
2023-08-13 |
zebrafish |
| Victoria Kacprzak, Neil A Patel, Elizabeth Riley, Lili Yu, Jing-Ruey J Yeh, Irina V Zhdanov. Dopaminergic control of anxiety in young and aged zebrafish. Pharmacology, biochemistry, and behavior. vol 157. 2018-01-12. PMID:28408289. |
changes in the expression of the dopamine transporter (dat), or the sensitivity of dopamine receptors, are associated with aging and substance abuse and may underlie some of the symptoms common to both conditions. |
2018-01-12 |
2023-08-13 |
zebrafish |
| Laurent Karila, Claire Leroy, Manon Dubol, Christian Trichard, Audrey Mabondo, Catherine Marill, Albertine Dubois, Nadège Bordas, Jean-Luc Martinot, Michel Reynaud, Eric Artige. Dopamine Transporter Correlates and Occupancy by Modafinil in Cocaine-Dependent Patients: A Controlled Study With High-Resolution PET and [(11)C]-PE2I. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 9. 2018-01-09. PMID:26892922. |
modafinil is a candidate compound for the treatment of cocaine addiction that binds to the dopamine transporter (dat) in healthy humans, as observed by positron emission tomography (pet). |
2018-01-09 |
2023-08-13 |
human |
| Joseph Kambeitz, Christian la Fougère, Natalie Werner, Oliver Pogarell, Michael Riedel, Peter Falkai, Ulrich Ettinge. Nicotine-dopamine-transporter interactions during reward-based decision making. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 26. issue 6. 2018-01-05. PMID:27112968. |
striatal dopamine transporter (dat) binding was measured by single-photon emission computed tomography (spect). |
2018-01-05 |
2023-08-13 |
human |
| Joseph Kambeitz, Christian la Fougère, Natalie Werner, Oliver Pogarell, Michael Riedel, Peter Falkai, Ulrich Ettinge. Nicotine-dopamine-transporter interactions during reward-based decision making. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 26. issue 6. 2018-01-05. PMID:27112968. |
the observed interaction is consistent with the hypothesized associations between dat expression and extracellular dopamine levels, suggestive of an inverted u-shape relationship between baseline dopamine and magnitude in response to a pro-dopaminergic compound. |
2018-01-05 |
2023-08-13 |
human |
| Lorenzo Antonio Justo, Rafael Durán, Miguel Alfonso, Daniel Fajardo, Lilian Rosana F Far. Effects and mechanism of action of isatin, a MAO inhibitor, on in vivo striatal dopamine release. Neurochemistry international. vol 99. 2018-01-03. PMID:27374845. |
the highest concentration of isatin (10 mm) was used to investigate whether the dopamine overflow is due to an exocytotic release or due to a possible action on dopamine transporter (dat). |
2018-01-03 |
2023-08-13 |
rat |
| Lorenzo Antonio Justo, Rafael Durán, Miguel Alfonso, Daniel Fajardo, Lilian Rosana F Far. Effects and mechanism of action of isatin, a MAO inhibitor, on in vivo striatal dopamine release. Neurochemistry international. vol 99. 2018-01-03. PMID:27374845. |
the blockade of dat with nomifensine (50 μm) did not alter the effect of isatin; and isatin significantly increased the depolarization-evoked release of dopamine. |
2018-01-03 |
2023-08-13 |
rat |
| Naoto Uyama, Hideki Otsuka, Takayoshi Shinya, Yoichi Otomi, Masafumi Harada, Wataru Sako, Yuishin Izumi, Ryuji Kaji, Yuya Watanabe, Satoru Takashi, Yamato Kunikan. The utility of the combination of a SPECT study with [123I]-FP-CIT of dopamine transporters and [123I]-MIBG myocardial scintigraphy in differentiating Parkinson disease from other degenerative parkinsonian syndromes. Nuclear medicine communications. vol 38. issue 6. 2017-12-26. PMID:28410288. |
molecular imaging of nigrostriatal dopamine transporters (dat) and sympathetic cardiac innervation with single-photon emission computed tomography (spect) are useful tools for differentiating idiopathic parkinson disease (pd) from other degenerative parkinsonian syndromes (non-pd). |
2017-12-26 |
2023-08-13 |
Not clear |
| Chung-Yin Lin, Han-Yi Hsieh, Chiung-Mei Chen, Shang-Rung Wu, Chih-Hung Tsai, Chiung-Yin Huang, Mu-Yi Hua, Kuo-Chen Wei, Chih-Kuang Yeh, Hao-Li Li. Non-invasive, neuron-specific gene therapy by focused ultrasound-induced blood-brain barrier opening in Parkinson's disease mouse model. Journal of controlled release : official journal of the Controlled Release Society. vol 235. 2017-12-25. PMID:27235980. |
dopamine (da) and its metabolites as well as dopamine active transporter (dat) were quantitatively analyzed to show dopaminergic neuronal dopamine secretion/activity/metabolism. |
2017-12-25 |
2023-08-13 |
mouse |
| Vinod Kumar, Brajesh Kumar Singh, Amit Kumar Chauhan, Deepali Singh, Devendra Kumar Patel, Chetna Sing. Minocycline Rescues from Zinc-Induced Nigrostriatal Dopaminergic Neurodegeneration: Biochemical and Molecular Interventions. Molecular neurobiology. vol 53. issue 5. 2017-12-22. PMID:25764516. |
zn attenuated the expression of tyrosine hydroxylase (th) and vesicular monoamine transporter-2 (vmat-2) while augmented the expression of dopamine transporter (dat) and heme oxygenase-1 (ho-1). |
2017-12-22 |
2023-08-13 |
rat |
| Soomaayeh Heysieattalab, Nasser Naghdi, Narges Hosseinmardi, Mohammad-Reza Zarrindast, Abbas Haghparast, Habibeh Khoshboue. Methamphetamine-induced enhancement of hippocampal long-term potentiation is modulated by NMDA and GABA receptors in the shell-accumbens. Synapse (New York, N.Y.). vol 70. issue 8. 2017-12-22. PMID:27029021. |
dopamine transporter (dat) is one of the main targets of meth. |
2017-12-22 |
2023-08-13 |
rat |
| Soomaayeh Heysieattalab, Nasser Naghdi, Narges Hosseinmardi, Mohammad-Reza Zarrindast, Abbas Haghparast, Habibeh Khoshboue. Methamphetamine-induced enhancement of hippocampal long-term potentiation is modulated by NMDA and GABA receptors in the shell-accumbens. Synapse (New York, N.Y.). vol 70. issue 8. 2017-12-22. PMID:27029021. |
as a substrate for dat, meth decreases dopamine uptake and increases dopamine efflux via the transporter in the target brain regions such as nucleus accumbens (nac) and hippocampus. |
2017-12-22 |
2023-08-13 |
rat |
| Susanne Nikolaus, Markus Beu, Maria Angelica De Souza Silva, Joseph P Huston, Hubertus Hautzel, Christina Antke, Hans-Wilhelm Mülle. DAT versus D2 receptor binding in the rat striatum: l-DOPA-induced motor activity is better predicted by reuptake than release of dopamine. Synapse (New York, N.Y.). vol 70. issue 9. 2017-12-22. PMID:27164322. |
dat versus d2 receptor binding in the rat striatum: l-dopa-induced motor activity is better predicted by reuptake than release of dopamine. |
2017-12-22 |
2023-08-13 |
rat |
| Susanne Nikolaus, Markus Beu, Maria Angelica De Souza Silva, Joseph P Huston, Hubertus Hautzel, Christina Antke, Hans-Wilhelm Mülle. DAT versus D2 receptor binding in the rat striatum: l-DOPA-induced motor activity is better predicted by reuptake than release of dopamine. Synapse (New York, N.Y.). vol 70. issue 9. 2017-12-22. PMID:27164322. |
the reuptake and release of dopamine (da) can be estimated using in vivo imaging methods by assessing the competition between endogenous da and an administered exogenous da transporter (dat) and d2 receptor (d2 r) radioligand, respectively. |
2017-12-22 |
2023-08-13 |
rat |
| Amir Seddik, Daan P Geerke, Thomas Stockner, Marion Holy, Oliver Kudlacek, Nicholas V Cozzi, Arnold E Ruoho, Harald H Sitte, Gerhard F Ecke. Combined Simulation and Mutation Studies to Elucidate Selectivity of Unsubstituted Amphetamine-like Cathinones at the Dopamine Transporter. Molecular informatics. vol 36. issue 5-6. 2017-12-22. PMID:27860344. |
the dopamine and serotonin transporter proteins (dat, sert) play a vital role in behavior and mental illness. |
2017-12-22 |
2023-08-13 |
Not clear |
| Ara M Abramyan, Sebastian Stolzenberg, Zheng Li, Claus J Loland, Frank Noé, Lei Sh. The Isomeric Preference of an Atypical Dopamine Transporter Inhibitor Contributes to Its Selection of the Transporter Conformation. ACS chemical neuroscience. vol 8. issue 8. 2017-12-22. PMID:28441487. |
cocaine, a widely abused psychostimulant, inhibits the dopamine transporter (dat) by trapping the protein in an outward-open conformation, whereas atypical dat inhibitors such as benztropine have low abuse liability and prefer less outward-open conformations. |
2017-12-22 |
2023-08-13 |
Not clear |
| Yoonju Lee, Jungsu S Oh, Seok Jong Chung, Su Jin Chung, Soo-Jong Kim, Chung Mo Nam, Phil Hyu Lee, Jae Seung Kim, Young H Soh. Does smoking impact dopamine neuronal loss in de novo Parkinson disease? Annals of neurology. vol 82. issue 5. 2017-12-22. PMID:29059491. |
this study analyzed data from dopamine transporter (dat) positron emission tomographic scans of 282 male patients with de novo parkinson disease to investigate whether smoking impacts striatal dopamine neuronal degeneration. |
2017-12-22 |
2023-08-13 |
Not clear |