| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Panagiotis Perdikaris, Martha Tsarouchi, Eleni Fanarioti, Evangelos Natsaridis, Ada Mitsacos, Panagiotis Giompre. Long lasting effects of chronic WIN55,212-2 treatment on mesostriatal dopaminergic and cannabinoid systems in the rat brain. Neuropharmacology. vol 129. 2018-07-27. PMID:29113897. |
acute and chronic administration of win55,212-2 decreased dopamine transporter (dat) binding and mrna levels, as well as tyrosine hydroxylase (th) mrna expression in the substantia nigra (sn) and ventral tegmental area (vta). |
2018-07-27 |
2023-08-13 |
rat |
| Panagiotis Perdikaris, Martha Tsarouchi, Eleni Fanarioti, Evangelos Natsaridis, Ada Mitsacos, Panagiotis Giompre. Long lasting effects of chronic WIN55,212-2 treatment on mesostriatal dopaminergic and cannabinoid systems in the rat brain. Neuropharmacology. vol 129. 2018-07-27. PMID:29113897. |
in the striatum, chronic win55,212-2 administration led to decreased protein expression of dat and th, whereas no alterations were observed after acute administration, suggesting a diminished dopamine uptake and synthesis after chronic agonist treatment. |
2018-07-27 |
2023-08-13 |
rat |
| Shaili Aggarwal, Ole V Mortense. In Vitro Assays for the Functional Characterization of the Dopamine Transporter (DAT). Current protocols in pharmacology. vol 79. 2018-07-26. PMID:29261226. |
in vitro assays for the functional characterization of the dopamine transporter (dat). |
2018-07-26 |
2023-08-13 |
Not clear |
| Shaili Aggarwal, Ole V Mortense. Overview of Monoamine Transporters. Current protocols in pharmacology. vol 79. 2018-07-26. PMID:29261228. |
the dopamine (dat), serotonin (sert), and norepinephrine (net) transporters, which are collectively referred to as monoamine transporters (mats), play significant roles in regulating the neuronal response to these neurotransmitters. |
2018-07-26 |
2023-08-13 |
Not clear |
| Anita Cybulska-Klosowicz, Marta Laczkowska, Renata Zakrzewska, Aleksandra Kaliszewsk. Attentional deficits and altered neuronal activation in medial prefrontal and posterior parietal cortices in mice with reduced dopamine transporter levels. Molecular and cellular neurosciences. vol 85. 2018-07-25. PMID:28923595. |
dopamine transporter (dat) likely plays a role in controlling the influence of da on cognitive processes. |
2018-07-25 |
2023-08-13 |
mouse |
| J Garcia-Olivares, T Baust, S Harris, P Hamilton, A Galli, S G Amara, G E Torre. Gβγ subunit activation promotes dopamine efflux through the dopamine transporter. Molecular psychiatry. vol 22. issue 12. 2018-07-10. PMID:28894302. |
the dopamine transporter (dat) is an important regulator of brain dopamine (da) homeostasis, controlling the intensity and duration of da signaling. |
2018-07-10 |
2023-08-13 |
Not clear |
| Xueting Li, Jia Yu, Yanping Wu, Baixiang L. Effect on the dopaminergic metabolism induced by oral exposure to simazine during the prepubertal period in rats. International journal of molecular medicine. vol 41. issue 1. 2018-07-09. PMID:29115391. |
quantitative polymerase chain reaction and western blotting were used to analyze the mrna and protein expression of aromatic amino acid decarboxylase (aadc), tyrosine hydroxylase, orphan nuclear hormone (nurr1), dopamine transporter (dat), vesicular monoamine transporter 2 (vmat2), monoamine oxidase (mao) and catechol-o-methyltransferase (comt). |
2018-07-09 |
2023-08-13 |
rat |
| Robert L Barry, Nellie E Byun, Jason M Williams, Michael A Siuta, Mohammed N Tantawy, Nicole K Speed, Christine Saunders, Aurelio Galli, Kevin D Niswender, Malcolm J Aviso. Brief exposure to obesogenic diet disrupts brain dopamine networks. PloS one. vol 13. issue 4. 2018-07-09. PMID:29698491. |
we have previously demonstrated that insulin signaling, through the downstream signaling kinase akt, is a potent modulator of dopamine transporter (dat) activity, which fine-tunes dopamine (da) signaling at the synapse. |
2018-07-09 |
2023-08-13 |
Not clear |
| Patrick Neiens, Angela De Simone, Anna Ramershoven, Georg Höfner, Lars Allmendinger, Klaus T Wanne. Development and validation of an LC-ESI-MS/MS method for the quantification of D-84, reboxetine and citalopram for their use in MS Binding Assays addressing the monoamine transporters hDAT, hSERT and hNET. Biomedical chromatography : BMC. vol 32. issue 7. 2018-06-25. PMID:29500932. |
in this study, we present an lc-esi-ms/ms method for the quantification of (r,r)-4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidin-3-ol [(r,r)-d-84, (r,r)-1], (s,s)-reboxetine [(s,s)-2], and (s)-citalopram [(s)-3] employed as highly selective nonlabeled reporter ligands in ms binding assays addressing the dopamine [dat, (r,r)-d-84], norepinephrine [net, (s,s)-reboxetine] and serotonin transporter [sert, (s)-citalopram], respectively. |
2018-06-25 |
2023-08-13 |
Not clear |
| Ravit Hadar, Henriette Edemann-Callesen, Claudia Reinel, Franziska Wieske, Mareike Voget, Elena Popova, Reinhard Sohr, Yosef Avchalumov, Josef Priller, Christoph van Riesen, Imke Puls, Michael Bader, Christine Winte. Rats overexpressing the dopamine transporter display behavioral and neurobiological abnormalities with relevance to repetitive disorders. Scientific reports. vol 6. 2018-06-19. PMID:27974817. |
the dopamine transporter (dat) plays a pivotal role in maintaining optimal dopamine signaling. |
2018-06-19 |
2023-08-13 |
rat |
| Pamela M Quizon, Wei-Lun Sun, Yaxia Yuan, Narasimha M Midde, Chang-Guo Zhan, Jun Zh. Molecular mechanism: the human dopamine transporter histidine 547 regulates basal and HIV-1 Tat protein-inhibited dopamine transport. Scientific reports. vol 6. 2018-06-18. PMID:27966610. |
hiv-1 tat protein increases synaptic dopamine (da) levels by directly inhibiting da transporter (dat) activity, ultimately leading to dopaminergic neuron damage. |
2018-06-18 |
2023-08-13 |
human |
| Talia Zeppelin, Lucy Kate Ladefoged, Steffen Sinning, Xavier Periole, Birgit Schiøt. A direct interaction of cholesterol with the dopamine transporter prevents its out-to-inward transition. PLoS computational biology. vol 14. issue 1. 2018-06-18. PMID:29329285. |
recent crystal structures of the dopamine transporter (dat) revealed the presence of two conserved chol-like molecules, suggesting a functional protein-chol direct interaction. |
2018-06-18 |
2023-08-13 |
human |
| Talia Zeppelin, Lucy Kate Ladefoged, Steffen Sinning, Xavier Periole, Birgit Schiøt. A direct interaction of cholesterol with the dopamine transporter prevents its out-to-inward transition. PLoS computational biology. vol 14. issue 1. 2018-06-18. PMID:29329285. |
in the absence of bound chol, dat undergoes structural changes reflecting early events of dopamine transport: transition to an inward-facing conformation. |
2018-06-18 |
2023-08-13 |
human |
| Talia Zeppelin, Lucy Kate Ladefoged, Steffen Sinning, Xavier Periole, Birgit Schiøt. A direct interaction of cholesterol with the dopamine transporter prevents its out-to-inward transition. PLoS computational biology. vol 14. issue 1. 2018-06-18. PMID:29329285. |
we also provide evidence, from coarse grain md simulations that the chol sites observed in the dat crystal structures are preserved in all human monoamine transporters (dopamine, serotonin and norepinephrine), suggesting that our findings might extend to the entire family. |
2018-06-18 |
2023-08-13 |
human |
| Eric J Royston, Yang-En Kao, Kevin M Nakamur. DaT's Awesome: Hawai'i's First Dopamine Transporter (DaT) Nuclear Medicine Study. Hawai'i journal of medicine & public health : a journal of Asia Pacific Medicine & Public Health. vol 76. issue 11 Suppl 2. 2018-06-15. PMID:29164011. |
dat's awesome: hawai'i's first dopamine transporter (dat) nuclear medicine study. |
2018-06-15 |
2023-08-13 |
Not clear |
| Ashley L Green, Le Zhan, Aseel Eid, Helmut Zarbl, Grace L Guo, Jason R Richardso. Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1. Neuropharmacology. vol 125. 2018-06-12. PMID:28743636. |
the dopamine transporter (dat) is the key regulator of dopaminergic transmission and is a target of several xenobiotics, including pesticides and pharmacological agents. |
2018-06-12 |
2023-08-13 |
rat |
| David Bäckström, Magdalena Eriksson Domellöf, Gabriel Granåsen, Jan Linder, Sofia Mayans, Eva Elgh, Susanna Jakobson Mo, Lars Forsgre. PITX3 genotype and risk of dementia in Parkinson's disease: A population-based study. Journal of the neurological sciences. vol 381. 2018-06-11. PMID:28991698. |
this study investigates whether a common polymorphism in the pitx3 gene (rs2281983), which is of importance for the function of dopaminergic neurons, affects the risk of developing dementia in pd and whether it affects dopamine transporter (dat) uptake. |
2018-06-11 |
2023-08-13 |
Not clear |
| Koji Kamagata, Tomoya Nakatsuka, Ryuji Sakakibara, Yohei Tsuyusaki, Tomohiro Takamura, Kanako Sato, Michimasa Suzuki, Masaaki Hori, Kanako K Kumamaru, Tsutomu Inaoka, Shigeki Aoki, Hitoshi Terad. Diagnostic imaging of dementia with Lewy bodies by susceptibility-weighted imaging of nigrosomes versus striatal dopamine transporter single-photon emission computed tomography: a retrospective observational study. Neuroradiology. vol 59. issue 1. 2018-06-08. PMID:28035426. |
assessment of dopamine uptake in the striatum using dopamine transporter (dat) single-photon emission computed tomography (spect) is the gold standard for diagnosing dlb; however, this modality is expensive, time consuming and involves radiation exposure. |
2018-06-08 |
2023-08-13 |
Not clear |
| Gwynne L Davis, Adele Stewart, Gregg D Stanwood, Raajaram Gowrishankar, Maureen K Hahn, Randy D Blakel. Functional coding variation in the presynaptic dopamine transporter associated with neuropsychiatric disorders drives enhanced motivation and context-dependent impulsivity in mice. Behavioural brain research. vol 337. 2018-06-08. PMID:28964912. |
in keeping with studies suggesting dopaminergic contributions to attention-deficit hyperactivity disorder (adhd), bipolar disorder (bpd) and autism spectrum disorder (asd), subjects with these diagnoses have been found to express a rare, functional coding substitution in the dopamine (da) transporter (dat), ala559val. |
2018-06-08 |
2023-08-13 |
mouse |
| Elina Mäkinen, Juho Joutsa, Tero Vahlberg, Valtteri Kaasine. Survival in Parkinson's disease in relation to striatal dopamine transporter binding. Parkinsonism & related disorders. vol 42. 2018-06-07. PMID:28662820. |
to investigate whether dopamine transporter (dat) binding, as measured with single photon emission computed tomography (spect), can be used to predict mortality in patients with parkinson's disease (pd). |
2018-06-07 |
2023-08-13 |
Not clear |