| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David J Brook. Molecular imaging of dopamine transporters. Ageing research reviews. vol 30. 2017-08-07. PMID:26802555. |
dat imaging with positron emission tomography (pet) or single photon emission computed tomography (spect) can be used to support or refute a diagnosis of dopamine deficient parkinsonism in cases where this is unclear and rationalise a trial of dopamine replacement agents as therapy. |
2017-08-07 |
2023-08-13 |
human |
| David J Brook. Molecular imaging of dopamine transporters. Ageing research reviews. vol 30. 2017-08-07. PMID:26802555. |
the presence of normal dat availability on imaging can help categorise "subjects without evidence of dopamine deficiency" (swedds) who on occasion mimic pd and include dystonic tremors, drug-induced and psychogenic parkinsonism in their ranks. |
2017-08-07 |
2023-08-13 |
human |
| David J Brook. Molecular imaging of dopamine transporters. Ageing research reviews. vol 30. 2017-08-07. PMID:26802555. |
reduced levels of baseline striatal dat availability on pet or spect scanning, however, should be regarded as supportive rather than diagnostic of dopamine deficient parkinsonism. |
2017-08-07 |
2023-08-13 |
human |
| Lu Gao, Wenbo Zhou, Breanna Symmes, Curt R Free. Re-Cloning the N27 Dopamine Cell Line to Improve a Cell Culture Model of Parkinson's Disease. PloS one. vol 11. issue 8. 2017-08-07. PMID:27512998. |
in the current study, we have performed multiple rounds of clonal cultures and have identified a dopaminergic cell clone expressing high levels of th and the dopamine transporter (dat). |
2017-08-07 |
2023-08-13 |
rat |
| Yang Li, Felix P Mayer, Peter S Hasenhuetl, Verena Burtscher, Klaus Schicker, Harald H Sitte, Michael Freissmuth, Walter Sandtne. Occupancy of the Zinc-binding Site by Transition Metals Decreases the Substrate Affinity of the Human Dopamine Transporter by an Allosteric Mechanism. The Journal of biological chemistry. vol 292. issue 10. 2017-07-27. PMID:28096460. |
the human dopamine transporter (dat) has a tetrahedral zn |
2017-07-27 |
2023-08-13 |
human |
| Qiang Wang, Nancy Bubula, Jason Brown, Yunliang Wang, Veronika Kondev, Paul Vezin. PKC phosphorylates residues in the N-terminal of the DA transporter to regulate amphetamine-induced DA efflux. Neuroscience letters. vol 622. 2017-07-19. PMID:27113203. |
the da transporter (dat), a phosphoprotein, controls extracellular dopamine (da) levels in the central nervous system through transport or reverse transport (efflux). |
2017-07-19 |
2023-08-13 |
Not clear |
| Armando G Salinas, Margaret I Davis, David M Lovinger, Yolanda Mate. Dopamine dynamics and cocaine sensitivity differ between striosome and matrix compartments of the striatum. Neuropharmacology. vol 108. 2017-07-18. PMID:27036891. |
the striatum is also divided into striosome and matrix compartments, based on the differential expression of a number of proteins, including the mu opioid receptor, dopamine transporter (dat), and nr4a1 (nuclear receptor subfamily 4, group a, member 1). |
2017-07-18 |
2023-08-13 |
mouse |
| Armando G Salinas, Margaret I Davis, David M Lovinger, Yolanda Mate. Dopamine dynamics and cocaine sensitivity differ between striosome and matrix compartments of the striatum. Neuropharmacology. vol 108. 2017-07-18. PMID:27036891. |
these findings demonstrate a level of exquisite microanatomical regulation of dopamine by the dat in striosomes relative to the matrix. |
2017-07-18 |
2023-08-13 |
mouse |
| Jin Yong Hong, Mun Kyung Sunwoo, Jungsu S Oh, Jae Seung Kim, Young H Sohn, Phil Hyu Le. Persistent Drug-Induced Parkinsonism in Patients with Normal Dopamine Transporter Imaging. PloS one. vol 11. issue 6. 2017-07-18. PMID:27294367. |
functional neuroimaging for the dopamine transporter (dat) is used to distinguish drug-induced parkinsonism (dip) from subclinical parkinson's disease (pd). |
2017-07-18 |
2023-08-13 |
human |
| Gavin McLaughlin, Noreen Morris, Pierce V Kavanagh, John D Power, Geraldine Dowling, Brendan Twamley, John O'Brien, Brian Talbot, Donna Walther, John S Partilla, Michael H Baumann, Simon D Brand. Synthesis, characterization and monoamine transporter activity of the new psychoactive substance mexedrone and its N-methoxy positional isomer, N-methoxymephedrone. Drug testing and analysis. vol 9. issue 3. 2017-07-18. PMID:27524685. |
all three substances were also studied for their uptake and releasing properties at dopamine transporters (dat), norepinephrine transporters (net) and serotonin transporters (sert) using in vitro monoamine transporter assays in rat brain synaptosomes and compared to mephedrone. |
2017-07-18 |
2023-08-13 |
rat |
| Sarah R Mikelman, Bipasha Guptaroy, Margaret E Gneg. Tamoxifen and its active metabolites inhibit dopamine transporter function independently of the estrogen receptors. Journal of neurochemistry. vol 141. issue 1. 2017-07-13. PMID:28075498. |
as one of the primary mechanisms by which dopamine signaling is regulated, the dopamine transporter (dat) is an attractive pharmacological target for the treatment of diseases based in dopaminergic dysfunction. |
2017-07-13 |
2023-08-13 |
Not clear |
| Weimin Conrad Hong, Hideaki Yano, Takato Hiranita, Frederick T Chin, Christopher R McCurdy, Tsung-Ping Su, Susan G Amara, Jonathan L Kat. The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats. The Journal of biological chemistry. vol 292. issue 27. 2017-07-12. PMID:28495886. |
the dopamine transporter (dat) regulates dopamine (da) neurotransmission by recapturing da into the presynaptic terminals and is a principal target of the psychostimulant cocaine. |
2017-07-12 |
2023-08-13 |
rat |
| Renee Cockerham, Shaolin Liu, Roger Cachope, Emi Kiyokage, Joseph F Cheer, Michael T Shipley, Adam C Puch. Subsecond Regulation of Synaptically Released Dopamine by COMT in the Olfactory Bulb. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 29. 2017-07-11. PMID:27445153. |
in most systems, vesicular release of da is cleared by the dopamine transporter (dat). |
2017-07-11 |
2023-08-13 |
mouse |
| S Stevens Negus, Matthew L Bank. Decoding the Structure of Abuse Potential for New Psychoactive Substances: Structure-Activity Relationships for Abuse-Related Effects of 4-Substituted Methcathinone Analogs. Current topics in behavioral neurosciences. vol 32. 2017-07-11. PMID:27696217. |
many cathinone analogs act as substrates or inhibitors at dopamine, norepinephrine, and serotonin transporters (dat, net, sert, respectively). |
2017-07-11 |
2023-08-13 |
rat |
| Michael H Baumann, Mohammad O Bukhari, Kurt R Lehner, Sebastien Anizan, Kenner C Rice, Marta Concheiro, Marilyn A Huesti. Neuropharmacology of 3,4-Methylenedioxypyrovalerone (MDPV), Its Metabolites, and Related Analogs. Current topics in behavioral neurosciences. vol 32. 2017-07-11. PMID:27830575. |
mdpv acts as a potent uptake inhibitor at plasma membrane transporters for dopamine (dat) and norepinephrine (net) in nervous tissue. |
2017-07-11 |
2023-08-13 |
rat |
| Michael H Baumann, Mohammad O Bukhari, Kurt R Lehner, Sebastien Anizan, Kenner C Rice, Marta Concheiro, Marilyn A Huesti. Neuropharmacology of 3,4-Methylenedioxypyrovalerone (MDPV), Its Metabolites, and Related Analogs. Current topics in behavioral neurosciences. vol 32. 2017-07-11. PMID:27830575. |
mdpv analogs, such as α-pyrrolidinovalerophenone (α-pvp), display similar ability to inhibit dat and increase extracellular dopamine concentrations. |
2017-07-11 |
2023-08-13 |
rat |
| Melissa M Conti, Samantha M Meadows, Mitchell Melikhov-Sosin, David Lindenbach, Joy Hallmark, David F Werner, Christopher Bisho. Monoamine transporter contributions to l-DOPA effects in hemi-parkinsonian rats. Neuropharmacology. vol 110. issue Pt A. 2017-07-10. PMID:27452719. |
serotonin and norepinephrine transporters (sert and net, respectively) have affinity for dopamine uptake especially when dopamine transporters (dat) are scant. |
2017-07-10 |
2023-08-13 |
rat |
| Erik Mille, Johannes Levin, Matthias Brendel, Christian Zach, Henryk Barthel, Osama Sabri, Kai Bötzel, Peter Bartenstein, Adrian Danek, Axel Rominge. Cerebral Glucose Metabolism and Dopaminergic Function in Patients with Corticobasal Syndrome. Journal of neuroimaging : official journal of the American Society of Neuroimaging. vol 27. issue 2. 2017-07-10. PMID:27572945. |
therefore, we investigated the pattern of cerebral glucose metabolism, as well as dopamine transporter (dat) availability in a large and clinically well-defined cohort. |
2017-07-10 |
2023-08-13 |
Not clear |
| A H Ashok, T R Marques, S Jauhar, M M Nour, G M Goodwin, A H Young, O D Howe. The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment. Molecular psychiatry. vol 22. issue 5. 2017-06-29. PMID:28289283. |
tentatively, this evidence suggests a model where an elevation in striatal d2/3 receptor availability would lead to increased dopaminergic neurotransmission and mania, whilst increased striatal dopamine transporter (dat) levels would lead to reduced dopaminergic function and depression. |
2017-06-29 |
2023-08-13 |
Not clear |
| A H Ashok, T R Marques, S Jauhar, M M Nour, G M Goodwin, A H Young, O D Howe. The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment. Molecular psychiatry. vol 22. issue 5. 2017-06-29. PMID:28289283. |
this model, if confirmed, has implications for developing new treatment strategies such as reducing the dopamine synthesis and/or release in mania and dat blockade in bipolar depression. |
2017-06-29 |
2023-08-13 |
Not clear |