| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pier Francesca Porceddu, Ismail Ogunbayode Ishola, Liliana Contu, Micaela Morell. Metformin Prevented Dopaminergic Neurotoxicity Induced by 3,4-Methylenedioxymethamphetamine Administration. Neurotoxicity research. vol 30. issue 1. 2017-06-26. PMID:27251371. |
the neuroprotective effect of metformin on mdma-induced dopaminergic damage was evaluated by dopamine transporter (dat) and tyrosine hydroxylase (th) immunohistochemistry in snc and cpu. |
2017-06-26 |
2023-08-13 |
mouse |
| Kymry T Jones, Catherine Woods, Juan Zhen, Tamara Antonio, Kenneth D Carr, Maarten E A Reit. Effects of diet and insulin on dopamine transporter activity and expression in rat caudate-putamen, nucleus accumbens, and midbrain. Journal of neurochemistry. vol 140. issue 5. 2017-06-23. PMID:27973691. |
in this study, we examined diet effects on expression and function of the dopamine transporter (dat) in caudate-putamen (cpu), nucleus accumbens (nac), and midbrain regions. |
2017-06-23 |
2023-08-13 |
rat |
| Jacob Andersen, Lucy Kate Ladefoged, Trine N Bjerre Kristensen, Lachlan Munro, Julie Grouleff, Nicolai Stuhr-Hansen, Anders S Kristensen, Birgit Schiøtt, Kristian Strømgaar. Interrogating the Molecular Basis for Substrate Recognition in Serotonin and Dopamine Transporters with High-Affinity Substrate-Based Bivalent Ligands. ACS chemical neuroscience. vol 7. issue 10. 2017-06-21. PMID:27425420. |
the transporters for the neurotransmitters serotonin and dopamine (sert and dat, respectively) are targets for drugs used in the treatment of mental disorders and widely used drugs of abuse. |
2017-06-21 |
2023-08-13 |
human |
| Jacob Andersen, Lucy Kate Ladefoged, Trine N Bjerre Kristensen, Lachlan Munro, Julie Grouleff, Nicolai Stuhr-Hansen, Anders S Kristensen, Birgit Schiøtt, Kristian Strømgaar. Interrogating the Molecular Basis for Substrate Recognition in Serotonin and Dopamine Transporters with High-Affinity Substrate-Based Bivalent Ligands. ACS chemical neuroscience. vol 7. issue 10. 2017-06-21. PMID:27425420. |
we have designed and employed 24 bivalent ligands possessing a highly systematic combination of substrate moieties (serotonin and/or dopamine) and aliphatic or poly(ethylene glycol) spacers to reveal insight into substrate recognition in sert and dat. |
2017-06-21 |
2023-08-13 |
human |
| Matan Soll, Orit Bar Am, Atif Mahammed, Irena Saltsman, Silvia Mandel, Moussa B H Youdim, Zeev Gros. Neurorescue by a ROS Decomposition Catalyst. ACS chemical neuroscience. vol 7. issue 10. 2017-06-21. PMID:27442690. |
important findings that accompanied the ability to rescue dopaminergic neurons were increased expression of phenotypic dopaminergic proteins, such as tyrosine hydroxylase (th) and dopamine transporter (dat), which were significantly depleted upon 6-ohda-mediated damage. |
2017-06-21 |
2023-08-13 |
Not clear |
| Chi Wang Ip, Ioannis U Isaias, Burak B Kusche-Tekin, Dennis Klein, Janos Groh, Aet O'Leary, Susanne Knorr, Takahiro Higuchi, James B Koprich, Jonathan M Brotchie, Klaus V Toyka, Andreas Reif, Jens Volkman. Tor1a+/- mice develop dystonia-like movements via a striatal dopaminergic dysregulation triggered by peripheral nerve injury. Acta neuropathologica communications. vol 4. issue 1. 2017-06-21. PMID:27716431. |
western blot analysis was performed for dopamine transporter (dat), d1 and d2 receptors from striatal and quantitative rt-pcr analysis for dat from midbrain dissections. |
2017-06-21 |
2023-08-13 |
mouse |
| Takato Hiranita, Weimin C Hong, Theresa Kopajtic, Jonathan L Kat. σ Receptor Effects of N-Substituted Benztropine Analogs: Implications for Antagonism of Cocaine Self-Administration. The Journal of pharmacology and experimental therapeutics. vol 362. issue 1. 2017-06-21. PMID:28442581. |
several n-substituted benztropine (bzt) analogs are atypical dopamine transport inhibitors as they have affinity for the dopamine transporter (dat) but have minimal cocaine-like pharmacologic effects and can block numerous effects of cocaine, including its self-administration. |
2017-06-21 |
2023-08-13 |
Not clear |
| Steve C Fordahl, Jason L Locke, Sara R Jone. High fat diet augments amphetamine sensitization in mice: Role of feeding pattern, obesity, and dopamine terminal changes. Neuropharmacology. vol 109. 2017-06-19. PMID:27267686. |
additionally, we observed reduced membrane dopamine transporter (dat) levels after hf, and a shift in dat localization to the cytosol was detected with limited access to hf. |
2017-06-19 |
2023-08-13 |
mouse |
| Samantha E Yohn, Emily E Errante, Aaron Rosenbloom-Snow, Matthew Somerville, Margaret Rowland, Kristin Tokarski, Nadia Zafar, Merce Correa, John D Salamon. Blockade of uptake for dopamine, but not norepinephrine or 5-HT, increases selection of high effort instrumental activity: Implications for treatment of effort-related motivational symptoms in psychopathology. Neuropharmacology. vol 109. 2017-06-19. PMID:27329556. |
the present studies investigated the ability of drugs that block dopamine transport (dat), norepinephrine transport (net), and serotonin transport (sert) to modulate work output in rats responding on a test of effort-related decision making (i.e., a progressive ratio (prog)/chow feeding choice task). |
2017-06-19 |
2023-08-13 |
rat |
| Jianjing Cao, Rachel D Slack, Oluyomi M Bakare, Caitlin Burzynski, Rana Rais, Barbara S Slusher, Theresa Kopajtic, Alessandro Bonifazi, Michael P Ellenberger, Hideaki Yano, Yi He, Guo-Hua Bi, Zheng-Xiong Xi, Claus J Loland, Amy Hauck Newma. Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors. Journal of medicinal chemistry. vol 59. issue 23. 2017-06-15. PMID:27933960. |
the development of pharmacotherapeutic treatments of psychostimulant abuse has remained a challenge, despite significant efforts made toward relevant mechanistic targets, such as the dopamine transporter (dat). |
2017-06-15 |
2023-08-13 |
Not clear |
| Carolyn G Sweeney, Bradford P Tremblay, Thomas Stockner, Harald H Sitte, Haley E Melikia. Dopamine Transporter Amino and Carboxyl Termini Synergistically Contribute to Substrate and Inhibitor Affinities. The Journal of biological chemistry. vol 292. issue 4. 2017-06-05. PMID:27986813. |
extracellular dopamine and serotonin concentrations are determined by the presynaptic dopamine (dat) and serotonin (sert) transporters, respectively. |
2017-06-05 |
2023-08-13 |
Not clear |
| Philippe Huot, Susan H Fox, Jonathan M Brotchi. Dopamine Reuptake Inhibitors in Parkinson's Disease: A Review of Nonhuman Primate Studies and Clinical Trials. The Journal of pharmacology and experimental therapeutics. vol 357. issue 3. 2017-05-23. PMID:27190169. |
inasmuch as they increase synaptic dopamine levels, dopamine transporter (dat) inhibitors, whether they are selective or have actions on noradrenaline or serotonin transporters, theoretically represent an attractive way to alleviate parkinsonism per se and potentially enhance l-dopa antiparkinsonian action (provided that sufficient dopamine terminals remain within the striatum). |
2017-05-23 |
2023-08-13 |
Not clear |
| Pieter Beerepoot, Vincent M Lam, Ali Salahpou. Pharmacological Chaperones of the Dopamine Transporter Rescue Dopamine Transporter Deficiency Syndrome Mutations in Heterologous Cells. The Journal of biological chemistry. vol 291. issue 42. 2017-05-22. PMID:27555326. |
dtds is a rare condition that is caused by autosomal recessive loss-of-function mutations in the dopamine transporter (dat), which often affects transporter trafficking and folding. |
2017-05-22 |
2023-08-13 |
Not clear |
| Brittney A Nowicki, Matt A Hamada, Gina Y Robinson, Douglas C Jone. Adverse effects of bisphenol A (BPA) on the dopamine system in two distinct cell models and corpus striatum of the Sprague-Dawley rat. Journal of toxicology and environmental health. Part A. vol 79. issue 20. 2017-05-18. PMID:27494678. |
bpa exerted no marked effect on dopamine active transporter levels in gh3 cells exposed for 8 or 24 h. however, sh-sy5y cells displayed an increase in dopamine transporter (dat) levels following 24 h of exposure to bpa. |
2017-05-18 |
2023-08-13 |
human |
| Marco Lucarelli, Elisabetta Visalberghi, Walter Adriani, Elsa Addessi, Silvia Pierandrei, Arianna Manciocco, Francesca Zoratto, Andrea Tamellini, Augusto Vitale, Giovanni Laviola, Jessica Lynch Alfaro, Esterina Pascal. Polymorphism of the 3'-UTR of the dopamine transporter gene (DAT) in New World monkeys. Primates; journal of primatology. vol 58. issue 1. 2017-05-17. PMID:27503104. |
polymorphism of the 3'-utr of the dopamine transporter gene (dat) in new world monkeys. |
2017-05-17 |
2023-08-13 |
human |
| Marco Lucarelli, Elisabetta Visalberghi, Walter Adriani, Elsa Addessi, Silvia Pierandrei, Arianna Manciocco, Francesca Zoratto, Andrea Tamellini, Augusto Vitale, Giovanni Laviola, Jessica Lynch Alfaro, Esterina Pascal. Polymorphism of the 3'-UTR of the dopamine transporter gene (DAT) in New World monkeys. Primates; journal of primatology. vol 58. issue 1. 2017-05-17. PMID:27503104. |
genetic polymorphism in the 3'-untranslated region (3'-utr) of the dopamine transporter (dat) gene has been reported in both human and nonhuman primates, and the variable number of tandem repeats (vntr) polymorphism has been related to several neurological and psychiatric disorders. |
2017-05-17 |
2023-08-13 |
human |
| Marco Lucarelli, Elisabetta Visalberghi, Walter Adriani, Elsa Addessi, Silvia Pierandrei, Arianna Manciocco, Francesca Zoratto, Andrea Tamellini, Augusto Vitale, Giovanni Laviola, Jessica Lynch Alfaro, Esterina Pascal. Polymorphism of the 3'-UTR of the dopamine transporter gene (DAT) in New World monkeys. Primates; journal of primatology. vol 58. issue 1. 2017-05-17. PMID:27503104. |
future research should focus on the relationship between these dat polymorphisms, dopamine reuptake via the dopamine transporter, and behavioral and cognitive variation across new world monkey individuals. |
2017-05-17 |
2023-08-13 |
human |
| Jenny McCleery, Shirlony Morgan, Kevin M Bradley, Anna H Noel-Storr, Olaf Ansorge, Chris Hyd. Dopamine transporter imaging for the diagnosis of dementia with Lewy bodies. The Cochrane database of systematic reviews. vol 1. 2017-05-16. PMID:25632881. |
dopamine transporter (dat) imaging using single-photon emission computed tomography (spect) is the most highly developed supplementary test for dlb, and is now incorporated as a suggestive feature in the consensus diagnostic criteria. |
2017-05-16 |
2023-08-13 |
Not clear |
| Martin J Bobak, Matthew W Weber, Melissa A Doellman, Douglas R Schuweiler, Jeana M Athens, Steven A Juliano, Paul A Garri. Modafinil Activates Phasic Dopamine Signaling in Dorsal and Ventral Striata. The Journal of pharmacology and experimental therapeutics. vol 359. issue 3. 2017-05-16. PMID:27733628. |
compared with other psychostimulants inhibiting dopamine (da) uptake, mod weakly interacts with the dopamine transporter (dat) and modestly elevates striatal dialysate da, suggesting additional targets besides dat. |
2017-05-16 |
2023-08-13 |
rat |
| Wei Hung Chang, Kao Chin Chen, I Hui Lee, Mei Hung Chi, Po See Chen, Wei Jen Yao, Nan Tsing Chiu, Yen Kuang Yan. Unaltered Dopamine Transporter Availability in Drug-Naive Patients With Schizophrenia After 6 Months of Antipsychotics Treatment: A Naturalistic Study. Journal of clinical psychopharmacology. vol 37. issue 1. 2017-05-10. PMID:28027110. |
dopaminergic dysfunction, namely, dopamine transporter (dat) availability variations in patients with drug-naive schizophrenia after long-term treatment, is still not well understood. |
2017-05-10 |
2023-08-13 |
Not clear |