| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Regina Célia Cussa Kubrusly, Robertta Silva Martins, Lisiane de Santana Souza, Mariana Pinheiro de Carvalho, Vladimir Pedro Peralva Borges-Martins, Matheus Figueiredo Sathler, Danielle Dias Pinto Ferreira, Maurício Dos Santos Pereira, Ney Ronner Peccinalli, Pablo Pandolfo, Ricardo Augusto de Melo Reis, Gustavo Costa Ferreira, Alex Christian Manhãe. Single Cocaine Exposure Inhibits GABA Uptake via Dopamine D1-Like Receptors in Adolescent Mice Frontal Cortex. Neurotoxicity research. vol 38. issue 3. 2021-07-09. PMID:32696437. |
cocaine (coc) is a psychostimulant that acts by increasing catecholaminergic neurotransmission mainly due to its effects on the dopamine transporter (dat). |
2021-07-09 |
2023-08-13 |
mouse |
| Matthew P Adams, Arman Rahmim, Jing Tan. Improved motor outcome prediction in Parkinson's disease applying deep learning to DaTscan SPECT images. Computers in biology and medicine. vol 132. 2021-07-05. PMID:33892414. |
dopamine transporter (dat) spect imaging is routinely used in the diagnosis of parkinson's disease (pd). |
2021-07-05 |
2023-08-13 |
Not clear |
| Shaili Aggarwal, Mary Hongying Cheng, Joseph M Salvino, Ivet Bahar, Ole Valente Mortense. Functional Characterization of the Dopaminergic Psychostimulant Sydnocarb as an Allosteric Modulator of the Human Dopamine Transporter. Biomedicines. vol 9. issue 6. 2021-07-05. PMID:34199621. |
the dopamine transporter (dat) serves a critical role in controlling dopamine (da)-mediated neurotransmission by regulating the clearance of da from the synapse and extrasynaptic regions and thereby modulating da action at postsynaptic da receptors. |
2021-07-05 |
2023-08-13 |
human |
| Shaili Aggarwal, Mary Hongying Cheng, Joseph M Salvino, Ivet Bahar, Ole Valente Mortense. Functional Characterization of the Dopaminergic Psychostimulant Sydnocarb as an Allosteric Modulator of the Human Dopamine Transporter. Biomedicines. vol 9. issue 6. 2021-07-05. PMID:34199621. |
functional dopamine uptake studies have further shown that sydnocarb is a noncompetitive inhibitor of dat in accord with the involvement of a site different from the orthosteric site in binding this psychostimulant. |
2021-07-05 |
2023-08-13 |
human |
| Liga Zvejniece, Baiba Zvejniece, Melita Videja, Gundega Stelfa, Edijs Vavers, Solveiga Grinberga, Baiba Svalbe, Maija Dambrov. Neuroprotective and anti-inflammatory activity of DAT inhibitor R-phenylpiracetam in experimental models of inflammation in male mice. Inflammopharmacology. vol 28. issue 5. 2021-07-01. PMID:32279140. |
recently, r-php was shown to bind to the dopamine transporter (dat). |
2021-07-01 |
2023-08-13 |
mouse |
| Kyoungjune Pak, Ju Won Seok, Hyun-Yeol Nam, Seongho Seo, Myung Jun Lee, Keunyoung Kim, In Joo Ki. The association of DAT gene methylation with striatal DAT availability in healthy subjects. EJNMMI research. vol 11. issue 1. 2021-06-29. PMID:34120227. |
functioning of nigrostriatal dopaminergic neurons is influenced by the expression of the dopamine transporter (dat), and genetic variations in the gene encoding dat contribute to differences in reward processing. |
2021-06-29 |
2023-08-13 |
human |
| Christopher W Tschumi, Anna W Daszkowski, Amanda L Sharpe, Marta Trzeciak, Michael J Beckstea. A history of ethanol drinking increases locomotor stimulation and blunts enhancement of dendritic dopamine transmission by methamphetamine. Addiction biology. vol 25. issue 4. 2021-06-28. PMID:31062485. |
ethanol acutely increases dopamine neuron excitability, and psychostimulants such as cocaine or methamphetamine increase extracellular dopamine through inhibition of uptake through the dopamine transporter (dat) and/or vesicular monoamine transporter 2 (vmat2). |
2021-06-28 |
2023-08-13 |
mouse |
| Stefano Mariano, Marta Pardo, Clelia Buccheri, Placido Illiano, Annalisa Adinolfi, Sara Lucia M Lo Russo, Enrico Alleva, Cristiana Carbone, Walter Adrian. Own or dam's genotype? Classical colony breeding may bias spontaneous and stress-challenged activity in DAT-mutant rats. Developmental psychobiology. vol 62. issue 4. 2021-06-28. PMID:31599465. |
from candidate genes, dopamine (da) and dopamine transporter (dat) have been linked to anxiety, depression, and post-traumatic stress disorder. |
2021-06-28 |
2023-08-13 |
rat |
| Sara R Jones, Steve C Fordah. Bingeing on High-Fat Food Enhances Evoked Dopamine Release and Reduces Dopamine Uptake in the Nucleus Accumbens. Obesity (Silver Spring, Md.). vol 29. issue 4. 2021-06-25. PMID:33660412. |
binge-eating disorder (bed) disrupts dopamine neuron function, in part by altering dopamine transporter (dat) activity. |
2021-06-25 |
2023-08-13 |
Not clear |
| Sara R Jones, Steve C Fordah. Bingeing on High-Fat Food Enhances Evoked Dopamine Release and Reduces Dopamine Uptake in the Nucleus Accumbens. Obesity (Silver Spring, Md.). vol 29. issue 4. 2021-06-25. PMID:33660412. |
this study characterized the effects of high-fat bingeing on presynaptic dopamine terminals and tested the hypothesis that acute low-dose amphetamine would restore dat function. |
2021-06-25 |
2023-08-13 |
Not clear |
| Ottavia Dipasquale, Daniel Martins, Arjun Sethi, Mattia Veronese, Swen Hesse, Michael Rullmann, Osama Sabri, Federico Turkheimer, Neil A Harrison, Mitul A Mehta, Mara Cercignan. Unravelling the effects of methylphenidate on the dopaminergic and noradrenergic functional circuits. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 9. 2021-06-23. PMID:32473593. |
here, we focus on methylphenidate (mph), which binds to the dopamine transporter (dat) and the norepinephrine transporter (net), to unravel its effects on dopaminergic and noradrenergic functional circuits in the healthy brain at rest. |
2021-06-23 |
2023-08-13 |
Not clear |
| Florence Allain, Benoît Delignat-Lavaud, Marie-Pierre Beaudoin, Vincent Jacquemet, Terry E Robinson, Louis-Eric Trudeau, Anne-Noël Samah. Amphetamine maintenance therapy during intermittent cocaine self-administration in rats attenuates psychomotor and dopamine sensitization and reduces addiction-like behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 2. 2021-06-23. PMID:32682325. |
preclinical studies using long access (lga) cocaine self-administration procedures suggest d-amphetamine may act by preventing tolerance to cocaine's effects at the dopamine transporter (dat). |
2021-06-23 |
2023-08-13 |
human |
| I P Alonso, J A Pino, S Kortagere, G E Torres, R A Españ. Dopamine transporter function fluctuates across sleep/wake state: potential impact for addiction. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 4. 2021-06-23. PMID:33032296. |
the dopamine transporter (dat) has been implicated in a variety of arousal-related processes including the regulation of motor activity, learning, motivated behavior, psychostimulant abuse, and, more recently, sleep/wake state. |
2021-06-23 |
2023-08-13 |
rat |
| I P Alonso, J A Pino, S Kortagere, G E Torres, R A Españ. Dopamine transporter function fluctuates across sleep/wake state: potential impact for addiction. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 4. 2021-06-23. PMID:33032296. |
we previously demonstrated that dat uptake regulates fluctuations in extracellular dopamine (da) in the striatum across the light/dark cycle with da levels at their highest during the dark phase and lowest during the light phase. |
2021-06-23 |
2023-08-13 |
rat |
| F Y Wong, A Gogos, N Hale, S A Ingelse, N Brew, K L Shepherd, M van den Buuse, D W Walke. Impact of hypoxia-ischemia and dopamine treatment on dopamine receptor binding density in the preterm fetal sheep brain. Journal of applied physiology (Bethesda, Md. : 1985). vol 129. issue 6. 2021-06-23. PMID:33054660. |
we determined the effect of hi and dopamine on d1 and d2 receptor binding and expressions of dopamine transporter (dat) and tyrosine hydroxylase (th) in the striatum of the preterm fetal sheep. |
2021-06-23 |
2023-08-13 |
Not clear |
| Mary K Estes, Jasric J Bland, Kenya K Ector, Melissa J Puppa, Douglas W Powell, Deranda B Leste. A high fat western diet attenuates phasic dopamine release. Neuroscience letters. vol 756. 2021-06-22. PMID:33979702. |
injection of the dopamine transporter (dat) inhibitor nomifensine. |
2021-06-22 |
2023-08-13 |
mouse |
| Mary K Estes, Jasric J Bland, Kenya K Ector, Melissa J Puppa, Douglas W Powell, Deranda B Leste. A high fat western diet attenuates phasic dopamine release. Neuroscience letters. vol 756. 2021-06-22. PMID:33979702. |
mice that consumed the wd demonstrated a hypodopaminergic profile, specifically reduced baseline dopamine release and an attenuated dopaminergic response to dat inhibition compared to the control diet group. |
2021-06-22 |
2023-08-13 |
mouse |
| Kung-Chun Kao, Tatsuhiro Hisatsun. Differential effects of dopamine D1-like and D2-like receptor agonists on water drinking behaviour under thirsty conditions in mice with reduced dopamine secretion. The European journal of neuroscience. vol 51. issue 2. 2021-06-21. PMID:31472080. |
here, we generated triple transgenic mice harbouring slc6a3(dat)-icre/ert2, camk2a-loxp-stop-loxp-tetracycline transactivator and teto-tetanus toxin constructs, in which the release of dopamine is blocked by tetanus toxin. |
2021-06-21 |
2023-08-13 |
mouse |
| Adeline Gazan, Daniel Rial, Serge N Schiffman. Ablation of striatal somatostatin interneurons affects MSN morphology and electrophysiological properties, and increases cocaine-induced hyperlocomotion in mice. The European journal of neuroscience. vol 51. issue 6. 2021-06-21. PMID:31549447. |
this was accompanied by increased expression of the dopamine transporter (dat) in the ventral striatum. |
2021-06-21 |
2023-08-13 |
mouse |
| Katherine M Holleran, Jamie H Rose, Steven C Fordahl, Kelsey C Benton, Kayla E Rohr, Paul J Gasser, Sara R Jone. Organic cation transporter 3 and the dopamine transporter differentially regulate catecholamine uptake in the basolateral amygdala and nucleus accumbens. The European journal of neuroscience. vol 52. issue 11. 2021-06-21. PMID:32725894. |
previous work has shown that catecholamine clearance in the nacc is largely mediated by the dopamine transporter (dat), but clearance in the bla is less dat-dependent. |
2021-06-21 |
2023-08-13 |
Not clear |