| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vinod Metta, Lucia Batzu, Valentina Leta, Dhaval Trivedi, Aleksandra Powdleska, Kandadai Rukmini Mridula, Prashanth Kukle, Vinay Goyal, Rupam Borgohain, Guy Chung-Faye, K Ray Chaudhur. Parkinson's Disease: Personalized Pathway of Care for Device-Aided Therapies (DAT) and the Role of Continuous Objective Monitoring (COM) Using Wearable Sensors. Journal of personalized medicine. vol 11. issue 7. 2021-08-09. PMID:34357147. |
the management of pd should focus on personalized care addressing both motor and non-motor symptoms, ideally including not only dopamine replacement but also associated non-dopaminergic circuits, particularly focusing on noradrenergic, serotonergic, and cholinergic therapies bypassing the gastrointestinal tract (git) by infusion or device-aided therapies (dat), including levodopa-carbidopa intestinal gel infusion, apomorphine subcutaneous infusion, and deep brain stimulation, which are available in many countries for the management of the advanced stage of parkinson's disease (apd). |
2021-08-09 |
2023-08-13 |
Not clear |
| Jing Deng, Kyungbo Kim, Xirong Zheng, Linyue Shang, Chang-Guo Zhan, Fang Zhen. Cocaine hydrolase blocks cocaine-induced dopamine transporter trafficking to the plasma membrane. Addiction biology. 2021-08-07. PMID:34363291. |
cocaine blocks dopamine uptake via dopamine transporter (dat) on plasma membrane of neuron cells and, as a result, produces the high and induces dat trafficking to plasma membrane which contributes to the drug seeking or craving. |
2021-08-07 |
2023-08-13 |
rat |
| Ashequr Rahman, Yansong Zhu, Eric Clarkson, Matthew A Kupinski, Eric C Frey, Abhinav K Jh. Fisher information analysis of list-mode SPECT emission data for joint estimation of activity and attenuation distribution. Inverse problems. vol 36. issue 8. 2021-08-02. PMID:33071423. |
experiments with anthropomorphic phantoms simulated myocardial perfusion and dopamine transporter (dat)-scan spect studies. |
2021-08-02 |
2023-08-13 |
Not clear |
| Mathias E Jensen, Aurelio Galli, Morgane Thomsen, Kathrine L Jensen, Gerda K Thomsen, Mette K Klausen, Tina Vilsbøll, Mikkel B Christensen, Jens J Holst, Anthony Owens, Sabrina Robertson, Lynette Daws, Daniele Zanella, Ulrik Gether, Gitte M Knudsen, Anders Fink-Jense. Glucagon-like peptide-1 receptor regulation of basal dopamine transporter activity is species-dependent. Neurochemistry international. vol 138. 2021-07-30. PMID:32464226. |
in the present study, we hypothesized that glp-1r activation modulates dopaminetransporter (dat) and thus dopamine (da) homeostasis in striatum. |
2021-07-30 |
2023-08-13 |
Not clear |
| Joachim Brumberg, Vera Kerstens, Zsolt Cselényi, Per Svenningsson, Mathias Sundgren, Patrik Fazio, Andrea Varron. Simplified quantification of [ Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 41. issue 6. 2021-07-30. PMID:32955955. |
simplified quantification of [ quantification of dopamine transporter (dat) availability with [ |
2021-07-30 |
2023-08-13 |
Not clear |
| Ani Gasparyan, Francisco Navarrete, Marta Rodríguez-Arias, José Miñarro, Jorge Manzanare. Cannabidiol Modulates Behavioural and Gene Expression Alterations Induced by Spontaneous Cocaine Withdrawal. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 18. issue 1. 2021-07-30. PMID:33230690. |
furthermore, gene expression changes in dopamine transporter (dat) and tyrosine hydroxylase (th) in the ventral tegmental area, and in cannabinoid receptors 1 (cnr1) and 2 (cnr2) in the nucleus accumbens, were analysed by real-time pcr. |
2021-07-30 |
2023-08-13 |
mouse |
| Yonghai Li, Junzheng Yang, Meng Li, Xiaoyue Zhang, Jiang Du, Xinghua Zhao, Zhihao Xu, Juntang Li. The Extracts of Human Fetal Brain Induce the Differentiation of Human Umbilical Cord Mesenchymal Stem Cells into Dopaminergic Neuron Containing Cells. Cellular reprogramming. vol 22. issue 5. 2021-07-22. PMID:32833524. |
moreover, after treatment of ehfbt (extracts of human fetal brain tissue), hucmscs can express neuronal markers such as nestin, lim homeobox transcription factor 1 beta (lmx1b), dopamine beta hydroxylase (dbh), and dopamine transporter (dat). |
2021-07-22 |
2023-08-13 |
human |
| Rong Ye, Joseph J Locascio, Anna E Goodheart, Moqing Quan, Baorong Zhang, Stephen N Gompert. Serum NFL levels predict progression of motor impairment and reduction in putamen dopamine transporter binding ratios in de novo Parkinson's disease: An 8-year longitudinal study. Parkinsonism & related disorders. vol 85. 2021-07-22. PMID:33639572. |
to determine whether serum nfl at baseline in de novo pd predicts motor decline, differentially impacts specific motor features, predicts cognitive decline, and predicts loss of dopamine terminals, here we evaluated 376 de novo pd patients from the ppmi database and analyzed the effect of baseline serum nfl levels on progression over eight years of motor impairment measured with the updrs, cognitive function measured with the moca, and putamen dopamine transporter (dat) binding ratio measured with datscan. |
2021-07-22 |
2023-08-13 |
Not clear |
| Mahsa Dadar, Janis Miyasaki, Simon Duchesne, Richard Camiciol. White matter hyperintensities mediate the impact of amyloid ß on future freezing of gait in Parkinson's disease. Parkinsonism & related disorders. vol 85. 2021-07-22. PMID:33770671. |
previous studies have reported relationships between fog, substantia nigra (sn) degeneration, dopamine transporter (dat) concentration, as well as amyloid β deposition. |
2021-07-22 |
2023-08-13 |
Not clear |
| Shin Kurose, Manabu Kubota, Keisuke Takahata, Yasuharu Yamamoto, Hironobu Fujiwara, Yasuyuki Kimura, Hiroshi Ito, Hiroyoshi Takeuchi, Masaru Mimura, Tetsuya Suhara, Makoto Higuch. Relationship between regional gray matter volumes and dopamine D Human brain mapping. vol 42. issue 12. 2021-07-22. PMID:34014611. |
here, we aimed to investigate associations of striatal dopamine transporter (dat) and d |
2021-07-22 |
2023-08-13 |
human |
| Haesoo Kim, Daeun Lee, Kisok Ki. Combined Exposure to Metals in Drinking Water Alters the Dopamine System in Mouse Striatum. International journal of environmental research and public health. vol 18. issue 12. 2021-07-21. PMID:34207128. |
in this study, motor coordination and dopamine content, along with the expression of tyrosine hydroxylase (th), dopamine transporter (dat), vesicular monoamine transporter 2 (vmat2), and dopamine receptors (drs), were examined in the striatum of adult male mice following exposure to drinking water containing as, pb, and/or cd. |
2021-07-21 |
2023-08-13 |
mouse |
| Haesoo Kim, Daeun Lee, Kisok Ki. Combined Exposure to Metals in Drinking Water Alters the Dopamine System in Mouse Striatum. International journal of environmental research and public health. vol 18. issue 12. 2021-07-21. PMID:34207128. |
after 4 weeks of treatment, a significant decrease in dopamine content and expression of th, dat, and vmat2 was observed in the striatum of metal-mixture-treated mice, compared to the controls or single-metal-exposed groups. |
2021-07-21 |
2023-08-13 |
mouse |
| Diego Luis-Ravelo, Felipe Fumagallo-Reading, Javier Castro-Hernandez, Pedro Barroso-Chinea, Domingo Afonso-Oramas, Alejandro Febles-Casquero, Ignacio Cruz-Muros, Josmar Salas-Hernandez, Virginia Mesa-Infante, Julia Rodriguez-Nuñez, Tomas Gonzalez-Hernande. Prolonged dopamine D Pharmacological research. vol 165. 2021-07-16. PMID:33484816. |
prolonged dopamine d the dopamine transporter (dat) is a membrane glycoprotein in dopaminergic neurons, which modulates extracellular and intracellular dopamine levels. |
2021-07-16 |
2023-08-13 |
Not clear |
| Diego Luis-Ravelo, Felipe Fumagallo-Reading, Javier Castro-Hernandez, Pedro Barroso-Chinea, Domingo Afonso-Oramas, Alejandro Febles-Casquero, Ignacio Cruz-Muros, Josmar Salas-Hernandez, Virginia Mesa-Infante, Julia Rodriguez-Nuñez, Tomas Gonzalez-Hernande. Prolonged dopamine D Pharmacological research. vol 165. 2021-07-16. PMID:33484816. |
dat is regulated by different presynaptic proteins, including dopamine d |
2021-07-16 |
2023-08-13 |
Not clear |
| Sara Simorgh, Zohreh Bagher, Mohammad Farhadi, Seyed Kamran Kamrava, Mahdi Eskandarian Boroujeni, Zeinab Namjoo, Farshid Qiyami Hour, Salah Moradi, Rafieh Alizade. Magnetic Targeting of Human Olfactory Mucosa Stem Cells Following Intranasal Administration: a Novel Approach to Parkinson's Disease Treatment. Molecular neurobiology. vol 58. issue 8. 2021-07-15. PMID:33860441. |
further, histological evaluations confirmed the functional enhancement of dopaminergic neuron cells by the expression of nurr1, dopamine transporter (dat), and paired-like homeodomain transcription factor 3 (th). |
2021-07-15 |
2023-08-13 |
human |
| S Cimino, L Cerniglia, P De Carli, A Simonell. DNA Methylation and Allelic Polymorphism at the Dopamine Transporter Promoter Affect Internalizing and Externalizing Symptoms in Preschoolers. Child psychiatry and human development. vol 52. issue 2. 2021-07-13. PMID:32462358. |
the role of the dopamine transporter (dat) in the onset and maintenance of emotional-behavioral difficulties is recognized in adults, adolescents and school-age children, whereas few studies in this field have focused on preschoolers. |
2021-07-13 |
2023-08-13 |
Not clear |
| Massimiliano Todisco, Roberta Zangaglia, Brigida Minafra, Patrizia Pisano, Giuseppe Trifirò, Irene Bossert, Nicoló Gabriele Pozzi, Joachim Brumberg, Roberto Ceravolo, Ioannis Ugo Isaias, Alfonso Fasano, Claudio Pacchett. Clinical Outcome and Striatal Dopaminergic Function After Shunt Surgery in Patients With Idiopathic Normal Pressure Hydrocephalus. Neurology. vol 96. issue 23. 2021-07-13. PMID:33893195. |
to determine changes in clinical features and striatal dopamine reuptake transporter (dat) density after shunt surgery in patients with idiopathic normal pressure hydrocephalus (inph). |
2021-07-13 |
2023-08-13 |
Not clear |
| Jana Lubec, Predrag Kalaba, Ahmed M Hussein, Daniel Daba Feyissa, Mohamed H Kotob, Rasha R Mahmmoud, Oliver Wieder, Arthur Garon, Claudia Sagheddu, Marija Ilic, Vladimir Dragačević, Anita Cybulska-Klosowicz, Martin Zehl, Judith Wackerlig, Simone B Sartori, Karl Ebner, Shima Kouhnavardi, Alexander Roller, Natalie Gajic, Marco Pistis, Nicolas Singewald, Johann Jakob Leban, Volker Korz, Jovana Malikovic, Roberto Plasenzotti, Harald H Sitte, Francisco J Monje, Thierry Langer, Ernst Urban, Christian Pifl, Gert Lube. Reinstatement of synaptic plasticity in the aging brain through specific dopamine transporter inhibition. Molecular psychiatry. 2021-07-10. PMID:34244620. |
since declining brain dopamine signaling during aging is associated with the onset of neurological impairments, we produced a selective dopamine transporter (dat) inhibitor to restore endogenous dopamine levels and improve cognitive function. |
2021-07-10 |
2023-08-13 |
rat |
| Jana Lubec, Predrag Kalaba, Ahmed M Hussein, Daniel Daba Feyissa, Mohamed H Kotob, Rasha R Mahmmoud, Oliver Wieder, Arthur Garon, Claudia Sagheddu, Marija Ilic, Vladimir Dragačević, Anita Cybulska-Klosowicz, Martin Zehl, Judith Wackerlig, Simone B Sartori, Karl Ebner, Shima Kouhnavardi, Alexander Roller, Natalie Gajic, Marco Pistis, Nicolas Singewald, Johann Jakob Leban, Volker Korz, Jovana Malikovic, Roberto Plasenzotti, Harald H Sitte, Francisco J Monje, Thierry Langer, Ernst Urban, Christian Pifl, Gert Lube. Reinstatement of synaptic plasticity in the aging brain through specific dopamine transporter inhibition. Molecular psychiatry. 2021-07-10. PMID:34244620. |
we describe the synthesis and pharmacological profile of (s,s)-ce-158, a highly specific dat inhibitor, which increases dopamine levels in brain regions associated with cognition. |
2021-07-10 |
2023-08-13 |
rat |
| Jana Lubec, Predrag Kalaba, Ahmed M Hussein, Daniel Daba Feyissa, Mohamed H Kotob, Rasha R Mahmmoud, Oliver Wieder, Arthur Garon, Claudia Sagheddu, Marija Ilic, Vladimir Dragačević, Anita Cybulska-Klosowicz, Martin Zehl, Judith Wackerlig, Simone B Sartori, Karl Ebner, Shima Kouhnavardi, Alexander Roller, Natalie Gajic, Marco Pistis, Nicolas Singewald, Johann Jakob Leban, Volker Korz, Jovana Malikovic, Roberto Plasenzotti, Harald H Sitte, Francisco J Monje, Thierry Langer, Ernst Urban, Christian Pifl, Gert Lube. Reinstatement of synaptic plasticity in the aging brain through specific dopamine transporter inhibition. Molecular psychiatry. 2021-07-10. PMID:34244620. |
in sum, we present a well-tolerated, highly selective dat inhibitor that normalizes the age-related decline in cognitive function at a synaptic level through increased dopamine signaling. |
2021-07-10 |
2023-08-13 |
rat |