| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David J Lapinsky, Nageswari Yarravarapu, Tammy L Nolan, Christopher K Surratt, John R Lever, Michael Tomlinson, Roxanne A Vaughan, Howard M Deutsc. Evolution of a Compact Photoprobe for the Dopamine Transporter Based on (±)-threo-Methylphenidate. ACS medicinal chemistry letters. vol 3. issue 5. 2021-10-21. PMID:23066448. |
the development of photoaffinity ligands for determining covalent points of attachment to the dopamine transporter (dat) has predominantly focused on tropane-based compounds bearing variable-length linkers between the photoreactive group and inhibitor pharmacophore. |
2021-10-21 |
2023-08-12 |
rat |
| Mikhail U Inyushin, Francisco Arencibia-Albite, Angel de la Cruz, Rafael Vázquez-Torres, Katiria Colon, Priscila Sanabria, Carlos A Jiménez-River. New method to visualize neurons with DAT in slices of rat VTA using fluorescent substrate for DAT, ASP+ Journal of neuroscience and neuroengineering. vol 2. issue 2. 2021-10-21. PMID:24052926. |
new method to visualize neurons with dat in slices of rat vta using fluorescent substrate for dat, asp+ the ventral tegmental area (vta), and in particular dopamine (da) neurons in this region of midbrain, has been shown to play an important role in motivation (goal-directed behavior), reward, and drug addiction. |
2021-10-21 |
2023-08-12 |
rat |
| Mikhail U Inyushin, Francisco Arencibia-Albite, Angel de la Cruz, Rafael Vázquez-Torres, Katiria Colon, Priscila Sanabria, Carlos A Jiménez-River. New method to visualize neurons with DAT in slices of rat VTA using fluorescent substrate for DAT, ASP+ Journal of neuroscience and neuroengineering. vol 2. issue 2. 2021-10-21. PMID:24052926. |
in this study, we used a known neuronal dopamine transporter (dat) fluorescent substrate [4-(4- (dimethylamino) styryl)-n-methylpyridinium iodide] (asp+) to visualize dat-containing cell bodies of da neurons in vta region in rat brain slices. |
2021-10-21 |
2023-08-12 |
rat |
| Chao-Yue Li, Li-Ming Zhao, Xi-Wen Shi, Jia-Dong Zhan. Lobeline shows protective effects against MPTP-induced dopaminergic neuron death and attenuates behavior deficits in animals. Experimental and therapeutic medicine. vol 7. issue 2. 2021-10-21. PMID:24396408. |
we previously demonstrated that lobeline effectively inhibited dopamine transporter (dat)-mediated dopamine (da) transportation. |
2021-10-21 |
2023-08-12 |
Not clear |
| S De Bruyne, T L Boos, L Wyffels, J L Goeman, K C Rice, F De Vo. Synthesis, radiosynthesis and in vivo evaluation of [I]-4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(4-iodobenzyl)piperidine as a selective tracer for imaging the dopamine transporter. Journal of labelled compounds & radiopharmaceuticals. vol 52. issue 8. 2021-10-20. PMID:19746191. |
dopamine transporter (dat) neuroimaging is a useful tool in parkinson's disease diagnosis, staging and follow-up providing information on the integrity of the dopaminergic neurotransmitter system in vivo. |
2021-10-20 |
2023-08-12 |
mouse |
| Rong Chen, Cheryse A Furman, Margaret E Gneg. Dopamine transporter trafficking: rapid response on demand. Future neurology. vol 5. issue 1. 2021-10-20. PMID:20174452. |
the dopamine transporter (dat) is a primary determinant of the concentration of dopamine in the synapse and is involved in a number of psychiatric and neurological diseases. |
2021-10-20 |
2023-08-12 |
Not clear |
| Rong Chen, Cheryse A Furman, Margaret E Gneg. Dopamine transporter trafficking: rapid response on demand. Future neurology. vol 5. issue 1. 2021-10-20. PMID:20174452. |
the transporter actively takes up its physiological substrate, dopamine, when it is on the surface of the plasmalemmal membrane, but the concentration of dat in the membrane is highly regulated by substrate. |
2021-10-20 |
2023-08-12 |
Not clear |
| Martín Indarte, Yi Liu, Jeffry D Madura, Christopher K Surrat. Receptor-Based Discovery of a Plasmalemmal Monoamine Transporter Inhibitor via High Throughput Docking and Pharmacophore Modeling. ACS chemical neuroscience. vol 1. issue 3. 2021-10-20. PMID:20352074. |
recognition of psychostimulants such as cocaine and the amphetamines by the dopamine transporter (dat) protein is principally responsible for the euphoria and addiction associated with these drugs. |
2021-10-20 |
2023-08-12 |
Not clear |
| Shreyas Bhat, Marco Niello, Klaus Schicker, Christian Pifl, Harald H Sitte, Michael Freissmuth, Walter Sandtne. Handling of intracellular K eLife. vol 10. 2021-10-19. PMID:34061030. |
handling of intracellular k the concentrative power of the transporters for dopamine (dat), norepinephrine (net), and serotonin (sert) is thought to be fueled by the transmembrane na |
2021-10-19 |
2023-08-13 |
Not clear |
| Ewa Gibula-Tarlowska, Volker Korz, Malgorzata Lopatynska-Mazurek, Agnieszka Chlopas-Konowalek, Pawel Grochecki, Predrag Kalaba, Vladimir Dragacevic, Robert Kotlinski, Radosław Kujawski, Michał Szulc, Kamila Czora-Poczwardowska, Przemyslaw L Mikolajczak, Gert Lubec, Jolanta H Kotlinsk. CE-123, a novel dopamine transporter inhibitor, attenuates locomotor hyperactivity and improves cognitive functions in rat model of fetal alcohol spectrum disorders. Behavioural brain research. vol 410. 2021-10-18. PMID:33940050. |
to test the hypothesis that dopamine signaling is one of the main factors underlying these impairments, a new atypical dopamine transporter (dat) inhibitor, ce-123 (1, 3 or 10 mg/kg) was assessed for its potential to overcome the ethanol-induced behavioral effects in a rat model of fasd. |
2021-10-18 |
2023-08-13 |
human |
| Mahmood Nazari, Andreas Kluge, Ivayla Apostolova, Susanne Klutmann, Sharok Kimiaei, Michael Schroeder, Ralph Bucher. Explainable AI to improve acceptance of convolutional neural networks for automatic classification of dopamine transporter SPECT in the diagnosis of clinically uncertain parkinsonian syndromes. European journal of nuclear medicine and molecular imaging. 2021-10-15. PMID:34651223. |
deep convolutional neural networks (cnn) provide high accuracy for automatic classification of dopamine transporter (dat) spect images. |
2021-10-15 |
2023-08-13 |
Not clear |
| Dorsa Rafiei, Nathan J Koll. DAT1 polymorphism associated with poor decision-making in males with antisocial personality disorder and high psychopathic traits. Behavioral sciences & the law. 2021-10-12. PMID:34636082. |
the dopamine transporter gene (dat1) is of particular interest due to a polymorphism that controls dopamine transporter (dat) activity. |
2021-10-12 |
2023-08-13 |
human |
| Freja Herborg, Kathrine L Jensen, Sasha Tolstoy, Natascha V Arends, Leonie P Posselt, Aparna Shekar, Jenny I Aguilar, Viktor K Lund, Kevin Erreger, Mattias Rickhag, Matthew D Lycas, Markus N Lonsdale, Troels Rahbek-Clemmensen, Andreas T Sørensen, Amy H Newman, Annemette Løkkegaard, Ole Kjærulff, Thomas Werge, Lisbeth B Møller, Heinrich Jg Matthies, Aurelio Galli, Lena E Hjermind, Ulrik Gethe. Identifying dominant-negative actions of a dopamine transporter variant in patients with parkinsonism and neuropsychiatric disease. JCI insight. vol 6. issue 18. 2021-10-09. PMID:34375312. |
the dopamine transporter (dat) regulates extracellular dopamine levels, but the genetic and mechanistic link between dat function and dopamine-related pathologies is not clear. |
2021-10-09 |
2023-08-13 |
mouse |
| Lana M Chahine, Michael C Brumm, Chelsea Caspell-Garcia, Wolfgang Oertel, Brit Mollenhauer, Amy Amara, Ana Fernandez-Arcos, Eduardo Tolosa, Cristina Simonet, Birgit Hogl, Aleksandar Videnovic, Samantha J Hutten, Caroline Tanner, Daniel Weintraub, Elliot Burghardt, Christopher Coffey, Hyunkeun R Cho, Karl Kieburtz, Kathleen L Poston, Kalpana Merchant, Douglas Galasko, Tatiana Foroud, Andrew Siderowf, Kenneth Marek, Tanya Simuni, Alex Iranz. Dopamine transporter imaging predicts clinically-defined α-synucleinopathy in REM sleep behavior disorder. Annals of clinical and translational neurology. vol 8. issue 1. 2021-10-08. PMID:33321002. |
abnormal dopamine transporter (dat) imaging is a strong candidate biomarker for risk of asn diagnosis in irbd. |
2021-10-08 |
2023-08-13 |
Not clear |
| Mohammad Farhadi, Mahdi Eskandarian Boroujeni, Seyed Kamran Kamrava, Zohreh Bagher, Ava Modirzadeh Tehrani, Fakhroddin Aghajanpour, Samira Ezi, Reza Soltani, Aysan Khatmi, Rafieh Alizade. Implantation of human olfactory ecto-mesenchymal stem cells restores locomotion in a rat model of Parkinson's disease. Journal of chemical neuroanatomy. vol 114. 2021-10-05. PMID:33933574. |
our results displayed that the grafting of oe-mscs increased the expression of daergic markers namely dopamine transporter (dat), tyrosine hydroxylase (th), nuclear receptor related-1 (nurr1) in a 6-ohda model compared with that of control, detected by immunohistochemical staining and western blot. |
2021-10-05 |
2023-08-13 |
human |
| Guillermo Fernández, Favio Krapacher, Soledad Ferreras, Gonzalo Quassollo, Macarena Mariel Mari, María Victoria Pisano, Antonella Montemerlo, María Dolores Rubianes, Claudia Bregonzio, Carlos Arias, María Gabriela Paglin. Lack of Cdk5 activity is involved on Dopamine Transporter expression and function: Evidences from an animal model of Attention-Deficit Hyperactivity Disorder. Experimental neurology. vol 346. 2021-10-04. PMID:34537209. |
the main pharmacological treatment consists of psychostimulant drugs affecting dopamine transporter (dat) function. |
2021-10-04 |
2023-08-13 |
mouse |
| Sara Andersson, Maria Josefsson, Lars J Stiernman, Anna Rieckman. Cognitive Decline in Parkinson's Disease: A Subgroup of Extreme Decliners Revealed by a Data-Driven Analysis of Longitudinal Progression. Frontiers in psychology. vol 12. 2021-09-29. PMID:34566817. |
resultant latent classes were compared on a number of baseline demographics and clinical variables, as well as cerebrospinal fluid (csf) biomarkers and striatal dopamine transporter (dat) density markers of neuropathology. |
2021-09-29 |
2023-08-13 |
Not clear |
| Virgilio Gerald H Evidente, Danica H Evidente, Susan C Ortega, Todd D Levine, Roy Freeman, ChristopherH Gibbon. X-Linked Dystonia-Parkinsonism ("Lubag") May Present with Peripheral Synucleinopathy. Movement disorders : official journal of the Movement Disorder Society. 2021-09-28. PMID:34582053. |
x-linked dystonia parkinsonism (xdp) or "lubag" is a genetic dystonia syndrome observed among filipinos that can present with levodopa-responsive parkinsonism and abnormal dopamine transporter (dat) imaging. |
2021-09-28 |
2023-08-13 |
Not clear |
| Zebin Lin, Chenyang Liu, Enshan Fan, Yurong Zhang, Shuiqing Zheng, Yulan Ra. An efficient and label-free LC-MS/MS method for assessing drug's activity at dopamine and serotonin transporters using transporter-transfected HEK293T cells. Journal of psychopharmacology (Oxford, England). vol 35. issue 6. 2021-09-24. PMID:33888022. |
dopamine transporter (dat) and serotonin transporter (sert) are targets for many psychoactive substances. |
2021-09-24 |
2023-08-13 |
Not clear |
| Sanne K Meles, Wolfgang H Oertel, Klaus L Leender. Circuit imaging biomarkers in preclinical and prodromal Parkinson's disease. Molecular medicine (Cambridge, Mass.). vol 27. issue 1. 2021-09-23. PMID:34530732. |
studies have focused on radiotracer imaging of the dopaminergic nigrostriatal system, which can be assessed with dopamine transporter (dat) single photon emission computed tomography (spect). |
2021-09-23 |
2023-08-13 |
human |