| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| X Zhang, J Talpos, M S Berridge, S M Apana, W Slikker, C Wang, M G Paul. MicroPET/CT assessment of neurochemical effects in the brain after long-term methylphenidate treatment in nonhuman primates. Neurotoxicology and teratology. vol 87. 2021-09-21. PMID:34265415. |
mph is believed to exert its pharmacological effects via preferential blockade of the dopamine transporter (dat) and the norepinephrine transporter (net), resulting in increased monoamine levels in the synapse. |
2021-09-21 |
2023-08-13 |
monkey |
| Seunghyeon Shin, Hyun-Yeol Nam, Myung Jun Lee, Kyoungjune Pak, Keunyoung Kim, In Joo Ki. Effect of sex on aging-related decline of dopamine transporter in healthy subjects. Annals of nuclear medicine. vol 35. issue 1. 2021-09-20. PMID:33052524. |
aging decreases dopamine transporter (dat) availability of striatum both in humans and rodents. |
2021-09-20 |
2023-08-13 |
human |
| Sven R Suwijn, Hamdia Samim, Carsten Eggers, Alberto J Espay, Susan Fox, Anthony E Lang, Mike Samuel, Monty Silverdale, Constant V M Verschuur, Joke M Dijk, Hein J Verberne, Jan Booij, Rob M A de Bi. Value of Clinical Signs in Identifying Patients with Scans without Evidence of Dopaminergic Deficit (SWEDD). Journal of Parkinson's disease. vol 10. issue 4. 2021-09-17. PMID:32597819. |
in clinical trials that recruited patients with early parkinson's disease (pd), 4-15% of the participants with a clinical diagnosis of pd had normal dopamine transporter single photon emission computed tomography (dat spect) scans, also called "scans without evidence of dopaminergic deficit" (swedd). |
2021-09-17 |
2023-08-13 |
human |
| Rita R Fagan, Patrick J Kearney, Dino Luethi, Nicholas C Bolden, Harald H Sitte, Patrick Emery, Haley E Melikia. Dopaminergic Ric GTPase activity impacts amphetamine sensitivity and sleep quality in a dopamine transporter-dependent manner in Drosophila melanogaster. Molecular psychiatry. 2021-09-17. PMID:34471250. |
dopamine (da) is required for movement, sleep, and reward, and da signaling is tightly controlled by the presynaptic da transporter (dat). |
2021-09-17 |
2023-08-13 |
mouse |
| Lars Frings, Franziska Henninger, Martin Treppner, Göran Köber, Martin Boeker, Philipp T Meye. DAT SPECT Predicts Survival in Patients Assessed for Differential Diagnosis of Dementia. Journal of Alzheimer's disease : JAD. vol 82. issue 1. 2021-09-16. PMID:33998542. |
dopamine transporter (dat) spect is an established diagnostic procedure in dementia diagnostics, yet its prognostic value is currently unknown. |
2021-09-16 |
2023-08-13 |
Not clear |
| Vindhya Nawaratne, Sean P McLaughlin, Felix P Mayer, Zayna Gichi, Alyssa Mastriano, Lucia Carvell. Prolonged Amphetamine Exposures Increase the Endogenous Human Dopamine Receptors 2 at the Cellular Membrane in Cells Lacking the Dopamine Transporter. Frontiers in cellular neuroscience. vol 15. 2021-09-14. PMID:34512264. |
previous studies have indicated that the effects of amph at the d2r mainly rely on the ability of amph to robustly increase extracellular dopamine through the dopamine transporter (dat). |
2021-09-14 |
2023-08-13 |
human |
| Vindhya Nawaratne, Sean P McLaughlin, Felix P Mayer, Zayna Gichi, Alyssa Mastriano, Lucia Carvell. Prolonged Amphetamine Exposures Increase the Endogenous Human Dopamine Receptors 2 at the Cellular Membrane in Cells Lacking the Dopamine Transporter. Frontiers in cellular neuroscience. vol 15. 2021-09-14. PMID:34512264. |
however, because of its lipophilic nature, amph can cross the cellular membrane and thus potentially affect d2r expression independently of dopamine and dat, |
2021-09-14 |
2023-08-13 |
human |
| Renee A Rotolo, Rose E Presby, Olivia Tracy, Sokaina Asar, Jen-Hau Yang, Merce Correa, Fraser Murray, John D Salamon. The novel atypical dopamine transport inhibitor CT-005404 has pro-motivational effects in neurochemical and inflammatory models of effort-based dysfunctions related to psychopathology. Neuropharmacology. vol 183. 2021-09-13. PMID:32956676. |
while drugs that block dopamine transport (dat) reportedly have positive motivational effects, dat inhibitors such as cocaine and amphetamines produce undesirable side effects. |
2021-09-13 |
2023-08-13 |
rat |
| Valeska Cid-Jofré, Macarena Gárate-Pérez, Philip J Clark, Viviana Valero-Jara, Rodrigo A España, Ramón Sotomayor-Zárate, Gonzalo Cruz, Georgina M Renar. Chronic modafinil administration to preadolescent rats impairs social play behavior and dopaminergic system. Neuropharmacology. vol 183. 2021-09-13. PMID:33197467. |
mod increases dopamine (da) levels in the reward system by blocking dopamine transporter (dat). |
2021-09-13 |
2023-08-13 |
rat |
| Clio Korn, Thomas Akam, Kristian H R Jensen, Cristiana Vagnoni, Anna Huber, Elizabeth M Tunbridge, Mark E Walto. Distinct roles for dopamine clearance mechanisms in regulating behavioral flexibility. Molecular psychiatry. 2021-09-11. PMID:34193974. |
one reason is that, while many studies have focused on the activity of dopamine neurons, efficient dopamine signaling also relies on clearance mechanisms, notably the dopamine transporter (dat), which predominates in striatum, and catechol-o-methyltransferase (comt), which predominates in cortex. |
2021-09-11 |
2023-08-13 |
mouse |
| Clio Korn, Thomas Akam, Kristian H R Jensen, Cristiana Vagnoni, Anna Huber, Elizabeth M Tunbridge, Mark E Walto. Distinct roles for dopamine clearance mechanisms in regulating behavioral flexibility. Molecular psychiatry. 2021-09-11. PMID:34193974. |
dat blockade, but not comt inhibition, regulated sub-second dopamine release in the nucleus accumbens core, but surprisingly neither clearance mechanism affected evoked release in prelimbic cortex. |
2021-09-11 |
2023-08-13 |
mouse |
| Clio Korn, Thomas Akam, Kristian H R Jensen, Cristiana Vagnoni, Anna Huber, Elizabeth M Tunbridge, Mark E Walto. Distinct roles for dopamine clearance mechanisms in regulating behavioral flexibility. Molecular psychiatry. 2021-09-11. PMID:34193974. |
together, our data suggest that dat and comt shape specific aspects of behavioral flexibility by regulating different aspects of the kinetics of striatal and cortical dopamine, respectively. |
2021-09-11 |
2023-08-13 |
mouse |
| Emma A Honkanen, Tommi Noponen, Risto Hirvilammi, Kari Lindholm, Riitta Parkkola, Juho Joutsa, Andrea Varrone, Valtteri Kaasine. Sex correction improves the accuracy of clinical dopamine transporter imaging. EJNMMI research. vol 11. issue 1. 2021-09-10. PMID:34424408. |
in clinical diagnostic imaging, dopamine transporter (dat) spect scans are commonly evaluated using automated semiquantitative analysis software. |
2021-09-10 |
2023-08-13 |
human |
| Pattama Panmak, Chutikorn Nopparat, Kannika Permpoonpattana, Jatuporn Namyen, Piyarat Govitrapon. Melatonin protects against methamphetamine-induced Alzheimer's disease-like pathological changes in rat hippocampus. Neurochemistry international. vol 148. 2021-09-08. PMID:34224806. |
melatonin prevented meth-induced decrease in dopamine transporter (dat) expression in rat hippocampus. |
2021-09-08 |
2023-08-13 |
rat |
| Karolina E Kolaczynska, Jan Thomann, Marius C Hoener, Matthias E Liecht. The Pharmacological Profile of Second Generation Pyrovalerone Cathinones and Related Cathinone Derivative. International journal of molecular sciences. vol 22. issue 15. 2021-09-08. PMID:34361040. |
we assessed several pyrovalerone and related cathinone derivatives at the human norepinephrine (net), dopamine (dat), and serotonin (sert) uptake transporters using hek293 cells overexpressing each respective transporter. |
2021-09-08 |
2023-08-13 |
human |
| KyungAh Chun, EunJung Kong, IhnHo Ch. Comparison of perfusion 18F-FP-CIT PET and 99mTc-ECD SPECT in parkinsonian disorders. Medicine. vol 100. issue 34. 2021-09-08. PMID:34449475. |
currently dopamine transporter (dat) imaging using fp-cit, glucose metabolism imaging using fluorodeoxyglucose, cerebral blood flow image using ethyl cysteinate dimer (ecd), and others are used for differentiation. |
2021-09-08 |
2023-08-13 |
Not clear |
| Zackary A Cope, Johnny A Kenton, Arpi Minassian, Maureen V Martin, William Perry, Christoffer Bundgaard, Jørn Arnt, Jordy van Enkhuizen, Mark A Geyer, Jared W Youn. Chronic antipsychotic treatment exerts limited effects on the mania-like behavior of dopamine transporter knockdown mice. Behavioural brain research. vol 405. 2021-09-02. PMID:33577882. |
bipolar disorder is a life-threatening disorder linked to dopamine transporter (dat) polymorphisms, with reduced dat levels seen in positron emission tomography and postmortem brains. |
2021-09-02 |
2023-08-13 |
mouse |
| Valentina Carpentieri, Luca Cerniglia, Silvia Cimino, Mariangela Pucci, Esterina Pascale, Claudio D'Addario, Walter Adrian. Epigenetic regulation of DAT gene promoter modulates the risk of externalizing and internalizing behaviors on a normative population: An explorative study. Behavioural brain research. vol 406. 2021-09-02. PMID:33745985. |
we recently proposed to study methylation dynamics of two cpg motifs within the 5'-utr of dopamine transporter (dat) gene. |
2021-09-02 |
2023-08-13 |
human |
| Durairaj Ragu Varman, Mark A Subler, Jolene J Windle, Lankupalle D Jayanthi, Sammanda Ramamoorth. Novelty-induced hyperactivity and suppressed cocaine induced locomotor activation in mice lacking threonine 53 phosphorylation of dopamine transporter. Behavioural brain research. vol 408. 2021-09-02. PMID:33794225. |
dopamine (da) transporter (dat) is dynamically regulated by several protein kinases and the thr53 phosphorylation of dat (pt53-dat) is documented in heterologous cell models and in rat brain. |
2021-09-02 |
2023-08-13 |
mouse |
| Frederic Sampedro, Juan Marín-Lahoz, Saul Martínez-Horta, Valle Camacho, Diego-Alfonso Lopez-Mora, Javier Pagonabarraga, Jaime Kulisevsk. Extrastriatal SPECT-DAT uptake correlates with clinical and biological features of de novo Parkinson's disease. Neurobiology of aging. vol 97. 2021-09-01. PMID:33212336. |
striatal dopamine transporter (dat) uptake assessment through i |
2021-09-01 |
2023-08-13 |
Not clear |