| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael J Banno. The dopamine transporter: role in neurotoxicity and human disease. Toxicology and applied pharmacology. vol 204. issue 3. 2005-06-13. PMID:15845424. |
the dopamine transporter (dat) is a plasma membrane transport protein expressed exclusively within a small subset of cns neurons. |
2005-06-13 |
2023-08-12 |
human |
| Daniele Simoni, Marcello Rossi, Valerio Bertolasi, Marinella Roberti, Daniela Pizzirani, Riccardo Rondanin, Riccardo Baruchello, Francesco Paolo Invidiata, Manlio Tolomeo, Stefania Grimaudo, Stefania Merighi, Katia Varani, Stefania Gessi, Pier Andrea Borea, Silvia Marino, Sabrina Cavallini, Clementina Bianchi, Anna Siniscalch. Synthesis and pharmacology of 6-substituted benztropines: discovery of novel dopamine uptake inhibitors possessing low binding affinity to the dopamine transporter. Journal of medicinal chemistry. vol 48. issue 9. 2005-06-03. PMID:15857139. |
it has been found that modifications at the 6-position of benztropine might reduce the dat binding affinity, maintaining otherwise a significant dopamine uptake inhibitory activity. |
2005-06-03 |
2023-08-12 |
Not clear |
| Annemieke Kavelaars, Pieter M Cobelens, Marc A T Teunis, Cobi J Heijne. Changes in innate and acquired immune responses in mice with targeted deletion of the dopamine transporter gene. Journal of neuroimmunology. vol 161. issue 1-2. 2005-05-27. PMID:15748955. |
the dopamine transporter (dat) is responsible for the re-uptake of dopamine into presynaptic nerve terminals and thereby controls dopaminergic neurotransmission. |
2005-05-27 |
2023-08-12 |
mouse |
| Tatiana Sorkina, Brian R Hoover, Nancy R Zahniser, Alexander Sorki. Constitutive and protein kinase C-induced internalization of the dopamine transporter is mediated by a clathrin-dependent mechanism. Traffic (Copenhagen, Denmark). vol 6. issue 2. 2005-05-26. PMID:15634215. |
the amount of dopamine transporter (dat) present at the cell surface is rapidly regulated by the rates of dat internalization to endosomes and dat recycling back to the plasma membrane. |
2005-05-26 |
2023-08-12 |
human |
| Kaori Koike, Kenji Hashimoto, Goro Fukami, Naoe Okamura, Lin Zhang, Shintaro Ohgake, Hiroki Koizumi, Daisuke Matsuzawa, Noriyuki Kawamura, Eiji Shimizu, Masaomi Iy. The immunophilin ligand FK506 protects against methamphetamine-induced dopaminergic neurotoxicity in mouse striatum. Neuropharmacology. vol 48. issue 3. 2005-05-24. PMID:15721171. |
we also examined the immunohistochemistry of dopamine transporter (dat) and tyrosine hydroxylase (th) in the mouse brain. |
2005-05-24 |
2023-08-12 |
mouse |
| F Ivy Carroll, Bruce E Blough, Zhe Nie, Michael J Kuhar, Leonard L Howell, Hernan A Navarr. Synthesis and monoamine transporter binding properties of 3beta-(3',4'-disubstituted phenyl)tropane-2beta-carboxylic acid methyl esters. Journal of medicinal chemistry. vol 48. issue 8. 2005-05-24. PMID:15828814. |
3beta-(3'-methyl-4'-chlorophenyl)tropane-2-carboxylic acid methyl ester (3b, rti-112) is a 3-phenyltropane analogue that has high affinity for both the dopamine and serotonin transporters (dat and 5-htt, respectively). |
2005-05-24 |
2023-08-12 |
monkey |
| Sandeep D Bhatt, Dean E Dluze. Dopamine transporter function differences between male and female CD-1 mice. Brain research. vol 1035. issue 2. 2005-05-16. PMID:15722058. |
since ma utilizes the dopamine transporter (dat) to exert its effects, in the present study, we tested for differences in the dynamics of dat function between male and female mice as an approach to understand some of the bases for this sex difference in ma-induced nsda neurotoxicity. |
2005-05-16 |
2023-08-12 |
mouse |
| R Mark Richardson, William C Broaddus, Kathryn L Holloway, Helen L Fillmor. Grafts of adult subependymal zone neuronal progenitor cells rescue hemiparkinsonian behavioral decline. Brain research. vol 1032. issue 1-2. 2005-05-12. PMID:15680936. |
grafted cells continued to express nestin at the survival time point, and dopamine transporter (dat) immunoreactivity was restored in the graft body. |
2005-05-12 |
2023-08-12 |
rat |
| F Calon, N Lavertu, A M Lemieux, M Morissette, M Goulet, R Grondin, P J Blanchet, P J Bédard, T Di Paol. Effect of MPTP-induced denervation on basal ganglia GABA(B) receptors: correlation with dopamine concentrations and dopamine transporter. Synapse (New York, N.Y.). vol 40. issue 3. 2005-05-09. PMID:11304760. |
the extent of the lesion was measured with striatal catecholamine content, striatal binding of (125)i-rti-121 to dopamine transporter (dat), and dat expression in the snpc. |
2005-05-09 |
2023-08-12 |
mouse |
| F Calon, N Lavertu, A M Lemieux, M Morissette, M Goulet, R Grondin, P J Blanchet, P J Bédard, T Di Paol. Effect of MPTP-induced denervation on basal ganglia GABA(B) receptors: correlation with dopamine concentrations and dopamine transporter. Synapse (New York, N.Y.). vol 40. issue 3. 2005-05-09. PMID:11304760. |
in mice, dopamine content, (125)i-rti-121 binding, and dat expression were reduced by 44%, 40%, and 39% after a dose of 40 mg/kg of mptp and 74%, 70%, and 34% after 120 mg/kg of mptp, respectively. |
2005-05-09 |
2023-08-12 |
mouse |
| F Calon, N Lavertu, A M Lemieux, M Morissette, M Goulet, R Grondin, P J Blanchet, P J Bédard, T Di Paol. Effect of MPTP-induced denervation on basal ganglia GABA(B) receptors: correlation with dopamine concentrations and dopamine transporter. Synapse (New York, N.Y.). vol 40. issue 3. 2005-05-09. PMID:11304760. |
in monkeys, dopamine content and dat expression were decreased by more than 90% and 80%, respectively. |
2005-05-09 |
2023-08-12 |
mouse |
| F Calon, N Lavertu, A M Lemieux, M Morissette, M Goulet, R Grondin, P J Blanchet, P J Bédard, T Di Paol. Effect of MPTP-induced denervation on basal ganglia GABA(B) receptors: correlation with dopamine concentrations and dopamine transporter. Synapse (New York, N.Y.). vol 40. issue 3. 2005-05-09. PMID:11304760. |
the decrease of the expression of gaba(b(1a+b)) mrna was correlated with dopamine content, (125)i-rti-121 binding and dat expression. |
2005-05-09 |
2023-08-12 |
mouse |
| M Bliziotes, M Gunness, A Eshleman, K Wire. The role of dopamine and serotonin in regulating bone mass and strength: studies on dopamine and serotonin transporter null mice. Journal of musculoskeletal & neuronal interactions. vol 2. issue 3. 2005-05-09. PMID:15758457. |
the dopamine transporter (dat) is believed to control the temporal and spatial activity of released da by rapid uptake of the neurotransmitter into presynaptic terminals. |
2005-05-09 |
2023-08-12 |
human |
| Yiyun Huang, Sung-A Bae, Zhihong Zhu, Ningning Guo, Bryan L Roth, Marc Laruell. Fluorinated diaryl sulfides as serotonin transporter ligands: synthesis, structure-activity relationship study, and in vivo evaluation of fluorine-18-labeled compounds as PET imaging agents. Journal of medicinal chemistry. vol 48. issue 7. 2005-05-05. PMID:15801845. |
candidate compounds were assayed for their affinities to the monoamine transporters (sert, norepinephrine transporter (net), and dopamine transporter (dat)) in competitive binding experiments in vitro using cloned human transporters. |
2005-05-05 |
2023-08-12 |
human |
| Nina Erixon-Lindroth, Lars Farde, Tarja-Brita Robins Wahlin, Judit Sovago, Christer Halldin, Lars Bäckma. The role of the striatal dopamine transporter in cognitive aging. Psychiatry research. vol 138. issue 1. 2005-04-26. PMID:15708296. |
we examined the relationship of age-related losses of striatal dopamine transporter (dat) density to age-related deficits in episodic memory and executive functioning in a group of subjects (n = 12) ranging from 34 to 81 years of age. |
2005-04-26 |
2023-08-12 |
human |
| Markus Mitterhauser, Wolfgang Wadsak, Leonhard-Key Mien, Alexander Hoepping, Helmut Viernstein, Robert Dudczak, Kurt Klette. Synthesis and biodistribution of [18F]FE@CIT, a new potential tracer for the dopamine transporter. Synapse (New York, N.Y.). vol 55. issue 2. 2005-04-25. PMID:15529336. |
an important improvement, yielding in higher affinity to the dopamine transporter (dat) vs. serotonin transporter (sert), can be achieved by a simple replacement of the carboxylic methyl ester group in beta-cit by a fluoroethyl ester. |
2005-04-25 |
2023-08-12 |
rat |
| Andreas Leng, Anna Mura, Joram Feldon, Boris Ferge. Tumor necrosis factor-alpha receptor ablation in a chronic MPTP mouse model of Parkinson's disease. Neuroscience letters. vol 375. issue 2. 2005-04-22. PMID:15670651. |
one week after the last mptp treatment, hplc determination of striatal dopamine (da) and immunostaining for the dopamine transporter (dat) in the substantia nigra pars compacta (snpc) was performed. |
2005-04-22 |
2023-08-12 |
mouse |
| Elise Morice, Cécile Denis, Alessandro Macario, Bruno Giros, Marika Nosten-Bertran. Constitutive hyperdopaminergia is functionally associated with reduced behavioral lateralization. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 3. 2005-04-21. PMID:15354185. |
mice lacking the dopamine transporter (dat) gene were used as a genetic model of persistent hyperdopaminergia. |
2005-04-21 |
2023-08-12 |
mouse |
| L'Aurelle A Johnson, Bipasha Guptaroy, David Lund, Susanna Shamban, Margaret E Gneg. Regulation of amphetamine-stimulated dopamine efflux by protein kinase C beta. The Journal of biological chemistry. vol 280. issue 12. 2005-04-21. PMID:15647254. |
pkc beta(i) and pkc beta(ii), but not pkc alpha or pkc gamma, were co-immunoprecipitated from rat striatal membranes with the dopamine transporter (dat). |
2005-04-21 |
2023-08-12 |
rat |
| L'Aurelle A Johnson, Bipasha Guptaroy, David Lund, Susanna Shamban, Margaret E Gneg. Regulation of amphetamine-stimulated dopamine efflux by protein kinase C beta. The Journal of biological chemistry. vol 280. issue 12. 2005-04-21. PMID:15647254. |
these results suggest that classical pkc beta(ii) is physically associated with dat and is important in maintaining the amphetamine-stimulated outward transport of dopamine in rat striatum. |
2005-04-21 |
2023-08-12 |
rat |