| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Erik Ryding, Mats Lindström, Björn Brådvik, Martin Grabowski, Peter Bosson, Lil Träskman-Bendz, Ingmar Rosé. A new model for separation between brain dopamine and serotonin transporters in 123I-beta-CIT SPECT measurements: normal values and sex and age dependence. European journal of nuclear medicine and molecular imaging. vol 31. issue 8. 2005-02-25. PMID:15014902. |
123i-beta-cit is a radioactive ligand for single-photon emission computed tomography (spect) imaging of the pre-synaptic (transporter) re-uptake sites for dopamine (dat) and serotonin (5htt), and it is widely used to visualize monoamine turnover. |
2005-02-25 |
2023-08-12 |
human |
| Yiyun Huang, Raj Narendran, Sung-A Bae, David Erritzoe, Ningning Guo, Zhihong Zhu, Dah-Ren Hwang, Marc Laruell. A PET imaging agent with fast kinetics: synthesis and in vivo evaluation of the serotonin transporter ligand [11C]2-[2-dimethylaminomethylphenylthio)]-5-fluorophenylamine ([11C]AFA). Nuclear medicine and biology. vol 31. issue 6. 2005-02-25. PMID:15246363. |
in vitro, afa displayed high affinity for sert (ki 1.46 +/- 0.15 nm) and lower affinity for norepinephrine transporter (net, ki 141.7 +/- 47.4 nm) or dopamine transporter (dat, ki > 10,000 nm). |
2005-02-25 |
2023-08-12 |
rat |
| Makoto Kimura, Tomoko Masuda, Koji Yamada, Nobuyuki Kawakatsu, Nobuo Kubota, Masaki Mitani, Kenichi Kishii, Masato Inazu, Yuji Kiuchi, Katsuji Oguchi, Takayuki Namik. Antioxidative activities of novel diphenylalkyl piperazine derivatives with high affinities for the dopamine transporter. Bioorganic & medicinal chemistry letters. vol 14. issue 16. 2005-02-23. PMID:15261288. |
a new series of diphenylalkyl piperazine derivatives with high affinities for the dopamine transporter (dat), which were modified at both the diphenylalkyl moiety and the phenyl ring in the phenylamino moiety of 1-[4,4-bis(4-fluorophenyl)butyl]-4-[2-hydroxy-3-(phenylamino)propyl]piperazine 1, was evaluated for their inhibitory activities against auto-oxidative lipid peroxidation in canine brain homogenates. |
2005-02-23 |
2023-08-12 |
Not clear |
| F Scott Hall, Ichiro Sora, Jana Drgonova, Xiao-Fei Li, Michelle Goeb, George R Uh. Molecular mechanisms underlying the rewarding effects of cocaine. Annals of the New York Academy of Sciences. vol 1025. 2005-02-18. PMID:15542699. |
the initially surprising observation that cocaine retains its rewarding effects in dopamine transporter (dat) knockout (ko) mice led our laboratory to examine the effects of deletion of other monoaminergic genes on cocaine reward. |
2005-02-18 |
2023-08-12 |
mouse |
| Jesus A Angulo, Nieves Angulo, Jing Y. Antagonists of the neurokinin-1 or dopamine D1 receptors confer protection from methamphetamine on dopamine terminals of the mouse striatum. Annals of the New York Academy of Sciences. vol 1025. 2005-02-18. PMID:15542715. |
exposure to meth induces long-term deficits in dopamine transporter (dat) and tyrosine hydroxylase (th) levels as well as induction of glial fibrillary acidic protein (gfap) in the caudate putamen (cpu) and the nucleus accumbens (nac). |
2005-02-18 |
2023-08-12 |
mouse |
| Kenji Hashimoto, Hideo Tsukada, Shingo Nishiyama, Dai Fukumoto, Takehau Kakiuchi, Eiji Shimizu, Masaomi Iy. Effects of N-acetyl-L-cysteine on the reduction of brain dopamine transporters in monkey treated with methamphetamine. Annals of the New York Academy of Sciences. vol 1025. 2005-02-18. PMID:15542721. |
the present study undertakes to determine whether intravenous administration of n-acetyl-l-cysteine (nac), a potent antioxidant drug, could attenuate the reduction of dopamine transporter (dat) in the striatum of monkey brain after administration of map. |
2005-02-18 |
2023-08-12 |
monkey |
| Hideaki Kobayashi, Soichiro Ide, Junko Hasegawa, Hiroshi Ujike, Yoshimoto Sekine, Norio Ozaki, Toshiya Inada, Mutsuo Harano, Tokutaro Komiyama, Mitsuhiko Yamada, Masaomi Iyo, Hao-Wei Shen, Kazutaka Ikeda, Ichiro Sor. Study of association between alpha-synuclein gene polymorphism and methamphetamine psychosis/dependence. Annals of the New York Academy of Sciences. vol 1025. 2005-02-18. PMID:15542733. |
map is taken into the cytosol by the dopamine transporter (dat) on the synaptic terminals of da neurons, and endogenous da is concurrently released through the transporter by carrier exchange mechanisms, resulting in a robust increase in da concentration in the synaptic clefts. |
2005-02-18 |
2023-08-12 |
human |
| Z Xu, D Cawthon, K A McCastlain, W Slikker, S F Al. Selective alterations of gene expression in mice induced by MPTP. Synapse (New York, N.Y.). vol 55. issue 1. 2005-02-17. PMID:15499605. |
our data demonstrated that mptp significantly decreased gene expression of th, dopamine transporter (dat), and vesicle monoamine transporter (vmat), coinciding with the pattern of dopamine concentration changes and protein expression after mptp treatment. |
2005-02-17 |
2023-08-12 |
mouse |
| Virginia Maria Vidigal Fernandes, Marco Aurélio Romano-Silva, Dawidson Assis Gomes, Marco Antonio Máximo Prado, Tasso Moraes Santos, Marcus Vinicius Gome. Dopamine release evoked by beta scorpion toxin, tityus gamma, in prefrontal cortical slices is mediated by intracellular calcium stores. Cellular and molecular neurobiology. vol 24. issue 6. 2005-02-17. PMID:15672678. |
nomifensine and ascorbic acid, blockers of dopamine transporter (dat), caused an inhibition of 27 and 29%, respectively, on the toxin-induced release of [3h]dopamine suggesting that most of the titx gamma-induced release of dopamine is not due to the reversal of na+ gradient. |
2005-02-17 |
2023-08-12 |
rat |
| Sophia K Briegleb, Joshua M Gulley, Brian R Hoover, Nancy R Zahnise. Individual differences in cocaine- and amphetamine-induced activation of male Sprague-Dawley rats: contribution of the dopamine transporter. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 12. 2005-02-14. PMID:15292903. |
differences in drug-induced activation could involve differential dopamine transporter (dat) function/trafficking. |
2005-02-14 |
2023-08-12 |
rat |
| Myreille D'Astous, Marc Morissette, Thérèse Di Paol. Effect of estrogen receptor agonists treatment in MPTP mice: evidence of neuroprotection by an ER alpha agonist. Neuropharmacology. vol 47. issue 8. 2005-02-10. PMID:15567427. |
the striatal dopamine transporter (dat) was assayed by autoradiography with [(125)i]rti-121-specific binding. |
2005-02-10 |
2023-08-12 |
mouse |
| Anne-Kristine Meinild, Harald H Sitte, Ulrik Gethe. Zinc potentiates an uncoupled anion conductance associated with the dopamine transporter. The Journal of biological chemistry. vol 279. issue 48. 2005-02-07. PMID:15358780. |
binding of zn(2+) to an endogenous binding site in the dopamine transporter (dat) leads to inhibition of dopamine (da) uptake and enhancement of carrier-mediated substrate efflux. |
2005-02-07 |
2023-08-12 |
xenopus_laevis |
| Deepak R Thakker, Francois Natt, Dieter Hüsken, Rainer Maier, Matthias Müller, Herman van der Putten, Daniel Hoyer, John F Crya. Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain by using nonviral RNA interference. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 49. 2005-02-04. PMID:15569935. |
we challenged our rnai approach to generate a specific knockdown of an endogenous gene, encoding the dopamine transporter (dat) in regions (ventral midbrain) far distal to the infusion site. |
2005-02-04 |
2023-08-12 |
mouse |
| Trent J Volz, James O Schen. L-arginine increases dopamine transporter activity in rat striatum via a nitric oxide synthase-dependent mechanism. Synapse (New York, N.Y.). vol 54. issue 3. 2005-01-31. PMID:15452864. |
literature reports suggest that nitric oxide (no) participates in the regulation of dopaminergic neurotransmission, possibly through interaction with cysteine residues of the dopamine transporter (dat). |
2005-01-31 |
2023-08-12 |
rat |
| Trent J Volz, James O Schen. L-arginine increases dopamine transporter activity in rat striatum via a nitric oxide synthase-dependent mechanism. Synapse (New York, N.Y.). vol 54. issue 3. 2005-01-31. PMID:15452864. |
rotating disk electrode voltammetry was used to measure dopamine (da) transport in rat striatum to determine if 1) the nitric oxide synthase (nos) substrate, l-arginine (l-arg), could affect dat activity; 2) l-arg-dependent effects on dat activity could be blocked by nos and guanylate cyclase inhibitors, a no scavenger, da, and cocaine; 3) a no donor could affect dat activity; and 4) l-arg could protect the dat from a sulfhydryl agent. |
2005-01-31 |
2023-08-12 |
rat |
| A Storch, A C Ludolph, J Schwar. Dopamine transporter: involvement in selective dopaminergic neurotoxicity and degeneration. Journal of neural transmission (Vienna, Austria : 1996). vol 111. issue 10-11. 2005-01-26. PMID:15480838. |
the carrier molecule that transports dopamine (da) into dopamine neurons by an electrogenic, na(+)- and cl(-)-transport-coupled mechanism is known as the dopamine transporter (dat). |
2005-01-26 |
2023-08-12 |
Not clear |
| Paul W Czoty, Chinnasamy R Ramanathan, Nicole H Mutschler, Alexandros Makriyannis, Jack Bergma. Drug discrimination in methamphetamine-trained monkeys: effects of monoamine transporter inhibitors. The Journal of pharmacology and experimental therapeutics. vol 311. issue 2. 2005-01-25. PMID:15240827. |
injections of 0.3 mg/kg ma from saline, methamphetamine (0.01-0.3 mg/kg), and dopamine transporter (dat) inhibitors, including 1-[2-(bis(4-fluorophenyl)-methoxy)ethyl]-4-(3-phenylpropyl)piperazine (gbr 12909; 1.0-17.8 mg/kg) and its analogs am2502 (1.0-17.8 mg/kg), am2506 (1.0-30.0 mg/kg), am2515 (1.0-17.8 mg/kg), and am2517 (1.0-5.6 mg/kg), produced dose-related increases in responding on the ma-associated lever and, at the highest doses, full substitution. |
2005-01-25 |
2023-08-12 |
monkey |
| Matthew C Willett, Dean E Dluze. Tamoxifen increases methamphetamine-evoked dopamine output from superfused striatal tissue fragments of male mice. Brain research. vol 1029. issue 2. 2005-01-24. PMID:15542073. |
in experiment 3, we assessed whether these effects of tmx may be exerted upon the dopamine transporter (dat) by coinfusing da (1 microm) in the presence or absence of tmx (100 pg/ml). |
2005-01-24 |
2023-08-12 |
mouse |
| Gene-Jack Wang, Linda Chang, Nora D Volkow, Frank Telang, Jean Logan, Thomas Ernst, Joanna S Fowle. Decreased brain dopaminergic transporters in HIV-associated dementia patients. Brain : a journal of neurology. vol 127. issue Pt 11. 2005-01-18. PMID:15319273. |
therefore, we aimed to assess whether dopamine (da) d2 receptors and transporters (dat) are affected in the basal ganglia of subjects with hiv, and how these changes relate to dementia status. |
2005-01-18 |
2023-08-12 |
human |
| Nichole M Neugebauer, S Tiffany Cunningham, Jun Zhu, Rachel I Bryant, Lisa S Middleton, Linda P Dwoski. Effects of environmental enrichment on behavior and dopamine transporter function in medial prefrontal cortex in adult rats prenatally treated with cocaine. Brain research. Developmental brain research. vol 153. issue 2. 2005-01-13. PMID:15527889. |
the present study determined if environmental enrichment modifies the effects of prenatal cocaine on open field activity, social interaction and dopamine transporter (dat) function in the medial prefrontal cortex (mpfc) in rats. |
2005-01-13 |
2023-08-12 |
rat |