| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thomas J Spencer, Joseph Biederman, Bertha K Madras, Stephen V Faraone, Darin D Dougherty, Ali A Bonab, Alan J Fischma. In vivo neuroreceptor imaging in attention-deficit/hyperactivity disorder: a focus on the dopamine transporter. Biological psychiatry. vol 57. issue 11. 2005-07-29. PMID:15950001. |
the dopamine transporter (dat) is known to be a key regulator of dopamine, and recent genetic, treatment, and imaging studies have highlighted the role of dat in adhd. |
2005-07-29 |
2023-08-12 |
human |
| Bertha K Madras, Gregory M Miller, Alan J Fischma. The dopamine transporter and attention-deficit/hyperactivity disorder. Biological psychiatry. vol 57. issue 11. 2005-07-29. PMID:15950014. |
of these, the dopamine transporter (dat) is a principal target of the most widely used antihyperactivity medications (amphetamine and methylphenidate); the dat gene is associated with adhd, and some studies have detected abnormal levels of the dat in brain striatum of adhd subjects. |
2005-07-29 |
2023-08-12 |
human |
| Bertha K Madras, Gregory M Miller, Alan J Fischma. The dopamine transporter and attention-deficit/hyperactivity disorder. Biological psychiatry. vol 57. issue 11. 2005-07-29. PMID:15950014. |
in brain regions expressing both the dat and the norepinephrine transporter (net), the relative contributions of dopamine and norepinephrine to adhd pathophysiology and therapeutic response are obfuscated by the capacity of the net to clear dopamine as well as norepinephrine. |
2005-07-29 |
2023-08-12 |
human |
| Bertha K Madras, Gregory M Miller, Alan J Fischma. The dopamine transporter and attention-deficit/hyperactivity disorder. Biological psychiatry. vol 57. issue 11. 2005-07-29. PMID:15950014. |
thus, adhd medications targeting dat or net might disperse dopamine widely and consign dopamine storage and release to regulation by noradrenergic, as well as dopaminergic neurons. |
2005-07-29 |
2023-08-12 |
human |
| Nora D Volkow, Gene-Jack Wang, Joanna S Fowler, Yu-Shin Din. Imaging the effects of methylphenidate on brain dopamine: new model on its therapeutic actions for attention-deficit/hyperactivity disorder. Biological psychiatry. vol 57. issue 11. 2005-07-29. PMID:15950015. |
methylphenidate hydrochloride blocks the dopamine transporters (dat), the main mechanism for removing dopamine (da) from the synapse, is believed to be involved in its therapeutic properties. |
2005-07-29 |
2023-08-12 |
human |
| D Purper-Ouakil, M Wohl, M C Mouren, P Verpillat, J Adès, P Gorwoo. Meta-analysis of family-based association studies between the dopamine transporter gene and attention deficit hyperactivity disorder. Psychiatric genetics. vol 15. issue 1. 2005-07-28. PMID:15722958. |
molecular genetic research has mainly focused on the d4 dopamine receptor (drd4) and the dopamine transporter (dat) genes in attention-deficit hyperactivity disorder (adhd). |
2005-07-28 |
2023-08-12 |
Not clear |
| Donita L Robinson, Trent J Volz, James O Schenk, R Mark Wightma. Acute ethanol decreases dopamine transporter velocity in rat striatum: in vivo and in vitro electrochemical measurements. Alcoholism, clinical and experimental research. vol 29. issue 5. 2005-07-27. PMID:15897718. |
ethanol increases dopamine transporter (dat) velocity when measured in cell expression systems, but its effects in vivo are mixed. |
2005-07-27 |
2023-08-12 |
rat |
| Donita L Robinson, Trent J Volz, James O Schenk, R Mark Wightma. Acute ethanol decreases dopamine transporter velocity in rat striatum: in vivo and in vitro electrochemical measurements. Alcoholism, clinical and experimental research. vol 29. issue 5. 2005-07-27. PMID:15897718. |
the present experiments examined the effect of acute ethanol on dopamine transmission, particularly dat velocity, in anesthetized animals as well as rat striatal suspensions. |
2005-07-27 |
2023-08-12 |
rat |
| Gianluigi Tanda, Aaron Ebbs, Amy H Newman, Jonathan L Kat. Effects of 4'-chloro-3 alpha-(diphenylmethoxy)-tropane on mesostriatal, mesocortical, and mesolimbic dopamine transmission: comparison with effects of cocaine. The Journal of pharmacology and experimental therapeutics. vol 313. issue 2. 2005-07-05. PMID:15681658. |
increase in dopamine (da) neurotransmission resulting from blockade of the da transporter (dat) after administration of cocaine is believed to play a major role in mediating its behavioral and reinforcing effects. |
2005-07-05 |
2023-08-12 |
rat |
| J N Mason, H Farmer, I D Tomlinson, J W Schwartz, V Savchenko, L J DeFelice, S J Rosenthal, R D Blakel. Novel fluorescence-based approaches for the study of biogenic amine transporter localization, activity, and regulation. Journal of neuroscience methods. vol 143. issue 1. 2005-06-30. PMID:15763132. |
pre-synaptic norepinephrine (ne) and dopamine (da) transporters (net and dat) terminate catecholamine synaptic transmission through reuptake of released neurotransmitter. |
2005-06-30 |
2023-08-12 |
Not clear |
| Roxanne A Vaughan, M Laura Parnas, Jon D Gaffaney, Margaret J Lowe, Sara Wirtz, Anh Pham, Brian Reed, Sucharita M Dutta, Kermit K Murray, Joseph B Justic. Affinity labeling the dopamine transporter ligand binding site. Journal of neuroscience methods. vol 143. issue 1. 2005-06-30. PMID:15763134. |
photoaffinity labeling is a positive function approach that has been used in an effort to identify the cocaine-binding site on the dopamine transporter (dat). |
2005-06-30 |
2023-08-12 |
Not clear |
| Roxanne A Vaughan, M Laura Parnas, Jon D Gaffaney, Margaret J Lowe, Sara Wirtz, Anh Pham, Brian Reed, Sucharita M Dutta, Kermit K Murray, Joseph B Justic. Affinity labeling the dopamine transporter ligand binding site. Journal of neuroscience methods. vol 143. issue 1. 2005-06-30. PMID:15763134. |
radioactive and non-radioactive analogs of cocaine and other dopamine uptake blockers are used to irreversibly label the dat ligand-binding site and the protein is subjected to chemical or enzymatic treatments that cleave at specific amino acid residues. |
2005-06-30 |
2023-08-12 |
Not clear |
| James O Schenk, Cortney Wright, Nicole Bjorklun. Unraveling neuronal dopamine transporter mechanisms with rotating disk electrode voltammetry. Journal of neuroscience methods. vol 143. issue 1. 2005-06-30. PMID:15763135. |
herein we describe how the rotating disk electrode voltammetric technique can be used to examine the mechanism(s) of the inward transport of dopamine by the neuronal transporter for dopamine (dat). |
2005-06-30 |
2023-08-12 |
Not clear |
| James O Schenk, Cortney Wright, Nicole Bjorklun. Unraveling neuronal dopamine transporter mechanisms with rotating disk electrode voltammetry. Journal of neuroscience methods. vol 143. issue 1. 2005-06-30. PMID:15763135. |
the usefulness of making measurements kinetically resolving dopamine transport, interpretations of changes in km and vmax, approaches to defining pre-steady-state binding of dopamine to dat, interactions between competing inhibitors, chemical modification of functional groups within dat, and a presentation of a hypothetical multi-state model of dopamine transport are presented and discussed. |
2005-06-30 |
2023-08-12 |
Not clear |
| Nachwa Jarkas, Jonathan McConathy, John R Votaw, Ronald J Voll, Eugene Malveaux, Vernon M Camp, Larry Williams, Robin R Goodman, Clinton D Kilts, Mark M Goodma. Synthesis and characterization of EADAM: a selective radioligand for mapping the brain serotonin transporters by positron emission tomography. Nuclear medicine and biology. vol 32. issue 1. 2005-06-24. PMID:15691664. |
competition binding assays in cells stably expressing the transfected human dopamine transporter (dat), sert and norepinephrine transporter (net) labeled with [3h]win 35428 or [(125)i]rti-55, [3h]citalopram and [3h]nisoxetine, respectively, indicated the following order of sert affinity: adam>eadam>>fluvoxamine. |
2005-06-24 |
2023-08-12 |
human |
| Christopher H van Dyck, Robert T Malison, Leslie K Jacobsen, John P Seibyl, Julie K Staley, Marc Laruelle, Ronald M Baldwin, Robert B Innis, Joel Gelernte. Increased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 gene. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 46. issue 5. 2005-06-24. PMID:15872345. |
a polymorphism involving a variable number of tandem repeats (vntr) has been described in the 3' untranslated region of the gene (slc6a3) coding for the dopamine transporter (dat). |
2005-06-24 |
2023-08-12 |
human |
| Nora D Volkow, Gene-Jack Wang, Joanna S Fowler, Susan Learned-Coughlin, Julia Yang, Jean Logan, David Schlyer, John S Gatley, Christopher Wong, Wei Zhu, Naomi Pappas, Michael Schueller, Millard Jayne, Pauline Carter, Donald Warner, Yu-Shin Ding, Colleen Shea, Youwen X. The slow and long-lasting blockade of dopamine transporters in human brain induced by the new antidepressant drug radafaxine predict poor reinforcing effects. Biological psychiatry. vol 57. issue 6. 2005-06-20. PMID:15780851. |
(2s,3s)-2-(3-chlorophenyl)-3,5,5,-trimethyl-2-morpholinol hydrochloride (radafaxine) is a new antidepressant that blocks dopamine transporters (dat). |
2005-06-20 |
2023-08-12 |
human |
| Gilles Tamagnan, David Alagille, Xing Fu, Nora S Kula, Ross J Baldessarini, Robert B Innis, Ronald M Baldwi. Synthesis and monoamine transporter affinity of new 2beta-carbomethoxy-3beta-[4-(substituted thiophenyl)]phenyltropanes: discovery of a selective SERT antagonist with picomolar potency. Bioorganic & medicinal chemistry letters. vol 15. issue 4. 2005-06-15. PMID:15686927. |
preparation of cocaine analogues has been aimed largely at development of stable compounds with high affinity and selectivity for the dopamine transporter (dat). |
2005-06-15 |
2023-08-12 |
Not clear |
| Gilles Tamagnan, David Alagille, Xing Fu, Nora S Kula, Ross J Baldessarini, Robert B Innis, Ronald M Baldwi. Synthesis and monoamine transporter affinity of new 2beta-carbomethoxy-3beta-[4-(substituted thiophenyl)]phenyltropanes: discovery of a selective SERT antagonist with picomolar potency. Bioorganic & medicinal chemistry letters. vol 15. issue 4. 2005-06-15. PMID:15686927. |
among these, compound 4b exhibited very high affinity for the serotonin transporter (sert: k(i)=17 pm) and good selectivity over dopamine (dat: 710-fold) and norepinephrine transporters (net: 11,100-fold). |
2005-06-15 |
2023-08-12 |
Not clear |
| Ciaran J Faherty, Kennie Raviie Shepherd, Anna Herasimtschuk, Richard J Smeyn. Environmental enrichment in adulthood eliminates neuronal death in experimental Parkinsonism. Brain research. Molecular brain research. vol 134. issue 1. 2005-06-13. PMID:15790541. |
dopamine transporter, dat; vesicular monoamine transporter, vmat2), contribute to the observed neuroprotection of dopamine neurons in the nigrostriatal system following mptp exposure. |
2005-06-13 |
2023-08-12 |
Not clear |