| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| John R Lever, Mu-Fa Zou, M Laura Parnas, Romain A Duval, Sara E Wirtz, Joseph B Justice, Roxanne A Vaughan, Amy Hauck Newma. Radioiodinated azide and isothiocyanate derivatives of cocaine for irreversible labeling of dopamine transporters: synthesis and covalent binding studies. Bioconjugate chemistry. vol 16. issue 3. 2005-09-08. PMID:15898733. |
two novel n-substituted-3beta-phenyltropane alkaloids have been labeled with iodine-125 for use as irreversible probes of dopamine transporter (dat) binding sites. |
2005-09-08 |
2023-08-12 |
rat |
| Paul D Callaghan, Rodney J Irvine, Lynette C Daw. Differences in the in vivo dynamics of neurotransmitter release and serotonin uptake after acute para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine revealed by chronoamperometry. Neurochemistry international. vol 47. issue 5. 2005-09-08. PMID:15979209. |
in contrast to the striatum where 5-ht is cleared by both the sert and the dopamine transporter (dat), 5-ht is cleared primarily by the sert in the ca3 region. |
2005-09-08 |
2023-08-12 |
rat |
| Ronald J Voll, Jonathan McConathy, Michael S Waldrep, Ronald J Crowe, Mark M Goodma. Semi-automated preparation of the dopamine transporter ligand [(18)F]FECNT for human PET imaging studies. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. vol 63. issue 3. 2005-09-08. PMID:15985372. |
the fluorine-18 labeled dopamine transport (dat) ligand 2 beta-carbomethoxy-3beta-(4-chlorophenyl)-8-(2-fluoroethyl)nortropane (fecnt) has shown promising properties as an in vivo dat imaging agent in human and monkey pet studies. |
2005-09-08 |
2023-08-12 |
human |
| Rong Chen, Dawn D Han, Howard H G. A triple mutation in the second transmembrane domain of mouse dopamine transporter markedly decreases sensitivity to cocaine and methylphenidate. Journal of neurochemistry. vol 94. issue 2. 2005-09-07. PMID:15998286. |
previously, we reported that phe105 in transmembrane domain 2 of the mouse dopamine transporter (dat) is crucial for high-affinity cocaine binding. |
2005-09-07 |
2023-08-12 |
mouse |
| Panagiotis Giompres, Foteini Deli. Dopamine transporters in the cerebellum of mutant mice. Cerebellum (London, England). vol 4. issue 2. 2005-08-30. PMID:16035192. |
in order to better understand the functional role of this system and to delineate its specific interactions within the cerebellum, the distribution and properties of dopamine transporter (dat) in the cerebellum of reeler and purkinje cell degeneration (nna1pcd) mutant mice, which are characterized by severe loss of different cell populations and abnormalities in synapse formation, have been studied. |
2005-08-30 |
2023-08-12 |
mouse |
| Anu J Airaksinen, Marko Huotari, Alexander Shvetsov, Pirjo Vainiotalo, Pekka T Männisto, Leena Tuomisto, Kim A Bergström, Jouko Vepsäläine. Synthesis and biological evaluation of 6/7-exo-methyl-3beta-(4-iodo)phenyltropane-2beta-carboxylic acid methyl esters. European journal of medicinal chemistry. vol 40. issue 3. 2005-08-29. PMID:15725499. |
the effect of 6/7-groups was evaluated by in vitro receptor binding to dopamine (dat), serotonin (sert) and norepinephrine (net) transporters. |
2005-08-29 |
2023-08-12 |
mouse |
| Christian Pifl, Gabor Nagy, Sándor Berényi, Alexandra Kattinger, Harald Reither, Sándor Antu. Pharmacological characterization of ecstasy synthesis byproducts with recombinant human monoamine transporters. The Journal of pharmacology and experimental therapeutics. vol 314. issue 1. 2005-08-26. PMID:15831439. |
mdma and eight chemically defined byproducts of mdma synthesis were investigated for their interaction with the primary sites of action of mdma, namely the human plasmalemmal monamine transporters for norepinephrine, serotonin, and dopamine [(norepinephrine transporter (net), serotonin transporter (sert), and dopamine transporter (dat)]. |
2005-08-26 |
2023-08-12 |
human |
| Gerda Andringa, Benjamin Drukarch, John G J M Bol, Kora de Bruin, Karolina Sorman, Jan B A Habraken, Jan Booi. Pinhole SPECT imaging of dopamine transporters correlates with dopamine transporter immunohistochemical analysis in the MPTP mouse model of Parkinson's disease. NeuroImage. vol 26. issue 4. 2005-08-23. PMID:15908232. |
previously, we demonstrated that striatal dopamine transporter (dat) levels in rats could be analyzed reproducibly, using pinhole spect with the dat probe [(123)i]n-omega-fluoropropyl-2beta-carbomethoxy-3beta-{4-iodophenyl}nortropane (fp-cit). |
2005-08-23 |
2023-08-12 |
mouse |
| Nachwa Jarkas, Jonathan McConathy, Ronald J Voll, Mark M Goodma. Synthesis, in vitro characterization, and radiolabeling of N,N-dimethyl-2-(2'-amino-4'-substituted-phenylthio)benzylamines: potential candidates as selective serotonin transporter radioligands. Journal of medicinal chemistry. vol 48. issue 13. 2005-08-23. PMID:15974579. |
competition binding in cells stably expressing the transfected human sert, dopamine transporter (dat), and norepinephrine transporter (net) using [(3)h]citalopram, [(3)h]win 35,428 or [(125)i]rti-55, and [(3)h]nisoxetine, respectively, demonstrated the following order of sert affinity (k(i) (nm)): 14a (0.25) > 16 (0.49) > 20 (0.57) > 14b (1.12) > 13 (1.59) > 33b (1.94) = 35 (2.04) >> 23 (8.50) = 28 (8.55) > 41 (15.11) >> 22 (51) > 33a (83.43) > 27 (92). |
2005-08-23 |
2023-08-12 |
human |
| Walter Koch, Perry E Radau, Christine Hamann, Klaus Tatsc. Clinical testing of an optimized software solution for an automated, observer-independent evaluation of dopamine transporter SPECT studies. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 46. issue 7. 2005-08-23. PMID:16000279. |
a lack of standardized evaluation procedures for dopamine transporter (dat) spect investigations impairs both intra- and interindividual comparisons as well as multicenter trials-for example, for assessment of disease progression or the response to various drug treatments. |
2005-08-23 |
2023-08-12 |
Not clear |
| Shijun Zhang, Juan Zhen, Maarten E A Reith, Aloke K Dutt. Discovery of novel trisubstituted asymmetric derivatives of (2S,4R,5R)-2-benzhydryl-5-benzylaminotetrahydropyran-4-ol, exhibiting high affinity for serotonin and norepinephrine transporters in a stereospecific manner. Journal of medicinal chemistry. vol 48. issue 15. 2005-08-23. PMID:16033275. |
all synthesized derivatives were tested for their affinities for the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) in the brain by measuring their potency in inhibiting the uptake of [(3)h]da, [(3)h]-5-ht, and [(3)h]ne, respectively. |
2005-08-23 |
2023-08-12 |
Not clear |
| Dalit E Dar, Cheryl Mayo, George R Uh. The interaction of methylphenidate and benztropine with the dopamine transporter is different than other substrates and ligands. Biochemical pharmacology. vol 70. issue 3. 2005-08-18. PMID:15950948. |
a substantial body of evidence suggests that the dopamine transporter (dat) is the principal site for cocaine-induced reward and euphoria. |
2005-08-18 |
2023-08-12 |
Not clear |
| Dalit E Dar, Cheryl Mayo, George R Uh. The interaction of methylphenidate and benztropine with the dopamine transporter is different than other substrates and ligands. Biochemical pharmacology. vol 70. issue 3. 2005-08-18. PMID:15950948. |
relative to the wt dat, they both showed reduced affinity for the s356,359a mutant when displacing radioactive carboxyfluorotropane (cft) binding, but similar affinity when inhibiting radioactive dopamine uptake. |
2005-08-18 |
2023-08-12 |
Not clear |
| Brett C Ginsburg, Heather L Kimmel, F Ivy Carroll, Mark M Goodman, Leonard L Howel. Interaction of cocaine and dopamine transporter inhibitors on behavior and neurochemistry in monkeys. Pharmacology, biochemistry, and behavior. vol 80. issue 3. 2005-08-16. PMID:15740791. |
drugs that target the dopamine transporter (dat) have been proposed as pharmacotherapies to treat cocaine abuse. |
2005-08-16 |
2023-08-12 |
human |
| Satoshi Fuke, Noboru Sasagawa, Shoichi Ishiur. Identification and characterization of the Hesr1/Hey1 as a candidate trans-acting factor on gene expression through the 3' non-coding polymorphic region of the human dopamine transporter (DAT1) gene. Journal of biochemistry. vol 137. issue 2. 2005-08-16. PMID:15749835. |
expression of the dopamine transporter (dat) gene affects dopaminergic neurotransmission. |
2005-08-16 |
2023-08-12 |
human |
| Mark A Stein, Irwin D Waldman, Christopher S Sarampote, Karen E Seymour, Adelaide S Robb, Charles Conlon, Soo-Jeong Kim, Edwin H Coo. Dopamine transporter genotype and methylphenidate dose response in children with ADHD. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 7. 2005-08-09. PMID:15827573. |
mph acts primarily by inhibiting the dopamine transporter (dat), a protein responsible for the reuptake of dopamine from the synapse into presynaptic terminals. |
2005-08-09 |
2023-08-12 |
Not clear |
| Luca Filippi, Carlo Manni, Mariangela Pierantozzi, Livia Brusa, Roberta Danieli, Paolo Stanzione, Orazio Schillac. 123I-FP-CIT semi-quantitative SPECT detects preclinical bilateral dopaminergic deficit in early Parkinson's disease with unilateral symptoms. Nuclear medicine communications. vol 26. issue 5. 2005-08-08. PMID:15838424. |
in this study we evaluated the capacity of 123i-fp-cit spect to assess bilateral dopamine transporter (dat) loss in de-novo hemi-parkinson's disease (pd) patients with one-sided clinical symptoms. |
2005-08-08 |
2023-08-12 |
Not clear |
| Zhicheng Lin, George R Uh. Proline mutations induce negative-dosage effects on uptake velocity of the dopamine transporter. Journal of neurochemistry. vol 94. issue 1. 2005-08-08. PMID:15953370. |
ala and gly substitutions for pro 101 (p101) located in transmembrane domain 2 of the dopamine transporter (dat) abolished transport activity but did not disrupt plasma membrane expression. |
2005-08-08 |
2023-08-12 |
Not clear |
| Kazunori Yukawa, Hiroyuki Iso, Tetsuji Tanaka, Yuji Tsubota, Kyoko Owada-Makabe, Tao Bai, Kiyoshi Takeda, Shizuo Akira, Masanobu Maed. Down-regulation of dopamine transporter and abnormal behavior in STAT6-deficient mice. International journal of molecular medicine. vol 15. issue 5. 2005-08-02. PMID:15806304. |
rt-pcr analysis suggested that the levels of dopamine transporter (dat) mrna may be lower in the midbrain of the mutant. |
2005-08-02 |
2023-08-12 |
mouse |
| B G Garcia, Y Wei, J A Moron, R Z Lin, J A Javitch, A Gall. Akt is essential for insulin modulation of amphetamine-induced human dopamine transporter cell-surface redistribution. Molecular pharmacology. vol 68. issue 1. 2005-08-01. PMID:15795321. |
uptake by the dopamine transporter (dat) is the primary pathway for the clearance of extracellular dopamine (da) and consequently for regulating the magnitude and duration of dopaminergic signaling. |
2005-08-01 |
2023-08-12 |
human |