| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Trent J Volz, Nicole L Bjorklund, James O Schen. Methylphenidate analogs with behavioral differences interact differently with arginine residues on the dopamine transporter in rat striatum. Synapse (New York, N.Y.). vol 57. issue 3. 2005-10-27. PMID:15945061. |
the methylphenidate analogs n-methyl-4-methyl-methylphenidate and n-benzylmethylphenidate are believed to interact differently with the dopamine transporter (dat) in vitro and in vivo. |
2005-10-27 |
2023-08-12 |
rat |
| Rajeev I Desai, Theresa A Kopajtic, Mikhail Koffarnus, Amy Hauck Newman, Jonathan L Kat. Identification of a dopamine transporter ligand that blocks the stimulant effects of cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 8. 2005-10-26. PMID:15728828. |
studies have indicated that the dopamine transporter (dat) is the primary biological target of cocaine, and most drugs that have dat affinity have behavioral effects like those of cocaine. |
2005-10-26 |
2023-08-12 |
Not clear |
| Judy P Q Zhu, Wenjing Xu, Jesus A Angul. Disparity in the temporal appearance of methamphetamine-induced apoptosis and depletion of dopamine terminal markers in the striatum of mice. Brain research. vol 1049. issue 2. 2005-10-19. PMID:16043139. |
exposure to meth induces long-term depletions of dopamine (da) terminal markers such as tyrosine hydroxylase (th) and da transporters (dat). |
2005-10-19 |
2023-08-12 |
mouse |
| W Michael Caudle, Jason R Richardson, Minzheng Wang, Gary W Mille. Perinatal heptachlor exposure increases expression of presynaptic dopaminergic markers in mouse striatum. Neurotoxicology. vol 26. issue 4. 2005-10-19. PMID:16112329. |
studies from our laboratory and others have demonstrated that exposure of laboratory animals to heptachlor alters the levels and function of the dopamine transporter (dat), an integral component of dopaminergic neurotransmission and a gateway for the dopaminergic neurotoxin mptp. |
2005-10-19 |
2023-08-12 |
mouse |
| W Michael Caudle, Jason R Richardson, Minzheng Wang, Gary W Mille. Perinatal heptachlor exposure increases expression of presynaptic dopaminergic markers in mouse striatum. Neurotoxicology. vol 26. issue 4. 2005-10-19. PMID:16112329. |
on postnatal day 28, dat, vmat2, and th levels were increased by 100, 70, and 30%, respectively, with no change in aadc levels or total dopamine levels. |
2005-10-19 |
2023-08-12 |
mouse |
| W Michael Caudle, Jason R Richardson, Minzheng Wang, Gary W Mille. Perinatal heptachlor exposure increases expression of presynaptic dopaminergic markers in mouse striatum. Neurotoxicology. vol 26. issue 4. 2005-10-19. PMID:16112329. |
since an increase in the dat:vmat2 ratio appears to predict susceptibility of brain regions to parkinson's disease (pd) and results in increased toxicity of mptp, these results suggest that alterations of the dopaminergic system by developmental heptachlor exposure may increase the susceptibility of dopamine neurons to toxic insult. |
2005-10-19 |
2023-08-12 |
mouse |
| Samir N Kelada, Paola Costa-Mallen, Harvey Checkoway, Christopher S Carlson, Terri-Smith Weller, Phillip D Swanson, Gary M Franklin, W T Longstreth, Zahra Afsharinejad, Lucio G Cost. Dopamine transporter (SLC6A3) 5' region haplotypes significantly affect transcriptional activity in vitro but are not associated with Parkinson's disease. Pharmacogenetics and genomics. vol 15. issue 9. 2005-10-18. PMID:16041244. |
the dopamine transporter (dat) plays a critical role in dopaminergic neurotransmission and is also the major site of action for some drugs of abuse. |
2005-10-18 |
2023-08-12 |
human |
| Guangrong Zheng, Linda P Dwoskin, Agripina G Deaciuc, Seth D Norrholm, Peter A Crook. Defunctionalized lobeline analogues: structure-activity of novel ligands for the vesicular monoamine transporter. Journal of medicinal chemistry. vol 48. issue 17. 2005-10-14. PMID:16107155. |
(-)-lobeline (2r,6s,10s), an antagonist at nicotinic acetylcholine receptors (nachrs), inhibits the neurochemical and behavioral effects of methamphetamine and inhibits dopamine transporter (dat) and vesicular monoamine transporter (vmat2) function. |
2005-10-14 |
2023-08-12 |
Not clear |
| Okechukwu T Ukairo, Corry D Bondi, Amy Hauck Newman, Santosh S Kulkarni, Alan P Kozikowski, Stephen Pan, Christopher K Surrat. Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue. The Journal of pharmacology and experimental therapeutics. vol 314. issue 2. 2005-09-30. PMID:15879005. |
recognition of benztropine by the dopamine transporter (dat) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a dat transmembrane 1 aspartic acid residue. |
2005-09-30 |
2023-08-12 |
Not clear |
| Okechukwu T Ukairo, Corry D Bondi, Amy Hauck Newman, Santosh S Kulkarni, Alan P Kozikowski, Stephen Pan, Christopher K Surrat. Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue. The Journal of pharmacology and experimental therapeutics. vol 314. issue 2. 2005-09-30. PMID:15879005. |
binding of cocaine to the dopamine transporter (dat) protein blocks synaptic dopamine clearance, triggering the psychoactive effects associated with the drug; the discrete drug-protein interactions, however, remain poorly understood. |
2005-09-30 |
2023-08-12 |
Not clear |
| Okechukwu T Ukairo, Corry D Bondi, Amy Hauck Newman, Santosh S Kulkarni, Alan P Kozikowski, Stephen Pan, Christopher K Surrat. Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue. The Journal of pharmacology and experimental therapeutics. vol 314. issue 2. 2005-09-30. PMID:15879005. |
a longstanding postulate holds that cocaine inhibits dat-mediated dopamine transport via competition with dopamine for formation of an ionic bond with the dat transmembrane aspartic acid residue d79. |
2005-09-30 |
2023-08-12 |
Not clear |
| Okechukwu T Ukairo, Corry D Bondi, Amy Hauck Newman, Santosh S Kulkarni, Alan P Kozikowski, Stephen Pan, Christopher K Surrat. Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue. The Journal of pharmacology and experimental therapeutics. vol 314. issue 2. 2005-09-30. PMID:15879005. |
in the present study, dat mutations of this residue were generated and assayed for translocation of radiolabeled dopamine and binding of radiolabeled dat inhibitors under identical conditions. |
2005-09-30 |
2023-08-12 |
Not clear |
| Okechukwu T Ukairo, Corry D Bondi, Amy Hauck Newman, Santosh S Kulkarni, Alan P Kozikowski, Stephen Pan, Christopher K Surrat. Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue. The Journal of pharmacology and experimental therapeutics. vol 314. issue 2. 2005-09-30. PMID:15879005. |
when feasible, dopamine uptake inhibition potency and apparent binding affinity k(i) values were determined for structurally diverse dat inhibitors. |
2005-09-30 |
2023-08-12 |
Not clear |
| Okechukwu T Ukairo, Corry D Bondi, Amy Hauck Newman, Santosh S Kulkarni, Alan P Kozikowski, Stephen Pan, Christopher K Surrat. Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue. The Journal of pharmacology and experimental therapeutics. vol 314. issue 2. 2005-09-30. PMID:15879005. |
in addressing whether the d79 side chain contributes to the dat binding sites of other portions of the cocaine pharmacophore, only inhibitors with modifications of the tropane ring c-3 substituent, i.e., benztropine and its analogs, displayed a substantially altered dopamine uptake inhibition potency as a function of the d79e mutation. |
2005-09-30 |
2023-08-12 |
Not clear |
| W Anthony Owens, Rajkumar J Sevak, Ruggero Galici, Xiaoying Chang, Martin A Javors, Aurelio Galli, Charles P France, Lynette C Daw. Deficits in dopamine clearance and locomotion in hypoinsulinemic rats unmask novel modulation of dopamine transporters by amphetamine. Journal of neurochemistry. vol 94. issue 5. 2005-09-22. PMID:15992364. |
insulin affects brain reward pathways and there is converging evidence that this occurs through insulin regulation of the dopamine (da) transporter (dat). |
2005-09-22 |
2023-08-12 |
rat |
| Katherine L Holton, Merewyn K Loder, Haley E Melikia. Nonclassical, distinct endocytic signals dictate constitutive and PKC-regulated neurotransmitter transporter internalization. Nature neuroscience. vol 8. issue 7. 2005-09-20. PMID:15924135. |
here, we identify nonclassical, distinct endocytic signals in the dopamine transporter (dat) that are necessary and sufficient to drive constitutive and protein kinase c-regulated dat internalization. |
2005-09-20 |
2023-08-12 |
Not clear |
| Richard Nass, Maureen K Hahn, Tammy Jessen, Paul W McDonald, Lucia Carvelli, Randy D Blakel. A genetic screen in Caenorhabditis elegans for dopamine neuron insensitivity to 6-hydroxydopamine identifies dopamine transporter mutants impacting transporter biosynthesis and trafficking. Journal of neurochemistry. vol 94. issue 3. 2005-09-19. PMID:15992384. |
the presynaptic dopamine (da) transporter (dat) is a major determinant of synaptic da inactivation, an important target for psychostimulants including cocaine and amphetamine, and a mediator of da neuron vulnerability to the neurotoxins 6-hydroxydopamine (6-ohda) and 1-methyl-4-phenylpyridinium ion. |
2005-09-19 |
2023-08-12 |
caenorhabditis_elegans |
| Céline Guigoni, Sandra Dovero, Incarnation Aubert, Qin Li, Bernard H Bioulac, Bertrand Bloch, Eugenia V Gurevich, Christian E Gross, Erwan Bezar. Levodopa-induced dyskinesia in MPTP-treated macaques is not dependent on the extent and pattern of nigrostrial lesioning. The European journal of neuroscience. vol 22. issue 1. 2005-09-19. PMID:16029219. |
indeed, the number of tyrosine-hydroxylase (th)-immunopositive neurons in the substantia nigra pars compacta, striatal dopamine transporter (dat) binding and th immunostaining, as well as the overall th striatal content measured by western blotting were identical. |
2005-09-19 |
2023-08-12 |
monkey |
| Yu Watanabe, Toshiki Himeda, Tsutomu Arak. Mechanisms of MPTP toxicity and their implications for therapy of Parkinson's disease. Medical science monitor : international medical journal of experimental and clinical research. vol 11. issue 1. 2005-09-13. PMID:15614202. |
on the other hand, dopamine transporters (dat) are important to the appearance of mptp neurotoxicity because to be neurotoxin, an mptp metabolite must first gain access to the dopaminergic neurons via dat. |
2005-09-13 |
2023-08-12 |
Not clear |
| Yu Watanabe, Toshiki Himeda, Tsutomu Arak. Mechanisms of MPTP toxicity and their implications for therapy of Parkinson's disease. Medical science monitor : international medical journal of experimental and clinical research. vol 11. issue 1. 2005-09-13. PMID:15614202. |
therefore, dat is thought to play an important role in the mptp neurotoxic process and specific blockade of dat with high-affinity inhibitors in neurodegenerative diseases such as parkinson's disease, where the effective levels of dopamine are markedly reduced, may have beneficial consequences. |
2005-09-13 |
2023-08-12 |
Not clear |