| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohamed A Elwan, Jason R Richardson, Thomas S Guillot, W Michael Caudle, Gary W Mille. Pyrethroid pesticide-induced alterations in dopamine transporter function. Toxicology and applied pharmacology. vol 211. issue 3. 2006-04-20. PMID:16005927. |
using cells stably expressing dat, we determined that exposure (10 min) to deltamethrin and permethrin (1 nm-100 microm) had no effect on dat-mediated dopamine uptake. |
2006-04-20 |
2023-08-12 |
mouse |
| Mohamed A Elwan, Jason R Richardson, Thomas S Guillot, W Michael Caudle, Gary W Mille. Pyrethroid pesticide-induced alterations in dopamine transporter function. Toxicology and applied pharmacology. vol 211. issue 3. 2006-04-20. PMID:16005927. |
since dat can greatly affect the vulnerability of dopamine neurons to neurotoxicants, up-regulation of dat by deltamethrin and permethrin may increase the susceptibility of dopamine neurons to toxic insult, which may provide insight into the association between pesticide exposure and pd. |
2006-04-20 |
2023-08-12 |
mouse |
| Aina Westrheim Ravna, Ingebrigt Sylte, Kurt Kristiansen, Svein G Dah. Putative drug binding conformations of monoamine transporters. Bioorganic & medicinal chemistry. vol 14. issue 3. 2006-04-20. PMID:16216517. |
based on the hypothesis that the 12 transmembrane alpha-helix (tmh) secondary transporters belong to a common folding class, the lac permease structure was used for molecular modeling of the serotonin transporter (sert), the dopamine transporter (dat), and the noradrenaline transporter (net). |
2006-04-20 |
2023-08-12 |
Not clear |
| David R Wallace, Stephanie Dodson, Avindra Nath, Rosemarie M Booz. Estrogen attenuates gp120- and tat1-72-induced oxidative stress and prevents loss of dopamine transporter function. Synapse (New York, N.Y.). vol 59. issue 1. 2006-04-12. PMID:16237680. |
both gp120 and tat decreased [(3)h] dopamine uptake into striatal synaptosomes by decreasing the v(max) of the dopamine transporter (dat). |
2006-04-12 |
2023-08-12 |
rat |
| Jose J Mateos, Francisco Lomeña, Eduardo Parellada, Mireia Font, Emili Fernandez, Javier Pavia, Alberto Prats, Francisca Pons, Miquel Bernard. Decreased striatal dopamine transporter binding assessed with [123I] FP-CIT in first-episode schizophrenic patients with and without short-term antipsychotic-induced parkinsonism. Psychopharmacology. vol 181. issue 2. 2006-04-10. PMID:15830229. |
the dopaminergic nigrostriatal pathway is involved in the movement control, so the study of the dopamine transporter (dat) could be of great value to determine its implication in the appearance of dip. |
2006-04-10 |
2023-08-12 |
Not clear |
| Maria Elena Reveron, Terrence J Monks, Christine L Duvauchell. Age-dependent (+)MDMA-mediated neurotoxicity in mice. Neurotoxicology. vol 26. issue 6. 2006-04-05. PMID:15998542. |
dopamine transporter (dat) expression was significantly reduced in both 4- and 10-week-old animals (26 and 69.7%, respectively). |
2006-04-05 |
2023-08-12 |
mouse |
| Jonathan Cavanagh, James Patterson, Sally Pimlott, Deborah Dewar, Jos Eersels, Mary Frances Dempsey, David Wype. Serotonin transporter residual availability during long-term antidepressant therapy does not differentiate responder and nonresponder unipolar patients. Biological psychiatry. vol 59. issue 4. 2006-04-04. PMID:16197922. |
dopamine transporter (dat) availability was also assessed in the same patients to examine the relationship between the two transporter systems. |
2006-04-04 |
2023-08-12 |
Not clear |
| Myreille D'Astous, Katherine R Mickley, Dean E Dluzen, Thérèse Di Paol. Differential protective properties of estradiol and tamoxifen against methamphetamine-induced nigrostriatal dopaminergic toxicity in mice. Neuroendocrinology. vol 82. issue 2. 2006-04-04. PMID:16446547. |
the effects of the lesion and treatments were studied on striatal dopamine (da) concentrations, dopamine and monoamine vesicular transporters (dat and vmat2), and preproenkephalin (ppe) mrna levels. |
2006-04-04 |
2023-08-12 |
mouse |
| Miklós Argyelán, Zoltán Szabó, Balázs Kanyó, Attila Tanács, Zsuzsanna Kovács, Zoltán Janka, László Pávic. Dopamine transporter availability in medication free and in bupropion treated depression: a 99mTc-TRODAT-1 SPECT study. Journal of affective disorders. vol 89. issue 1-3. 2006-04-03. PMID:16213028. |
bupropion is thought to exert its antidepressive effect by blocking the dopamine transporter (dat). |
2006-04-03 |
2023-08-12 |
Not clear |
| Orazio Schillaci, Mariangela Pierantozzi, Luca Filippi, Carlo Manni, Livia Brusa, Roberta Danieli, Giorgio Bernardi, Giovanni Simonetti, Paolo Stanzion. The effect of levodopa therapy on dopamine transporter SPECT imaging with( 123)I-FP-CIT in patients with Parkinson's disease. European journal of nuclear medicine and molecular imaging. vol 32. issue 12. 2006-03-29. PMID:16151764. |
the aim of this study was to evaluate, by means of (123)i-fp-cit spect, the effect of chronic treatment with levodopa on striatal dopamine transporter (dat) in patients with parkinson's disease. |
2006-03-29 |
2023-08-12 |
Not clear |
| Enid T McKinley, Timothy C Baranowski, Delali O Blavo, Candace Cato, Thanh N Doan, Amy L Rubinstei. Neuroprotection of MPTP-induced toxicity in zebrafish dopaminergic neurons. Brain research. Molecular brain research. vol 141. issue 2. 2006-03-21. PMID:16209898. |
mptp-induced neurodegeneration was prevented by co-incubation with either the monoamine oxidase-b (mao-b) inhibitor l-deprenyl or the dopamine transporter (dat) inhibitor nomifensine. |
2006-03-21 |
2023-08-12 |
mouse |
| Frédéric Dollé, Patrick Emond, Sylvie Mavel, Stéphane Demphel, Françoise Hinnen, Zoïa Mincheva, Wadad Saba, Heric Valette, Sylvie Chalon, Christer Halldin, Julie Helfenbein, Joël Legaillard, Jean-Claude Madelmont, Jean-Bernard Deloye, Michel Bottlaender, Denis Guillotea. Synthesis, radiosynthesis and in vivo preliminary evaluation of [11C]LBT-999, a selective radioligand for the visualisation of the dopamine transporter with PET. Bioorganic & medicinal chemistry. vol 14. issue 4. 2006-03-17. PMID:16219467. |
lbt-999 (8-((e)-4-fluoro-but-2-enyl)-3beta-p-tolyl-8-aza-bicyclo[3.2.1]octane-2beta-carboxylic acid methyl ester), a cocaine derivative belonging to a new generation of highly selective dopamine transporter (dat) ligands, and its corresponding carboxylic acid derivative, the latter used as precursor for labelling both with tritium and the positron-emitter carbon-11 (half-life: 20.38 min), were synthesized from (r)-cocaine. |
2006-03-17 |
2023-08-12 |
rat |
| Christophe Wersinger, Anita Sidh. Disruption of the interaction of alpha-synuclein with microtubules enhances cell surface recruitment of the dopamine transporter. Biochemistry. vol 44. issue 41. 2006-03-14. PMID:16216085. |
a probable normative function of alpha-synuclein is the maintenance of dopamine homeostasis, partly through a negative modulation of dopamine transporter (dat) activity, by reducing its level at the cell surface. |
2006-03-14 |
2023-08-12 |
rat |
| Christophe Wersinger, Anita Sidh. Disruption of the interaction of alpha-synuclein with microtubules enhances cell surface recruitment of the dopamine transporter. Biochemistry. vol 44. issue 41. 2006-03-14. PMID:16216085. |
treatment of both types of cells with vinblastine, colchicine, or nocodazole reversed alpha-synuclein-mediated inhibition of dat activity, resulting in an increased rate of dopamine uptake and and increased level of extracellular dopamine-induced oxidative stress, with accelerated cell death. |
2006-03-14 |
2023-08-12 |
rat |
| Juan Zhen, Nianhang Chen, Maarten E A Reit. Differences in interactions with the dopamine transporter as revealed by diminishment of Na(+) gradient and membrane potential: dopamine versus other substrates. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16122767. |
in heterologous cells expressing the dopamine transporter (dat), simultaneous elevation of intracellular na(+) and depolarization of the membrane with gramicidin reduced the potency of various dat substrates, including dopamine, d-amphetamine, beta-phenethylamine, p-tyramine, and mpp(+), in inhibiting binding of the cocaine analog [(3)h]cft, with the greatest reduction observed for d-amphetamine. |
2006-03-10 |
2023-08-12 |
rat |
| Juan Zhen, Nianhang Chen, Maarten E A Reit. Differences in interactions with the dopamine transporter as revealed by diminishment of Na(+) gradient and membrane potential: dopamine versus other substrates. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16122767. |
these results suggest that diminishing na(+) gradient and membrane potential may convert dat to a conformational state that dopamine could easily bind to when gaining free access to its intracellular portion. |
2006-03-10 |
2023-08-12 |
rat |
| Julie Kniazeff, Claus Juul Loland, Naomi Goldberg, Matthias Quick, Shonit Das, Harald H Sitte, Jonathan A Javitch, Ulrik Gethe. Intramolecular cross-linking in a bacterial homolog of mammalian SLC6 neurotransmitter transporters suggests an evolutionary conserved role of transmembrane segments 7 and 8. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16129457. |
it was not possible, however, to transfer to tnat binding sites for another metal ion, zn(2+), that we previously engineered in the dopamine (dat) and gaba (gat-1) transporters between tm 7 and 8. |
2006-03-10 |
2023-08-12 |
Not clear |
| Michelle S Mazei-Robison, R Steven Couch, Richard C Shelton, Mark A Stein, Randy D Blakel. Sequence variation in the human dopamine transporter gene in children with attention deficit hyperactivity disorder. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16171832. |
the activity of the presynaptic dopamine (da) transporter (dat) is critical in mediating the magnitude and duration of dopaminergic signaling in the brain. |
2006-03-10 |
2023-08-12 |
human |
| Balachandra K Gorentla, Roxanne A Vaugha. Differential effects of dopamine and psychoactive drugs on dopamine transporter phosphorylation and regulation. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16181646. |
the dopamine transporter (dat) is a phosphoprotein whose activity and phosphorylation state are acutely regulated by both protein kinase c (pkc) and substrate transport. |
2006-03-10 |
2023-08-12 |
Not clear |
| Balachandra K Gorentla, Roxanne A Vaugha. Differential effects of dopamine and psychoactive drugs on dopamine transporter phosphorylation and regulation. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16181646. |
to examine these issues we subjected rdat llc-pk(1) cells to acute in vitro pretreatments with the endogenous, psychostimulant, and therapeutic compounds dopamine (da), (-)-cocaine, 2 beta-carbomethoxy-3beta-(4-fluorophenyl)tropane (beta-cft), gbr 12909, mazindol, and methylphenidate (mph), in the presence or absence of the pkc activator phorbol 12 myristate 13 acetate (pma), followed by analysis of dat metabolic phosphorylation and transport activity. |
2006-03-10 |
2023-08-12 |
Not clear |