| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sunmee Wee, F Ivy Carroll, William L Woolverto. A reduced rate of in vivo dopamine transporter binding is associated with lower relative reinforcing efficacy of stimulants. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 2. 2006-07-06. PMID:15957006. |
in in vivo binding in rat striatum, equipotent doses of cocaine, win 35428, rti 31, and rti 51 were estimated to displace 25% of [(3)h]win 35428 binding at the dopamine transporters (dat), respectively, 5.8, 22.4, 30.8, and 44.1 min after the intravenous injection. |
2006-07-06 |
2023-08-12 |
rat |
| Henry H Yin, Xiaoxi Zhuang, Bernard W Ballein. Instrumental learning in hyperdopaminergic mice. Neurobiology of learning and memory. vol 85. issue 3. 2006-07-06. PMID:16423542. |
in two experiments we investigated the effects of elevated dopaminergic tone on instrumental learning and performance using dopamine transporter knockdown (dat kd) mice. |
2006-07-06 |
2023-08-12 |
mouse |
| Jarod Swant, John J Wagne. Dopamine transporter blockade increases LTP in the CA1 region of the rat hippocampus via activation of the D3 dopamine receptor. Learning & memory (Cold Spring Harbor, N.Y.). vol 13. issue 2. 2006-06-29. PMID:16585791. |
as monoamine transporter blockade will increase the actions of endogenous monoamine neurotransmitters, the effect of a dopamine transporter (dat) antagonist on ltp was assessed using field excitatory postsynaptic potentials recorded in the ca1 region of the rat hippocampal slice preparation. |
2006-06-29 |
2023-08-12 |
rat |
| Jarod Swant, John J Wagne. Dopamine transporter blockade increases LTP in the CA1 region of the rat hippocampus via activation of the D3 dopamine receptor. Learning & memory (Cold Spring Harbor, N.Y.). vol 13. issue 2. 2006-06-29. PMID:16585791. |
these results suggest that either endogenously released dopamine (facilitated by dat blockade) or exogenously applied dopamine agonist can act to increase ltp in the ca1 of the hippocampus via activation of the d3 subtype of dopamine receptor. |
2006-06-29 |
2023-08-12 |
rat |
| Johanna Krause, Klaus-Henning Krause, Stefan H Dresel, Christian la Fougere, Manfred Ackenhei. ADHD in adolescence and adulthood, with a special focus on the dopamine transporter and nicotine. Dialogues in clinical neuroscience. vol 8. issue 1. 2006-06-28. PMID:16640111. |
neuroimaging studies show a high striatal dopamine transporter (dat) availability in most adults with adhd; this can be reduced by stimulants. |
2006-06-28 |
2023-08-12 |
Not clear |
| Peter Grundt, Theresa A Kopajtic, Jonathan L Katz, Amy Hauck Newma. N-8-Substituted benztropinamine analogs as selective dopamine transporter ligands. Bioorganic & medicinal chemistry letters. vol 15. issue 24. 2006-06-27. PMID:16213721. |
a series of n-8-substituted benztropinamines was synthesized and evaluated for binding at the dopamine (dat), serotonin (sert), norepinephrine (net) transporters, and muscarinic m1 receptors. |
2006-06-27 |
2023-08-12 |
Not clear |
| Samer J Nuwayhid, Linda L Werlin. Sigma2 (sigma2) receptors as a target for cocaine action in the rat striatum. European journal of pharmacology. vol 535. issue 1-3. 2006-06-21. PMID:16480713. |
cocaine inhibited n-methyl-d-aspartate-stimulated [3h]dopamine release in a concentration-dependent manner with a ki of approximately 10 microm, under conditions in which the dopamine transporter (dat) was blocked by 10 microm nomifensine. |
2006-06-21 |
2023-08-12 |
rat |
| Eleni T Tzavara, Dominic L Li, Larissa Moutsimilli, Tiziana Bisogno, Vincenzo Di Marzo, Lee A Phebus, George G Nomikos, Bruno Giro. Endocannabinoids activate transient receptor potential vanilloid 1 receptors to reduce hyperdopaminergia-related hyperactivity: therapeutic implications. Biological psychiatry. vol 59. issue 6. 2006-06-12. PMID:16199010. |
knockout (ko) mice invalidated for the dopamine transporter (dat) constitute a powerful animal model of neurobiological alterations associated with hyperdopaminergia relevant to schizophrenia and attention-deficit/hyperactivity disorder (adhd). |
2006-06-12 |
2023-08-12 |
mouse |
| Syed Z Imam, Helen M Duhart, John T Skinner, Syed F Al. Cocaine induces a differential dose-dependent alteration in the expression profile of immediate early genes, transcription factors, and caspases in PC12 cells: a possible mechanism of neurotoxic damage in cocaine addiction. Annals of the New York Academy of Sciences. vol 1053. 2006-06-06. PMID:16179556. |
we also evaluated the effect of increasing doses of cocaine on da concentration and the expression of dopamine transporter (dat). |
2006-06-06 |
2023-08-12 |
rat |
| T A Greenwood, N J Schork, E Eskin, J R Kelso. Identification of additional variants within the human dopamine transporter gene provides further evidence for an association with bipolar disorder in two independent samples. Molecular psychiatry. vol 11. issue 2. 2006-06-06. PMID:16261167. |
the dopamine transporter (dat) is the site of action of stimulants, and variations in the human dat gene (dat1) have been associated with susceptibility to several psychiatric disorders including attention deficit hyperactivity disorder (adhd) and bipolar disorder. |
2006-06-06 |
2023-08-12 |
human |
| Vera Lehmensiek, Eva-Maria Tan, Stefan Liebau, Thomas Lenk, Heinz Zettlmeisl, Johannes Schwarz, Alexander Storc. Dopamine transporter-mediated cytotoxicity of 6-hydroxydopamine in vitro depends on expression of mutant alpha-synucleins related to Parkinson's disease. Neurochemistry international. vol 48. issue 5. 2006-06-01. PMID:16406146. |
mutant (a30p and a53t) alpha-synuclein isoforms cause increased vulnerability of cells towards various toxic insults and enhance dopamine transporter (dat)-mediated toxicity of the selective dopaminergic neurotoxin and mitochondrial complex i inhibitor mpp(+) in vitro. |
2006-06-01 |
2023-08-12 |
human |
| Dominique Tandé, Günter Höglinger, Thomas Debeir, Nils Freundlieb, Etienne C Hirsch, Chantal Françoi. New striatal dopamine neurons in MPTP-treated macaques result from a phenotypic shift and not neurogenesis. Brain : a journal of neurology. vol 129. issue Pt 5. 2006-05-31. PMID:16481374. |
these th-ir striatal cells did not express dopamine beta hydroxylase (dbh) but the dopamine transporter (dat), suggesting that they are functional da neurons. |
2006-05-31 |
2023-08-12 |
monkey |
| G J E Schmitt, E M Meisenzahl, T Frodl, C La Fougère, K Hahn, H-J Möller, S Drese. The striatal dopamine transporter in first-episode, drug-naive schizophrenic patients: evaluation by the new SPECT-ligand[99mTc]TRODAT-1. Journal of psychopharmacology (Oxford, England). vol 19. issue 5. 2006-05-30. PMID:16166186. |
following the current hypothesis that acute schizophrenic psychotic illness is associated with a striatal 'hyperdopaminergic state', presynaptic integrity and dopamine transporter (dat) density in first-episode, neuroleptic-naive schizophrenic patients was measured by single-photon-emission-tomography (spect) and compared with that in healthy control subjects. |
2006-05-30 |
2023-08-12 |
human |
| YiFeng Li, ChunHong Shao, Dandan Zhang, Min Zhao, Ling Lin, Pengrong Yan, Yuying Xie, Kaida Jiang, Li Ji. The effect of dopamine D2, D5 receptor and transporter (SLC6A3) polymorphisms on the cue-elicited heroin craving in Chinese. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 141B. issue 3. 2006-05-30. PMID:16526040. |
furthermore, we did not observed significant association of cue-elicited craving with the nine-repeat allelic variants in dopamine transporter gene (dat) slc6a3 and with the dinucleotide repeat polymorphism (drp) 148bp allele in d5 dopamine receptor gene (drd5). |
2006-05-30 |
2023-08-12 |
human |
| Sylvie Chalon, Hakan Hall, Wadad Saba, Lucette Garreau, Frédéric Dollé, Christer Halldin, Patrick Emond, Michel Bottlaender, Jean-Bernard Deloye, Julie Helfenbein, Jean-Claude Madelmont, Sylvie Bodard, Zoïa Mincheva, Jean-Claude Besnard, Denis Guillotea. Pharmacological characterization of (E)-N-(4-fluorobut-2-enyl)-2beta-carbomethoxy-3beta-(4'-tolyl)nortropane (LBT-999) as a highly promising fluorinated ligand for the dopamine transporter. The Journal of pharmacology and experimental therapeutics. vol 317. issue 1. 2006-05-25. PMID:16339913. |
in the aim to develop an efficient fluorinated probe for positron emission tomography (pet) exploration of the dopamine transporter (dat), we studied several in vitro and in vivo characteristics of the phenyltropane derivative (e)-n-(4-fluorobut-2-enyl)-2beta-carbomethoxy-3beta-(4'-tolyl)nortropane (lbt-999). |
2006-05-25 |
2023-08-12 |
human |
| Giselle M Petzinger, Beth Fisher, Elizabeth Hogg, Avery Abernathy, Pablo Arevalo, Kerry Nixon, Michael W Jakowe. Behavioral motor recovery in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned squirrel monkey (Saimiri sciureus): changes in striatal dopamine and expression of tyrosine hydroxylase and dopamine transporter proteins. Journal of neuroscience research. vol 83. issue 2. 2006-05-25. PMID:16385585. |
brain tissue was harvested at 6 weeks or 9 months after the last injection and analyzed for dopamine and its metabolites by high performance liquid chromatography (hplc), and by immunohistochemical staining and western immunoblotting for the expression of tyrosine hydroxylase (th), dopamine transporter (dat), and dopamine- and camp-responsive protein phosphatase of 32 kda (darpp-32), an effector molecule enriched in striatal medium spiny neurons. |
2006-05-25 |
2023-08-12 |
monkey |
| Giselle M Petzinger, Beth Fisher, Elizabeth Hogg, Avery Abernathy, Pablo Arevalo, Kerry Nixon, Michael W Jakowe. Behavioral motor recovery in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned squirrel monkey (Saimiri sciureus): changes in striatal dopamine and expression of tyrosine hydroxylase and dopamine transporter proteins. Journal of neuroscience research. vol 83. issue 2. 2006-05-25. PMID:16385585. |
elevated dopamine turnover ratio and decreased dat expression appeared in early behavioral recovery at the 6-week time point in both mild- and moderate-parkinsonian monkeys. |
2006-05-25 |
2023-08-12 |
monkey |
| Paul E A Glaser, Stewart P Surgener, Richard Grondin, C R Gash, Mike Palmer, F Xavier Castellanos, Greg A Gerhard. Cerebellar neurotransmission in attention-deficit/hyperactivity disorder: does dopamine neurotransmission occur in the cerebellar vermis? Journal of neuroscience methods. vol 151. issue 1. 2006-05-25. PMID:16451810. |
there is no well-characterized dopaminergic pathway that projects to the posterior-inferior cerebellar vermis, although the dopamine transporter (dat) and tyrosine hydroxylase (th) have been localized in the posterior-inferior vermis in the non-human primate by immunohistochemistry. |
2006-05-25 |
2023-08-12 |
human |
| Gonzalo E Torre. The dopamine transporter proteome. Journal of neurochemistry. vol 97 Suppl 1. 2006-05-23. PMID:16635244. |
dopamine (da) uptake through the neuronal plasma membrane da transporter (dat) is essential for the maintenance of normal da homeostasis in the brain. |
2006-05-23 |
2023-08-12 |
Not clear |
| Ming-Kai Chen, Jae-Sung Lee, Jennifer L McGlothan, Eri Furukawa, Robert J Adams, Mohab Alexander, Dean F Wong, Tomás R Guilart. Acute manganese administration alters dopamine transporter levels in the non-human primate striatum. Neurotoxicology. vol 27. issue 2. 2006-05-22. PMID:16325911. |
we used positron emission tomography (pet) to measure non-invasively the effect of acute systemic administration to manganese sulfate (mnso4) on dopamine transporter (dat) levels in the living non-human primate brain. |
2006-05-22 |
2023-08-12 |
rat |