| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jacob U Fog, Habibeh Khoshbouei, Marion Holy, William A Owens, Christian Bjerggaard Vaegter, Namita Sen, Yelyzaveta Nikandrova, Erica Bowton, Douglas G McMahon, Roger J Colbran, Lynette C Daws, Harald H Sitte, Jonathan A Javitch, Aurelio Galli, Ulrik Gethe. Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport. Neuron. vol 51. issue 4. 2006-09-26. PMID:16908408. |
efflux of dopamine through the dopamine transporter (dat) is critical for the psychostimulatory properties of amphetamines, but the underlying mechanism is unclear. |
2006-09-26 |
2023-08-12 |
Not clear |
| Jacob U Fog, Habibeh Khoshbouei, Marion Holy, William A Owens, Christian Bjerggaard Vaegter, Namita Sen, Yelyzaveta Nikandrova, Erica Bowton, Douglas G McMahon, Roger J Colbran, Lynette C Daws, Harald H Sitte, Jonathan A Javitch, Aurelio Galli, Ulrik Gethe. Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport. Neuron. vol 51. issue 4. 2006-09-26. PMID:16908408. |
camkiialpha stimulated dopamine efflux via dat in response to amphetamine in heterologous cells and in dopaminergic neurons. |
2006-09-26 |
2023-08-12 |
Not clear |
| Jacob U Fog, Habibeh Khoshbouei, Marion Holy, William A Owens, Christian Bjerggaard Vaegter, Namita Sen, Yelyzaveta Nikandrova, Erica Bowton, Douglas G McMahon, Roger J Colbran, Lynette C Daws, Harald H Sitte, Jonathan A Javitch, Aurelio Galli, Ulrik Gethe. Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport. Neuron. vol 51. issue 4. 2006-09-26. PMID:16908408. |
a mutation of the dat c terminus impairing camkiialpha binding also impaired amphetamine-induced dopamine efflux. |
2006-09-26 |
2023-08-12 |
Not clear |
| Jacob U Fog, Habibeh Khoshbouei, Marion Holy, William A Owens, Christian Bjerggaard Vaegter, Namita Sen, Yelyzaveta Nikandrova, Erica Bowton, Douglas G McMahon, Roger J Colbran, Lynette C Daws, Harald H Sitte, Jonathan A Javitch, Aurelio Galli, Ulrik Gethe. Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport. Neuron. vol 51. issue 4. 2006-09-26. PMID:16908408. |
our data suggest that camkiialpha binding to the dat c terminus facilitates phosphorylation of the dat n terminus and mediates amphetamine-induced dopamine efflux. |
2006-09-26 |
2023-08-12 |
Not clear |
| Nicoletta Cini, Elisa Danieli, Gloria Menchi, Andrea Trabocchi, Anna Bottoncetti, Silvia Raspanti, Alberto Pupi, Antonio Guarn. 3-Aza-6,8-dioxabicyclo[3.2.1]octanes as new enantiopure heteroatom-rich tropane-like ligands of human dopamine transporter. Bioorganic & medicinal chemistry. vol 14. issue 15. 2006-09-22. PMID:16678430. |
cns diseases such as parkinson, schizophrenia, and attention deficit hyperactivity disorder (adhd) are characterized by a significant alteration of dopamine transporter (dat) density. |
2006-09-22 |
2023-08-12 |
human |
| Jennifer L Tillerson, W Michael Caudle, Jack M Parent, C Gong, Timothy Schallert, Gary W Mille. Olfactory discrimination deficits in mice lacking the dopamine transporter or the D2 dopamine receptor. Behavioural brain research. vol 172. issue 1. 2006-09-20. PMID:16765459. |
to further characterize the role of dopamine in olfactory processing, we subjected dopamine transporter knockout mice (dat -/-) and dopamine receptor 2 knockout mice (d2 -/-) to a battery of olfactory tests. |
2006-09-20 |
2023-08-12 |
mouse |
| Jennifer L Tillerson, W Michael Caudle, Jack M Parent, C Gong, Timothy Schallert, Gary W Mille. Olfactory discrimination deficits in mice lacking the dopamine transporter or the D2 dopamine receptor. Behavioural brain research. vol 172. issue 1. 2006-09-20. PMID:16765459. |
d2 -/- mice exhibited the same olfactory deficit as the dat -/- mice, further supporting the role of dopamine at the d2 synapse in olfactory discrimination processing. |
2006-09-20 |
2023-08-12 |
mouse |
| Jennifer L Tillerson, W Michael Caudle, Jack M Parent, C Gong, Timothy Schallert, Gary W Mille. Olfactory discrimination deficits in mice lacking the dopamine transporter or the D2 dopamine receptor. Behavioural brain research. vol 172. issue 1. 2006-09-20. PMID:16765459. |
the findings presented in this paper reinforce the functional significance of dopamine and more specifically the d2 receptor in olfactory discrimination and may help explain the behavioral phenotype in the dat and d2 knockout mice. |
2006-09-20 |
2023-08-12 |
mouse |
| Tiffany A Mathews, Carrie E John, Gennady B Lapa, Evgeny A Budygin, Sara R Jone. No role of the dopamine transporter in acute ethanol effects on striatal dopamine dynamics. Synapse (New York, N.Y.). vol 60. issue 4. 2006-09-20. PMID:16786536. |
the acute effects of ethanol on dopamine (da) release and clearance in the caudate-putamen were evaluated in wild-type and dopamine transporter (dat) knockout (dat-ko) mice, using microdialysis and voltammetry. |
2006-09-20 |
2023-08-12 |
mouse |
| Oliver Pogarell, Walter Koch, Franz J Gildehaus, Andreas Kupsch, Olle Lindvall, Wolfgang H Oertel, Klaus Tatsc. Long-term assessment of striatal dopamine transporters in Parkinsonian patients with intrastriatal embryonic mesencephalic grafts. European journal of nuclear medicine and molecular imaging. vol 33. issue 4. 2006-09-19. PMID:16447045. |
single-photon emission computed tomography (spect) of striatal dopamine transporters (dat) has been used to demonstrate presynaptic dopaminergic dysfunction and to monitor the progression of parkinson's disease. |
2006-09-19 |
2023-08-12 |
human |
| Stephen V Faraone, Sajjad A Kha. Candidate gene studies of attention-deficit/hyperactivity disorder. The Journal of clinical psychiatry. vol 67 Suppl 8. 2006-09-18. PMID:16961425. |
for the 8 genes for which the same variant has been studied in 3 or more case-control or family-based studies, 7 show statistically significant evidence of association with adhd based on pooled odds ratios across studies: the dopamine d4 receptor gene (drd4), the dopamine d5 receptor gene (drd5), the dopamine transporter gene (dat), the dopamine beta-hydroxylase gene (dbh), the serotonin transporter gene (5-htt), the serotonin receptor 1b gene (htr1b), and the synaptosomal-associated protein 25 gene (snap25). |
2006-09-18 |
2023-08-12 |
human |
| Rong Chen, Michael R Tilley, Hua Wei, Fuwen Zhou, Fu-Ming Zhou, San Ching, Ning Quan, Robert L Stephens, Erik R Hill, Timothy Nottoli, Dawn D Han, Howard H G. Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 24. 2006-09-11. PMID:16754872. |
there are three known high-affinity targets for cocaine: the dopamine transporter (dat), the serotonin transporter (sert), and the norepinephrine transporter (net). |
2006-09-11 |
2023-08-12 |
mouse |
| Rong Chen, Michael R Tilley, Hua Wei, Fuwen Zhou, Fu-Ming Zhou, San Ching, Ning Quan, Robert L Stephens, Erik R Hill, Timothy Nottoli, Dawn D Han, Howard H G. Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 24. 2006-09-11. PMID:16754872. |
decades of studies support the dopamine (da) hypothesis that the blockade of dat and the subsequent increase in extracellular da primarily mediate cocaine reward and reinforcement. |
2006-09-11 |
2023-08-12 |
mouse |
| Shijun Zhang, Fernando Fernandez, Stuart Hazeldine, Jeffrey Deschamps, Juan Zhen, Maarten E A Reith, Aloke K Dutt. Further structural exploration of trisubstituted asymmetric pyran derivatives (2S,4R,5R)-2-benzhydryl-5-benzylamino-tetrahydropyran-4-ol and their corresponding disubstituted (3S,6S) pyran derivatives: a proposed pharmacophore model for high-affinity interaction with the dopamine, serotonin, and norepinephrine transporters. Journal of medicinal chemistry. vol 49. issue 14. 2006-09-11. PMID:16821783. |
all synthesized derivatives were tested for their affinities for the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) in the brain by measuring their potency in inhibiting the uptake of [(3)h]da, [(3)h]5-ht, and [(3)h]ne, respectively. |
2006-09-11 |
2023-08-12 |
Not clear |
| S Cevoli, M Mochi, C Scapoli, N Marzocchi, G Pierangeli, L A Pini, P Cortelli, P Montagn. A genetic association study of dopamine metabolism-related genes and chronic headache with drug abuse. European journal of neurology. vol 13. issue 9. 2006-09-11. PMID:16930369. |
we performed a genetic association study using four functional polymorphisms of the dopamine receptor 4 (drd4), dopamine transporter (dat), mono-amino-oxidase a (maoa) and cathecol-o-methyl-transferase (comt) genes in 103 patients with chronic daily headache associated with da (cdhda). |
2006-09-11 |
2023-08-12 |
Not clear |
| Krystyna Ossowska, Jadwiga Wardas, Katarzyna Kuter, Przemysław Nowak, Joanna Dabrowska, Aleksandra Bortel, Łukasz Labus, Adam Kwieciński, Anna Krygowska-Wajs, Stainsław Wolfart. Influence of paraquat on dopaminergic transporter in the rat brain. Pharmacological reports : PR. vol 57. issue 3. 2006-09-07. PMID:15985715. |
selective toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), a parkinsonism inducing compound, is well known to be related to an uptake of its active metabolite mpp+ into dopaminergic neurons by dopamine transporter (dat). |
2006-09-07 |
2023-08-12 |
rat |
| Krystyna Ossowska, Jadwiga Wardas, Katarzyna Kuter, Przemysław Nowak, Joanna Dabrowska, Aleksandra Bortel, Łukasz Labus, Adam Kwieciński, Anna Krygowska-Wajs, Stainsław Wolfart. Influence of paraquat on dopaminergic transporter in the rat brain. Pharmacological reports : PR. vol 57. issue 3. 2006-09-07. PMID:15985715. |
the present study seems to suggest that systemic paraquat administration affects striatal dat and dopamine metabolism in the nigrostriatal neurons in rats which may be crucial for its neurotoxic effects on dopaminergic neurons. |
2006-09-07 |
2023-08-12 |
rat |
| Barbara Cagniard, Peter D Balsam, Daniela Brunner, Xiaoxi Zhuan. Mice with chronically elevated dopamine exhibit enhanced motivation, but not learning, for a food reward. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 7. 2006-09-05. PMID:16319913. |
in order to investigate the involvement of dopamine in learning and motivation for a food reward, we used dopamine transporter knockdown mice (dat kd) that have chronically elevated levels of extracellular dopamine. |
2006-09-05 |
2023-08-12 |
mouse |
| Osnat Ben-Shahar, Justin M Moscarello, Aaron Ettenber. One hour, but not six hours, of daily access to self-administered cocaine results in elevated levels of the dopamine transporter. Brain research. vol 1095. issue 1. 2006-09-05. PMID:16712814. |
in an extension of our previous work, the current study, using receptor autoradiography, compared binding (by [3h]win35428) of the dopamine transporter (dat) in animals having experienced either brief or extended daily access to cocaine over 8 days, followed by 14 days of withdrawal. |
2006-09-05 |
2023-08-12 |
human |
| Zane B Andrews, Alicia Rivera, John D Elsworth, Robert H Roth, Luigi Agnati, Belen Gago, Alfonso Abizaid, Michael Schwartz, Kjell Fuxe, Tamas L Horvat. Uncoupling protein-2 promotes nigrostriatal dopamine neuronal function. The European journal of neuroscience. vol 24. issue 1. 2006-09-05. PMID:16882005. |
ucp2-knockout (ko) mice also had reduced dopamine transporter immunoreactivity (dat ir) in the snc but not other brain regions examined. |
2006-09-05 |
2023-08-12 |
mouse |