| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sangeeta Raje, Jennifer Cornish, Amy H Newman, Jianjing Cao, Jonathan L Katz, Natalie D Eddingto. Investigation of the potential pharmacokinetic and pharmaco-dynamic drug interaction between AHN 1-055, a potent benztropine analog used for cocaine abuse, and cocaine after dosing in rats using intracerebral microdialysis. Biopharmaceutics & drug disposition. vol 27. issue 5. 2006-11-14. PMID:16586462. |
ahn 1-055, a benztropine (bzt) analog, binds with high affinity to the dopamine transporter (dat), possesses behavioral, pharmacokinetic (pk) and brain microdialysate dopamine (da) profiles distinct from cocaine. |
2006-11-14 |
2023-08-12 |
rat |
| Daijiro Yanagisawa, Meirigeng Qi, Do-hoon Kim, Yoshihisa Kitamura, Masatoshi Inden, Daiju Tsuchiya, Kazuyuki Takata, Takashi Taniguchi, Kanji Yoshimoto, Shun Shimohama, Akinori Akaike, Shoichiro Sumi, Kazutomo Inou. Improvement of focal ischemia-induced rat dopaminergic dysfunction by striatal transplantation of mouse embryonic stem cells. Neuroscience letters. vol 407. issue 1. 2006-11-14. PMID:16959414. |
at 15 weeks after transplantation, immunoreactivities for tyrosine hydroxylase (th) and dopamine transporter (dat) in the striatum were significantly recovered in rats grafted with es or es-n cells compared to vehicle-injected rats. |
2006-11-14 |
2023-08-12 |
mouse |
| Geeta Ravindran, Harinarayana S Ra. Enriched NCAM-positive cells form functional dopaminergic neurons in the rat model of Parkinson's disease. Stem cells and development. vol 15. issue 4. 2006-11-13. PMID:16978060. |
the predifferentiated cells when analyzed by rt-pcr showed expression of dopaminergic markers such as nurr1, engrailed-1, aromatic amino decarboxylase (aadc), vmat2, tyrosine hydroxylase (th), and dopamine transporter (dat). |
2006-11-13 |
2023-08-12 |
human |
| Janusz K Rybakowski, Alina Borkowska, Piotr M Czerski, Monika Dmitrzak-Weglarz, Maria Skibinska, Pawel Kapelski, Joanna Hause. Performance on the Wisconsin Card Sorting Test in schizophrenia and genes of dopaminergic inactivation (COMT, DAT, NET). Psychiatry research. vol 143. issue 1. 2006-11-09. PMID:16712949. |
the aim of the study was to test an association between polymorphisms of genes connected with dopaminergic inactivation in prefrontal cortex [catechol-o-methyltransferase (comt), dopamine transporter (dat), norepinephrine transporter (net)], and performance on the wisconsin card sorting test (wcst), in schizophrenic patients. |
2006-11-09 |
2023-08-12 |
cat |
| Aina Westrheim Ravn. Three-dimensional models of neurotransmitter transporters and their interactions with cocaine and S-citalopram. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 7. issue 2. 2006-11-08. PMID:16684682. |
then three-dimensional models of the neurotransmitter transporters hdat, hsert and hnet were constructed based on the nhaa model and studies of ligand binding to mutated dopamine transporter (dat) and serotonin transporter (sert). |
2006-11-08 |
2023-08-12 |
human |
| Guangrong Zheng, David B Horton, Agripina G Deaciuc, Linda P Dwoskin, Peter A Crook. Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters. Bioorganic & medicinal chemistry letters. vol 16. issue 19. 2006-11-02. PMID:16905316. |
a series of des-keto lobeline analogs has been synthesized and evaluated for their ability to inhibit the dopamine transporter (dat) and serotonin transporter (sert) function and for their affinity for the synaptic vesicle monoamine transporter (vmat2), as well as for alpha4beta2( *) and alpha7( *) neuronal nicotinic acetylcholine receptors (nachrs). |
2006-11-02 |
2023-08-12 |
Not clear |
| Motoyasu Yamashita, Setsu Fukushima, Hao-wei Shen, F Scott Hall, George R Uhl, Yohtaro Numachi, Hideaki Kobayashi, Ichiro Sor. Norepinephrine transporter blockade can normalize the prepulse inhibition deficits found in dopamine transporter knockout mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 10. 2006-11-01. PMID:16407898. |
dopamine transporter knockout (dat ko) mice display deficits in sensorimotor gating that are manifested by reduced prepulse inhibition (ppi) of the acoustic startle reflex. |
2006-11-01 |
2023-08-12 |
mouse |
| Motoyasu Yamashita, Setsu Fukushima, Hao-wei Shen, F Scott Hall, George R Uhl, Yohtaro Numachi, Hideaki Kobayashi, Ichiro Sor. Norepinephrine transporter blockade can normalize the prepulse inhibition deficits found in dopamine transporter knockout mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 10. 2006-11-01. PMID:16407898. |
together with recent microdialysis data, these results support the hypothesis that prefrontal cortical net blockade and consequent enhancement of prefrontal cortical extracellular dopamine mediates the reversal of ppi deficits in dat ko mice. |
2006-11-01 |
2023-08-12 |
mouse |
| Soili Lehto, Tommi Tolmunen, Mikko Joensuu, Pirjo Irmeli Saarinen, Ritva Vanninen, Pasi Ahola, Jari Tiihonen, Jyrki Kuikka, Johannes Lehtone. Midbrain binding of [123I]nor-beta-CIT in atypical depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 30. issue 7. 2006-10-31. PMID:16644083. |
altered serotonin (sert) and dopamine transporter (dat) densities have been recorded in major depression. |
2006-10-31 |
2023-08-12 |
Not clear |
| Jinghong Kou, David C Klorig, Jeffrey R Bloomquis. Potentiating effect of the ATP-sensitive potassium channel blocker glibenclamide on complex I inhibitor neurotoxicity in vitro and in vivo. Neurotoxicology. vol 27. issue 5. 2006-10-31. PMID:16725203. |
western blots of striatal dopamine transporter (dat) and tyrosine hydroxylase (th) proteins demonstrated that 30 mg/kg of glibenclamide alone did not affect the expression of dat and th after two weeks of daily treatments, but it significantly enhanced the reduction of dat and th by a single dose of 20 mg/kg of mptp. |
2006-10-31 |
2023-08-12 |
mouse |
| Keith Chiasson, Benoît Daoust, Daniel Levesque, Maria-Grazia Martinol. Dopamine D2 agonists, bromocriptine and quinpirole, increase MPP+ -induced toxicity in PC12 cells. Neurotoxicity research. vol 10. issue 1. 2006-10-31. PMID:17000468. |
dopamine agonists and antagonists also modulate the expression of the dopamine transporter in pc12 cells; in particular, bromocriptine may alter mpp+ uptake by increasing dat expression we also show that, in our cellular paradigm, d2 receptor mrna levels are more abundant that d3 mrna levels and mpp+ and /or bromocriptine could not modulate d2 gene expression while d3 gene expression clearly decrease after mpp+ and /or bromocriptine treatment. |
2006-10-31 |
2023-08-12 |
Not clear |
| Ping-Ho Wu, Yuh-Chiang Shen, Yea-Hwey Wang, Chin-Wen Chi, Jiin-Cherng Ye. Baicalein attenuates methamphetamine-induced loss of dopamine transporter in mouse striatum. Toxicology. vol 226. issue 2-3. 2006-10-25. PMID:16887252. |
by using the loss of dopamine transporter (dat) as a marker of neurotoxicity, this study was aimed to investigate the neuroprotective effect of baicalein against meth-induced striatal damages in mice. |
2006-10-25 |
2023-08-12 |
mouse |
| Miguel Garzón, Virginia M Picke. Subcellular distribution of M2 muscarinic receptors in relation to dopaminergic neurons of the rat ventral tegmental area. The Journal of comparative neurology. vol 498. issue 6. 2006-10-25. PMID:16927256. |
we sought to determine the functionally relevant sites for m2r activation in relation to vta dopaminergic neurons by examining the electron microscopic immunolabeling of m2r and the dopamine transporter (dat) in the vta of rat brain. |
2006-10-25 |
2023-08-12 |
rat |
| Barbara Cagniard, Jeff A Beeler, Jonathan P Britt, Daniel S McGehee, Michela Marinelli, Xiaoxi Zhuan. Dopamine scales performance in the absence of new learning. Neuron. vol 51. issue 5. 2006-10-25. PMID:16950153. |
an inducible dopamine transporter (dat) knockdown mouse line has been generated, which exhibits significantly slower reuptake of released dopamine and increased tonic firing of dopamine neurons without altering phasic burst firing. |
2006-10-25 |
2023-08-12 |
mouse |
| C S Lu, Y H Wu Chou, Y H Weng, R S Che. Genetic and DAT imaging studies of familial parkinsonism in a Taiwanese cohort. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017535. |
in the available patients with parkin, pink1, sca2 and sca3, the dopamine transporter (dat) scan revealed that the reduction of uptake was primarily observed in the bilateral putamen, basically sharing a similar pattern with that in idiopathic parkinson's disease. |
2006-10-24 |
2023-08-12 |
Not clear |
| Meghan L O'Neil, Ronald Kuczenski, David S Segal, Arthur K Cho, Goran Lacan, William P Meleg. Escalating dose pretreatment induces pharmacodynamic and not pharmacokinetic tolerance to a subsequent high-dose methamphetamine binge. Synapse (New York, N.Y.). vol 60. issue 6. 2006-10-19. PMID:16897726. |
the ed-meth regimen itself reduced [(3)h]win35,428 (win) binding to the dopamine transporter (dat) by 15% in cp, but did not affect da content. |
2006-10-19 |
2023-08-12 |
human |
| Ian D Tomlinson, John N Mason, Randy D Blakely, Sandra J Rosentha. High affinity inhibitors of the dopamine transporter (DAT): novel biotinylated ligands for conjugation to quantum dots. Bioorganic & medicinal chemistry letters. vol 16. issue 17. 2006-10-16. PMID:16784853. |
high affinity inhibitors of the dopamine transporter (dat): novel biotinylated ligands for conjugation to quantum dots. |
2006-10-16 |
2023-08-12 |
Not clear |
| Ian D Tomlinson, John N Mason, Randy D Blakely, Sandra J Rosentha. High affinity inhibitors of the dopamine transporter (DAT): novel biotinylated ligands for conjugation to quantum dots. Bioorganic & medicinal chemistry letters. vol 16. issue 17. 2006-10-16. PMID:16784853. |
compounds capable of inhibiting the dopamine transporter protein (dat) that can be conjugated to cadmium selenide/zinc sulfide/core shell nanocrystals may be used to image the location and distribution of the dat in neuronal cell membranes. |
2006-10-16 |
2023-08-12 |
Not clear |
| Fanxing Zeng, Nachwa Jarkas, Michael J Owens, Clinton D Kilts, Charles B Nemeroff, Mark M Goodma. Synthesis and monoamine transporter affinity of front bridged tricyclic 3beta-(4'-halo or 4'-methyl)phenyltropanes bearing methylene or carbomethoxymethylene on the bridge to the 2beta-position. Bioorganic & medicinal chemistry letters. vol 16. issue 17. 2006-10-16. PMID:16784855. |
a series of front bridged tricyclic 3beta-(4'-halo or 4'-methyl)phenyltropanes bearing methylene or carbomethoxymethylene on the bridge to the 2beta-position was synthesized, and their binding affinities were determined in cells transfected to express human norepinephrine transporter (net), serotonin transporter (sert), and dopamine transporter (dat) via competition binding assays. |
2006-10-16 |
2023-08-12 |
human |
| R Cilia, G Marotta, R Benti, G Pezzoli, A Antonin. Brain SPECT imaging in multiple system atrophy. Journal of neural transmission (Vienna, Austria : 1996). vol 112. issue 12. 2006-10-12. PMID:16284908. |
dopamine transporter imaging (dat) shows striatal decrements in both msa and parkinson's disease (pd) making it not sensitive for differential diagnosis. |
2006-10-12 |
2023-08-12 |
Not clear |