| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kathleen M Gilbert, Terrence L Boos, Christina M Dersch, Elisabeth Greiner, Arthur E Jacobson, David Lewis, Dorota Matecka, Thomas E Prisinzano, Ying Zhang, Richard B Rothman, Kenner C Rice, Carol A Venanz. DAT/SERT selectivity of flexible GBR 12909 analogs modeled using 3D-QSAR methods. Bioorganic & medicinal chemistry. vol 15. issue 2. 2007-03-13. PMID:17127069. |
the dopamine reuptake inhibitor gbr 12909 (1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine, 1) and its analogs have been developed as tools to test the hypothesis that selective dopamine transporter (dat) inhibitors will be useful therapeutics for cocaine addiction. |
2007-03-13 |
2023-08-12 |
Not clear |
| Okechukwu T Ukairo, Suneetha Ramanujapuram, Christopher K Surrat. Fluctuation of the dopamine uptake inhibition potency of cocaine, but not amphetamine, at mammalian cells expressing the dopamine transporter. Brain research. vol 1131. issue 1. 2007-03-09. PMID:17169338. |
cocaine, amphetamines and other psychostimulants inhibit synaptic dopamine uptake by interfering with dopamine transporter (dat) function. |
2007-03-09 |
2023-08-12 |
Not clear |
| Okechukwu T Ukairo, Suneetha Ramanujapuram, Christopher K Surrat. Fluctuation of the dopamine uptake inhibition potency of cocaine, but not amphetamine, at mammalian cells expressing the dopamine transporter. Brain research. vol 1131. issue 1. 2007-03-09. PMID:17169338. |
fluctuations in dopamine uptake inhibition potency (duip) were observed for classical dat blockers including cocaine, mazindol, methylphenidate (ritalintrade mark) and benztropine in cho cells expressing wild type dat; cocaine potency also decreased in dat-expressing non-neuronal cos-7 cells and neuronal n2a neuroblastoma cells. |
2007-03-09 |
2023-08-12 |
Not clear |
| Yuan-Hwa Chou, Wen-Sheng Huang, Tung-Ping Su, Ru-Band Lu, Fang-Jung Wan, Ying-Kay F. Dopamine transporters and cognitive function in methamphetamine abuser after a short abstinence: A SPECT study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 17. issue 1. 2007-03-06. PMID:16842981. |
the purpose of this study was to examine the change of dopamine transporters (dat) binding in methamphetamine (meth) abusers in a two-week period of abstinence and its association with cognitive function. |
2007-03-06 |
2023-08-12 |
human |
| Daniel Hoyer, Deepak R Thakker, François Natt, Rainer Maier, Dieter Huesken, Matthias Müller, Peter Flor, Herman VAN DER Putten, Markus Schmutz, Graeme Bilbe, John F Crya. Global down-regulation of gene expression in the brain using RNA interference, with emphasis on monoamine transporters and GPCRs: implications for target characterization in psychiatric and neurological disorders. Journal of receptor and signal transduction research. vol 26. issue 5-6. 2007-03-06. PMID:17118797. |
we then targeted endogenous genes, encoding the dopamine (dat) and serotonin transporters (sert). |
2007-03-06 |
2023-08-12 |
mouse |
| Linda P Dwoskin, Anthony S Rauhut, Kelley A King-Pospisil, Michael T Bard. Review of the pharmacology and clinical profile of bupropion, an antidepressant and tobacco use cessation agent. CNS drug reviews. vol 12. issue 3-4. 2007-03-02. PMID:17227286. |
bupropion hydrochloride ((+/-)-2-tert-butylamino)-3'-chloropropiophenone x hcl) is a nonselective inhibitor of the dopamine transporter (dat) and the norepinephrine transporter (net) and is also an antagonist at neuronal nicotinic acetylcholine receptors (nachrs). |
2007-03-02 |
2023-08-12 |
human |
| John S Markowitz, C Lindsay DeVane, Linda K Pestreich, Kennerly S Patrick, Rafael Muni. A comprehensive in vitro screening of d-, l-, and dl-threo-methylphenidate: an exploratory study. Journal of child and adolescent psychopharmacology. vol 16. issue 6. 2007-03-01. PMID:17201613. |
d-mph exhibited prominent affinity at the norepinephrine transporter (net) site, even exceeding such affinity at the dopamine transporter (dat). |
2007-03-01 |
2023-08-12 |
Not clear |
| Jessica Lasky-Su, Joseph Biederman, Alysa E Doyle, Timothy Wilens, Michael Monuteaux, Jordan W Smoller, Stephen Faraon. Family based association analysis of statistically derived quantitative traits for drug use in ADHD and the dopamine transporter gene. Addictive behaviors. vol 31. issue 6. 2007-02-28. PMID:16647218. |
to determine whether snps within the dopamine transporter gene (dat) are associated with quantitative phenotypes generated from drug frequency variables in an adhd sample. |
2007-02-28 |
2023-08-12 |
Not clear |
| Stanley Caveney, Wendy Cladman, LouAnn Verellen, Cam Donl. Ancestry of neuronal monoamine transporters in the Metazoa. The Journal of experimental biology. vol 209. issue Pt 24. 2007-02-28. PMID:17142674. |
furthermore, the genes for dopamine and norepinephrine transporters of vertebrates are paralogous, apparently having arisen through duplication of an invertebrate mat gene after the loss of an invertebrate-type dat gene in a basal protochordate. |
2007-02-28 |
2023-08-12 |
Not clear |
| Andrew Newberg, Jay Amsterdam, Justine Shult. Dopamine transporter density may be associated with the depressed affect in healthy subjects. Nuclear medicine communications. vol 28. issue 1. 2007-02-27. PMID:17159542. |
increased levels of dopamine transporter (dat) binding have been reported in patients with major depression. |
2007-02-27 |
2023-08-12 |
human |
| Manuel Miranda, Kalen R Dionne, Tatiana Sorkina, Alexander Sorki. Three ubiquitin conjugation sites in the amino terminus of the dopamine transporter mediate protein kinase C-dependent endocytosis of the transporter. Molecular biology of the cell. vol 18. issue 1. 2007-02-26. PMID:17079728. |
dopamine levels in the brain are controlled by the plasma membrane dopamine transporter (dat). |
2007-02-26 |
2023-08-12 |
Not clear |
| D S Melchitzky, S L Erickson, D A Lewi. Dopamine innervation of the monkey mediodorsal thalamus: Location of projection neurons and ultrastructural characteristics of axon terminals. Neuroscience. vol 143. issue 4. 2007-02-23. PMID:17029800. |
in order to determine whether the da innervation of the primate md shares the anatomical features of the mesocortical or nigrostriatal da projections, we performed tract-tracing and immunocytochemistry studies in macaque monkeys (macaca fascicularis) to identify the location of the da neurons that project to md and immuno-electron microscopy to determine the distribution of the dopamine transporter (dat) in axons within the md. |
2007-02-23 |
2023-08-12 |
monkey |
| Jason A Wiesinger, James P Buwen, Christopher J Cifelli, Erica L Unger, Byron C Jones, John L Bear. Down-regulation of dopamine transporter by iron chelation in vitro is mediated by altered trafficking, not synthesis. Journal of neurochemistry. vol 100. issue 1. 2007-02-22. PMID:17227437. |
iron-deficient rats demonstrate significant elevations in extracellular da and a reduction in dopamine transporter (dat) densities in the caudate putamen and nucleus accumbens. |
2007-02-22 |
2023-08-12 |
human |
| Erkki Tupala, Pirjo Halonen, Jari Tiihone. Visualization of the cortical dopamine transporter in type 1 and 2 alcoholics with human whole hemisphere autoradiography. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 16. issue 8. 2007-02-20. PMID:16626947. |
we measured cortical dopamine transporter (dat) in cloninger type 1 and 2 alcoholics by using [(125)i]pe2i as a radioligand in human postmortem whole hemispheric autoradiography, and evaluated the putative correlations of dat between cortical areas and nucleus accumbens. |
2007-02-20 |
2023-08-12 |
human |
| Carles Gaig, Maria José Martí, Eduardo Tolosa, Francesc Valldeoriola, Pilar Paredes, Francisco Juan Lomeña, Fernando Nakama. 123I-Ioflupane SPECT in the diagnosis of suspected psychogenic Parkinsonism. Movement disorders : official journal of the Movement Disorder Society. vol 21. issue 11. 2007-02-20. PMID:16941463. |
striatal dopamine transporter (dat) imaging could be helpful in differentiating them. |
2007-02-20 |
2023-08-12 |
Not clear |
| Hongbin Yuan, Pavel A Petukho. Improved 3D-QSAR CoMFA of the dopamine transporter blockers with multiple conformations using the genetic algorithm. Bioorganic & medicinal chemistry letters. vol 16. issue 24. 2007-02-16. PMID:17027270. |
a 3d-qsar/comfa was performed for a series of 42 piperidine-based dopamine transporter (dat) blockers. |
2007-02-16 |
2023-08-12 |
Not clear |
| Christian la Fougère, Johanna Krause, Klaus-Henning Krause, Franz Josef Gildehaus, Marcus Hacker, Walter Koch, Klaus Hahn, Klaus Tatsch, Stefan Drese. Value of 99mTc-TRODAT-1 SPECT to predict clinical response to methylphenidate treatment in adults with attention deficit hyperactivity disorder. Nuclear medicine communications. vol 27. issue 9. 2007-02-12. PMID:16894328. |
in a previous study, binding of tc-trodat-1 to the dopamine transporter (dat) was found to be higher in patients with attention deficit hyperactivity disorder (adhd) as compared to healthy controls. |
2007-02-12 |
2023-08-12 |
Not clear |
| Erik Ryding, Jan-Anders Ahnlide, Mats Lindström, Ingmar Rosén, Lil Träskman-Bend. Regional brain serotonin and dopamine transporter binding capacity in suicide attempters relate to impulsiveness and mental energy. Psychiatry research. vol 148. issue 2-3. 2007-02-12. PMID:17085020. |
to study different aspects of regional pre-synaptic brain (123)i-beta-cit uptake on serotonin and dopamine re-uptake sites in drug-free suicide attempters in comparison with age- and sex matched control subjects, single photon emission computed tomography (spect) measurements were analysed for regional serotonin re-uptake (5htt) and dopamine re-uptake (dat) capacity (binding potential, bp()) after i.v. |
2007-02-12 |
2023-08-12 |
human |
| P T Redman, B S Jefferson, C B Ziegler, O V Mortensen, G E Torres, E S Levitan, E Aizenma. A vital role for voltage-dependent potassium channels in dopamine transporter-mediated 6-hydroxydopamine neurotoxicity. Neuroscience. vol 143. issue 1. 2007-01-26. PMID:17027171. |
6-hydroxydopamine (6-ohda), a neurotoxic substrate of the dopamine transporter (dat), is widely used in parkinson's disease models. |
2007-01-26 |
2023-08-12 |
rat |
| P T Redman, B S Jefferson, C B Ziegler, O V Mortensen, G E Torres, E S Levitan, E Aizenma. A vital role for voltage-dependent potassium channels in dopamine transporter-mediated 6-hydroxydopamine neurotoxicity. Neuroscience. vol 143. issue 1. 2007-01-26. PMID:17027171. |
we tested whether ectopic expression of dat induces sensitivity to 6-ohda in non-dopaminergic rat cortical neurons and evaluated the contribution of voltage-dependent potassium channel (kv)-dependent apoptosis to the toxicity of this compound in rat cortical and midbrain dopamine neurons. |
2007-01-26 |
2023-08-12 |
rat |