| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J D Foster, M A Cervinski, B K Gorentla, R A Vaugha. Regulation of the dopamine transporter by phosphorylation. Handbook of experimental pharmacology. issue 175. 2007-05-23. PMID:16722237. |
control of dat activity and plasma membrane expression are therefore central to drug actions and the spatial and temporal regulation of synaptic dopamine levels. |
2007-05-23 |
2023-08-12 |
Not clear |
| J M Williams, A Gall. The dopamine transporter: a vigilant border control for psychostimulant action. Handbook of experimental pharmacology. issue 175. 2007-05-23. PMID:16722238. |
the primary means by which dopamine transmission in the synapse is terminated is via the dopamine transporter (dat), the presynaptic plasmalemmal protein that is responsible for the reuptake of released dopamine. |
2007-05-23 |
2023-08-12 |
Not clear |
| J M Williams, A Gall. The dopamine transporter: a vigilant border control for psychostimulant action. Handbook of experimental pharmacology. issue 175. 2007-05-23. PMID:16722238. |
in addition, presynaptic autoreceptors for dopamine have been implicated in the modulation of dat surface expression and function. |
2007-05-23 |
2023-08-12 |
Not clear |
| J M Williams, A Gall. The dopamine transporter: a vigilant border control for psychostimulant action. Handbook of experimental pharmacology. issue 175. 2007-05-23. PMID:16722238. |
although there are a number of intracellular and extracellular modulatory influences on dopamine clearance that may play particular roles in psychostimulant action, we specifically focus on the differential direct modulation of dat function by transport substrates and inhibitors, and we also discusses the role of presynaptic d2 receptors in transport regulation. |
2007-05-23 |
2023-08-12 |
Not clear |
| Heather L Kimmel, Joann A O'Connor, F Ivy Carroll, Leonard L Howel. Faster onset and dopamine transporter selectivity predict stimulant and reinforcing effects of cocaine analogs in squirrel monkeys. Pharmacology, biochemistry, and behavior. vol 86. issue 1. 2007-05-22. PMID:17258302. |
although the behavioral-stimulant and reinforcing effects of cocaine and related psychomotor stimulants have been attributed to their actions at the dopamine transporter (dat), the reinforcing effectiveness of these compounds varies. |
2007-05-22 |
2023-08-12 |
monkey |
| Claire Leroy, Claude Comtat, Régine Trébossen, André Syrota, Jean-Luc Martinot, Maria-João Ribeir. Assessment of 11C-PE2I binding to the neuronal dopamine transporter in humans with the high-spatial-resolution PET scanner HRRT. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 48. issue 4. 2007-05-16. PMID:17401089. |
the present study aimed at evaluating the hrrt for measurement of the dopamine transporter (dat) binding to validate its quantification and explore the gain induced by the increased spatial resolution in comparison with conventional pet scanners. |
2007-05-16 |
2023-08-12 |
Not clear |
| Zhihua Xie, Gregory M Mille. Trace amine-associated receptor 1 is a modulator of the dopamine transporter. The Journal of pharmacology and experimental therapeutics. vol 321. issue 1. 2007-05-14. PMID:17234899. |
recent studies demonstrated wide distribution of taar1 in brain, coexpression of taar1 with dopamine transporter (dat) in a subset of dopamine neurons in both mouse and rhesus monkey substantia nigra, and monoamine transporter-modulated activation. |
2007-05-14 |
2023-08-12 |
mouse |
| Zhihua Xie, Gregory M Mille. Trace amine-associated receptor 1 is a modulator of the dopamine transporter. The Journal of pharmacology and experimental therapeutics. vol 321. issue 1. 2007-05-14. PMID:17234899. |
rhesus monkey taar1 expressed with dat in human embryonic kidney 293 cells was dose-dependently activated by dopamine or (+)-methamphetamine. |
2007-05-14 |
2023-08-12 |
mouse |
| Zhihua Xie, Gregory M Mille. Trace amine-associated receptor 1 is a modulator of the dopamine transporter. The Journal of pharmacology and experimental therapeutics. vol 321. issue 1. 2007-05-14. PMID:17234899. |
dat cells in krebs-hepes buffer had an apparent spontaneous [3h]dopamine loss, but it could not be blocked by either methylphenidate or a pkc inhibitor. |
2007-05-14 |
2023-08-12 |
mouse |
| Zhihua Xie, Susan V Westmoreland, Mary E Bahn, Guo-Lin Chen, Hong Yang, Eric J Vallender, Wei-Dong Yao, Bertha K Madras, Gregory M Mille. Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitro. The Journal of pharmacology and experimental therapeutics. vol 321. issue 1. 2007-05-14. PMID:17234900. |
in the present study, we demonstrate taar1 mrna and protein expression in rhesus monkey brain regions associated with monoaminergic systems, variable cellular distribution of taar1 in rhesus monkey brain, and taar1 coexpression with the dopamine transporter (dat) in a subset of dopamine neurons in both rhesus monkey and mouse substantia nigra. |
2007-05-14 |
2023-08-12 |
mouse |
| Zhihua Xie, Susan V Westmoreland, Mary E Bahn, Guo-Lin Chen, Hong Yang, Eric J Vallender, Wei-Dong Yao, Bertha K Madras, Gregory M Mille. Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitro. The Journal of pharmacology and experimental therapeutics. vol 321. issue 1. 2007-05-14. PMID:17234900. |
last, dopamine activation of taar1 could induce c-fos-luciferase expression but only in the presence of dat, whereas dopamine activation of d1 resulted in equivalent c-fos expression in the presence or absence of dat. |
2007-05-14 |
2023-08-12 |
mouse |
| Ian McKeith, John O'Brien, Zuzana Walker, Klaus Tatsch, Jan Booij, Jacques Darcourt, Alessandro Padovani, Raffaele Giubbini, Ubaldo Bonuccelli, Duccio Volterrani, Clive Holmes, Paul Kemp, Naji Tabet, Ines Meyer, Cornelia Reininge. Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study. The Lancet. Neurology. vol 6. issue 4. 2007-05-11. PMID:17362834. |
the primary aim of this study was to investigate the sensitivity and specificity, in the ante-mortem differentiation of probable dlb from other causes of dementia, of single photon emission computed tomography (spect) brain imaging with the ligand (123)i-2beta-carbometoxy-3beta-(4-iodophenyl)-n-(3-fluoropropyl) nortropane ((123)i-fp-cit), which binds to the dopamine transporter (dat) reuptake site. |
2007-05-11 |
2023-08-12 |
Not clear |
| M Canesi, R Benti, G Marotta, R Cilia, I U Isaias, P Gerundini, G Pezzoli, A Antonin. Striatal dopamine transporter binding in patients with Parkinson's disease and severe occupational hydrocarbon exposure. European journal of neurology. vol 14. issue 3. 2007-05-10. PMID:17355550. |
we used 123i-ioflupane spect to study striatal dopamine transporter (dat) binding in 36 parkinson's disease (pd) patients with history of severe occupational exposure to hydrocarbons. |
2007-05-10 |
2023-08-12 |
Not clear |
| Loredana D'Este, Arianna Casini, Stefano Puglisi-Allegra, Simona Cabib, Tindaro G Rend. Comparative immunohistochemical study of the dopaminergic systems in two inbred mouse strains (C57BL/6J and DBA/2J). Journal of chemical neuroanatomy. vol 33. issue 2. 2007-05-08. PMID:17276033. |
the number of dopamine transporter (dat), vesicular monoamine transporter of type 2 (vmt) and tyrosine hydroxylase (th) immunoreactive cell bodies was significantly higher in the midbrain of dba mice than in c57 mice (on average +21.5%, p<0.001 in a10: +9.4% in a9, p<0.05: and +5.9% in a8, p<0.1). |
2007-05-08 |
2023-08-12 |
mouse |
| S Hesse, C Oehlwein, H Barthel, J Schwarz, D Polster, A Wagner, O Sabr. Possible impact of dopamine SPECT on decision-making for drug treatment in Parkinsonian syndrome. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 9. 2007-05-02. PMID:16463120. |
we used dopamine transporter (dat) spect with [(123)i]fp-cit and dopamine d(2)/d(3) receptor spect with [(123)i]ibzm to evaluate whether there is a reduction of dat and/or d(2)/d(3) receptor spect in treated and untreated patients with parkinsonian syndrome (ps). |
2007-05-02 |
2023-08-12 |
Not clear |
| Roxanne A Vaughan, Dhananjay S Sakrikar, M Laura Parnas, Steven Adkins, James D Foster, Romain A Duval, John R Lever, Santosh S Kulkarni, Amy Hauck-Newma. Localization of cocaine analog [125I]RTI 82 irreversible binding to transmembrane domain 6 of the dopamine transporter. The Journal of biological chemistry. vol 282. issue 12. 2007-05-02. PMID:17255098. |
the site of cocaine binding on the dopamine transporter (dat) was investigated using the photoactivatable irreversible cocaine analog [125i]3beta-(p-chlorophenyl)tropane-2beta-carboxylic acid, 4'-azido-3'-iodophenylethyl ester ([125i]rti 82). |
2007-05-02 |
2023-08-12 |
human |
| Amy K Wagner, Dianxu Ren, Yvette P Conley, Xiecheng Ma, Mary E Kerr, Ross D Zafonte, Ava M Puccio, Donald W Marion, C Edward Dixo. Sex and genetic associations with cerebrospinal fluid dopamine and metabolite production after severe traumatic brain injury. Journal of neurosurgery. vol 106. issue 4. 2007-05-02. PMID:17432702. |
both sex and the dopamine transporter (dat) 3' variable number of tandem repeat polymorphism have been associated with differences in dat protein density, and dat protein affects both presynaptic da release, through reverse transport, and da reuptake. |
2007-05-02 |
2023-08-12 |
human |
| Xiang Liu, Samuel D Banister, MacDonald J Christie, Richard Banati, Steve Meikle, Mark J Coster, Michael Kassio. Trishomocubanes: novel sigma ligands modulate cocaine-induced behavioural effects. European journal of pharmacology. vol 555. issue 1. 2007-04-26. PMID:17113074. |
both compounds have negligible affinity for the dopamine (dat), serotonin (sert), and norepinephrine (net) transporters. |
2007-04-26 |
2023-08-12 |
Not clear |
| Piotr Popik, Martyna Krawczyk, Krystyna Golembiowska, Gabriel Nowak, Aaron Janowsky, Phil Skolnick, Arnold Lippa, Anthony S Basil. Pharmacological profile of the "triple" monoamine neurotransmitter uptake inhibitor, DOV 102,677. Cellular and molecular neurobiology. vol 26. issue 4-6. 2007-04-24. PMID:16636898. |
radioligand binding to the dopamine (dat), norepinephrine (net), and serotonin (sert) transporters is inhibited with k (i) values of 222, 1030, and 740 nm, respectively. |
2007-04-24 |
2023-08-12 |
mouse |
| Tomas Drgon, Zhicheng Lin, Gene-Jack Wang, Joanna Fowler, Johnfn Pablo, Deborah C Mash, Nora Volkow, George R Uh. Common human 5' dopamine transporter (SLC6A3) haplotypes yield varying expression levels in vivo. Cellular and molecular neurobiology. vol 26. issue 4-6. 2007-04-24. PMID:16710758. |
individuals display significant differences in their levels of expression of the dopamine transporter (dat; slc6a3). |
2007-04-24 |
2023-08-12 |
human |