| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jan Booij, Jan de Jong, Kora de Bruin, Remco Knol, Maartje M L de Win, Berthe L F van Eck-Smi. Quantification of striatal dopamine transporters with 123I-FP-CIT SPECT is influenced by the selective serotonin reuptake inhibitor paroxetine: a double-blind, placebo-controlled, crossover study in healthy control subjects. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 48. issue 3. 2007-04-24. PMID:17332612. |
dopamine transporter (dat) imaging with (123)i-fp-cit ((123)i-n-omega-fluoropropyl-2beta-carbomethoxy-3beta-(4-iodophenyl)nortropane) spect is frequently used to detect loss of nigrostriatal cells in parkinsonism. |
2007-04-24 |
2023-08-12 |
human |
| Kenji Hashimoto, Hideo Tsukada, Shingo Nishiyama, Dai Fukumoto, Takeharu Kakiuchi, Masaomi Iy. Protective effects of minocycline on the reduction of dopamine transporters in the striatum after administration of methamphetamine: a positron emission tomography study in conscious monkeys. Biological psychiatry. vol 61. issue 5. 2007-04-17. PMID:16712806. |
positron emission tomography (pet) studies of methamphetamine (meth) abusers suggest that psychotic symptoms of meth abusers may be attributable to the reduction of dopamine transporters (dat) in the human brain. |
2007-04-17 |
2023-08-12 |
human |
| Júlia P Genro, Cristian Zeni, Guilherme V Polanczyk, Tatiana Roman, Luis A Rohde, Mara H Hut. A promoter polymorphism (-839 C > T) at the dopamine transporter gene is associated with attention deficit/hyperactivity disorder in Brazilian children. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 2. 2007-04-11. PMID:17044101. |
the dopamine transporter (dat) plays a key role in the regulation of dopaminergic neurotransmission and is also the major site of action for methylphenidate which is one of the main drugs used to treat attention deficit hyperactivity disorder (adhd). |
2007-04-11 |
2023-08-12 |
Not clear |
| Gregory D Lyng, Abigail Snyder-Keller, Richard F Seega. Dopaminergic development of prenatal ventral mesencephalon and striatum in organotypic co-cultures. Brain research. vol 1133. issue 1. 2007-04-05. PMID:17196555. |
using organotypic co-cultures of rat embryonic day 14 (e14) ventral mesencephalon (vm) and e21 striatum, we have described the developmental changes in (i) dopamine (da) neurochemistry; (ii) numbers of da neurons; and (iii) protein expression of tyrosine hydroxylase (th), da transporter (dat), and glutamic acid decarboxylase (gad 65/67), over 17 days in vitro (div). |
2007-04-05 |
2023-08-12 |
rat |
| Meleik Hebert Goodwill, David A Lawrence, Richard F Seega. Polychlorinated biphenyls induce proinflammatory cytokine release and dopaminergic dysfunction: protection in interleukin-6 knockout mice. Journal of neuroimmunology. vol 183. issue 1-2. 2007-04-05. PMID:17229471. |
pcbs induced inflammatory responses in c57bl/6 adult male mice, significantly elevating serum levels of il-6 (31%), il-1beta (71%) and tnf-alpha (22%) and significantly reducing striatal dopamine (da, 21%), tyrosine hydroxylase (th, 26%), dopamine transporter (dat, 39%), and synaptophysin (29%) concentrations. |
2007-04-05 |
2023-08-12 |
mouse |
| Michelle R Carroll, Zachary A Rodd, James M Murphy, Jay R Simo. Chronic ethanol consumption increases dopamine uptake in the nucleus accumbens of high alcohol drinking rats. Alcohol (Fayetteville, N.Y.). vol 40. issue 2. 2007-04-02. PMID:17307646. |
the present study examined the effects of chronic ethanol drinking on dopamine transporter (dat) function in the nucleus accumbens (acb) of high-alcohol-drinking replicate line 1 (had-1) rats. |
2007-04-02 |
2023-08-12 |
rat |
| Timothy M Fountaine, Richard Wade-Martin. RNA interference-mediated knockdown of alpha-synuclein protects human dopaminergic neuroblastoma cells from MPP(+) toxicity and reduces dopamine transport. Journal of neuroscience research. vol 85. issue 2. 2007-03-29. PMID:17131421. |
knockdown does, however, confer resistance to the dopamine transporter (dat)-dependent neurotoxin n-methyl-4-phenylpyridinium (mpp(+)). |
2007-03-29 |
2023-08-12 |
human |
| Lisa S Middleton, Peter A Crooks, Peter J Wedlund, Wayne A Cass, Linda P Dwoski. Nornicotine inhibition of dopamine transporter function in striatum via nicotinic receptor activation. Synapse (New York, N.Y.). vol 61. issue 3. 2007-03-27. PMID:17146768. |
the current study determined the effect of nornicotine on rat striatal dopamine transporter (dat) function using in vivo voltammetry. |
2007-03-27 |
2023-08-12 |
rat |
| Evan P Sleipness, Barbara A Sorg, Heiko T Janse. Diurnal differences in dopamine transporter and tyrosine hydroxylase levels in rat brain: dependence on the suprachiasmatic nucleus. Brain research. vol 1129. issue 1. 2007-03-22. PMID:17156761. |
we used western blots to measure expression of dopamine transporter (dat) and tyrosine hydroxylase (th) proteins in the medial prefrontal cortex (mpfc), nucleus accumbens (nac), and caudate in sham and scn-lesioned (scnx) rats at zt4 (zeitgeber time 4, 4 h after lights-on) or zt20 (8 h after lights-off). |
2007-03-22 |
2023-08-12 |
rat |
| Y Wei, J M Williams, C Dipace, U Sung, J A Javitch, A Galli, C Saunder. Dopamine transporter activity mediates amphetamine-induced inhibition of Akt through a Ca2+/calmodulin-dependent kinase II-dependent mechanism. Molecular pharmacology. vol 71. issue 3. 2007-03-22. PMID:17164407. |
the primary mechanism for clearance of extracellular dopamine (da) is uptake mediated by the dopamine transporter (dat), which is governed, in part, by the number of functional dats on the cell surface. |
2007-03-22 |
2023-08-12 |
Not clear |
| Neal C Burton, Thomas W Kensler, Tomás R Guilart. In vivo modulation of the Parkinsonian phenotype by Nrf2. Neurotoxicology. vol 27. issue 6. 2007-03-21. PMID:16959318. |
seven days after mptp administration dopamine transporter (dat) levels were measured using [(125)i]-rti-121 quantitative autoradiography as an index of dopamine terminal integrity in the striatum. |
2007-03-21 |
2023-08-12 |
mouse |
| R Maiya, I Ponomarev, K D Linse, R A Harris, R D Mayfiel. Defining the dopamine transporter proteome by convergent biochemical and in silico analyses. Genes, brain, and behavior. vol 6. issue 1. 2007-03-20. PMID:16643512. |
the function of the dopamine transporter (dat), an important member of this family of transporters, is regulated by multiple signaling mechanisms, which result in altered cell surface trafficking of dat. |
2007-03-20 |
2023-08-12 |
Not clear |
| Agnieszka Słopién, Monika Dmitrzak-Weglarz, Filip Rybakowski, Andrzej Rajewski, Joanna Hause. [Genetic background of ADHD: population studies, genes of the catecholamine system]. Psychiatria polska. vol 40. issue 1. 2007-03-20. PMID:16756025. |
according to other studies there is a relationship between polymorphism of dopamine transporter gene (dat), dopamine receptors genes: drd2, drd3, drd4, drd5, dopamine-beta-hydroxylase gene (dbh) and catechol-o-methyltransferase gene (comt) and adhd. |
2007-03-20 |
2023-08-12 |
Not clear |
| M Saldaña, M Bonastre, E Aguilar, C Mari. Differential nigral expression of Bcl-2 protein family in chronically haloperidol and clozapine-treated rats: role in neurotoxicity and stereotyped behavior. Experimental neurology. vol 203. issue 2. 2007-03-20. PMID:17069804. |
western blotting was performed to evaluate the nigral expression of the dopamine transporter (dat), bax, bcl-x(l) and bcl-2 proteins. |
2007-03-20 |
2023-08-12 |
rat |
| Simon McArthur, Hilary E Murray, Alihusein Dhankot, David T Dexter, Glenda E Gillie. Striatal susceptibility to a dopaminergic neurotoxin is independent of sex hormone effects on cell survival and DAT expression but is exacerbated by central aromatase inhibition. Journal of neurochemistry. vol 100. issue 3. 2007-03-20. PMID:17116232. |
in addition, hormonally induced changes in striatal expression of the dopamine transporter (dat), an important factor for 6-ohda toxicity, did not correlate with hormonal influences on striatal dopamine loss and, in males, central inhibition of aromatase prior to 6-ohda infusion exacerbated striatal dopamine loss with no effect on snc tyrosine hydroxylase-immunoreactive survival, suggesting locally generated oestrogen is neuroprotective. |
2007-03-20 |
2023-08-12 |
rat |
| C Mehler-Wex, P Riederer, M Gerlac. Dopaminergic dysbalance in distinct basal ganglia neurocircuits: implications for the pathophysiology of Parkinson's disease, schizophrenia and attention deficit hyperactivity disorder. Neurotoxicity research. vol 10. issue 3-4. 2007-03-20. PMID:17197367. |
the most convincing evidence comes from the demonstration of the efficacy of psychostimulants such as the dopamine transporter (dat) blocker methylphenidate in the symptomatic treatment of adhd. |
2007-03-20 |
2023-08-12 |
mouse |
| Yili Shang, Megan A Gibbs, Gerard J Marek, Thomas Stiger, Aaron H Burstein, Kenneth Marek, John P Seibyl, Janyce F Roger. Displacement of serotonin and dopamine transporters by venlafaxine extended release capsule at steady state: a [123I]2beta-carbomethoxy-3beta-(4-iodophenyl)-tropane single photon emission computed tomography imaging study. Journal of clinical psychopharmacology. vol 27. issue 1. 2007-03-20. PMID:17224717. |
selective serotonin reuptake inhibitors also appear to increase the availability of dopamine transporters (dat). |
2007-03-20 |
2023-08-12 |
human |
| Magdalena Cakała, Jacek Drabik, Anna Kaźmierczak, Dorota Kopczuk, Agata Adamczy. Inhibition of mitochondrial complex II affects dopamine metabolism and decreases its uptake into striatal synaptosomes. Folia neuropathologica. vol 44. issue 4. 2007-03-15. PMID:17183449. |
moreover, 3-np significantly inhibited [3h]da uptake into striatal synaptosomes by specific dopamine transporter (dat). |
2007-03-15 |
2023-08-12 |
rat |
| Duy-Phong Pham-Huu, Jeffrey R Deschamps, Shanghao Liu, Bertha K Madras, Peter C Meltze. Synthesis of 8-thiabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters. Bioorganic & medicinal chemistry. vol 15. issue 2. 2007-03-13. PMID:17070057. |
its reinforcing and stimulant properties have been associated with inhibition of the dopamine transporter (dat) on presynaptic neurons. |
2007-03-13 |
2023-08-12 |
Not clear |
| Leonard L Howell, F Ivy Carroll, John R Votaw, Mark M Goodman, Heather L Kimme. Effects of combined dopamine and serotonin transporter inhibitors on cocaine self-administration in rhesus monkeys. The Journal of pharmacology and experimental therapeutics. vol 320. issue 2. 2007-03-13. PMID:17105829. |
dopamine transporter (dat) inhibitors may represent a promising class of drugs in the development of cocaine pharmacotherapies. |
2007-03-13 |
2023-08-12 |
monkey |