| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vivienne Ann Russel. Neurobiology of animal models of attention-deficit hyperactivity disorder. Journal of neuroscience methods. vol 161. issue 2. 2007-06-12. PMID:17275916. |
consistent with adhd being a developmental disorder, animal models are either genetic (spontaneously hypertensive rats (shr), dopamine transporter (dat) knock-out mice, snap-25 mutant mice, mice expressing a mutant thyroid receptor) or have suffered an insult to the central nervous system during the early stages of development (anoxia, 6-hydroxydopamine). |
2007-06-12 |
2023-08-12 |
mouse |
| Michael Decker, Jochen Lehman. Agonistic and antagonistic bivalent ligands for serotonin and dopamine receptors including their transporters. Current topics in medicinal chemistry. vol 7. issue 4. 2007-06-07. PMID:17305576. |
selectivity profiles and affinities depend strongly on the length of the alkylene-spacer: for some dimeric inhibitors the norepinephrine transporter (net) and the dopamine transporter (dat) affinities changed gradually, but for the serotonin transporter (sert) a pentamethylene spacer showed the highest potency. |
2007-06-07 |
2023-08-12 |
Not clear |
| Rong Chen, Hua Wei, Erik R Hill, Lucy Chen, Liying Jiang, Dawn D Han, Howard H G. Direct evidence that two cysteines in the dopamine transporter form a disulfide bond. Molecular and cellular biochemistry. vol 298. issue 1-2. 2007-06-06. PMID:17131045. |
we have generated a fully functional dopamine transporter (dat) mutant (dmdatx7) with all cysteines removed except the two cysteines in extracellular loop 2 (el2). |
2007-06-06 |
2023-08-12 |
Not clear |
| Dustin Y Yoon, Colin D Gause, James F Leckman, Harvey S Singe. Frontal dopaminergic abnormality in Tourette syndrome: a postmortem analysis. Journal of the neurological sciences. vol 255. issue 1-2. 2007-06-05. PMID:17337006. |
relative densities were measured for a variety of neurochemical markers including dopamine (d1, d2), serotonin (5ht-1a), and alpha-adrenergic (alpha-2a) receptors, the dopamine transporter (dat), a monoamine terminal marker (vesicular monoamine transporter type 2, vmat-2), and vesicular docking and release proteins (vamp-2, synaptotagmin, snap-25, syntaxin, synaptophysin). |
2007-06-05 |
2023-08-12 |
human |
| Nianhang Chen, Maarten E A Reit. Substrates and inhibitors display different sensitivity to expression level of the dopamine transporter in heterologously expressing cells. Journal of neurochemistry. vol 101. issue 2. 2007-06-01. PMID:17250655. |
the use of heterologous expression systems for studying dopamine (da) transporter (dat) function has provided important information corroborating and complementing in situ obtained knowledge. |
2007-06-01 |
2023-08-12 |
human |
| Alberto Ambesi-Impiombato, Fabio Panariello, Carmela Dell'aversano, Carmine Tomasetti, Giovanni Muscettola, Andrea de Bartolomei. Differential expression of Homer 1 gene by acute and chronic administration of antipsychotics and dopamine transporter inhibitors in the rat forebrain. Synapse (New York, N.Y.). vol 61. issue 6. 2007-06-01. PMID:17372981. |
rats were treated with the "typical" antipsychotic haloperidol, the "atypical" quetiapine, or the selective dopamine transporter (dat) inhibitor gbr 12909 in acute and chronic paradigms. |
2007-06-01 |
2023-08-12 |
rat |
| C Sogawa, N Sogawa, J Tagawa, A Fujino, K Ohyama, M Asanuma, M Funada, S Kitayam. 5-Methoxy-N,N-diisopropyltryptamine (Foxy), a selective and high affinity inhibitor of serotonin transporter. Toxicology letters. vol 170. issue 1. 2007-06-01. PMID:17382495. |
in the present study, we investigated the actions of 5-meo-dipt against monoamine neurotransmitter transporters, including the transporters for dopamine (dat), norepinephrine (net), and serotonin (sert), using cos-7 cells heterologously expressing these transporters and rat brain synaptosomes. |
2007-06-01 |
2023-08-12 |
rat |
| Tamer Demiralp, Christoph S Herrmann, M Emin Erdal, Tolgay Ergenoglu, Yasemin H Keskin, Mehmet Ergen, Hüseyin Beydag. DRD4 and DAT1 polymorphisms modulate human gamma band responses. Cerebral cortex (New York, N.Y. : 1991). vol 17. issue 5. 2007-05-31. PMID:16751296. |
schizophrenia and attention deficit hyperactivity disorder, which lead to failure of attentional modulation and working memory, introduce significant changes in gamma responses and have significant associations with genetic polymorphisms of dopamine receptor d4 (drd4), dopamine transporter (dat), and catechol-o-methyltransferase (comt). |
2007-05-31 |
2023-08-12 |
human |
| Tamer Demiralp, Christoph S Herrmann, M Emin Erdal, Tolgay Ergenoglu, Yasemin H Keskin, Mehmet Ergen, Hüseyin Beydag. DRD4 and DAT1 polymorphisms modulate human gamma band responses. Cerebral cortex (New York, N.Y. : 1991). vol 17. issue 5. 2007-05-31. PMID:16751296. |
the 10/10 genotype of the dat1 polymorphism, which reduces dat expression and hence yields an increase in extracellular dopamine, specifically enhanced evoked gamma responses to target stimuli. |
2007-05-31 |
2023-08-12 |
human |
| Amalia Lafuente, Miquel Bernardo, Sergi Mas, Anna Crescenti, Monica Aparici, Patricia Gassó, Rosa Catalan, Jose J Mateos, Francisco Lomeña, Eduard Parellad. Dopamine transporter (DAT) genotype (VNTR) and phenotype in extrapyramidal symptoms induced by antipsychotics. Schizophrenia research. vol 90. issue 1-3. 2007-05-30. PMID:17150335. |
dopamine transporter (dat) genotype (vntr) and phenotype in extrapyramidal symptoms induced by antipsychotics. |
2007-05-30 |
2023-08-12 |
Not clear |
| Amalia Lafuente, Miquel Bernardo, Sergi Mas, Anna Crescenti, Monica Aparici, Patricia Gassó, Rosa Catalan, Jose J Mateos, Francisco Lomeña, Eduard Parellad. Dopamine transporter (DAT) genotype (VNTR) and phenotype in extrapyramidal symptoms induced by antipsychotics. Schizophrenia research. vol 90. issue 1-3. 2007-05-30. PMID:17150335. |
impaired dopamine transporter (dat) function may be involved in antipsychotic (ap)-induced extrapyramidal symptoms (eps). |
2007-05-30 |
2023-08-12 |
Not clear |
| Sandra G Vincent, Andrea E Waddell, Marc G Caron, Julia K L Walker, John T Fishe. A murine model of hyperdopaminergic state displays altered respiratory control. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 21. issue 7. 2007-05-30. PMID:17255472. |
the dopamine transporter (dat) protein plays an important role in the termination of dopamine signaling. |
2007-05-30 |
2023-08-12 |
mouse |
| Sandra G Vincent, Andrea E Waddell, Marc G Caron, Julia K L Walker, John T Fishe. A murine model of hyperdopaminergic state displays altered respiratory control. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 21. issue 7. 2007-05-30. PMID:17255472. |
we addressed the hypothesis that loss of dat function would result in a distinctive cardiorespiratory phenotype due to the significant role of dopamine in the control of breathing, especially with respect to chemical control, metabolism, and thermoregulation. |
2007-05-30 |
2023-08-12 |
mouse |
| Sandra G Vincent, Andrea E Waddell, Marc G Caron, Julia K L Walker, John T Fishe. A murine model of hyperdopaminergic state displays altered respiratory control. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 21. issue 7. 2007-05-30. PMID:17255472. |
we conclude that loss of the dat protein in this murine model of altered dopaminergic neurotransmission results in a significant respiratory and thermal phenotype that has possible implications for understanding of conditions associated with altered dopamine regulation. |
2007-05-30 |
2023-08-12 |
mouse |
| Rajkumar J Sevak, W Anthony Owens, Wouter Koek, Aurelio Galli, Lynette C Daws, Charles P Franc. Evidence for D2 receptor mediation of amphetamine-induced normalization of locomotion and dopamine transporter function in hypoinsulinemic rats. Journal of neurochemistry. vol 101. issue 1. 2007-05-29. PMID:17217413. |
dopamine (da) d2 receptors regulate da transporter (dat) activity, and mediate some behavioral effects of amphetamine. |
2007-05-29 |
2023-08-12 |
rat |
| Elizabeth A Bolan, Bronwyn Kivell, Vanaja Jaligam, Murat Oz, Lankupalle D Jayanthi, Yang Han, Namita Sen, Eneki Urizar, Ivone Gomes, Lakshmi A Devi, Sammanda Ramamoorthy, Jonathan A Javitch, Agustin Zapata, Toni S Shippenber. D2 receptors regulate dopamine transporter function via an extracellular signal-regulated kinases 1 and 2-dependent and phosphoinositide 3 kinase-independent mechanism. Molecular pharmacology. vol 71. issue 5. 2007-05-29. PMID:17267664. |
the dopamine transporter (dat) terminates dopamine (da) neurotransmission by reuptake of da into presynaptic neurons. |
2007-05-29 |
2023-08-12 |
human |
| Randy D Blakely, Louis J DeFelic. All aglow about presynaptic receptor regulation of neurotransmitter transporters. Molecular pharmacology. vol 71. issue 5. 2007-05-29. PMID:17329498. |
(p. 1222) capitalizes on the fluorescent properties of a recently introduced substrate for the dopamine (da) transporter (dat), termed 4-(4-(dimethylamino)styryl)-n-methylpyridinium (asp+), to illuminate a pertussis toxin-sensitive, extracellular signal-regulated kinase (erk1/2)-dependent pathway by which presynaptic da d(2) receptors regulate dats. |
2007-05-29 |
2023-08-12 |
human |
| P Manoharan, S Jamieson, R F Bur. Initial clinical experience with [123I]ioflupane scintigraphy in movement disorders. Clinical radiology. vol 62. issue 5. 2007-05-29. PMID:17398272. |
the objective of this study was to determine whether dopamine transporter (dat) scintigraphy influences the management of movement disorders in clinically indeterminate cases. |
2007-05-29 |
2023-08-12 |
Not clear |
| J W Schwartz, D Piston, L J DeFelic. Molecular microfluorometry: converting arbitrary fluorescence units into absolute molecular concentrations to study binding kinetics and stoichiometry in transporters. Handbook of experimental pharmacology. issue 175. 2007-05-23. PMID:16722229. |
cotransport in norepinephrine (net), epinephrine (epit), dopamine (dat), and serotonin (sert) transporters couples downhill na+ flux to uphill transmitter flux. |
2007-05-23 |
2023-08-12 |
Not clear |
| J D Foster, M A Cervinski, B K Gorentla, R A Vaugha. Regulation of the dopamine transporter by phosphorylation. Handbook of experimental pharmacology. issue 175. 2007-05-23. PMID:16722237. |
the dopamine transporter (dat) is a neuronal phosphoprotein and target for psychoactive drugs that plays a critical role in terminating dopaminergic transmission by reuptake of dopamine from the synaptic space. |
2007-05-23 |
2023-08-12 |
Not clear |