| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nobuyuki Maruoka, Tetsuhito Murata, Naoto Omata, Yasuhiro Takashima, Yasuhisa Fujibayashi, Yuji Wad. Biphasic mechanism of the toxicity induced by 1-methyl-4-phenylpyridinium ion (MPP+) as revealed by dynamic changes in glucose metabolism in rat brain slices. Neurotoxicology. vol 28. issue 3. 2007-10-18. PMID:17391768. |
the classical mechanism of mpp+ toxicity involves its entry into cells through the dopamine transporter (dat) to inhibit aerobic glucose metabolism, while recent studies suggest that an oxidative mechanism may contribute to the toxicity of mpp+. |
2007-10-18 |
2023-08-12 |
rat |
| Chun-Pai Yang, Wei-Shih Huang, Hsu-Tzu Shih, Chun-Yi Lin, Ming-Kuei Lu, Chia-Hung Kao, Te-Chun Hsieh, Kai-Ju Huang, Ying-Hsuan Lee, Chon-Haw Tsa. Diminution of basal ganglia dopaminergic function may play an important role in the generation of akinetic mutism in a patient with anterior cerebral arterial infarct. Clinical neurology and neurosurgery. vol 109. issue 7. 2007-10-18. PMID:17543443. |
trodat-1 is a cocaine analogue that can be labeled with technetium-99m and bound to the dopamine transporter (dat) site. |
2007-10-18 |
2023-08-12 |
Not clear |
| A Storch, Y-I Hwang, G Bringmann, D Feineis, S Ott, R Brückner, J Schwar. Cytotoxicity of chloral-derived beta-carbolines is not specific towards neuronal nor dopaminergic cells. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 12. 2007-10-17. PMID:16868795. |
here we examine the dopaminergic toxicity of taclo and related compounds by testing their differential cytotoxicities in dopaminergic sh-sy5y and non-dopaminergic murine neuro2a neuroblastoma cell lines as well as in heterologous expression systems of the dopamine transporter (dat) using both hek-293 and neuro2a cells. |
2007-10-17 |
2023-08-12 |
Not clear |
| Fereshteh Sedaghat, Anna Gotzamani-Psarrakou, Eleni Dedousi, Marianthi Arnaoutoglou, Kyriakos Psarrakos, Ioannis Baloyannis, Athanasios S Dimitriadis, Stavros J Baloyanni. Evaluation of dopaminergic function in frontotemporal dementia using I-FP-CIT single photon emission computed tomography. Neuro-degenerative diseases. vol 4. issue 5. 2007-10-17. PMID:17622781. |
(123)i-fp-cit (dat scan) single photon emission computed tomography (spect) can detect loss of presynaptic dopamine transporters in the striatum. |
2007-10-17 |
2023-08-12 |
Not clear |
| Jun Zhu, Michael T Bardo, Ronald C Bruntz, Dustin J Stairs, Linda P Dwoski. Individual differences in response to novelty predict prefrontal cortex dopamine transporter function and cell surface expression. The European journal of neuroscience. vol 26. issue 3. 2007-10-17. PMID:17651428. |
the aim of the present study was to determine if individual differences in response to novelty based on inescapable or free-choice novelty tests predict dopamine transporter (dat) function and trafficking as well as nicotine-induced modulation of dat. |
2007-10-17 |
2023-08-12 |
rat |
| Paul K Gong, Bruce E Blough, Lawrence E Brieaddy, Xiaodong Huang, Michael J Kuhar, Hernán A Navarro, F Ivy Carrol. Synthesis, monoamine transporter binding, properties, and functional monoamine uptake activity of 3beta-[4-methylphenyl and 4-chlorophenyl]-2 beta-[5-(substituted phenyl)thiazol-2-yl]tropanes. Journal of medicinal chemistry. vol 50. issue 15. 2007-10-15. PMID:17602602. |
in general, the compounds showed higher dopamine transporter (dat) affinity relative to the serotonin and norepinephrine transporters (sert and net, respectively) and greater [3h]dopamine uptake inhibition potency relative to [3h]serotonin and [3h]norepinephrine uptake inhibition. |
2007-10-15 |
2023-08-12 |
rat |
| Keyoumars Ashkan, Bradley A Wallace, John Mitrofanis, Claudio Pollo, Pierre-Yves Brard, Daniel Fagret, Alim-Louis Benabi. SPECT imaging, immunohistochemical and behavioural correlations in the primate models of Parkinson's disease. Parkinsonism & related disorders. vol 13. issue 5. 2007-10-12. PMID:17196871. |
dopamine active transporter (dat) single photon emission computerised tomography (spect) is considered a useful and practical technique for early diagnosis of parkinson's disease (pd) and assessment of its progression. |
2007-10-12 |
2023-08-12 |
human |
| Claudia Consales, Floriana Volpicelli, Dario Greco, Luigi Leone, Luca Colucci-D'Amato, Carla Perrone-Capano, Umberto di Porzi. GDNF signaling in embryonic midbrain neurons in vitro. Brain research. vol 1159. 2007-10-12. PMID:17574220. |
it modulates the expression of genes essential for da function (tyrosine hydroxylase, th and dopamine transporter, dat) and of da high affinity uptake. |
2007-10-12 |
2023-08-12 |
rat |
| Jongchul Kim, Jong-Min Kim, Yu Kyeong Kim, Jung Woo Shin, Seong Hoon Choi, Sang Eun Kim, Yangho Ki. Dopamine transporter SPECT of a liver cirrhotic with atypical parkinsonism. Industrial health. vol 45. issue 3. 2007-10-12. PMID:17634700. |
[123i]-fp-cit brain spect images of dopamine transporter (dat) demonstrated overall normal range of dat uptake in the striatum although there were scattered small hypodense regions. |
2007-10-12 |
2023-08-12 |
Not clear |
| G J E Schmitt, T Frodl, S Dresel, C la Fougère, R Bottlender, N Koutsouleris, K Hahn, H-J Möller, E M Meisenzah. Striatal dopamine transporter availability is associated with the productive psychotic state in first episode, drug-naive schizophrenic patients. European archives of psychiatry and clinical neuroscience. vol 256. issue 2. 2007-10-11. PMID:16284713. |
recently, a new spect ligand to the presynaptic dopamine transporter (dat) was introduced. |
2007-10-11 |
2023-08-12 |
Not clear |
| Frank J S Lee, Lin Pei, Anna Moszczynska, Brian Vukusic, Paul J Fletcher, Fang Li. Dopamine transporter cell surface localization facilitated by a direct interaction with the dopamine D2 receptor. The EMBO journal. vol 26. issue 8. 2007-10-04. PMID:17380124. |
one of the key presynaptic components involved in regulating dopaminergic tone is the dopamine transporter (dat). |
2007-10-04 |
2023-08-12 |
mouse |
| Frank J S Lee, Lin Pei, Anna Moszczynska, Brian Vukusic, Paul J Fletcher, Fang Li. Dopamine transporter cell surface localization facilitated by a direct interaction with the dopamine D2 receptor. The EMBO journal. vol 26. issue 8. 2007-10-04. PMID:17380124. |
here, we report that the dat is also regulated by the dopamine d2 receptor through a direct protein-protein interaction involving the dat amino-terminus and the third intracellular loop of the d2 receptor. |
2007-10-04 |
2023-08-12 |
mouse |
| Frank J S Lee, Lin Pei, Anna Moszczynska, Brian Vukusic, Paul J Fletcher, Fang Li. Dopamine transporter cell surface localization facilitated by a direct interaction with the dopamine D2 receptor. The EMBO journal. vol 26. issue 8. 2007-10-04. PMID:17380124. |
this physical coupling facilitates the recruitment of intracellular dat to the plasma membrane and leads to enhanced dopamine reuptake. |
2007-10-04 |
2023-08-12 |
mouse |
| Frank J S Lee, Lin Pei, Anna Moszczynska, Brian Vukusic, Paul J Fletcher, Fang Li. Dopamine transporter cell surface localization facilitated by a direct interaction with the dopamine D2 receptor. The EMBO journal. vol 26. issue 8. 2007-10-04. PMID:17380124. |
moreover, mice injected with peptides that disrupt d2-dat interaction exhibit decreased synaptosomal dopamine uptake and significantly increased locomotor activity, reminiscent of dat knockout mice. |
2007-10-04 |
2023-08-12 |
mouse |
| Emmanuelle Lagrue, Sylvie Chalon, Sylvie Bodard, Elie Saliba, Pierre Gressens, Pierre Castelna. Lamotrigine is neuroprotective in the energy deficiency model of MPTP intoxicated mice. Pediatric research. vol 62. issue 1. 2007-09-26. PMID:17515828. |
dopamine transporter (dat) density was assessed by quantitative autoradiography, tyrosine hydroxylase (th) was evaluated by immunohistochemistry and dopamine (da) levels by hplc-ed whereas neuronal apoptosis was monitored through active caspase-3. |
2007-09-26 |
2023-08-12 |
mouse |
| M Kabbaj, C Isgo. Effects of chronic environmental and social stimuli during adolescence on mesolimbic dopaminergic circuitry markers. Neuroscience letters. vol 422. issue 1. 2007-09-26. PMID:17590508. |
no change has been detected in any other dopaminergic markers [d2r, d3r, tyrosine hydroxylase (th) or dopamine transporter (dat) mrnas]. |
2007-09-26 |
2023-08-12 |
rat |
| Ahmed A Othman, Amy Hauck Newman, Natalie D Eddingto. Applicability of the dopamine and rate hypotheses in explaining the differences in behavioral pharmacology of the chloro-benztropine analogs: studies conducted using intracerebral microdialysis and population pharmacodynamic modeling. The Journal of pharmacology and experimental therapeutics. vol 322. issue 2. 2007-09-20. PMID:17519385. |
previous studies indicated that the chloro-benztropine analogs differed significantly in their cocaine-like activity, which was not expected based on the similarity in their in vitro binding affinity and functional potency at the dopamine transporter (dat). |
2007-09-20 |
2023-08-12 |
rat |
| Jinghong Kou, Jeffrey R Bloomquis. Neurotoxicity in murine striatal dopaminergic pathways following long-term application of low doses of permethrin and MPTP. Toxicology letters. vol 171. issue 3. 2007-09-11. PMID:17597311. |
alterations in the expression of tyrosine hydroxylase (th), dopamine transporter (dat), and alpha-synuclein proteins were analyzed 1 day after the last pm treatment using western blot assay. |
2007-09-11 |
2023-08-12 |
mouse |
| Setsu Fukushima, Haowei Shen, Harumi Hata, Arihisa Ohara, Kayo Ohmi, Kazutaka Ikeda, Yohtaro Numachi, Hideaki Kobayashi, F Scott Hall, George R Uhl, Ichiro Sor. Methamphetamine-induced locomotor activity and sensitization in dopamine transporter and vesicular monoamine transporter 2 double mutant mice. Psychopharmacology. vol 193. issue 1. 2007-09-06. PMID:17377774. |
the dopamine transporter (dat) and the vesicular monoamine transporter 2 (vmat2) play pivotal roles in the action of methamphetamine (map), including acute locomotor effects and behavioral sensitization. |
2007-09-06 |
2023-08-12 |
mouse |
| Stéphanie Weiss, Eleni T Tzavara, Richard J Davis, George G Nomikos, J Michael McIntosh, Bruno Giros, Marie-Pascale Martre. Functional alterations of nicotinic neurotransmission in dopamine transporter knock-out mice. Neuropharmacology. vol 52. issue 7. 2007-08-31. PMID:17433376. |
mice lacking the dopamine (da) transporter (dat) gene exhibit a phenotype reminiscent of schizophrenia and attention deficit hyperactivity disorder (adhd), including hyperdaergia, hyperactivity and deficits in cognitive performance, which are alleviated by antipsychotic agents. |
2007-08-31 |
2023-08-12 |
mouse |