| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Eugene Redmond, Kimberly B Bjugstad, Yang D Teng, Vaclav Ourednik, Jitka Ourednik, Dustin R Wakeman, Xuejun H Parsons, Rodolfo Gonzalez, Barbara C Blanchard, Seung U Kim, Zezong Gu, Stuart A Lipton, Eleni A Markakis, Robert H Roth, John D Elsworth, John R Sladek, Richard L Sidman, Evan Y Snyde. Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 29. 2007-08-30. PMID:17586681. |
a small number of hnsc progeny differentiated into tyrosine hydroxylase (th) and/or dopamine transporter (dat) immunopositive cells, suggesting that the microenvironment within and around the lesioned adult host sn still permits development of a da phenotype by responsive progenitor cells. |
2007-08-30 |
2023-08-12 |
human |
| James M Swanson, Marcel Kinsbourne, Joel Nigg, Bruce Lanphear, Gerry A Stefanatos, Nora Volkow, Eric Taylor, B J Casey, F Xavier Castellanos, Pathik D Wadhw. Etiologic subtypes of attention-deficit/hyperactivity disorder: brain imaging, molecular genetic and environmental factors and the dopamine hypothesis. Neuropsychology review. vol 17. issue 1. 2007-08-21. PMID:17318414. |
first, we consider evidence of the presence of dopamine deficits based on the recent literature that (1) confirms abnormalities in dopamine-modulated frontal-striatal circuits, reflected by size (smaller-than-average components) and function (hypoactivation); (2) clarifies the agonist effects of stimulant medication on dopaminergic mechanisms at the synaptic and circuit level of analysis; and (3) challenges the most-widely accepted adhd-related neural abnormality in the dopamine system (higher-than-normal dopamine transporter [dat] density). |
2007-08-21 |
2023-08-12 |
Not clear |
| James M Swanson, Marcel Kinsbourne, Joel Nigg, Bruce Lanphear, Gerry A Stefanatos, Nora Volkow, Eric Taylor, B J Casey, F Xavier Castellanos, Pathik D Wadhw. Etiologic subtypes of attention-deficit/hyperactivity disorder: brain imaging, molecular genetic and environmental factors and the dopamine hypothesis. Neuropsychology review. vol 17. issue 1. 2007-08-21. PMID:17318414. |
second, we discuss possible genetic etiologies of dopamine deficits based on recent molecular genetic literature, including (1) multiple replications that confirm the association of adhd with candidate genes related to the dopamine receptor d4 (drd4) and the dat; (2) replication of differences in performance of neuropsychological tasks as a function of the drd4 genotype; and (3) multiple genome-wide linkage scans that demonstrate the limitations of this method when applied to complex disorders but implicate additional genes that may contribute to the genetic basis of adhd. |
2007-08-21 |
2023-08-12 |
Not clear |
| Philippe Huot, André Paren. Dopaminergic neurons intrinsic to the striatum. Journal of neurochemistry. vol 101. issue 6. 2007-08-16. PMID:17286588. |
the dopaminergic nature of these neurons is further supported by the fact that they express the dopamine (da) transporter (dat) and the nuclear orphan receptor nurr1, a transcription factor essential for the expression of the da phenotype by midbrain neurons. |
2007-08-16 |
2023-08-12 |
Not clear |
| Amy K Wagner, Anthony E Kline, Dianxu Ren, Lauren A Willard, Michael K Wenger, Ross D Zafonte, C Edward Dixo. Gender associations with chronic methylphenidate treatment and behavioral performance following experimental traumatic brain injury. Behavioural brain research. vol 181. issue 2. 2007-08-16. PMID:17517440. |
methylphenidate (mph) is a da agonist that blocks the dopamine transporter (dat). |
2007-08-16 |
2023-08-12 |
rat |
| Vishakantha Murthy, Huw M L Davies, Simon J Hedley, Steven R Childer. Irreversible binding of a novel phenylisothiocyanate tropane analog to monoamine transporters in rat brain. Biochemical pharmacology. vol 74. issue 2. 2007-08-16. PMID:17540345. |
irreversible tropane analogs have been useful in identifying binding sites of cocaine on biogenic amine transporters, including transporters for dopamine (dat), serotonin (sert) and norepinephrine (net). |
2007-08-16 |
2023-08-12 |
rat |
| Binrang Yang, Raymond C K Chan, Jin Jing, Tao Li, Pak Sham, Ronald Y L Che. A meta-analysis of association studies between the 10-repeat allele of a VNTR polymorphism in the 3'-UTR of dopamine transporter gene and attention deficit hyperactivity disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 4. 2007-08-14. PMID:17440978. |
the association between the 10-repeat allele of the dopamine transporter gene (dat) and attention deficit hyperactivity disorder (adhd) is uncertain. |
2007-08-14 |
2023-08-12 |
Not clear |
| F Wuest, M Berndt, K Strobel, J van den Hoff, X Peng, J L Neumeyer, R Bergman. Synthesis and radiopharmacological characterization of 2beta-carbo-2'-[18F]fluoroethoxy-3beta-(4-bromo-phenyl)tropane ([18F]MCL-322) as a PET radiotracer for imaging the dopamine transporter (DAT). Bioorganic & medicinal chemistry. vol 15. issue 13. 2007-08-13. PMID:17467995. |
synthesis and radiopharmacological characterization of 2beta-carbo-2'-[18f]fluoroethoxy-3beta-(4-bromo-phenyl)tropane ([18f]mcl-322) as a pet radiotracer for imaging the dopamine transporter (dat). |
2007-08-13 |
2023-08-12 |
human |
| F Wuest, M Berndt, K Strobel, J van den Hoff, X Peng, J L Neumeyer, R Bergman. Synthesis and radiopharmacological characterization of 2beta-carbo-2'-[18F]fluoroethoxy-3beta-(4-bromo-phenyl)tropane ([18F]MCL-322) as a PET radiotracer for imaging the dopamine transporter (DAT). Bioorganic & medicinal chemistry. vol 15. issue 13. 2007-08-13. PMID:17467995. |
the fluoroalkyl-containing tropane derivative 2beta-carbo-2'-fluoroethoxy-3beta-(4-bromo-phenyl)tropane (mcl-322) is a highly potent and moderately selective ligand for the dopamine transporter (dat). |
2007-08-13 |
2023-08-12 |
human |
| Maria-João Ribeiro, Marcel Ricard, Marie-Angele Lièvre, Sandrine Bourgeois, Patrick Emond, Philippe Gervais, Frédéric Dollé, André Syrot. Whole-body distribution and radiation dosimetry of the dopamine transporter radioligand [(11)C]PE2I in healthy volunteers. Nuclear medicine and biology. vol 34. issue 4. 2007-08-13. PMID:17499737. |
[(11)c]pe2i is used in positron emission tomography (pet) for examination of the dopamine neuronal transporter (dat). |
2007-08-13 |
2023-08-12 |
human |
| Louis R Lucas, Ching-Jung Wang, Trudy J McCall, Bruce S McEwe. Effects of immobilization stress on neurochemical markers in the motivational system of the male rat. Brain research. vol 1155. 2007-08-13. PMID:17511973. |
a trio of indirect markers associated with dopaminergic activity was measured including dopamine transporter (dat) and dopamine d2 receptor subtype (d2r) ligand levels as well as mrna levels of the endogenous opioid enkephalin (enk-mrna). |
2007-08-13 |
2023-08-12 |
rat |
| Morten Ziebell, Gerda Thomsen, Gitte M Knudsen, Robin de Nijs, Claus Svarer, Aase Wagner, Lars H Pinbor. Reproducibility of [123I]PE2I binding to dopamine transporters with SPECT. European journal of nuclear medicine and molecular imaging. vol 34. issue 1. 2007-08-09. PMID:16896668. |
the iodinated cocaine derivative [(123)i]pe2i is a new selective ligand for in vivo studies of the dopamine transporter (dat) with spect. |
2007-08-09 |
2023-08-12 |
human |
| Rong Chen, Minjia Zhang, Soo Park, Margaret E Gneg. C57BL/6J mice show greater amphetamine-induced locomotor activation and dopamine efflux in the striatum than 129S2/SvHsd mice. Pharmacology, biochemistry, and behavior. vol 87. issue 1. 2007-08-06. PMID:17524461. |
the differential amph effects could not be explained by differences in presynaptic dopamine components such as surface and total dopamine transporter (dat) expression levels, striatal dopamine contents, and dat activity. |
2007-08-06 |
2023-08-12 |
mouse |
| W Michael Caudle, Jennifer L Tillerson, María E Reverón, Gary W Mille. Use-dependent behavioral and neurochemical asymmetry in MPTP mice. Neuroscience letters. vol 418. issue 3. 2007-08-03. PMID:16603316. |
this was manifested as sustained asymmetrical use of the forelimbs during wall exploration, as well as a neurochemical imbalance between striatal hemispheres measured by immunoreactivity of the dopamine terminal markers, dat, vmat2 and th. |
2007-08-03 |
2023-08-12 |
mouse |
| Osamu Kitamura, Itsuo Tokunaga, Takako Gotohda, Shin-ichi Kub. Immunohistochemical investigation of dopaminergic terminal markers and caspase-3 activation in the striatum of human methamphetamine users. International journal of legal medicine. vol 121. issue 3. 2007-07-31. PMID:16622715. |
in this study, we examined the suitability of the immunohistochemical detection of tyrosine hydroxylase (th), dopamine transporter (dat), and vesicular monoamine transporter-2 (vmat2) levels, and caspase-3 activation in the striatum to diagnose meth abuse. |
2007-07-31 |
2023-08-12 |
human |
| Michael R Tilley, Barbara Cagniard, Xiaoxi Zhuang, Dawn D Han, Narry Tiao, Howard H G. Cocaine reward and locomotion stimulation in mice with reduced dopamine transporter expression. BMC neuroscience. vol 8. 2007-07-31. PMID:17584943. |
the dopamine transporter (dat) plays a critical role in regulating dopamine neurotransmission. |
2007-07-31 |
2023-08-12 |
mouse |
| Ming Chi Shih, Edson Amaro, Henrique Ballalai Ferraz, Marcelo Queiroz Hoexter, Fabricio Oliveira Goulart, Jairo Wagner, Li Fu Lin, Ying Kai Fu, Jair Jesus Mari, Acioly Luiz Tavares de Lacerda, Sergio Tufik, Rodrigo Affonseca Bressa. [Neuroimaging of the dopamine transporter in Parkinsons disease: first study using [99mTc]-TRODAT-1 and SPECT in Brazil]. Arquivos de neuro-psiquiatria. vol 64. issue 3A. 2007-07-30. PMID:17119808. |
dopamine transporter (dat) neuroimaging radiotracers were developed to estimate dopamine neuronal loss in vivo in parkinsons disease (pd). |
2007-07-30 |
2023-08-12 |
Not clear |
| Nicole L Bjorklund, Trent J Volz, James O Schen. Differential effects of Zn2+ on the kinetics and cocaine inhibition of dopamine transport by the human and rat dopamine transporters. European journal of pharmacology. vol 565. issue 1-3. 2007-07-26. PMID:17408612. |
recent literature has shown zn2+ inhibits dopamine transport by the dopamine transporter (dat), the main target of cocaine and some other drugs of abuse. |
2007-07-26 |
2023-08-12 |
human |
| Nicole L Bjorklund, Trent J Volz, James O Schen. Differential effects of Zn2+ on the kinetics and cocaine inhibition of dopamine transport by the human and rat dopamine transporters. European journal of pharmacology. vol 565. issue 1-3. 2007-07-26. PMID:17408612. |
cocaine inhibits dat and modulation of the dat by zn2+ may alter effects of cocaine on dopamine neurotransmission. |
2007-07-26 |
2023-08-12 |
human |
| Nicole L Bjorklund, Trent J Volz, James O Schen. Differential effects of Zn2+ on the kinetics and cocaine inhibition of dopamine transport by the human and rat dopamine transporters. European journal of pharmacology. vol 565. issue 1-3. 2007-07-26. PMID:17408612. |
in contrast, zn2+ did not alter transport by rat dat (rdat), with km and vmax values of 1.2+/-0.49 microm and 15.7+/-2.57 pmol/(sx10(6) cells), respectively, and removal of zn2+ did not increase dopamine transport values. |
2007-07-26 |
2023-08-12 |
human |