| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aurélie Kas, Pierre Payoux, Marie-Odile Habert, Zoulikha Malek, Yann Cointepas, Georges El Fakhri, Philippe Chaumet-Riffaud, Emmanuel Itti, Philippe Rem. Validation of a standardized normalization template for statistical parametric mapping analysis of 123I-FP-CIT images. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 48. issue 9. 2007-11-27. PMID:17704252. |
(123)i-fp-cit ((123)i-n-omega-fluoropropyl-2beta-carbomethoxy-3beta-(4-iodophenyl)nortropane) is a spect dopamine transporter (dat) tracer that probes dopaminergic cell loss in parkinson's disease (pd). |
2007-11-27 |
2023-08-12 |
Not clear |
| Elia Zomot, Annie Bendahan, Matthias Quick, Yongfang Zhao, Jonathan A Javitch, Baruch I Kanne. Mechanism of chloride interaction with neurotransmitter:sodium symporters. Nature. vol 449. issue 7163. 2007-11-26. PMID:17704762. |
equivalent mutations introduced in the mouse gaba transporter gat4 (slc6a11) and the human dopamine transporter dat (slc6a3) also result in chloride-independent transport, whereas the reciprocal mutations in leut and tyt1 render substrate binding and/or uptake by these bacterial nss chloride dependent. |
2007-11-26 |
2023-08-12 |
mouse |
| Anne Larsson, Susanna Jakobson Mo, Torbjörn Sundström, Katrine Riklun. Gaussian prefiltering of 123I DAT SPECT images when using depth-independent resolution recovery. Physics in medicine and biology. vol 52. issue 18. 2007-11-26. PMID:17804873. |
the evaluation was performed for (123)i dopamine transporter (dat) spect images. |
2007-11-26 |
2023-08-12 |
Not clear |
| Johnny Vercouillie, Winnie Deuther-Conrad, Matthias Scheunemann, Patrick Emond, Steffen Fischer, Uta Funke, Jörg Steinbach, Denis Guilloteau, Peter Brus. New fluoro-diphenylchalcogen derivatives to explore the serotonin transporter by PET. Bioorganic & medicinal chemistry letters. vol 17. issue 17. 2007-11-20. PMID:17658253. |
the compounds were synthesized and assayed toward the serotonin (sert), dopamine (dat), and norepinephrine (net) transporters. |
2007-11-20 |
2023-08-12 |
Not clear |
| b' Xavier Cald\\xc3\\xba, Pere Vendrell, David Bartr\\xc3\\xa9s-Faz, Inmaculada Clemente, N\\xc3\\xbaria Bargall\\xc3\\xb3, Mar\\xc3\\xada Angeles Jurado, Josep Maria Serra-Grabulosa, Carme Junqu\\xc3\\xa. Impact of the COMT Val108/158 Met and DAT genotypes on prefrontal function in healthy subjects. NeuroImage. vol 37. issue 4. 2007-11-20. PMID:17689985.' |
two limiting factors of dopamine activity are the catechol-o-methyltransferase (comt) and the dopamine transporter (dat), which terminate dopamine activity by degradation and uptake, respectively. |
2007-11-20 |
2023-08-12 |
human |
| E M Meisenzahl, G J Schmitt, J Scheuerecker, H-J Mölle. The role of dopamine for the pathophysiology of schizophrenia. International review of psychiatry (Abingdon, England). vol 19. issue 4. 2007-11-13. PMID:17671867. |
a third focus concentrates on giving a short survey of spect and pet studies measuring the amount of the striatal and extrastriatal da, the striatal and extrastriatal dopamine d2 receptor, and the dopamine transporter (dat) comparing first-episode, drug-naïve, treated, and relapsing schizophrenic patients and healthy control persons. |
2007-11-13 |
2023-08-12 |
Not clear |
| Anna Moszczynska, Jumana Saleh, Hongyu Zhang, Brian Vukusic, Frank J S Lee, Fang Li. Parkin disrupts the alpha-synuclein/dopamine transporter interaction: consequences toward dopamine-induced toxicity. Journal of molecular neuroscience : MN. vol 32. issue 3. 2007-11-13. PMID:17873367. |
previously, we have reported that alpha-synuclein directly couples to the carboxyl tail of the dopamine transporter (dat) and that the alpha-synuclein/dat protein complex formation accelerates dat-mediated cellular dopamine (da) uptake and da-induced cellular apoptosis. |
2007-11-13 |
2023-08-12 |
Not clear |
| Amy B Manning-Boğ, W Michael Caudle, Xiomara A Perez, Stephen H Reaney, Ronald Paletzki, Martha Z Isla, Vivian P Chou, Alison L McCormack, Gary W Miller, J William Langston, Charles R Gerfen, Donato A Dimont. Increased vulnerability of nigrostriatal terminals in DJ-1-deficient mice is mediated by the dopamine transporter. Neurobiology of disease. vol 27. issue 2. 2007-11-07. PMID:17560790. |
western analyses of synaptosomes revealed significantly higher dopamine transporter (dat) levels in pre-synaptic membrane fractions. |
2007-11-07 |
2023-08-12 |
mouse |
| Erika M Adkins, Devadoss J Samuvel, Jacob U Fog, Jacob Eriksen, Lankupalle D Jayanthi, Christian Bjerggaard Vaegter, Sammanda Ramamoorthy, Ulrik Gethe. Membrane mobility and microdomain association of the dopamine transporter studied with fluorescence correlation spectroscopy and fluorescence recovery after photobleaching. Biochemistry. vol 46. issue 37. 2007-11-06. PMID:17711354. |
to investigate microdomain association of the dopamine transporter (dat), we employed fcs (fluorescence correlation spectroscopy) and frap (fluorescence recovery after photobleaching). |
2007-11-06 |
2023-08-12 |
rat |
| Erika M Adkins, Devadoss J Samuvel, Jacob U Fog, Jacob Eriksen, Lankupalle D Jayanthi, Christian Bjerggaard Vaegter, Sammanda Ramamoorthy, Ulrik Gethe. Membrane mobility and microdomain association of the dopamine transporter studied with fluorescence correlation spectroscopy and fluorescence recovery after photobleaching. Biochemistry. vol 46. issue 37. 2007-11-06. PMID:17711354. |
it was, moreover, observed that cholesterol depletion, and thereby membrane raft disruption, decreased both the vmax and km values for [3h]dopamine uptake without altering dat surface expression. |
2007-11-06 |
2023-08-12 |
rat |
| Risa Sakai, Yoshifumi Irie, Takeshi Murata, Atsushi Ishige, Naoko Anjiki, Kenji Watanab. Toki-to protects dopaminergic neurons in the substantia nigra from neurotoxicity of MPTP in mice. Phytotherapy research : PTR. vol 21. issue 9. 2007-10-29. PMID:17486689. |
real-time rt-pcr analyses of mrna from sns demonstrated that expression of tyrosine hydroxylase (th) and dopamine transporter (dat) genes were decreased by mptp treatment and that these decreases were reversed by tkt administration prior to mptp treatment. |
2007-10-29 |
2023-08-12 |
mouse |
| Birte Drewes, Wiebke Sihver, Sabine Willbold, Ray A Olsson, Heinz H Coene. New 2alpha-tropane amides as potential PET ligands for the dopamine transporter. Nuclear medicine and biology. vol 34. issue 5. 2007-10-25. PMID:17591553. |
positron emission tomography (pet) imaging of dopamine transporter (dat) density in the brain is a potentially valuable tool for studying the etiopathology of degenerative brain disorders. |
2007-10-25 |
2023-08-12 |
rat |
| S Karakaya, M Kipp, C Beye. Oestrogen regulates the expression and function of dopamine transporters in astrocytes of the nigrostriatal system. Journal of neuroendocrinology. vol 19. issue 9. 2007-10-23. PMID:17680883. |
dopamine is actively and specifically eliminated from the extracellular space by astrocytes and neurones through dopamine transporters (dat) and, afterwards, either recycled into vesicles or metabolised. |
2007-10-23 |
2023-08-12 |
Not clear |
| S Karakaya, M Kipp, C Beye. Oestrogen regulates the expression and function of dopamine transporters in astrocytes of the nigrostriatal system. Journal of neuroendocrinology. vol 19. issue 9. 2007-10-23. PMID:17680883. |
accordingly, we investigated the contribution of local astroglial for extracellular dopamine elimination and the impact of oestrogen on dat expression and activity. |
2007-10-23 |
2023-08-12 |
Not clear |
| S Karakaya, M Kipp, C Beye. Oestrogen regulates the expression and function of dopamine transporters in astrocytes of the nigrostriatal system. Journal of neuroendocrinology. vol 19. issue 9. 2007-10-23. PMID:17680883. |
using neonatal striatal and midbrain astrocyte cultures, we could demonstrate that astrocytes possess a specific dopamine uptake machinery and express dat at considerable levels. |
2007-10-23 |
2023-08-12 |
Not clear |
| S Karakaya, M Kipp, C Beye. Oestrogen regulates the expression and function of dopamine transporters in astrocytes of the nigrostriatal system. Journal of neuroendocrinology. vol 19. issue 9. 2007-10-23. PMID:17680883. |
in conclusion, our data suggest that the positive reinforcement of dopamine transmission under physiological conditions and the alleviative impact of oestrogen under pathological conditions may be the result of a decline in dat expression and therefore delayed dopamine uptake by astroglia. |
2007-10-23 |
2023-08-12 |
Not clear |
| Christophe Plisson, Jeffrey S Stehouwer, Ronald J Voll, Leonard Howell, John R Votaw, Michael J Owens, Mark M Goodma. Synthesis and in vivo evaluation of fluorine-18 and iodine-123 labeled 2beta-carbo(2-fluoroethoxy)-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane as a candidate serotonin transporter imaging agent. Journal of medicinal chemistry. vol 50. issue 19. 2007-10-23. PMID:17705359. |
the binding affinity of 1 to human monoamine transporters showed a high affinity for the sert (ki = 0.08 nm) with respect to the dopamine transporter (dat) (ki = 13 nm) and the norepinephrine transporter (net) (ki = 28 nm). |
2007-10-23 |
2023-08-12 |
human |
| A Bailey, J H Yoo, I Racz, A Zimmer, I Kitche. Preprodynorphin mediates locomotion and D2 dopamine and mu-opioid receptor changes induced by chronic 'binge' cocaine administration. Journal of neurochemistry. vol 102. issue 6. 2007-10-19. PMID:17532787. |
furthermore, we have measured mu-opioid receptor (mop-r) agonist-stimulated [(35)s]gtpgammas, dopamine d(1), d(2) receptor and dopamine transporter (dat) binding. |
2007-10-19 |
2023-08-12 |
mouse |
| Catrin Wernicke, Yvonne Schott, Christoph Enzensperger, Gert Schulze, Jochen Lehmann, Hans Rommelspache. Cytotoxicity of beta-carbolines in dopamine transporter expressing cells: structure-activity relationships. Biochemical pharmacology. vol 74. issue 7. 2007-10-19. PMID:17692827. |
neutral, rather lipophilic bcs may pass the plasma membrane and the outer and inner mitochondrial membranes by diffusion whereas the cationic, more polar compounds, can be transported by the dopamine transporter (dat). |
2007-10-19 |
2023-08-12 |
human |
| Catrin Wernicke, Yvonne Schott, Christoph Enzensperger, Gert Schulze, Jochen Lehmann, Hans Rommelspache. Cytotoxicity of beta-carbolines in dopamine transporter expressing cells: structure-activity relationships. Biochemical pharmacology. vol 74. issue 7. 2007-10-19. PMID:17692827. |
a dimeric bc-cation was readily transported by the dat despite its much larger structure compared to dopamine. |
2007-10-19 |
2023-08-12 |
human |