| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Florian Doepp, Michail Plotkin, Lara Siegel, Anatol Kivi, Doreen Gruber, Elmar Lobsien, Andreas Kupsch, Stephan J Schreibe. Brain parenchyma sonography and 123I-FP-CIT SPECT in Parkinson's disease and essential tremor. Movement disorders : official journal of the Movement Disorder Society. vol 23. issue 3. 2008-05-08. PMID:18067184. |
the echogenicity of the substantia nigra (sn) and the striatal binding of dopamine transporters (dat) were evaluated by tcs and fp-cit spect, respectively. |
2008-05-08 |
2023-08-12 |
Not clear |
| J J Zaknun, H Schücktanz, F Aichne. Impact of instrumentation on DaTSCAN imaging: how feasible is the concept of cross-systems correction factor? The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of.... vol 51. issue 2. 2008-05-06. PMID:17220822. |
the aim of this investigation was to study the impact of applying different camera emission computed tomography (ect) systems on semi-quantitative analysis of the novel dopamine transporter (dat) radioligand [123i]-ioflupane (datscan) and whether applying a system-dependent correction factor is feasible to allow a migration of a ''normal'' reference data set between systems. |
2008-05-06 |
2023-08-12 |
Not clear |
| Timothy South, Xu-Feng Huan. High-fat diet exposure increases dopamine D2 receptor and decreases dopamine transporter receptor binding density in the nucleus accumbens and caudate putamen of mice. Neurochemical research. vol 33. issue 3. 2008-05-06. PMID:17940894. |
this experiment examined dopamine d2 receptor and its transporter (dat) density in mice fed a high-fat or low-fat diet for twenty days as well as fed twenty days of high-fat diet then changed to low-fat diet for one and seven days. |
2008-05-06 |
2023-08-12 |
mouse |
| Chun-Hung Lin, Jui-Yen Huang, Cheng-Hsin Ching, Jih-Ing Chuan. Melatonin reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats. Journal of pineal research. vol 44. issue 2. 2008-05-05. PMID:18289173. |
because the uptake of mpp(+) is mediated by the dopamine transporter (dat), we used a cell-permeable rotenone-induced pd model to investigate the role of dat and dopamine d2 receptor (d2r) on dopaminergic neuronal loss. |
2008-05-05 |
2023-08-12 |
rat |
| Chun-Hung Lin, Jui-Yen Huang, Cheng-Hsin Ching, Jih-Ing Chuan. Melatonin reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats. Journal of pineal research. vol 44. issue 2. 2008-05-05. PMID:18289173. |
rotenone subcutaneously infused for 14 days induced pd symptoms in rats, as indicated by reduced spontaneous locomotor activity (hypokinesis), loss of tyrosine hydroxylase (th, a marker enzyme for dopamine neurons) immunoreactivity in the substantia nigra and striatum, obvious alpha-synuclein accumulation, downregulated dat protein expression, and upregulated d2r expression. |
2008-05-05 |
2023-08-12 |
rat |
| Yen Kuang Yang, Wei Jen Yao, Tzung Lieh Yeh, I Hui Lee, Po See Chen, Ru Band Lu, Nan Tsing Chi. Decreased dopamine transporter availability in male smokers -- a dual isotope SPECT study. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 1. 2008-05-02. PMID:17900774. |
to delineate the role of tobacco addiction in central pre- and post-synaptic dopaminergic activities, we analyzed the central d2-family receptors, the dopamine transporters (dat), and degrees of dependence in male smokers. |
2008-05-02 |
2023-08-12 |
Not clear |
| Clare J Wilhelm, Robert A Johnson, Amy J Eshleman, Aaron Janowsk. Lobeline effects on tonic and methamphetamine-induced dopamine release. Biochemical pharmacology. vol 75. issue 6. 2008-04-29. PMID:18191815. |
the mechanisms of interaction between lobeline and the dopamine transporter (dat) or the vesicular monoamine transporter (vmat-2) are not clear. |
2008-04-29 |
2023-08-12 |
Not clear |
| Ming-Kai Chen, Hiroto Kuwabara, Yun Zhou, Robert J Adams, James R Brasić, Jennifer L McGlothan, Tatyana Verina, Neal C Burton, Mohab Alexander, Anil Kumar, Dean F Wong, Tomás R Guilart. VMAT2 and dopamine neuron loss in a primate model of Parkinson's disease. Journal of neurochemistry. vol 105. issue 1. 2008-04-28. PMID:17988241. |
in vivo levels of dopamine transporters (dat), vesicular monoamine transporter-type 2 (vmat2), amphetamine-induced dopamine release (amph-dar), d2-dopamine receptors (d2r) and translocator protein 18 kda (tspo) were measured longitudinally in the striatum of mptp-treated animals. |
2008-04-28 |
2023-08-12 |
Not clear |
| Po See Chen, Yen Kuang Yang, Tzung Lieh Yeh, I-Hui Lee, Wei Jen Yao, Nan Tsing Chiu, Ru Band L. Correlation between body mass index and striatal dopamine transporter availability in healthy volunteers--a SPECT study. NeuroImage. vol 40. issue 1. 2008-04-23. PMID:18096411. |
to investigate this relationship, the striatal dopamine transporter (dat) availability of 50 healthy volunteers was measured using single position emission computational topography (spect) and [99mtc]-trodat-1. |
2008-04-23 |
2023-08-12 |
human |
| Devadoss J Samuvel, Lankupalle D Jayanthi, Senthilvelan Manohar, Kolanjiappan Kaliyaperumal, Ronald E See, Sammanda Ramamoorth. Dysregulation of dopamine transporter trafficking and function after abstinence from cocaine self-administration in rats: evidence for differential regulation in caudate putamen and nucleus accumbens. The Journal of pharmacology and experimental therapeutics. vol 325. issue 1. 2008-04-22. PMID:18198344. |
the profound alterations produced by cocaine on dopamine (da) neurotransmission raise the possibility that dopamine transporter (dat)-expressing neurons may modify da transport in response to repeated cocaine exposure to maintain the appropriate efficiency of da clearance. |
2008-04-22 |
2023-08-12 |
rat |
| Satish K Chitneni, Lucette Garreau, Bernard Cleynhens, Nele Evens, Marva Bex, Peter Vermaelen, Sylvie Chalon, Roger Busson, Denis Guilloteau, Koen Van Laere, Alfons Verbruggen, Guy Borman. Improved synthesis and metabolic stability analysis of the dopamine transporter ligand [(18)F]FECT. Nuclear medicine and biology. vol 35. issue 1. 2008-04-21. PMID:18158946. |
[2'-[(18)f]fluoroethyl (lr-2-exo-3-exe)-8-methyl-3-(4-chlorophenyl)-8-azabicyclo[3.2.1]-octane-2-carboxylate] ([(18)f]fect) is a positron emission tomography (pet) tracer for imaging the dopamine transporter (dat) in vivo. |
2008-04-21 |
2023-08-12 |
rat |
| Martín Indarte, Jeffry D Madura, Christopher K Surrat. Dopamine transporter comparative molecular modeling and binding site prediction using the LeuT(Aa) leucine transporter as a template. Proteins. vol 70. issue 3. 2008-04-18. PMID:17847094. |
pharmacological and behavioral studies indicate that binding of cocaine and the amphetamines by the dopamine transporter (dat) protein is principally responsible for initiating the euphoria and addiction associated with these drugs. |
2008-04-18 |
2023-08-12 |
Not clear |
| Martín Indarte, Jeffry D Madura, Christopher K Surrat. Dopamine transporter comparative molecular modeling and binding site prediction using the LeuT(Aa) leucine transporter as a template. Proteins. vol 70. issue 3. 2008-04-18. PMID:17847094. |
probable dopamine and amphetamine binding sites were identified within the dat model using multiple docking approaches. |
2008-04-18 |
2023-08-12 |
Not clear |
| Li-Xing Liu, Wen-Fang Chen, Jun-Xia Xie, Man-Sau Won. Neuroprotective effects of genistein on dopaminergic neurons in the mice model of Parkinson's disease. Neuroscience research. vol 60. issue 2. 2008-04-18. PMID:18054104. |
the reverse transcription-pcr results also confirmed that the mptp-induced downregulation of th, dopamine transporter (dat) and bcl-2 mrna expression in the midbrain could be restored by genistein or estrogen pretreatment. |
2008-04-18 |
2023-08-12 |
mouse |
| Nachwa Jarkas, Ronald J Voll, Larry Williams, John R Votaw, Mike Owens, Mark M Goodma. Synthesis and in vivo evaluation of halogenated N,N-dimethyl-2-(2'-amino-4'-hydroxymethylphenylthio)benzylamine derivatives as PET serotonin transporter ligands. Journal of medicinal chemistry. vol 51. issue 2. 2008-04-17. PMID:18085744. |
the in vitro binding studies in cells transfected with human sert, norepinephrine transporter (net), and dopamine transporter (dat) showed that 35, 36, and 37 exhibited high sert affinity with k is (sert) = 1.26, 0.29, and 0.31 nm (vs [(3)h]citalopram), respectively. |
2008-04-17 |
2023-08-12 |
human |
| X Cen, A Nitta, D Ibi, Y Zhao, M Niwa, K Taguchi, M Hamada, Y Ito, Y Ito, L Wang, T Nabeshim. Identification of Piccolo as a regulator of behavioral plasticity and dopamine transporter internalization. Molecular psychiatry. vol 13. issue 4. 2008-04-17. PMID:18195717. |
dopamine transporter (dat) internalization is a mechanism underlying the decreased dopamine reuptake caused by addictive drugs like methamphetamine (meth). |
2008-04-17 |
2023-08-12 |
mouse |
| X Cen, A Nitta, D Ibi, Y Zhao, M Niwa, K Taguchi, M Hamada, Y Ito, Y Ito, L Wang, T Nabeshim. Identification of Piccolo as a regulator of behavioral plasticity and dopamine transporter internalization. Molecular psychiatry. vol 13. issue 4. 2008-04-17. PMID:18195717. |
expression of piccolo c2a domain attenuated meth-induced inhibition of dopamine uptake in pc12 cells expressing human dat. |
2008-04-17 |
2023-08-12 |
mouse |
| L Keith Henry, Jens Meiler, Randy D Blakel. Bound to be different: neurotransmitter transporters meet their bacterial cousins. Molecular interventions. vol 7. issue 6. 2008-04-17. PMID:18199851. |
the neurotransmitter transporters belonging to the solute carrier 6 (slc6) family, including the gamma-aminobutyric acid (gat), norepinephrine (net), serotonin (sert) and dopamine (dat) transporters are extremely important drug targets of great clinical relevance. |
2008-04-17 |
2023-08-12 |
human |
| Christoph Scherfler, Johannes Schwarz, Angelo Antonini, Donald Grosset, Francesc Valldeoriola, Kenneth Marek, Wolfgang Oertel, Eduardo Tolosa, Andrew J Lees, Werner Poew. Role of DAT-SPECT in the diagnostic work up of parkinsonism. Movement disorders : official journal of the Movement Disorder Society. vol 22. issue 9. 2008-04-16. PMID:17486648. |
loss of striatal dopamine nerve terminal function, a hallmark of neurodegenerative parkinsonism, is strongly related to decreases of dopamine transporter (dat) density, which can be measured by single photon emission computed tomography (spect). |
2008-04-16 |
2023-08-12 |
human |
| Jie Shi, Li-Yan Zhao, Marc L Copersino, Yu-Xia Fang, Yingmao Chen, Jiahe Tian, Yanping Deng, Yinliang Shuai, Jun Jin, Lin L. PET imaging of dopamine transporter and drug craving during methadone maintenance treatment and after prolonged abstinence in heroin users. European journal of pharmacology. vol 579. issue 1-3. 2008-04-15. PMID:17977528. |
to establish whether chronic opiate use might impair brain dopamine neurons in humans, we assessed dopamine transporter (dat) uptake function in the striatum (caudate and putamen), and analyzed the correlation between dat in the striatum and heroin craving and subjective anxiety in former heroin users with prolonged abstinence and in patients receiving methadone maintenance treatment. |
2008-04-15 |
2023-08-12 |
human |