| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patrick Emond, Denis Guilloteau, Sylvie Chalo. PE2I: a radiopharmaceutical for in vivo exploration of the dopamine transporter. CNS neuroscience & therapeutics. vol 14. issue 1. 2008-08-01. PMID:18482099. |
the membrane dopamine transporter (dat) has a pivotal role in the regulation of dopamine (da) neurotransmission involved in a number of physiological functions and brain disorders. |
2008-08-01 |
2023-08-12 |
human |
| Jin-Jun Qian, Yan-Bo Cheng, Ya-Ping Yang, Cheng-Jie Mao, Zheng-Hong Qin, Kai Li, Chun-Feng Li. Differential effects of overexpression of wild-type and mutant human alpha-synuclein on MPP+-induced neurotoxicity in PC12 cells. Neuroscience letters. vol 435. issue 2. 2008-07-30. PMID:18342443. |
increasing evidence suggests the involvement of alpha-synuclein, the dopamine transporter (dat), and neurotoxins in the pathogenesis of pd, but their relationships to the death of nigral cells remains poorly understood. |
2008-07-30 |
2023-08-12 |
human |
| Andrea Panzacchi, Rosa Maria Moresco, Valentina Garibotto, Angelo Antonini, Clara Gobbo, Ioannis U Isaias, Stefano Goldwurm, Lorena Bonaldi, Assunta Carpinelli, Gianni Pezzoli, Ferruccio Fazio, Daniela Peran. A voxel-based PET study of dopamine transporters in Parkinson's disease: relevance of age at onset. Neurobiology of disease. vol 31. issue 1. 2008-07-29. PMID:18502656. |
we used positron emission tomography (pet) and the dopamine transporter (dat) ligand [(11)c]fecit to measure loss of nigrostriatal dopaminergic neurons in early phase of early onset (eopd) and late onset parkinson's disease (lopd). |
2008-07-29 |
2023-08-12 |
human |
| Julie Kniazeff, Lei Shi, Claus J Loland, Jonathan A Javitch, Harel Weinstein, Ulrik Gethe. An intracellular interaction network regulates conformational transitions in the dopamine transporter. The Journal of biological chemistry. vol 283. issue 25. 2008-07-25. PMID:18426798. |
here we combine computational modeling and experimental probing in the dopamine transporter (dat) to demonstrate the functional importance of a conserved intracellular interaction network. |
2008-07-25 |
2023-08-12 |
Not clear |
| Donatella Marazziti, Stefano Baroni, Mario Catena Dell'Osso, Irene Masala, Laura Fabbrini, Laura Betti, Gino Giannaccini, Bernardo Dell'osso, Antonio Lucacchin. Presence and characterization of the dopamine transporter in human resting lymphocytes. Neurochemical research. vol 33. issue 6. 2008-07-24. PMID:18038207. |
the paucity of information on the presence of the dopamine transporter (dat) in blood cells, prompted us to explore it in human resting lymphocytes by means of the binding of 3h-win 35,428, a compound which is currently considered the most selective ligand for labelling this protein, and by means of the specific reuptake of 3h-dopamine (3h-da). |
2008-07-24 |
2023-08-12 |
human |
| Brandon J Lute, Habibeh Khoshbouei, Christine Saunders, Namita Sen, Richard Z Lin, Jonathan A Javitch, Aurelio Gall. PI3K signaling supports amphetamine-induced dopamine efflux. Biochemical and biophysical research communications. vol 372. issue 4. 2008-07-24. PMID:18510945. |
the dopamine (da) transporter (dat) is a major molecular target of the psychostimulant amphetamine (amph). |
2008-07-24 |
2023-08-12 |
Not clear |
| Cassandra M Miller-Butterworth, Jay R Kaplan, John Shaffer, Bernie Devlin, Stephen B Manuck, Robert E Ferrel. Sequence variation in the primate dopamine transporter gene and its relationship to social dominance. Molecular biology and evolution. vol 25. issue 1. 2008-07-16. PMID:17934207. |
dopaminergic activity is modulated by the dopamine transporter (dat), and the gene encoding this transporter is therefore an excellent candidate for studies aiming to identify variants of functional or evolutionary significance. |
2008-07-16 |
2023-08-12 |
human |
| Ling-Wei Hsin, Li-Te Chang, Richard B Rothman, Christina M Dersch, Arthur E Jacobson, Kenner C Ric. Design and synthesis of 2- and 3-substituted-3-phenylpropyl analogs of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine: role of amino, fluoro, hydroxyl, methoxyl, methyl, methylene, and oxo substituents on affinity for the dopamine and serotonin transporters. Journal of medicinal chemistry. vol 51. issue 9. 2008-07-09. PMID:18393401. |
novel derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (gbr 12909, 1) and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (gbr 12935, 2) with various substituents in positions c2 and c3 of the phenylpropyl side chain were synthesized and evaluated for their ability to bind to the dopamine transporter (dat) and the serotonin transporter (sert). |
2008-07-09 |
2023-08-12 |
Not clear |
| Masanori Asada, Satoru Ebihara, Yohtaro Numachi, Tatsuma Okazaki, Shinsuke Yamanda, Kazutaka Ikeda, Hiroyasu Yasuda, Ichiro Sora, Hiroyuki Ara. Reduced tumor growth in a mouse model of schizophrenia, lacking the dopamine transporter. International journal of cancer. vol 123. issue 3. 2008-07-03. PMID:18470912. |
here, we hypothesized that tumor growth was reduced in a mouse model of schizophrenia, lacking the dopamine transporter (dat), and investigated tumor growth and angiogenesis in dat knockout mice. |
2008-07-03 |
2023-08-12 |
mouse |
| R Djaldetti, B I Nageris, M Lorberboym, T A Treves, E Melamed, E Yani. [(123)I]-FP-CIT SPECT and olfaction test in patients with combined postural and rest tremor. Journal of neural transmission (Vienna, Austria : 1996). vol 115. issue 3. 2008-07-01. PMID:18250955. |
the mixed-tremor group was also evaluated with spect imaging using the dopamine transporter (dat) ligand (123)i-labeled fp-cit. |
2008-07-01 |
2023-08-12 |
human |
| Jussi Hirvonen, Jarkko Johansson, Mika Teräs, Vesa Oikonen, Ville Lumme, Pauliina Virsu, Anne Roivainen, Kjell Någren, Christer Halldin, Lars Farde, Jarmo Hietal. Measurement of striatal and extrastriatal dopamine transporter binding with high-resolution PET and [11C]PE2I: quantitative modeling and test-retest reproducibility. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 28. issue 5. 2008-06-26. PMID:18183028. |
[(11)c]pe2i is a novel positron emission tomography (pet) radiotracer for the dopamine transporter (dat). |
2008-06-26 |
2023-08-12 |
human |
| Susanne Jørgensen, Elsebet Østergaard Nielsen, Dan Peters, Tino Dyhrin. Validation of a fluorescence-based high-throughput assay for the measurement of neurotransmitter transporter uptake activity. Journal of neuroscience methods. vol 169. issue 1. 2008-06-23. PMID:18222006. |
pre-synaptic dopamine, norepinephrine and serotonin transporters (dat, net and sert) terminate synaptic catecholamine transmission through reuptake of released neurotransmitter. |
2008-06-23 |
2023-08-12 |
Not clear |
| R Díaz-Heijtz, F Mulas, H Forssber. [Alterations in the pattern of dopaminergic markers in attention-deficit/hyperactivity disorder]. Revista de neurologia. vol 42 Suppl 2. 2008-06-17. PMID:16555214. |
given support to this theory is the observation from human imaging studies that mph blocks the dopamine transporter (dat), the main mechanism for removing dopamine from the synapse; thereby increasing extracellular dopamine levels in the striatum. |
2008-06-17 |
2023-08-12 |
human |
| R Díaz-Heijtz, F Mulas, H Forssber. [Alterations in the pattern of dopaminergic markers in attention-deficit/hyperactivity disorder]. Revista de neurologia. vol 42 Suppl 2. 2008-06-17. PMID:16555214. |
genetic and molecular studies have also demonstrated an association between dopamine related genes (e.g., dat, dopamine d4 and d5 receptors) and adhd. |
2008-06-17 |
2023-08-12 |
human |
| Claudia M Szobot, Ming Chi Shih, Thais Schaefer, Neivo Júnior, Marcelo Q Hoexter, Ying Kai Fu, Flávio Pechansky, Rodrigo A Bressan, Luis A P Rohd. Methylphenidate DAT binding in adolescents with Attention-Deficit/ Hyperactivity Disorder comorbid with Substance Use Disorder--a single photon emission computed tomography with [Tc(99m)]TRODAT-1 study. NeuroImage. vol 40. issue 3. 2008-06-17. PMID:18282769. |
effects of methylphenidate (mph) on adhd are attributed to its properties of blocking the dopamine transporter (dat) in the striatum. |
2008-06-17 |
2023-08-12 |
human |
| Manoj Mishra, Rohit Kolhatkar, Juan Zhen, Ingrid Parrington, Maarten E A Reith, Aloke K Dutt. Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an exocyclic hydroxyl group: interaction with dopamine, serotonin, and norepinephrine transporters. Bioorganic & medicinal chemistry. vol 16. issue 6. 2008-06-13. PMID:18249549. |
all synthesized derivatives were tested for their affinities for the dopamine transporter (dat), serotonin (5-ht) transporter (sert), and norepinephrine transporter (net) in the brain by measuring their potency in inhibiting the uptake of [(3)h]da, [(3)h]5-ht, and [(3)h]ne, respectively. |
2008-06-13 |
2023-08-12 |
Not clear |
| Bin Liu, Jun Xia Xie, Lai Ling Tsang, Dewi Kenneth Rowlands, Lok Sze Ho, Yu Lin Gou, Yiu Wa Chung, Hsiao Chang Cha. Bak Foong protects dopaminergic neurons against MPTP-induced neurotoxicity by its anti-apoptotic activity. Cell biology international. vol 32. issue 1. 2008-06-12. PMID:17920944. |
in the present study, we have investigated the possible neuroprotective action of bfp upon the nigrostriatal dopaminergic system by examining its effect on the expression patterns of tyrosine hydroxylase (th) and dopamine transporter (dat) in the 1-methyl-4-phenyl-1,2,3,6-tetrahyrdropyridine (mptp)-induced parkinson's disease (pd) mouse model. |
2008-06-12 |
2023-08-12 |
mouse |
| Ekaterina Boudanova, Deanna M Navaroli, Haley E Melikia. Amphetamine-induced decreases in dopamine transporter surface expression are protein kinase C-independent. Neuropharmacology. vol 54. issue 3. 2008-06-12. PMID:18164041. |
amphetamine (amph) is a potent dopamine (da) transporter (dat) inhibitor that markedly increases extracellular da levels. |
2008-06-12 |
2023-08-12 |
Not clear |
| James D Foster, Steven D Adkins, John R Lever, Roxanne A Vaugha. Phorbol ester induced trafficking-independent regulation and enhanced phosphorylation of the dopamine transporter associated with membrane rafts and cholesterol. Journal of neurochemistry. vol 105. issue 5. 2008-06-12. PMID:18248623. |
we examined the mechanisms involved in protein kinase c (pkc)-dependent down-regulation of dopamine transporter (dat) activity and cell surface expression by treating heterologously expressing cells with the clathrin-mediated endocytosis inhibitor concanavalin a (con a) or the cholesterol depleter/membrane raft disrupter methyl-beta-cyclodextrin (mbetac) prior to treatment with the pkc activator phorbol 12-myristate, 13-acetate (pma). |
2008-06-12 |
2023-08-12 |
Not clear |
| Yen Kuang Yang, Tzung Lieh Yeh, Wei Jen Yao, I Hui Lee, Po See Chen, Nan Tsing Chiu, Ru Band L. Greater availability of dopamine transporters in patients with major depression--a dual-isotope SPECT study. Psychiatry research. vol 162. issue 3. 2008-06-10. PMID:18295460. |
in order to explore the neuropathology of the pre- and post-synaptic dopamine neurons of patients with major depression, we examined striatal d(2)/d(3) receptor uptake and dopamine transporter (dat) availability simultaneously in drug-free depressed patients using a dual-isotope single photon emission computed tomography (spect) imaging technique. |
2008-06-10 |
2023-08-12 |
Not clear |