| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Raul R Gainetdino. Dopamine transporter mutant mice in experimental neuropharmacology. Naunyn-Schmiedeberg's archives of pharmacology. vol 377. issue 4-6. 2008-12-03. PMID:18057916. |
one of the best examples of such use of genetic models in experimental pharmacology represents investigations involving mice deficient in the gene encoding the dopamine transporter (dat). |
2008-12-03 |
2023-08-12 |
mouse |
| Hilary R Smith, Linda J Porrin. The comparative distributions of the monoamine transporters in the rodent, monkey, and human amygdala. Brain structure & function. vol 213. issue 1-2. 2008-12-02. PMID:18283492. |
the dopamine transporter (dat) is consistently found to be extremely sparsely distributed, however the various accounts of its subregional topography are inconsistent, making any cross-species comparisons difficult. |
2008-12-02 |
2023-08-12 |
human |
| Regina C C Kubrusly, Rogerio Panizzutti, Patricia F Gardino, Bernardo Stutz, Ricardo A M Reis, Ana Lucia M Ventura, Maria Christina F de Mello, Fernando G de Mell. Expression of functional dopaminergic phenotype in purified cultured Müller cells from vertebrate retina. Neurochemistry international. vol 53. issue 3-4. 2008-11-06. PMID:18582514. |
müller cells purified from developing chick and mouse retinas express l-dopa decarboxylase (ddc; aromatic-l-amino-acid decarboxylase; ec 4.1.1.28) and the dopamine transporter dat. |
2008-11-06 |
2023-08-12 |
mouse |
| Jaime M Hatcher, Kristin C Delea, Jason R Richardson, Kurt D Pennell, Gary W Mille. Disruption of dopamine transport by DDT and its metabolites. Neurotoxicology. vol 29. issue 4. 2008-11-05. PMID:18533268. |
in vitro analyses in mouse synaptosomes and vesicles demonstrated that ddt and its metabolites inhibit the plasma membrane dopamine transporter (dat) and the vesicular monoamine transporter (vmat2). |
2008-11-05 |
2023-08-12 |
mouse |
| Kelly Lengyel, Rick Pieschl, Todd Strong, Thaddeus Molski, Gail Mattson, Nicholas J Lodge, Yu-Wen L. Ex vivo assessment of binding site occupancy of monoamine reuptake inhibitors: methodology and biological significance. Neuropharmacology. vol 55. issue 1. 2008-11-05. PMID:18538356. |
the goal of this study was to develop and validate ex vivo binding assays for serotonin (sert), norepinephrine (net) and dopamine (dat) transporters, and to use these assays to evaluate the binding site occupancy of triple and double monoamine reuptake inhibitors in rat brains. |
2008-11-05 |
2023-08-12 |
rat |
| Jun Mo Kang, Jae-Chul Jung, Heejeong Kim, Heena Lim, Soyong Jang, Seikwan O. Neuroprotective effect of benzylideneacetophenone derivative on the MPTP model of neurodegeneration in mice. Archives of pharmacal research. vol 31. issue 9. 2008-10-28. PMID:18806951. |
immunohistochemistry and western blot were used to determine the expression levels of tyrosine hydroxylase (th), dopamine transporter (dat), ox-42 (a marker of microglial activation), and glial fibrillary acid protein (gfap, a marker of astrocyte activation) in the substantia nigra (sn) and striatum (st). |
2008-10-28 |
2023-08-12 |
mouse |
| Francesca Binda, Concetta Dipace, Erica Bowton, Sabrina D Robertson, Brandon J Lute, Jacob U Fog, Minjia Zhang, Namita Sen, Roger J Colbran, Margaret E Gnegy, Ulrik Gether, Jonathan A Javitch, Kevin Erreger, Aurelio Gall. Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux. Molecular pharmacology. vol 74. issue 4. 2008-10-27. PMID:18617632. |
here, we define the first 33 amino acids of the n terminus of the dopamine (da) transporter (dat) as the site of direct interaction with syn1a. |
2008-10-27 |
2023-08-12 |
human |
| C Marin, E Aguilar, M Bonastr. Effect of locus coeruleus denervation on levodopa-induced motor fluctuations in hemiparkinsonian rats. Journal of neural transmission (Vienna, Austria : 1996). vol 115. issue 8. 2008-10-24. PMID:18528630. |
striatal dopamine transporter (dat) immunohistochemistry was performed to evaluate da depletion. |
2008-10-24 |
2023-08-12 |
rat |
| Aloke K Dutta, Balaram Ghosh, Swati Biswas, Maarten E A Reit. D-161, a novel pyran-based triple monoamine transporter blocker: behavioral pharmacological evidence for antidepressant-like action. European journal of pharmacology. vol 589. issue 1-3. 2008-10-24. PMID:18561912. |
one of our lead molecules, d-161 exhibited triple monoamine transporter inhibitory activity with the highest affinity for norepinephrine transporter (net) followed by its affinity for serotonin transporter (sert) and dopamine transporter (dat). |
2008-10-24 |
2023-08-12 |
mouse |
| Yan Sai, Qiang Wu, Weidong Le, Feng Ye, Yunpeng Li, Zhaojun Don. Rotenone-induced PC12 cell toxicity is caused by oxidative stress resulting from altered dopamine metabolism. Toxicology in vitro : an international journal published in association with BIBRA. vol 22. issue 6. 2008-10-21. PMID:18579341. |
tyrosine hydroxylase (th) and vesicular monoamine transporter 2 (vmat(2)) were markedly down-regulated, and dopamine transporter (dat) was up-regulated in the cells. |
2008-10-21 |
2023-08-12 |
rat |
| Soili M Lehto, Tommi Tolmunen, Jyrki Kuikka, Minna Valkonen-Korhonen, Mikko Joensuu, Pirjo I Saarinen, Ritva Vanninen, Pasi Ahola, Jari Tiihonen, Johannes Lehtone. Midbrain serotonin and striatum dopamine transporter binding in double depression: a one-year follow-up study. Neuroscience letters. vol 441. issue 3. 2008-10-20. PMID:18588943. |
we examined the striatum dopamine (dat) and midbrain serotonin transporter (sert) binding of [123i] nor-beta-cit in dd patients (n=8) and compared it to that in md patients (n=11) and healthy controls (n=19). |
2008-10-20 |
2023-08-12 |
Not clear |
| D Nicole Riherd, David G Galindo, Lucretia R Krause, R Dayne Mayfiel. Ethanol potentiates dopamine uptake and increases cell surface distribution of dopamine transporters expressed in SK-N-SH and HEK-293 cells. Alcohol (Fayetteville, N.Y.). vol 42. issue 6. 2008-10-16. PMID:18579334. |
the primary protein responsible for terminating dopamine (da) neurotransmission is the plasma membrane-bound dopamine transporter (dat). |
2008-10-16 |
2023-08-12 |
human |
| Xiaodan Jiang, Ruxiang Xu, Zhijun Yang, Peng Jin, Qiang Xu, Gang Li, Wei Wang, Keli Liao, Xiaoqiu Liu, Yiquan Ke, Shizhong Zhang, Mouxuan Du, Yuxi Zou, Yingqian Cai, Yanjun Zen. Experimental study on trace marking and oncogenicity of neural stem cells derived from bone marrow. Cellular and molecular neurobiology. vol 28. issue 5. 2008-10-14. PMID:17805959. |
the verified cd133/nestin-positive bmscs-d-nscs were then transplanted into nude mice to detect the oncogenicity, into the right lateral cerebral ventricle or right caudae putamen and substantia nigra to examine, whether the symptoms were improved in parkinson's disease (pd) models after transplantation, by both spect image assay of dopamine transporter (dat) in corpus striatum and its average standard uptake value (suvave) in corpus striatum and thalamus. |
2008-10-14 |
2023-08-12 |
mouse |
| Alessandro Bertolino, Annabella Di Giorgio, Giuseppe Blasi, Fabio Sambataro, Grazia Caforio, Lorenzo Sinibaldi, Valeria Latorre, Antonio Rampino, Paolo Taurisano, Leonardo Fazio, Raffaella Romano, Sofia Douzgou, Teresa Popolizio, Bhaskar Kolachana, Marcello Nardini, Daniel R Weinberger, Bruno Dallapiccol. Epistasis between dopamine regulating genes identifies a nonlinear response of the human hippocampus during memory tasks. Biological psychiatry. vol 64. issue 3. 2008-10-07. PMID:18374902. |
here, we investigated the effect of genetic variation of dopamine inactivation via catechol-o-methyltransferase (comt) and the dopamine transporter (dat) on hippocampal activity in healthy humans during different memory conditions. |
2008-10-07 |
2023-08-12 |
human |
| Jing Ji, Dean E Dluze. Sex differences in striatal dopaminergic function within heterozygous mutant dopamine transporter knock-out mice. Journal of neural transmission (Vienna, Austria : 1996). vol 115. issue 6. 2008-10-03. PMID:18197357. |
the issue of whether a deletion of the dopamine transporter (dat) allele (+/- dat) would differentially alter striatal dopamine (da) and dihydroxyphenylacetic acid (dopac) concentrations and da release upon potassium and methamphetamine (ma) stimulation between male and female mice was examined. |
2008-10-03 |
2023-08-12 |
mouse |
| Hironori Yokoyama, Sho Takagi, Yu Watanabe, Hiroyuki Kato, Tsutomu Arak. Role of reactive nitrogen and reactive oxygen species against MPTP neurotoxicity in mice. Journal of neural transmission (Vienna, Austria : 1996). vol 115. issue 6. 2008-10-03. PMID:18235988. |
our immunohistochemical study showed that th (tyrosine hydroxylase) and dat (dopamine transporter) immunoreactivity was decreased significantly in the striatum and substantia nigra 5 days after mptp treatment. |
2008-10-03 |
2023-08-12 |
mouse |
| Veronika Franekova, Martina Baliova, Frantisek Jursk. Truncation of human dopamine transporter by protease calpain. Neurochemistry international. vol 52. issue 8. 2008-09-30. PMID:18468730. |
it has been shown recently that the n-terminal domain of the dopamine transporter (dat) plays a role in several transporter functions. |
2008-09-30 |
2023-08-12 |
human |
| Veronika Franekova, Martina Baliova, Frantisek Jursk. Truncation of human dopamine transporter by protease calpain. Neurochemistry international. vol 52. issue 8. 2008-09-30. PMID:18468730. |
calpain truncation of the datn-terminus abolishes its interaction with the receptor of activated protein kinase c, rack1 and removes protein sequences previously implicated in amphetamine-induced dopamine release, pkc-dependent endocytosis and the interaction of dat with the dopamine d2 receptor. |
2008-09-30 |
2023-08-12 |
human |
| Veronika Franekova, Martina Baliova, Frantisek Jursk. Truncation of human dopamine transporter by protease calpain. Neurochemistry international. vol 52. issue 8. 2008-09-30. PMID:18468730. |
the above suggests that cleavage of dat by calpain may significantly modify dopamine homeostasis under pathological or physiological conditions. |
2008-09-30 |
2023-08-12 |
human |
| Ismo Makkonen, Raili Riikonen, Hannu Kokki, Mauno M Airaksinen, Jyrki T Kuikk. Serotonin and dopamine transporter binding in children with autism determined by SPECT. Developmental medicine and child neurology. vol 50. issue 8. 2008-09-26. PMID:18754896. |
in the individuals with autism dopamine transporter (dat) binding did not differ from that of the comparison group. |
2008-09-26 |
2023-08-12 |
Not clear |