| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cheryse A Furman, Rong Chen, Bipasha Guptaroy, Minjia Zhang, Ronald W Holz, Margaret Gneg. Dopamine and amphetamine rapidly increase dopamine transporter trafficking to the surface: live-cell imaging using total internal reflection fluorescence microscopy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 10. 2009-04-10. PMID:19279270. |
both the physiological substrate, dopamine, and amphetamine began to increase surface dat within 10 s of drug addition and steadily increased surface dat until removal 2 min later. |
2009-04-10 |
2023-08-12 |
mouse |
| Cheryse A Furman, Rong Chen, Bipasha Guptaroy, Minjia Zhang, Ronald W Holz, Margaret Gneg. Dopamine and amphetamine rapidly increase dopamine transporter trafficking to the surface: live-cell imaging using total internal reflection fluorescence microscopy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 10. 2009-04-10. PMID:19279270. |
these data demonstrate that the physiological substrate, dopamine, and amphetamine rapidly increase the trafficking of dat to the surface by a mechanism dependent on snare proteins and protein kinase c-beta but independent of dopamine d(2) receptor activation. |
2009-04-10 |
2023-08-12 |
mouse |
| Irena Rektorova, Hana Srovnalova, Radka Kubikova, Jiri Prase. Striatal dopamine transporter imaging correlates with depressive symptoms and tower of London task performance in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 23. issue 11. 2009-04-08. PMID:18618663. |
the association between neuropsychiatric measures and dopamine transporter (dat) availability was calculated; multiple regression analysis was used to assess association with age and disease duration. |
2009-04-08 |
2023-08-12 |
Not clear |
| Gabor G Kovacs, Ivan J Milenkovic, Matthias Preusser, Herbert Budk. Nigral burden of alpha-synuclein correlates with striatal dopamine deficit. Movement disorders : official journal of the Movement Disorder Society. vol 23. issue 11. 2009-04-08. PMID:18649394. |
physiologically, alpha-synuclein ensures normal functions of dopamine transporter (dat) and tyrosine hydoxylase. |
2009-04-08 |
2023-08-12 |
Not clear |
| Chao Guo, Hai-Yan Qiu, Ming Shi, Ying Huang, Randy L Johnson, Marcelo Rubinstein, Sheng-Di Chen, Yu-Qiang Din. Lmx1b-controlled isthmic organizer is essential for development of midbrain dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 52. 2009-04-08. PMID:19109492. |
we found that mda neurons revealed by tyrosine hydroxylase (th), pitx3, nurr1, and dopamine transporter were indistinguishable from wild-type controls during embryonic development as well as in adulthood in th-cre;lmx1b(flox/-) and dat(cre/+);lmx1b(flox/-) mice, in which lmx1b was selectively deleted in differentiating mda neurons. |
2009-04-08 |
2023-08-12 |
mouse |
| Kenji Ishibashi, Kenji Ishii, Keiichi Oda, Keiichi Kawasaki, Hidehiro Mizusawa, Kiichi Ishiwat. Regional analysis of age-related decline in dopamine transporters and dopamine D2-like receptors in human striatum. Synapse (New York, N.Y.). vol 63. issue 4. 2009-04-08. PMID:19116949. |
the purpose of this study was to evaluate the mechanisms of age-related decline of dopamine transporter (dat) and dopamine d(2)-like receptor (d2r) densities in the human striatum by focusing on regional difference. |
2009-04-08 |
2023-08-12 |
human |
| Morgane Thomsen, F Scott Hall, George R Uhl, S Barak Cain. Dramatically decreased cocaine self-administration in dopamine but not serotonin transporter knock-out mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 4. 2009-04-08. PMID:19176817. |
we tested the hypotheses that mice lacking the dopamine transporter (dat(-/-)), the serotonin transporter (sert(-/-)), or both (dat(-/-)sert(-/-)) exhibit decreased reinforcing effects of cocaine. |
2009-04-08 |
2023-08-12 |
mouse |
| Morgane Thomsen, F Scott Hall, George R Uhl, S Barak Cain. Dramatically decreased cocaine self-administration in dopamine but not serotonin transporter knock-out mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 4. 2009-04-08. PMID:19176817. |
food-maintained behaviors were not decreased by the dat mutation, and iv self-administration of a direct dopamine agonist was robust in the dat(-/-) mice. |
2009-04-08 |
2023-08-12 |
mouse |
| Alessandro Bertolino, Leonardo Fazio, Annabella Di Giorgio, Giuseppe Blasi, Raffaella Romano, Paolo Taurisano, Grazia Caforio, Lorenzo Sinibaldi, Gianluca Ursini, Teresa Popolizio, Emanuele Tirotta, Audrey Papp, Bruno Dallapiccola, Emiliana Borrelli, Wolfgang Sade. Genetically determined interaction between the dopamine transporter and the D2 receptor on prefronto-striatal activity and volume in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 4. 2009-04-08. PMID:19176830. |
both the dopamine transporter (dat) and dopamine d(2) receptors (encoded by drd(2)) critically regulate dopamine signaling in the striatum and in prefrontal cortex during memory. |
2009-04-08 |
2023-08-12 |
human |
| Alessandro Bertolino, Leonardo Fazio, Annabella Di Giorgio, Giuseppe Blasi, Raffaella Romano, Paolo Taurisano, Grazia Caforio, Lorenzo Sinibaldi, Gianluca Ursini, Teresa Popolizio, Emanuele Tirotta, Audrey Papp, Bruno Dallapiccola, Emiliana Borrelli, Wolfgang Sade. Genetically determined interaction between the dopamine transporter and the D2 receptor on prefronto-striatal activity and volume in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 4. 2009-04-08. PMID:19176830. |
together, our results demonstrate that the interaction between genetic variants in drd(2) and dat critically modulates the nonlinear relationship between dopamine and neuronal activity during memory processing. |
2009-04-08 |
2023-08-12 |
human |
| Toni L Richards, Nancy R Zahnise. Rapid substrate-induced down-regulation in function and surface localization of dopamine transporters: rat dorsal striatum versus nucleus accumbens. Journal of neurochemistry. vol 108. issue 6. 2009-04-02. PMID:19183252. |
the dopamine transporter (dat) substrates dopamine, d-amphetamine (amph), and methamphetamine are known to rapidly and transiently reduce dat activity and/or surface expression in dorsal striatum and heterologous expression systems. |
2009-04-02 |
2023-08-12 |
rat |
| A Jon Stoess. Positron emission tomography in premotor Parkinson's disease. Parkinsonism & related disorders. vol 13 Suppl 3. 2009-04-01. PMID:18267275. |
positron emission tomography (pet) using [11c]dihydrotetrabenazine to label the vesicular monoamine transporter type 2 (vmat2), a variety of 11c- or 18f-labeled ligands for the membrane dopamine transporter (dat), or 6-[18f]fluoro-l-dopa (fd), which assesses uptake and decarboxylation of levodopa as well as vesicular storage of radiolabeled dopamine, can all be used, and all provide comparable, but somewhat different information. |
2009-04-01 |
2023-08-12 |
human |
| A Jon Stoess. Positron emission tomography in premotor Parkinson's disease. Parkinsonism & related disorders. vol 13 Suppl 3. 2009-04-01. PMID:18267275. |
dat binding using either pet or spect appears to be the most sensitive marker of dopamine denervation, while fd uptake is subject to compensatory upregulation and its reduction may more closely herald the onset of clinical disease. |
2009-04-01 |
2023-08-12 |
human |
| Jan Booij, Remco J J Kno. SPECT imaging of the dopaminergic system in (premotor) Parkinson's disease. Parkinsonism & related disorders. vol 13 Suppl 3. 2009-04-01. PMID:18267276. |
in studies on (premotor) parkinson's disease (pd), single photon emission computed tomography (spect) studies have focused on imaging of the presynaptic dopamine transporter (dat) and postsynaptic dopamine d2 receptors (d2rs). |
2009-04-01 |
2023-08-12 |
Not clear |
| Michael Y Aksenov, Marina V Aksenova, Janelle M Silvers, Charles F Mactutus, Rosemarie M Booz. Different effects of selective dopamine uptake inhibitors, GBR 12909 and WIN 35428, on HIV-1 Tat toxicity in rat fetal midbrain neurons. Neurotoxicology. vol 29. issue 6. 2009-03-26. PMID:18606182. |
in this study, we found that the selective inhibitor of dopamine transporter (dat) function, 1-[2-[bis(4-fluorophenyl) methoxy]ethyl]-4-(3-phenylpropyl) piperazine (gbr 12909, vanoxerine), but not the selective inhibitors of serotonin and norepinephrine (sert and net) transporters, sertraline and nizoxetine, emulated cocaine-mediated enhancement of tat neurotoxicity in rat fetal midbrain primary cell cultures. |
2009-03-26 |
2023-08-12 |
rat |
| Yeong-Gon Choi, Jae-Hyun Park, Sabina Li. Acupuncture inhibits ferric iron deposition and ferritin-heavy chain reduction in an MPTP-induced parkinsonism model. Neuroscience letters. vol 450. issue 2. 2009-03-24. PMID:19056464. |
acupuncture inhibited decreases in the immunoreactivities of tyrosine hydroxylase (th) and dopamine transporter (dat) that occurred as a result of mptp neurotoxicity. |
2009-03-24 |
2023-08-12 |
mouse |
| Rong Chen, Cheryse A Furman, Minjia Zhang, Myung N Kim, Robert W Gereau, Michael Leitges, Margaret E Gneg. Protein kinase Cbeta is a critical regulator of dopamine transporter trafficking and regulates the behavioral response to amphetamine in mice. The Journal of pharmacology and experimental therapeutics. vol 328. issue 3. 2009-03-24. PMID:19098163. |
the dopamine transporter (dat) is a key mediator of dopaminergic neurotransmission and a major target for amphetamine. |
2009-03-24 |
2023-08-12 |
mouse |
| Rong Chen, Cheryse A Furman, Minjia Zhang, Myung N Kim, Robert W Gereau, Michael Leitges, Margaret E Gneg. Protein kinase Cbeta is a critical regulator of dopamine transporter trafficking and regulates the behavioral response to amphetamine in mice. The Journal of pharmacology and experimental therapeutics. vol 328. issue 3. 2009-03-24. PMID:19098163. |
pkcbeta ko mice have less striatal surface dat, [3h]dopamine uptake, and amphetamine-stimulated dopamine efflux, yet higher novelty-induced locomotor activity than wt mice. |
2009-03-24 |
2023-08-12 |
mouse |
| Rong Chen, Cheryse A Furman, Minjia Zhang, Myung N Kim, Robert W Gereau, Michael Leitges, Margaret E Gneg. Protein kinase Cbeta is a critical regulator of dopamine transporter trafficking and regulates the behavioral response to amphetamine in mice. The Journal of pharmacology and experimental therapeutics. vol 328. issue 3. 2009-03-24. PMID:19098163. |
although a short exposure (< or =90 s) to amphetamine rapidly increases striatal surface dat and [3h]dopamine uptake in wt mice, this treatment decreases surface dat and [3h]dopamine uptake in ko mice. |
2009-03-24 |
2023-08-12 |
mouse |
| Rong Chen, Cheryse A Furman, Minjia Zhang, Myung N Kim, Robert W Gereau, Michael Leitges, Margaret E Gneg. Protein kinase Cbeta is a critical regulator of dopamine transporter trafficking and regulates the behavioral response to amphetamine in mice. The Journal of pharmacology and experimental therapeutics. vol 328. issue 3. 2009-03-24. PMID:19098163. |
increases in surface dat and [3h]dopamine uptake are not evident in ko mice until a longer exposure (60 min) to amphetamine, by which time wt mice exhibit decreased surface dat and dopamine uptake. |
2009-03-24 |
2023-08-12 |
mouse |