| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M A Kulikova, E V Trushkin, M A Timofeeva, V A Shlepzova, J V Schegolkova, N V Maluchenko, A G Tonevitsk. Genetic markers of predisposition to increased anxiety. Bulletin of experimental biology and medicine. vol 146. issue 6. 2009-09-08. PMID:19513381. |
associations of functional polymorphism in genes of dopamine receptor drd2, dopamine transporter dat, and dopamine degrading enzyme comt with variations in anxiety sensitivity threshold were studied. |
2009-09-08 |
2023-08-12 |
Not clear |
| Michele Tinazzi, Angelo Antonini, Tommaso Bovi, Isabella Pasquin, Maria Steinmayr, Giuseppe Moretto, Antonio Fiaschi, Sarah Ottavian. Clinical and [123I]FP-CIT SPET imaging follow-up in patients with drug-induced parkinsonism. Journal of neurology. vol 256. issue 6. 2009-09-02. PMID:19252795. |
we recently found that patients with drug-induced parkinsonism (dip) may have normal (group i) or abnormal (group ii) putamen [(123)i]fp-cit dat (dopamine transporter) binding. |
2009-09-02 |
2023-08-12 |
human |
| Michele Tinazzi, Angelo Antonini, Tommaso Bovi, Isabella Pasquin, Maria Steinmayr, Giuseppe Moretto, Antonio Fiaschi, Sarah Ottavian. Clinical and [123I]FP-CIT SPET imaging follow-up in patients with drug-induced parkinsonism. Journal of neurology. vol 256. issue 6. 2009-09-02. PMID:19252795. |
this study shows that dat binding imaging may help to identify subjects with dip secondary to a loss of dopamine nerve terminals in the context of a progressive degenerative parkinsonism. |
2009-09-02 |
2023-08-12 |
human |
| Naoshi Shibuya, Mitsuhiro Kamata, Akihito Suzuki, Yoshihiko Matsumoto, Kaoru Goto, Koichi Otan. The -67 A/T promoter polymorphism in the dopamine transporter gene affects personality traits of Japanese healthy females. Behavioural brain research. vol 203. issue 1. 2009-08-31. PMID:19376159. |
dopamine transporter (dat) plays a major role in terminating dopamine neurotransmission, which may be involved in the characterization of personality traits. |
2009-08-31 |
2023-08-12 |
Not clear |
| Christine DeLorenzo, J S Dileep Kumar, Francesca Zanderigo, J John Mann, Ramin V Parse. Modeling considerations for in vivo quantification of the dopamine transporter using [(11)C]PE2I and positron emission tomography. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 29. issue 7. 2009-08-25. PMID:19458606. |
the dopamine transporter (dat) is an important imaging target as changes in dat have been implicated in a variety of neurologic and psychiatric disorders and can result from certain classes of medications. |
2009-08-25 |
2023-08-12 |
human |
| M J Ferris, D Frederick-Duus, J Fadel, C F Mactutus, R M Booz. The human immunodeficiency virus-1-associated protein, Tat1-86, impairs dopamine transporters and interacts with cocaine to reduce nerve terminal function: a no-net-flux microdialysis study. Neuroscience. vol 159. issue 4. 2009-08-20. PMID:19344635. |
one common area for their interaction is the nerve terminal, including dopamine transporter (dat) systems. |
2009-08-20 |
2023-08-12 |
human |
| M J Ferris, D Frederick-Duus, J Fadel, C F Mactutus, R M Booz. The human immunodeficiency virus-1-associated protein, Tat1-86, impairs dopamine transporters and interacts with cocaine to reduce nerve terminal function: a no-net-flux microdialysis study. Neuroscience. vol 159. issue 4. 2009-08-20. PMID:19344635. |
characterization of dat dysfunction in vivo may provide an early pharmacotherapeutic target, which in turn may prevent or attenuate downstream mediators of neurotoxicity (i.e., reactive species) to dopamine systems occurring in neuro-aids. |
2009-08-20 |
2023-08-12 |
human |
| M Larsson, L Farde, T Hummel, M Witt, N Erixon Lindroth, L Bäckma. Age-related loss of olfactory sensitivity: association to dopamine transporter binding in putamen. Neuroscience. vol 161. issue 2. 2009-08-19. PMID:19348872. |
the relationship between age-related reductions in the binding potential for the striatal dopamine transporter (dat) and age-related deficits in olfactory sensitivity was examined in 12 subjects ranging from 36 to 82 years of age. |
2009-08-19 |
2023-08-12 |
human |
| Jean-Pierre Louboutin, Lokesh Agrawal, Beverly A S Reyes, Elisabeth J Van Bockstaele, David S Straye. HIV-1 gp120 neurotoxicity proximally and at a distance from the point of exposure: protection by rSV40 delivery of antioxidant enzymes. Neurobiology of disease. vol 34. issue 3. 2009-08-17. PMID:19327399. |
dopaminergic sn neurons (expressing tyrosine hydroxylase, th, in the sn and dopamine transporter, dat, in the cp) were mostly affected: intra-cp gp120 caused approximately 50% dat+ sn neuron loss. |
2009-08-17 |
2023-08-12 |
rat |
| Rebecca A Alyea, Cheryl S Watso. Nongenomic mechanisms of physiological estrogen-mediated dopamine efflux. BMC neuroscience. vol 10. 2009-08-17. PMID:19531209. |
neurological diseases and neuropsychiatric disorders that vary depending on female life stages suggest that sex hormones may influence the function of neurotransmitter regulatory machinery such as the dopamine transporter (dat). |
2009-08-17 |
2023-08-12 |
Not clear |
| Laura E Bianco, Erica L Unger, Christopher J Earley, John L Bear. Iron deficiency alters the day-night variation in monoamine levels in mice. Chronobiology international. vol 26. issue 3. 2009-08-13. PMID:19360489. |
extracellular striatal da levels were 15-20% higher in all groups during the active dark phase compared to the inactive light phase, with correspondingly lower dopamine transporter (dat) and higher tyrosine hydroxylase levels. |
2009-08-13 |
2023-08-12 |
mouse |
| Martin Lotze, Matthias Reimold, Ulrike Heymans, Arto Laihinen, Marianne Patt, Ulrike Halsban. Reduced ventrolateral fMRI response during observation of emotional gestures related to the degree of dopaminergic impairment in Parkinson disease. Journal of cognitive neuroscience. vol 21. issue 7. 2009-08-12. PMID:18752414. |
in addition, we used pet to evaluate the striatal dopamine transporter availability (dat) with [(11)c]d-threo-methylphenidate in the patient group. |
2009-08-12 |
2023-08-12 |
Not clear |
| Shamol Saha, Maria D Guillily, Andrew Ferree, Joel Lanceta, Diane Chan, Joy Ghosh, Cindy H Hsu, Lilach Segal, Kesav Raghavan, Kunihiro Matsumoto, Naoki Hisamoto, Tomoki Kuwahara, Takeshi Iwatsubo, Landon Moore, Lee Goldstein, Mark Cookson, Benjamin Wolozi. LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 29. 2009-08-10. PMID:19625511. |
c. elegans expressing lrrk2 showed rapid loss of dopaminergic markers (dat::gfp fluorescence and dopamine levels) beginning in early adulthood. |
2009-08-10 |
2023-08-12 |
human |
| Hideaki Shimada, Naoko Yoshimura, Akiko Tsuji, Takahiro Kunisad. Differentiation of dopaminergic neurons from human embryonic stem cells: modulation of differentiation by FGF-20. Journal of bioscience and bioengineering. vol 107. issue 4. 2009-07-29. PMID:19332307. |
quantitative real-time pcr analysis showed a marked induction of the da neuron marker genes nurr1, paired-like homeodomain transcription factor 3 (pitx3), lim homeobox transcription- factor 1, beta (lmx1b), engrailed-1 (en1), dopamine transporter (dat), and aromatic amino acid decarboxylase (aadc) during differentiation. |
2009-07-29 |
2023-08-12 |
mouse |
| Zhihua Xie, Gregory M Mille. A receptor mechanism for methamphetamine action in dopamine transporter regulation in brain. The Journal of pharmacology and experimental therapeutics. vol 330. issue 1. 2009-07-27. PMID:19364908. |
this study reveals a novel receptor mechanism for methamphetamine action in dopamine transporter (dat) regulation. |
2009-07-27 |
2023-08-12 |
mouse |
| Zhihua Xie, Gregory M Mille. A receptor mechanism for methamphetamine action in dopamine transporter regulation in brain. The Journal of pharmacology and experimental therapeutics. vol 330. issue 1. 2009-07-27. PMID:19364908. |
here, we show that methamphetamine interaction with taar1 inhibits [(3)h]dopamine uptake, enhances or induces [(3)h]dopamine efflux, and triggers dat internalization. |
2009-07-27 |
2023-08-12 |
mouse |
| Manju A Kurian, Juan Zhen, Shu-Yuan Cheng, Yan Li, Santosh R Mordekar, Philip Jardine, Neil V Morgan, Esther Meyer, Louise Tee, Shanaz Pasha, Evangeline Wassmer, Simon J R Heales, Paul Gissen, Maarten E A Reith, Eamonn R Mahe. Homozygous loss-of-function mutations in the gene encoding the dopamine transporter are associated with infantile parkinsonism-dystonia. The Journal of clinical investigation. vol 119. issue 6. 2009-07-24. PMID:19478460. |
genetic variants of the slc6a3 gene that encodes the human dopamine transporter (dat) have been linked to a variety of neuropsychiatric disorders, particularly attention deficit hyperactivity disorder. |
2009-07-24 |
2023-08-12 |
mouse |
| Manju A Kurian, Juan Zhen, Shu-Yuan Cheng, Yan Li, Santosh R Mordekar, Philip Jardine, Neil V Morgan, Esther Meyer, Louise Tee, Shanaz Pasha, Evangeline Wassmer, Simon J R Heales, Paul Gissen, Maarten E A Reith, Eamonn R Mahe. Homozygous loss-of-function mutations in the gene encoding the dopamine transporter are associated with infantile parkinsonism-dystonia. The Journal of clinical investigation. vol 119. issue 6. 2009-07-24. PMID:19478460. |
functional studies demonstrated that both mutations were loss-of-function mutations that severely reduced levels of mature (85-kda) dat while having a differential effect on the apparent binding affinity of dopamine. |
2009-07-24 |
2023-08-12 |
mouse |
| Craig Blackston. Infantile parkinsonism-dystonia: a dopamine "transportopathy". The Journal of clinical investigation. vol 119. issue 6. 2009-07-24. PMID:19504720. |
the dopamine transporter (dat) retrieves the neurotransmitter dopamine from the synaptic cleft at dopaminergic synapses. |
2009-07-24 |
2023-08-12 |
human |
| Craig Blackston. Infantile parkinsonism-dystonia: a dopamine "transportopathy". The Journal of clinical investigation. vol 119. issue 6. 2009-07-24. PMID:19504720. |
report that an autosomal recessive infantile parkinsonism-dystonia is caused by loss-of-function mutations in dat that impair dopamine reuptake (see the related article beginning on page 1595). |
2009-07-24 |
2023-08-12 |
human |