| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiao-Fang Hou, Sheng-Bin L. Potential association of DRD2 and DAT1 genetic variation with heroin dependence. Neuroscience letters. vol 464. issue 2. 2009-11-23. PMID:19664686. |
the aim of our study was to investigate the potential association of dopamine receptor d2 gene (drd2) taqi rflp a (rs1800497) and dopamine transporter gene (dat) 3'untranslated region vntr genetic variations with heroin addiction. |
2009-11-23 |
2023-08-12 |
Not clear |
| Alex Ward, Vyvyca J Walker, Zhaoyang Feng, X Z Shawn X. Cocaine modulates locomotion behavior in C. elegans. PloS one. vol 4. issue 6. 2009-11-17. PMID:19536276. |
cocaine, a potent addictive substance, is an inhibitor of monoamine transporters, including dat (dopamine transporter), sert (serotonin transporter) and net (norepinephrine transporter). |
2009-11-17 |
2023-08-12 |
caenorhabditis_elegans |
| Esa Kauppila, Esko Vanninen, Tom Kuusela, Salla Kaurijoki, Leila Karhunen, Kirsi H Pietiläinen, Aila Rissanen, Jaakko Kaprio, Jari Tiihonen, Jyrki Kuikk. Cardiac repolarization and striatal dopamine transporter function are interrelated. Nuclear medicine communications. vol 30. issue 9. 2009-11-17. PMID:19550362. |
in parkinson's disease, striatal dopamine transporter (dat) binding and cardiac sympathetic function are disturbed. |
2009-11-17 |
2023-08-12 |
Not clear |
| Dardo Tomasi, Nora D Volkow, Ruiliang Wang, Frank Telang, Gene-Jack Wang, Linda Chang, Thomas Ernst, Joanna S Fowle. Dopamine transporters in striatum correlate with deactivation in the default mode network during visuospatial attention. PloS one. vol 4. issue 6. 2009-11-17. PMID:19564918. |
dopamine and dopamine transporters (dat, which regulate extracellular dopamine in the brain) are implicated in the modulation of attention but their specific roles are not well understood. |
2009-11-17 |
2023-08-12 |
Not clear |
| Dardo Tomasi, Nora D Volkow, Ruiliang Wang, Frank Telang, Gene-Jack Wang, Linda Chang, Thomas Ernst, Joanna S Fowle. Dopamine transporters in striatum correlate with deactivation in the default mode network during visuospatial attention. PloS one. vol 4. issue 6. 2009-11-17. PMID:19564918. |
thus, higher striatal dat levels, which would result in an enhanced clearance of dopamine and hence weaker dopamine signals, would be associated to lower deactivation in the dmn during an attention task. |
2009-11-17 |
2023-08-12 |
Not clear |
| F S Hall, X-F Li, J Randall-Thompson, I Sora, D L Murphy, K-P Lesch, M Caron, G R Uh. Cocaine-conditioned locomotion in dopamine transporter, norepinephrine transporter and 5-HT transporter knockout mice. Neuroscience. vol 162. issue 4. 2009-11-10. PMID:19482066. |
the behavioral effects of cocaine are affected by gene knockout (ko) of the dopamine transporter (dat), the serotonin transporter (sert) and the norepinephrine transporter (net). |
2009-11-10 |
2023-08-12 |
mouse |
| F S Hall, X-F Li, J Randall-Thompson, I Sora, D L Murphy, K-P Lesch, M Caron, G R Uh. Cocaine-conditioned locomotion in dopamine transporter, norepinephrine transporter and 5-HT transporter knockout mice. Neuroscience. vol 162. issue 4. 2009-11-10. PMID:19482066. |
these data reaffirm the central role of dopamine and dat in the behavioral effects of cocaine. |
2009-11-10 |
2023-08-12 |
mouse |
| Nadja Van Camp, Ines Blockx, Marleen Verhoye, Cindy Casteels, Frea Coun, Alexander Leemans, Jan Sijbers, Veerle Baekelandt, Koen Van Laere, Annemie Van der Linde. Diffusion tensor imaging in a rat model of Parkinson's disease after lesioning of the nigrostriatal tract. NMR in biomedicine. vol 22. issue 7. 2009-11-05. PMID:19378292. |
the degree of functional impairment was evaluated in vivo using the amphetamine rotation test and micropet imaging of the dopamine transporter (dat). |
2009-11-05 |
2023-08-12 |
rat |
| Eszter Kótyuk, Réka Kovács-Nagy, Gabor Faludi, Róbert Urbán, Zsolt Rónai, Maria Sasvári-Székely, Anna Székel. [Association between nicotine dependence and the -521 promoter polymorfism of the dopamine D4 receptor in patients with major depression]. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 11. issue 2. 2009-11-04. PMID:19827313. |
exon of the drd4 (drd4 vntr), two promoter snps of this gene (-521 ct and -616cg), as well as the repeat polymorphism of the dopamine transporter (dat vntr) polymorphism and the val/met polymorphism of the catechol-o-methyltransferase (comt) gene. |
2009-11-04 |
2023-08-12 |
Not clear |
| Shuang Liu, Zengmin Tian, Feng Yin, Quanjun Zhao, Ming Fa. Generation of dopaminergic neurons from human fetal mesencephalic progenitors after co-culture with striatal-conditioned media and exposure to lowered oxygen. Brain research bulletin. vol 80. issue 1-2. 2009-11-02. PMID:19463914. |
lowered o(2) significantly induced mrna expression of erythropoietin (epo) and p27, which affect neuronal differentiation, and was accompanied by upregulation of nurr1, pitx3 and dopamine transporter (dat) mrnas, which are correlated to the maturation of dopaminergic neurons. |
2009-11-02 |
2023-08-12 |
human |
| Andrea Varrone, Carsten Steiger, Magnus Schou, Akihiro Takano, Sjoerd J Finnema, Denis Guilloteau, Balázs Gulyás, Christer Halldi. In vitro autoradiography and in vivo evaluation in cynomolgus monkey of [18F]FE-PE2I, a new dopamine transporter PET radioligand. Synapse (New York, N.Y.). vol 63. issue 10. 2009-10-26. PMID:19562698. |
this study evaluated the in vitro and in vivo characteristics of a new dopamine transporter (dat) radioligand, [(18)f]fluoroethyl(fe)pe2i, by autoradiography from postmortem human brain and by positron emission tomography (pet) in three cynomolgus monkeys. |
2009-10-26 |
2023-08-12 |
human |
| Jing Ji, Mélanie Bourque, Thérèse Di Paolo, Dean E Dluze. Genetic alteration in the dopamine transporter differentially affects male and female nigrostriatal transporter systems. Biochemical pharmacology. vol 78. issue 11. 2009-10-26. PMID:19615345. |
female mice with a heterozygous mutation of their dopamine transporter (+/- dat) showed relatively robust reductions in striatal dat specific binding (38-50%), while +/- dat males showed modest reductions (24-32%). |
2009-10-26 |
2023-08-12 |
mouse |
| Seema Singh, Kavita Singh, Satya Prakash Gupta, Devendra Kumar Patel, Vinod Kumar Singh, Raj Kumar Singh, Mahendra Pratap Sing. Effect of caffeine on the expression of cytochrome P450 1A2, adenosine A2A receptor and dopamine transporter in control and 1-methyl 4-phenyl 1, 2, 3, 6-tetrahydropyridine treated mouse striatum. Brain research. vol 1283. 2009-10-23. PMID:19520064. |
caffeine, on the other hand, antagonizes adenosine a(2a) receptor and regulates dopamine signaling through dopamine transporter (dat). |
2009-10-23 |
2023-08-12 |
mouse |
| Seema Singh, Kavita Singh, Satya Prakash Gupta, Devendra Kumar Patel, Vinod Kumar Singh, Raj Kumar Singh, Mahendra Pratap Sing. Effect of caffeine on the expression of cytochrome P450 1A2, adenosine A2A receptor and dopamine transporter in control and 1-methyl 4-phenyl 1, 2, 3, 6-tetrahydropyridine treated mouse striatum. Brain research. vol 1283. 2009-10-23. PMID:19520064. |
tyrosine hydroxylase immunoreactivity, levels of dopamine and 1-methyl 4-phenylpyridinium ion (mpp(+)), expressions of cyp1a2, adenosine a(2a) receptor and dat and cyp1a2 catalytic activity were measured in control and treated mouse brain. |
2009-10-23 |
2023-08-12 |
mouse |
| Cheryse A Furman, Charles B Lo, Stephanie Stokes, Jose A Esteban, Margaret E Gneg. Rab 11 regulates constitutive dopamine transporter trafficking and function in N2A neuroblastoma cells. Neuroscience letters. vol 463. issue 1. 2009-10-23. PMID:19631257. |
the dopamine transporter (dat) is a crucial regulator of dopaminergic neurotransmission which undergoes constitutive and substrate-mediated trafficking to and from the membrane. |
2009-10-23 |
2023-08-12 |
Not clear |
| Xiangqian Liu, Linda Chang, Michael Vigorito, Marley Kass, He Li, Sulie L Chan. Methamphetamine-induced behavioral sensitization is enhanced in the HIV-1 transgenic rat. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 4. issue 3. 2009-10-13. PMID:19444617. |
the involvement of the dopaminergic system was investigated by examining dopamine receptors 1 (d1r) and 2 (d2r) and dopamine transporter (dat) expression in the striatum and prefrontal cortex. |
2009-10-13 |
2023-08-12 |
rat |
| Magnus Schou, Carsten Steiger, Andrea Varrone, Denis Guilloteau, Christer Halldi. Synthesis, radiolabeling and preliminary in vivo evaluation of [18F]FE-PE2I, a new probe for the dopamine transporter. Bioorganic & medicinal chemistry letters. vol 19. issue 16. 2009-10-13. PMID:19577467. |
a new dopamine transporter (dat) ligand, (e)-n-(3-iodoprop-2-enyl)-2beta-carbofluoroethoxy-3beta-(4'-methyl-phenyl) nortropane (fe-pe2i, 6), derived from pe2i (1), was prepared and found to be a potent inhibitor of rodent dat in vitro. |
2009-10-13 |
2023-08-12 |
human |
| Morgane Thomsen, Dawn D Han, Howard H Gu, S Barak Cain. Lack of cocaine self-administration in mice expressing a cocaine-insensitive dopamine transporter. The Journal of pharmacology and experimental therapeutics. vol 331. issue 1. 2009-10-13. PMID:19602552. |
the dopamine transporter (dat) is suspected as the primary target mediating cocaine's abuse-related effects based on numerous pharmacological studies. |
2009-10-13 |
2023-08-12 |
mouse |
| Morgane Thomsen, Dawn D Han, Howard H Gu, S Barak Cain. Lack of cocaine self-administration in mice expressing a cocaine-insensitive dopamine transporter. The Journal of pharmacology and experimental therapeutics. vol 331. issue 1. 2009-10-13. PMID:19602552. |
here, we show that mice expressing a "knockin" of a cocaine-insensitive but functional dat did not self-administer cocaine intravenously despite normal food-maintained responding and normal intravenous self-administration of amphetamine and a direct dopamine agonist. |
2009-10-13 |
2023-08-12 |
mouse |
| David J Lapinsky, Shaili Aggarwal, Yurong Huang, Christopher K Surratt, John R Lever, James D Foster, Roxanne A Vaugha. A novel photoaffinity ligand for the dopamine transporter based on pyrovalerone. Bioorganic & medicinal chemistry. vol 17. issue 11. 2009-10-08. PMID:19442525. |
non-tropane-based photoaffinity ligands for the dopamine transporter (dat) are relatively unexplored in contrast to tropane-based compounds such as cocaine. |
2009-10-08 |
2023-08-12 |
Not clear |