| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Denis Boulay, Olivier Bergis, Patrick Avenet, Guy Griebe. The glycine transporter-1 inhibitor SSR103800 displays a selective and specific antipsychotic-like profile in normal and transgenic mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 2. 2010-03-01. PMID:19759529. |
in contrast, ssr103800 failed to affect hyperactivity induced by amphetamine or naturally observed in dopamine transporter (dat(-/-)) knockout mice (10-30 mg/kg p.o.). |
2010-03-01 |
2023-08-12 |
mouse |
| André R Troiano, Michael Schulzer, Raul de la Fuente-Fernandez, Edwin Mak, Jess McKenzie, Vesna Sossi, Siobhan McCormick, Thomas J Ruth, A Jon Stoess. Dopamine transporter PET in normal aging: dopamine transporter decline and its possible role in preservation of motor function. Synapse (New York, N.Y.). vol 64. issue 2. 2010-03-01. PMID:19852071. |
to determine the impact of age-related decline in dopamine transporter (dat) expression on motor function in the elderly. |
2010-03-01 |
2023-08-12 |
Not clear |
| John A Gruner, Val R Marcy, Yin-Guo Lin, Donna Bozyczko-Coyne, Michael J Marino, Maciej Gasio. The roles of dopamine transport inhibition and dopamine release facilitation in wake enhancement and rebound hypersomnolence induced by dopaminergic agents. Sleep. vol 32. issue 11. 2010-02-25. PMID:19928382. |
in particular, rhs in the first few hours following wake appears to be associated with dopamine (da)-releasing agents, e.g., amphetamine, but whether it can also be produced by da transporter (dat) inhibition alone is unknown. |
2010-02-25 |
2023-08-12 |
Not clear |
| Trisha L Vickrey, Barry Condron, B Jill Vento. Detection of endogenous dopamine changes in Drosophila melanogaster using fast-scan cyclic voltammetry. Analytical chemistry. vol 81. issue 22. 2010-02-22. PMID:19842636. |
peak duration is extended after cocaine or nisoxetine, inhibitors of the dopamine transporter (dat). |
2010-02-22 |
2023-08-12 |
drosophila_melanogaster |
| Sammanda Ramamoorthy, Devadoss J Samuvel, Annamalai Balasubramaniam, Ronald E See, Lankupalle D Jayanth. Altered dopamine transporter function and phosphorylation following chronic cocaine self-administration and extinction in rats. Biochemical and biophysical research communications. vol 391. issue 3. 2010-02-22. PMID:20035724. |
cocaine binds with the dopamine transporter (dat), an effect that has been extensively implicated in its reinforcing effects. |
2010-02-22 |
2023-08-12 |
rat |
| Domingo Afonso-Oramas, Ignacio Cruz-Muros, Diego Alvarez de la Rosa, Pedro Abreu, Teresa Giráldez, Javier Castro-Hernández, Josmar Salas-Hernández, José L Lanciego, Manuel Rodríguez, Tomas González-Hernánde. Dopamine transporter glycosylation correlates with the vulnerability of midbrain dopaminergic cells in Parkinson's disease. Neurobiology of disease. vol 36. issue 3. 2010-02-18. PMID:19766189. |
the dopamine transporter (dat) is a membrane glycoprotein responsible for dopamine (da) uptake, which has been involved in the degeneration of da cells in parkinson's disease (pd). |
2010-02-18 |
2023-08-12 |
human |
| Zhen Qi, Gary W Miller, Eberhard O Voi. Computational analysis of determinants of dopamine (DA) dysfunction in DA nerve terminals. Synapse (New York, N.Y.). vol 63. issue 12. 2010-02-17. PMID:19670315. |
our model reveals that the dopamine transporter (dat), the vesicular monoamine transporter (vmat2), and the enzyme monoamine oxidase (mao) are the most influential components controlling the synaptic level of dopamine and the formation of toxic intracellular metabolites. |
2010-02-17 |
2023-08-12 |
Not clear |
| Katherine N Hewitt, Charles A Marsden, Chris P Hollis, Kevin C F Fon. Behavioural characterisation of the effects of acute and repeated administration of GBR 12909 in rats: further evaluation of a potential model of ADHD. Neuropharmacology. vol 57. issue 7-8. 2010-02-16. PMID:19699754. |
hypodopaminergic fronto-striatal function with associated overactivity of the dopamine transporter (dat) represents one possible neurobiological mechanism underlying adhd. |
2010-02-16 |
2023-08-12 |
rat |
| Q Bai, E A Burto. Cis-acting elements responsible for dopaminergic neuron-specific expression of zebrafish slc6a3 (dopamine transporter) in vivo are located remote from the transcriptional start site. Neuroscience. vol 164. issue 3. 2010-02-08. PMID:19755139. |
the purpose of this study was to analyze the transcriptional regulation of the zebrafish solute carrier family 6 member 3 gene (slc6a3, dopamine transporter, dat), as a first step towards isolating regulatory sequences useful for driving transgene expression within dopaminergic neurons of the zebrafish cns in vivo. |
2010-02-08 |
2023-08-12 |
human |
| Limin Liu, Yong Wang, Bo Li, Jun Jia, Zuoli Sun, Jinming Zhang, Jiahe Tian, Xiaomin Wan. Evaluation of nigrostriatal damage and its change over weeks in a rat model of Parkinson's disease: small animal positron emission tomography studies with [(11)C]beta-CFT. Nuclear medicine and biology. vol 36. issue 8. 2010-02-03. PMID:19875050. |
since dopamine transporter (dat) is a protein located presynaptically on dopaminergic nerve terminals, radioligands that bind to these sites are promising radiopharmaceuticals for evaluation of the integrity of the dopamine system. |
2010-02-03 |
2023-08-12 |
rat |
| Min Jung Lee, Chae Ha Yang, Jae-Pil Jeon, Meeyul Hwan. Protective effects of isoliquiritigenin against methamphetamine-induced neurotoxicity in mice. Journal of pharmacological sciences. vol 111. issue 2. 2010-01-28. PMID:19834288. |
repeated injections of methamphetamine cause the loss of striatal dopamine transporter (dat) and tyrosine hydroxylase (th). |
2010-01-28 |
2023-08-12 |
mouse |
| Osamu Kitamur. Detection of methamphetamine neurotoxicity in forensic autopsy cases. Legal medicine (Tokyo, Japan). vol 11 Suppl 1. 2010-01-26. PMID:19269222. |
the tyrosine hydroxylase (th), dopamine transporter (dat), and vesicular monoamine transporter 2 (vmat2) levels and glial reactions in the striata of meth abusers were examined using immunohistochemical technique. |
2010-01-26 |
2023-08-12 |
Not clear |
| Christoph Scherfler, Michael Nocke. Dopamine transporter SPECT: how to remove subjectivity? Movement disorders : official journal of the Movement Disorder Society. vol 24 Suppl 2. 2010-01-26. PMID:19877234. |
single photon emission computed tomography (spect) investigating the striatal dopamine transporter (dat) status have been suggested to increase the diagnostic accuracy in uncertain parkinsonian syndromes such as isolated tremor symptoms not fulfilling essential tremor criteria, as well as drug-induced, vascular and psychogenetic parkinsonism. |
2010-01-26 |
2023-08-12 |
Not clear |
| P Gassó, S Mas, M Bernardo, S Alvarez, E Parellada, A Lafuent. A common variant in DRD3 gene is associated with risperidone-induced extrapyramidal symptoms. The pharmacogenomics journal. vol 9. issue 6. 2010-01-20. PMID:19506579. |
we present a pharmacogenetic study of acute antipsychotic (ap)-induced extrapyramidal symptoms (eps) using an extensive linkage disequilibrium mapping approach in seven-candidate genes with a well-established link to dopamine (drd2, drd3, ace, comt, dat, mao-a, mao-b). |
2010-01-20 |
2023-08-12 |
Not clear |
| David L Gray, Wenjian Xu, Brian M Campbell, Amy B Dounay, Nancy Barta, Susan Boroski, Lynne Denny, Lori Evans, Nancy Stratman, Al Prober. Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1A partial agonists. Bioorganic & medicinal chemistry letters. vol 19. issue 23. 2010-01-19. PMID:19854053. |
in addition, optimization of these molecules provided compounds which exhibit selectivity for nri over the dopamine (dat) and serotonin (sert) reuptake transporters. |
2010-01-19 |
2023-08-12 |
Not clear |
| Luke Gabriel, Zachary Stevens, Haley Melikia. Measuring plasma membrane protein endocytic rates by reversible biotinylation. Journal of visualized experiments : JoVE. issue 34. 2010-01-15. PMID:20032927. |
in the present report, we describe a reversible biotinylation method that we employ to measure the dopamine transporter (dat) endocytic rate. |
2010-01-15 |
2023-08-12 |
Not clear |
| E Zakharova, J Miller, E Unterwald, D Wade, S Izenwasse. Social and physical environment alter cocaine conditioned place preference and dopaminergic markers in adolescent male rats. Neuroscience. vol 163. issue 3. 2010-01-14. PMID:19580849. |
enriched housing (se3) increased dopamine transporter (dat) protein in the nucleus accumbens compared to ii. |
2010-01-14 |
2023-08-12 |
rat |
| Werner J Geldenhuys, Lois-May Bezuidenhout, Dean E Dluze. Effects of a novel dopamine uptake inhibitor upon extracellular dopamine from superfused murine striatal tissue. European journal of pharmacology. vol 619. issue 1-3. 2010-01-14. PMID:19686731. |
the dopamine transporter (dat) plays an important role in substance abuse, schizophrenia, and dopaminergic toxicity associated with the parkinsonian animal model toxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). |
2010-01-14 |
2023-08-12 |
Not clear |
| Werner J Geldenhuys, Lois-May Bezuidenhout, Dean E Dluze. Effects of a novel dopamine uptake inhibitor upon extracellular dopamine from superfused murine striatal tissue. European journal of pharmacology. vol 619. issue 1-3. 2010-01-14. PMID:19686731. |
it appears that compound 1 exerts these effects primarily through interaction with the dat by blocking dopamine uptake via a calcium-dependent mechanism, and does not lead to extracellular efflux via the dat. |
2010-01-14 |
2023-08-12 |
Not clear |
| Xiaoqin Huang, Howard H Gu, Chang-Guo Zha. Mechanism for cocaine blocking the transport of dopamine: insights from molecular modeling and dynamics simulations. The journal of physical chemistry. B. vol 113. issue 45. 2010-01-14. PMID:19831380. |
molecular modeling and dynamics simulations have been performed to study how cocaine inhibits dopamine transporter (dat) for the transport of dopamine. |
2010-01-14 |
2023-08-12 |
Not clear |