| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cindy Casteels, Erwin Lauwers, Abdelbari Baitar, Guy Bormans, Veerle Baekelandt, Koen Van Laer. In vivo type 1 cannabinoid receptor mapping in the 6-hydroxydopamine lesion rat model of Parkinson's disease. Brain research. vol 1316. 2010-05-06. PMID:20026090. |
using the cb1 receptor radioligand [(18)f]mk-9470 and small-animal pet, we investigated for the first time in vivo cerebral changes in [(18)f]mk-9470 binding in the 6-hydroxydopamine (6-ohda) rat model of parkinson's disease (pd), parallel to dopamine transporter (dat) imaging, tyrosine hydroxylase (th) staining, and behavioral measurements. |
2010-05-06 |
2023-08-12 |
rat |
| Chun-Hui Pan, Lu-Ping Song, Jie Du, Jie Lan, Chun-Mei Wu, Li-Juan Wu, Lan Lin, Wei Wan. [Single nucleotide polymorphisms of DAT and DRD(2) genes in Han Chinese population and their association with stuttering]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 29. issue 3. 2010-05-04. PMID:19304505. |
to explore the correlations of dopamine transporter gene (dat) and dopamine d(2) receptor gene (drd2) to stuttering. |
2010-05-04 |
2023-08-12 |
Not clear |
| E N Rizos, S Chatziioannou, A Douzenis, N Siafakas, E Katsantoni, P Nikolaidou, M Papathanasiou, L Lykoura. Signs of striatal dopamine transporter density increase in association with improvement of tardive dyskinesia in a patient with schizophrenia, as demonstrated by a DAT scan. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 20. issue 2. 2010-04-30. PMID:19740630. |
signs of striatal dopamine transporter density increase in association with improvement of tardive dyskinesia in a patient with schizophrenia, as demonstrated by a dat scan. |
2010-04-30 |
2023-08-12 |
Not clear |
| E N Rizos, S Chatziioannou, A Douzenis, N Siafakas, E Katsantoni, P Nikolaidou, M Papathanasiou, L Lykoura. Signs of striatal dopamine transporter density increase in association with improvement of tardive dyskinesia in a patient with schizophrenia, as demonstrated by a DAT scan. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 20. issue 2. 2010-04-30. PMID:19740630. |
a dat scan showed decreased dopamine transporter uptake in the area of brain's basal gaglia. |
2010-04-30 |
2023-08-12 |
Not clear |
| Murat Oz, Vanaja Jaligam, Sehamuddin Galadari, George Petroianu, Yaroslav M Shuba, Toni S Shippenber. The endogenous cannabinoid, anandamide, inhibits dopamine transporter function by a receptor-independent mechanism. Journal of neurochemistry. vol 112. issue 6. 2010-04-30. PMID:20050977. |
the endocannabinoid, anandamide (aea), modulates the activity of the dopamine transporter (dat) in heterologous cells and synaptosomal preparations. |
2010-04-30 |
2023-08-12 |
human |
| Kyle C Schmitt, Sreeman Mamidyala, Swati Biswas, Aloke K Dutta, Maarten E A Reit. Bivalent phenethylamines as novel dopamine transporter inhibitors: evidence for multiple substrate-binding sites in a single transporter. Journal of neurochemistry. vol 112. issue 6. 2010-04-30. PMID:20067583. |
it is generally assumed that neurotransmitter sodium symporter (nss) proteins, such as the dopamine transporter (dat), contain a single domain responsible for recognition of substrate molecules. |
2010-04-30 |
2023-08-12 |
Not clear |
| Kyle C Schmitt, Sreeman Mamidyala, Swati Biswas, Aloke K Dutta, Maarten E A Reit. Bivalent phenethylamines as novel dopamine transporter inhibitors: evidence for multiple substrate-binding sites in a single transporter. Journal of neurochemistry. vol 112. issue 6. 2010-04-30. PMID:20067583. |
one compound bearing two dopamine (da)-like pharmacophoric 'heads' separated by an 8-carbon linker achieved an 82-fold gain in inhibition of [(3)h] 2beta-carbomethoxy-3beta-(4-fluorophenyl)-tropane (cft) binding compared with da itself; bivalent compounds with a 6-carbon linker and heterologous combinations of da-, amphetamine- and beta-phenethylamine-like heads all resulted in considerable and comparable gains in dat affinity. |
2010-04-30 |
2023-08-12 |
Not clear |
| Jacob Eriksen, Trine Nygaard Jørgensen, Ulrik Gethe. Regulation of dopamine transporter function by protein-protein interactions: new discoveries and methodological challenges. Journal of neurochemistry. vol 113. issue 1. 2010-04-30. PMID:20085610. |
the dopamine transporter (dat) plays a key role in regulating dopaminergic signalling in the brain by mediating rapid clearance of dopamine from the synaptic clefts. |
2010-04-30 |
2023-08-12 |
Not clear |
| Jacob Eriksen, Trine Nygaard Jørgensen, Ulrik Gethe. Regulation of dopamine transporter function by protein-protein interactions: new discoveries and methodological challenges. Journal of neurochemistry. vol 113. issue 1. 2010-04-30. PMID:20085610. |
the psychostimulatory actions of cocaine and amphetamine are primarily the result of a direct interaction of these compounds with dat leading to attenuated dopamine clearance and for amphetamine even increased dopamine release. |
2010-04-30 |
2023-08-12 |
Not clear |
| Jermaine D Jones, F Scott Hall, George R Uhl, Anthony L Rile. Dopamine, norepinephrine and serotonin transporter gene deletions differentially alter cocaine-induced taste aversion. Pharmacology, biochemistry, and behavior. vol 94. issue 4. 2010-04-29. PMID:19969013. |
monoamine transporter knockout mice have been useful in the study of many different aspects of cocaine effects relevant to human drug use and addiction, yet an assessment of the effects of deletion of the genes for the dopamine, norepinephrine and serotonin transporters (dat, net, and sert, respectively) on cocaine's aversive properties has yet to be performed (uhl et al., 2002). |
2010-04-29 |
2023-08-12 |
mouse |
| Arnau Vina-Vilaseca, Alexander Sorki. Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes. The Journal of biological chemistry. vol 285. issue 10. 2010-04-29. PMID:20051513. |
rna interference screen previously revealed that a hect-domain e3 ubiquitin ligase, neuronal precursor cell expressed, developmentally down-regulated 4-2 (nedd4-2), is necessary for ubiquitination and endocytosis of the dopamine transporter (dat) induced by the activation of protein kinase c (pkc). |
2010-04-29 |
2023-08-12 |
human |
| Ting Ting Chang, Tzung Lieh Yeh, Nan Tsing Chiu, Po See Chen, Hsiang Yu Huang, Yen Kuang Yang, I Hui Lee, Ru Band L. Higher striatal dopamine transporters in euthymic patients with bipolar disorder: a SPECT study with [Tc] TRODAT-1. Bipolar disorders. vol 12. issue 1. 2010-04-29. PMID:20148872. |
the aim of this study was to explore striatal dopamine transporter (dat) availability in euthymic bipolar patients. |
2010-04-29 |
2023-08-12 |
Not clear |
| Marhaba Hojahmat, David B Horton, Seth D Norrholm, Dennis K Miller, Vladimir P Grinevich, Agripina Gabriela Deaciuc, Linda P Dwoskin, Peter A Crook. Lobeline esters as novel ligands for neuronal nicotinic acetylcholine receptors and neurotransmitter transporters. Bioorganic & medicinal chemistry. vol 18. issue 2. 2010-04-27. PMID:20036131. |
a series of carboxylic acid and sulfonic acid ester analogs 2-20 of lobeline were synthesized and evaluated for interaction with alpha4beta2 * and alpha7 * neuronal nicotinic acetylcholine receptors (nachrs), the dopamine transporter (dat), serotonin transporter (sert) and vmat2. |
2010-04-27 |
2023-08-12 |
rat |
| I Peraile, E Torres, A Mayado, M Izco, A Lopez-Jimenez, J A Lopez-Moreno, M I Colado, E O'She. Dopamine transporter down-regulation following repeated cocaine: implications for 3,4-methylenedioxymethamphetamine-induced acute effects and long-term neurotoxicity in mice. British journal of pharmacology. vol 159. issue 1. 2010-04-23. PMID:20015297. |
3,4-methylenedioxymethamphetamine (mdma) and cocaine are two widely abused psychostimulant drugs targeting the dopamine transporter (dat). |
2010-04-23 |
2023-08-12 |
mouse |
| I Peraile, E Torres, A Mayado, M Izco, A Lopez-Jimenez, J A Lopez-Moreno, M I Colado, E O'She. Dopamine transporter down-regulation following repeated cocaine: implications for 3,4-methylenedioxymethamphetamine-induced acute effects and long-term neurotoxicity in mice. British journal of pharmacology. vol 159. issue 1. 2010-04-23. PMID:20015297. |
dat availability regulates dopamine neurotransmission and uptake of mdma-derived neurotoxic metabolites. |
2010-04-23 |
2023-08-12 |
mouse |
| Dirk Taubert, Gundula Grimberg, Werner Stenzel, Edgar Schömi. Identification of the endogenous key substrates of the human organic cation transporter OCT2 and their implication in function of dopaminergic neurons. PloS one. vol 2. issue 4. 2010-04-19. PMID:17460754. |
current hypotheses suggest an abnormal function of the neuronal sodium-dependent dopamine transporter dat to contribute to cell death in the dopaminergic system, but it has not been investigated whether sodium-independent amine transporters are implicated in the pathogenesis of parkinson's disease. |
2010-04-19 |
2023-08-12 |
human |
| Sergi Mas, Miquel Bernardo, Eduard Parellada, Clemente Garcia-Rizo, Patricia Gassó, Santi Alvarez, Amalia Lafuent. ARVCF single marker and haplotypic association with schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 6. 2010-04-12. PMID:19508883. |
we present a schizophrenia association study using an extensive linkage disequilibrium (ld) mapping approach in seven candidate genes with a well established link to dopamine, including receptors (drd2, drd3) and genes involved in its metabolism and transport (ace, comt, dat, mao-a, mao-b). |
2010-04-12 |
2023-08-12 |
human |
| Bruce H Mandt, Nancy R Zahnise. Low and high cocaine locomotor responding male Sprague-Dawley rats differ in rapid cocaine-induced regulation of striatal dopamine transporter function. Neuropharmacology. vol 58. issue 3. 2010-04-07. PMID:19951714. |
importantly, lcrs and hcrs are distinguished by their differential responsiveness to acute cocaine-induced (but not baseline) locomotor activity, inhibition of the dopamine transporter (dat) and resulting extracellular da (hcr > lcr), as well as by repeated cocaine-induced locomotor sensitization and measures of cocaine's rewarding and reinforcing effects (lcr > hcr). |
2010-04-07 |
2023-08-12 |
rat |
| Cheryl A Frye, Sandra M Petralia, Madeline E Rhodes, Joseph F DeBol. 6-hydroxydopamine lesions enhance progesterone-facilitated lordosis of rats and hamsters, independent of effects on motor behavior. Physiology & behavior. vol 99. issue 2. 2010-04-05. PMID:19778544. |
fixed brains were stained with cresyl violet and processed for dopamine transporter (dat) immunoreactivity. |
2010-04-05 |
2023-08-12 |
rat |
| BingJin Li, Yosefu Arime, F Scott Hall, George R Uhl, Ichiro Sor. Impaired spatial working memory and decreased frontal cortex BDNF protein level in dopamine transporter knockout mice. European journal of pharmacology. vol 628. issue 1-3. 2010-04-05. PMID:19932884. |
we have thus tested spatial working memory in dopamine transporter knockout (dat ko) and wild-type mice. |
2010-04-05 |
2023-08-12 |
mouse |