| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li Jijun, Li Zaiwang, Li Anyuan, Wang Shuzhen, Qi Fanghua, Zhao Lin, Lv Hon. Abnormal expression of dopamine and serotonin transporters associated with the pathophysiologic mechanism of Tourette syndrome. Neurology India. vol 58. issue 4. 2010-10-26. PMID:20739786. |
it is also well known that dopamine and serotonin transporters (dat and sert) are monoamine neurotransmitter transporters, which participate in the metabolism of da and 5-ht, respectively. |
2010-10-26 |
2023-08-12 |
Not clear |
| Q David Walker, Sarah E Morris, Andrew E Arrant, Jacqueline M Nagel, Sarah Parylak, Guiying Zhou, Joseph M Caster, Cynthia M Kuh. Dopamine uptake inhibitors but not dopamine releasers induce greater increases in motor behavior and extracellular dopamine in adolescent rats than in adult male rats. The Journal of pharmacology and experimental therapeutics. vol 335. issue 1. 2010-10-21. PMID:20605908. |
periadolescent male rats are particularly sensitive to psychostimulants that are dat inhibitors but are not internalized and do not release dopamine. |
2010-10-21 |
2023-08-12 |
rat |
| Gregory C Hadlock, Pei-Wen Chu, Elliot T Walters, Glen R Hanson, Annette E Fleckenstei. Methamphetamine-induced dopamine transporter complex formation and dopaminergic deficits: the role of D2 receptor activation. The Journal of pharmacology and experimental therapeutics. vol 335. issue 1. 2010-10-21. PMID:20622144. |
previous studies have also revealed that meth treatment causes alterations in the dopamine transporter (dat), including the formation of higher molecular mass dat-associated complexes. |
2010-10-21 |
2023-08-12 |
Not clear |
| b' Mikko K\\xc3\\xa4enm\\xc3\\xa4ki, Anne Tammim\\xc3\\xa4ki, Timo My\\xc3\\xb6h\\xc3\\xa4nen, Kaisa Pakarinen, Carolina Amberg, Maria Karayiorgou, Joseph A Gogos, Pekka T M\\xc3\\xa4nnist\\xc3\\xb. Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving mice. Journal of neurochemistry. vol 114. issue 6. 2010-10-19. PMID:20626558.' |
because of low levels of dopamine transporter (dat), it is proposed that the majority of released da is taken up by either norepinephrine transporter (net) and subsequently metabolized by monoamine oxidize (mao) or by uptake(2) (to glial cells and post-synaptic neurons) and metabolized by comt. |
2010-10-19 |
2023-08-12 |
mouse |
| Yan Li, Shu-Yuan Cheng, Nianhang Chen, Maarten E A Reit. Interrelation of dopamine transporter oligomerization and surface presence as studied with mutant transporter proteins and amphetamine. Journal of neurochemistry. vol 114. issue 3. 2010-10-06. PMID:20492355. |
our previous work suggested a role for oligomerization in regulating dopamine transporter (dat) internalization, with d-amphetamine dissociating dat oligomers and monomers being endocytosed. |
2010-10-06 |
2023-08-12 |
Not clear |
| Y Iris Chen, Ji-Kyung Choi, Haibo Xu, Jiaqian Ren, Susan L Andersen, Bruce G Jenkin. Pharmacologic neuroimaging of the ontogeny of dopamine receptor function. Developmental neuroscience. vol 32. issue 2. 2010-10-05. PMID:20523024. |
pharmacological mri (phmri) was used to determine the response to dopamine transporter (dat) blockers cocaine and methylphenidate (mph), the dopamine releaser d-amphetamine (amph), the selective d1 agonist dihydrexidine, and the d2/d3 agonist quinpirole in young (<30 days old) and adult (>60 days old) rats. |
2010-10-05 |
2023-08-12 |
rat |
| Deanna M Navaroli, Haley E Melikia. Insertion of tetracysteine motifs into dopamine transporter extracellular domains. PloS one. vol 5. issue 2. 2010-09-30. PMID:20161733. |
the neuronal dopamine transporter (dat) is a major determinant of extracellular dopamine (da) levels and is the primary target for a variety of addictive and therapeutic psychoactive drugs. |
2010-09-30 |
2023-08-12 |
Not clear |
| Andrea Varrone, Christer Halldi. Molecular imaging of the dopamine transporter. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 51. issue 9. 2010-09-27. PMID:20720060. |
the dopamine transporter (dat) is a transmembrane protein responsible for reuptake of dopamine from the synaptic cleft and termination of dopaminergic transmission. |
2010-09-27 |
2023-08-12 |
Not clear |
| Heather A O'Malley, Yanghae Park, Lori L Isom, Margaret E Gneg. PKCbeta co-localizes with the dopamine transporter in mesencephalic neurons. Neuroscience letters. vol 480. issue 1. 2010-09-24. PMID:20641161. |
the dopamine transporter (dat) is a critical regulator of dopaminergic neurotransmission. |
2010-09-24 |
2023-08-12 |
rat |
| Heather A O'Malley, Yanghae Park, Lori L Isom, Margaret E Gneg. PKCbeta co-localizes with the dopamine transporter in mesencephalic neurons. Neuroscience letters. vol 480. issue 1. 2010-09-24. PMID:20641161. |
using immunofluorescence and confocal microscopy, we demonstrated co-localization of dat and pkcbeta in primary cultures of mesencephalic neurons and in dopamine neurons in rat substantia nigra and ventral tegmental area. |
2010-09-24 |
2023-08-12 |
rat |
| Päivi Marjamäki, Merja Haaparanta, Sarita Forsback, Veronica Fagerholm, Olli Eskola, Tove Grönroos, Teija Koivula, Olof Soli. Comparison of 2beta-carbomethoxy-3beta-(4-[18F]fluorophenyl)tropane and N-(3-[18F]fluoropropyl)-2beta-carbomethoxy-3beta-(4-fluorophenyl)nortropane, tracers for imaging dopamine transporter in rat. Molecular imaging and biology. vol 12. issue 3. 2010-09-20. PMID:19949983. |
this study compares 2beta-carbomethoxy-3beta-(4-[(18)f]fluorophenyl)tropane ([(18)f]beta-cft) and n-(3-[(18)f]fluoropropyl)-2beta-carbomethoxy-3beta-(4-fluorophenyl)nortropane ([(18)f]beta-cft-fp) as radiotracers for imaging the dopamine transporter (dat) in rat. |
2010-09-20 |
2023-08-12 |
rat |
| Jacob Eriksen, Walden Emil Bjørn-Yoshimoto, Trine Nygaard Jørgensen, Amy Hauck Newman, Ulrik Gethe. Postendocytic sorting of constitutively internalized dopamine transporter in cell lines and dopaminergic neurons. The Journal of biological chemistry. vol 285. issue 35. 2010-09-17. PMID:20551317. |
the dopamine transporter (dat) mediates reuptake of released dopamine and is the target for psychostimulants, such as cocaine and amphetamine. |
2010-09-17 |
2023-08-12 |
Not clear |
| Helen N Panas, Laurie J Lynch, Eric J Vallender, Zhihua Xie, Guo-Lin Chen, Spencer K Lynn, Thomas S Scanlan, Gregory M Mille. Normal thermoregulatory responses to 3-iodothyronamine, trace amines and amphetamine-like psychostimulants in trace amine associated receptor 1 knockout mice. Journal of neuroscience research. vol 88. issue 9. 2010-09-16. PMID:20155805. |
here, t1am was studied using rhesus monkey taar1 and/or human dopamine transporter (dat) co-transfected cells, and wild-type (wt) and taar1 knock-out (ko) mice. |
2010-09-16 |
2023-08-12 |
mouse |
| Peng Zhang, George Cyriac, Theresa Kopajtic, Yongfang Zhao, Jonathan A Javitch, Jonathan L Katz, Amy Hauck Newma. Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) analogues at monoamine transporters. Journal of medicinal chemistry. vol 53. issue 16. 2010-09-16. PMID:20672825. |
to further explore structure-activity relationships at the serotonin transporter (sert), a series of (+/-)-4- and 5-substituted citalopram analogues were designed, synthesized, and evaluated for binding at the sert, dopamine transporter (dat) and norepinephrine transporter (net) in native rodent tissue. |
2010-09-16 |
2023-08-12 |
Not clear |
| Siroos Mirzaei, Rasoul Zakavi, Margarida Rodrigues, Thomas Schwarzgruber, Thomas Brücke, Jiri Bakala, Katalin Borbély, Norbert Leners, Peter Knoll, Rene Donne. Fully automated 3D basal ganglia activity measurement in dopamine transporter scintigraphy (Spectalyzer). Annals of nuclear medicine. vol 24. issue 4. 2010-09-10. PMID:20232177. |
semiquantitative evaluation of tracer uptake in basal ganglia is superior to visual assessment of images in dopamine transporter (dat) scintigraphy especially in follow-up of the patients. |
2010-09-10 |
2023-08-12 |
Not clear |
| Chie Seki, Hiroshi Ito, Tetsuya Ichimiya, Ryosuke Arakawa, Yoko Ikoma, Miho Shidahara, Jun Maeda, Akihiro Takano, Hidehiko Takahashi, Yuichi Kimura, Kazutoshi Suzuki, Iwao Kanno, Tetsuya Suhar. Quantitative analysis of dopamine transporters in human brain using [11C]PE2I and positron emission tomography: evaluation of reference tissue models. Annals of nuclear medicine. vol 24. issue 4. 2010-09-10. PMID:20364374. |
dopamine transporter (dat) is a reuptake carrier of dopamine at presynapse that regulates dopaminergic neural transmission. |
2010-09-10 |
2023-08-12 |
human |
| Andre C Felicio, Tais S Moriyama, Clecio Godeiro-Junior, Ming C Shih, Marcelo Q Hoexter, Vanderci Borges, Sonia M A Silva, Edson Amaro-Junior, Luiz A F Andrade, Henrique B Ferraz, Rodrigo A Bressa. Higher dopamine transporter density in Parkinson's disease patients with depression. Psychopharmacology. vol 211. issue 1. 2010-09-10. PMID:20495790. |
molecular imaging studies have shown a reduction of dopamine transporter (dat) density in depressed pd patients (dpd); however, dat role in the pathophysiology of pd depression is not clear since clinical matching was inappropriate and dat reduction could be attributed to pd severity. |
2010-09-10 |
2023-08-12 |
Not clear |
| Ji-Hoon Yoo, Alexis Bailey, Micheal Ansonoff, John E Pintar, Audrey Matifas, Brigitte L Kieffer, Ian Kitche. Lack of genotype effect on D1, D2 receptors and dopamine transporter binding in triple MOP-, DOP-, and KOP-opioid receptor knockout mice of three different genetic backgrounds. Synapse (New York, N.Y.). vol 64. issue 7. 2010-09-08. PMID:20196137. |
we investigated d1, d2 receptors and dopamine transporter (dat) binding levels in mice lacking all three opioid receptors and wild-type (wt) mice on three different genetic backgrounds. |
2010-09-08 |
2023-08-12 |
mouse |
| Jeffrey S Stehouwer, Lauryn M Daniel, Ping Chen, Ronald J Voll, Larry Williams, Susan J Plott, John R Votaw, Michael J Owens, Leonard Howell, Mark M Goodma. Synthesis, fluorine-18 radiolabeling, and biological evaluation of N-((E)-4-fluorobut-2-en-1-yl)-2beta-carbomethoxy-3beta-(4'-halophenyl)nortropanes: candidate radioligands for in vivo imaging of the brain dopamine transporter with positron emission tomography. Journal of medicinal chemistry. vol 53. issue 15. 2010-09-08. PMID:20597489. |
the n-(e)-fluorobutenyl-3beta-(para-halo-phenyl)nortropanes 9-12 were synthesized as ligands of the dopamine transporter (dat) for use as (18)f-labeled positron emission tomography (pet) imaging agents. |
2010-09-08 |
2023-08-12 |
monkey |
| Francesco Napolitano, Alessandra Bonito-Oliva, Mauro Federici, Manolo Carta, Francesco Errico, Salvatore Magara, Giuseppina Martella, Robert Nisticò, Diego Centonze, Antonio Pisani, Howard H Gu, Nicola B Mercuri, Alessandro Usiell. Role of aberrant striatal dopamine D1 receptor/cAMP/protein kinase A/DARPP32 signaling in the paradoxical calming effect of amphetamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 33. 2010-09-03. PMID:20720111. |
several lines of research support a crucial role for the dopamine transporter (dat) gene in this psychiatric disease. |
2010-09-03 |
2023-08-12 |
mouse |