| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Mignini, M Sabbatini, V D'Andrea, C Cavallott. Intrinsic innervation and dopaminergic markers after experimental denervation in rat thymus. European journal of histochemistry : EJH. vol 54. issue 2. 2011-02-04. PMID:20558339. |
after chemical or surgical sympathectomy however, neither dopamine nor dat immune reaction was noted again. |
2011-02-04 |
2023-08-12 |
rat |
| David J Brook. Imaging dopamine transporters in Parkinson's disease. Biomarkers in medicine. vol 4. issue 5. 2011-02-04. PMID:20945978. |
the dopamine transporter (dat) is responsible for clearance of dopamine from the synaptic cleft after its release. |
2011-02-04 |
2023-08-12 |
human |
| David J Brook. Imaging dopamine transporters in Parkinson's disease. Biomarkers in medicine. vol 4. issue 5. 2011-02-04. PMID:20945978. |
imaging dat availability provides a measure of dopamine terminal function and a method for detecting striatal dopamine deficiency states present in idiopathic parkinson's disease and atypical neurodegenerative parkinsonian disorders such as multiple system atrophy and progressive supranuclear palsy. |
2011-02-04 |
2023-08-12 |
human |
| Kurt A Jellinge. Interaction between α-synuclein and tau in Parkinson's disease comment on Wills et al.: elevated tauopathy and α-synuclein pathology in postmortem Parkinson's disease brains with and without dementia. Exp Neurol 2010; 225: 210-218. Experimental neurology. vol 227. issue 1. 2011-02-04. PMID:20965169. |
recent neurochemical studies in postmortem brains of patients with parkinson's disease (pd), pd with dementia (pdd) and age-matched controls revealed significant decrease of tyrosine hydroxylase (th) and dopamine transporter (dat) in striatum, confirming previous studies indicating substantial loss of dopaminergic neurons and terminals. |
2011-02-04 |
2023-08-12 |
mouse |
| Theresa A Kopajtic, Yi Liu, Christopher K Surratt, David M Donovan, Amy H Newman, Jonathan L Kat. Dopamine transporter-dependent and -independent striatal binding of the benztropine analog JHW 007, a cocaine antagonist with low abuse liability. The Journal of pharmacology and experimental therapeutics. vol 335. issue 3. 2011-02-03. PMID:20855444. |
the benztropine analog n-(n-butyl)-3α-[bis(4'-fluorophenyl)methoxy]-tropane (jhw 007) displays high affinity for the dopamine transporter (dat), but unlike typical dat ligands, has relatively low abuse liability and blocks the effects of cocaine, including its self-administration. |
2011-02-03 |
2023-08-12 |
mouse |
| Barbara J Caldarone, Neil E Paterson, Jia Zhou, Daniela Brunner, Alan P Kozikowski, Koen G C Westphal, Gerdien A H Korte-Bouws, Jolanda Prins, S Mechiel Korte, Berend Olivier, Afshin Ghavam. The novel triple reuptake inhibitor JZAD-IV-22 exhibits an antidepressant pharmacological profile without locomotor stimulant or sensitization properties. The Journal of pharmacology and experimental therapeutics. vol 335. issue 3. 2011-02-03. PMID:20864506. |
triple reuptake inhibitors (tris) that block the dopamine transporter (dat), norepinephrine transporter, and serotonin transporter are being developed as a new class of antidepressant that may have better efficacy and fewer side effects compared with traditional antidepressants. |
2011-02-03 |
2023-08-12 |
mouse |
| Pei Chun Hsieh, I Hui Lee, Tzung Lieh Yeh, Kao Chin Chen, Hui Chun Huang, Po See Chen, Yen Kuang Yang, Wei Jen Yao, Ru-Band Lu, Nan Tsing Chi. Distribution volume ratio of serotonin and dopamine transporters in euthymic patients with a history of major depression - a dual-isotope SPECT study. Psychiatry research. vol 184. issue 3. 2011-02-03. PMID:21030217. |
serotonin transporter (sert) and dopamine transporter (dat) levels differ in patients with major depression who are in a depressed state in comparison with healthy controls. |
2011-02-03 |
2023-08-12 |
human |
| Andrea Varrone, Miklós Tóth, Carsten Steiger, Akihiro Takano, Denis Guilloteau, Masanori Ichise, Balázs Gulyás, Christer Halldi. Kinetic analysis and quantification of the dopamine transporter in the nonhuman primate brain with 11C-PE2I and 18F-FE-PE2I. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 52. issue 1. 2011-02-02. PMID:21189414. |
18f-(e)-n-(3-iodoprop-2-enyl)-2β-carbofluoroethoxy-3β- (4'-methyl-phenyl)nortropane (18f-fe-pe2i) is a novel radioligand for dopamine transporter (dat) pet. |
2011-02-02 |
2023-08-12 |
rat |
| Domingo Afonso-Oramas, Ignacio Cruz-Muros, Pedro Barroso-Chinea, Diego Álvarez de la Rosa, Javier Castro-Hernández, Josmar Salas-Hernández, Teresa Giráldez, Tomás González-Hernánde. The dopamine transporter is differentially regulated after dopaminergic lesion. Neurobiology of disease. vol 40. issue 3. 2011-01-25. PMID:20688165. |
the dopamine transporter (dat) is a transmembrane glycoprotein responsible for dopamine (da) uptake, which has been shown to be involved in da-cell degeneration in parkinson's disease (pd). |
2011-01-25 |
2023-08-12 |
rat |
| Milind Misra, Qing Shi, Xiaocong Ye, Ewa Gruszecka-Kowalik, Wei Bu, Zhanzhu Liu, Margaret M Schweri, Howard M Deutsch, Carol A Venanz. Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorganic & medicinal chemistry. vol 18. issue 20. 2011-01-24. PMID:20846865. |
complementary two-dimensional (2d) and three-dimensional (3d) quantitative structure-activity relationship (qsar) techniques were used to derive a preliminary model for the dopamine transporter (dat) binding affinity of 80 racemic threo-methylphenidate (mp) analogs. |
2011-01-24 |
2023-08-12 |
Not clear |
| Angela M Batman, Aloke K Dutta, Maarten E A Reith, Patrick M Beardsle. The selective dopamine uptake inhibitor, D-84, suppresses cocaine self-administration, but does not occasion cocaine-like levels of generalization. European journal of pharmacology. vol 648. issue 1-3. 2011-01-21. PMID:20840845. |
inhibitors with varying selectivity at the dopamine transporter (dat) have approximated these properties. |
2011-01-21 |
2023-08-12 |
Not clear |
| M A Cervinski, J D Foster, R A Vaugha. Syntaxin 1A regulates dopamine transporter activity, phosphorylation and surface expression. Neuroscience. vol 170. issue 2. 2011-01-20. PMID:20643191. |
we investigated the functional relationship between the soluble n-ethylmaleimide-sensitive factor attachment receptor (snare) protein syntaxin 1a (syn 1a) and the dopamine transporter (dat) by treating rat striatal tissue with botulinum neurotoxin c (bont/c) and co-transfecting syn 1a with dat in non-neuronal cells, followed by analysis of dat activity, phosphorylation, and regulation. |
2011-01-20 |
2023-08-12 |
rat |
| M A Cervinski, J D Foster, R A Vaugha. Syntaxin 1A regulates dopamine transporter activity, phosphorylation and surface expression. Neuroscience. vol 170. issue 2. 2011-01-20. PMID:20643191. |
treatment of striatal slices with bont/c resulted in elevated dopamine (da) transport vmax and reduced dat phosphorylation, while heterologous co-expression of syn 1a led to reduction in dat surface expression and transport vmax. |
2011-01-20 |
2023-08-12 |
rat |
| b' Anne Tammim\\xc3\\xa4ki, Pekka T M\\xc3\\xa4nnist\\xc3\\xb. Effect of genetic modifications in the synaptic dopamine clearance systems on addiction-like behaviour in mice. Basic & clinical pharmacology & toxicology. vol 108. issue 1. 2011-01-20. PMID:21118356.' |
in the dopamine transporter (dat), a vesicular monoamine transporter 2 (vmat2) or two dopamine-metabolizing enzymes (monoamine oxidase, mao, mainly mao-a isoenzyme, and catechol-o-methyltransferase, comt). |
2011-01-20 |
2023-08-12 |
mouse |
| Catrin Wernicke, Julian Hellmann, Ulrich Finckh, Hans Rommelspache. Chronic ethanol exposure changes dopamine D2 receptor splicing during retinoic acid-induced differentiation of human SH-SY5Y cells. Pharmacological reports : PR. vol 62. issue 4. 2011-01-12. PMID:20885005. |
the dopamine d2 receptor (drd2) and the dopamine transporter (dat) are decisively involved in dopaminergic signaling. |
2011-01-12 |
2023-08-12 |
human |
| Catrin Wernicke, Julian Hellmann, Ulrich Finckh, Hans Rommelspache. Chronic ethanol exposure changes dopamine D2 receptor splicing during retinoic acid-induced differentiation of human SH-SY5Y cells. Pharmacological reports : PR. vol 62. issue 4. 2011-01-12. PMID:20885005. |
the dat is functional both in undifferentiated and ra-differentiated cells as demonstrated by [(3)h]dopamine uptake. |
2011-01-12 |
2023-08-12 |
human |
| Michela Di Salvio, Luca Giovanni Di Giovannantonio, Dario Acampora, Raffaele Prosperi, Daniela Omodei, Nilima Prakash, Wolfgang Wurst, Antonio Simeon. Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP. Nature neuroscience. vol 13. issue 12. 2011-01-06. PMID:21057506. |
the homeoprotein otx2 is restricted to ventral tegmental area (vta) neurons that are prevalently complementary to those expressing girk2 and glycosylated active form of the dopamine transporter (dat). |
2011-01-06 |
2023-08-12 |
Not clear |
| Michela Di Salvio, Luca Giovanni Di Giovannantonio, Dario Acampora, Raffaele Prosperi, Daniela Omodei, Nilima Prakash, Wolfgang Wurst, Antonio Simeon. Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP. Nature neuroscience. vol 13. issue 12. 2011-01-06. PMID:21057506. |
high levels of glycosylated dat mark neurons with efficient dopamine uptake and pronounced vulnerability to parkinsonian degeneration. |
2011-01-06 |
2023-08-12 |
Not clear |
| Shashwath A Meda, Kanchana Jagannathan, Joel Gelernter, Vince D Calhoun, Jingyu Liu, Michael C Stevens, Godfrey D Pearlso. A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia. NeuroImage. vol 53. issue 3. 2011-01-03. PMID:19944766. |
the fmri components, along with their significant genetic profile (dominant snp) correlations were as follows: (1) inferior frontal-anterior/posterior cingulate-thalamus-caudate with snps from brain derived neurotropic factor (bdnf) and dopamine transporter (dat) [r=-0.51; p<0.0001], (2) superior/middle temporal gyrus-cingulate-premotor with slc6a4_pr and slc6a4_pr_ag (serotonin transporter promoter; 5httlpr) [r=0.27; p=0.03], and (3) default mode-fronto-temporal gyrus with brain derived neurotropic factor and dopamine transporter (bdnf, dat) [r=-0.25; p=0.04]. |
2011-01-03 |
2023-08-12 |
human |
| Mikhil N Bamne, Michael E Talkowski, Kodavali V Chowdari, Vishwajit L Nimgaonka. Functional analysis of upstream common polymorphisms of the dopamine transporter gene. Schizophrenia bulletin. vol 36. issue 5. 2010-12-28. PMID:19273584. |
the human dopamine transporter (dat, slc6a3) has been extensively investigated because of its potential involvement in neuropsychiatric disorders. |
2010-12-28 |
2023-08-12 |
human |