| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christopher J Earley, Hiroto Kuwabara, Dean F Wong, Charlene Gamaldo, Rachel Salas, James Brasic, Hayden T Ravert, Robert F Dannals, Richard P Alle. The dopamine transporter is decreased in the striatum of subjects with restless legs syndrome. Sleep. vol 34. issue 3. 2011-07-14. PMID:21358851. |
prior studies, all using spect techniques, failed to find any differences for dopamine transporter (dat) in restless legs syndrome (rls) subjects. |
2011-07-14 |
2023-08-12 |
human |
| Thomas E Wooters, Michael T Bardo, Linda P Dwoskin, Narasimha M Midde, Adrian M Gomez, Charles F Mactutus, Rosemarie M Booze, Jun Zh. Effect of environmental enrichment on methylphenidate-induced locomotion and dopamine transporter dynamics. Behavioural brain research. vol 219. issue 1. 2011-07-13. PMID:21219939. |
this study determined whether environmental enrichment differentially altered the effects of mpd on locomotor activity and dopamine (da) transporter (dat) function. |
2011-07-13 |
2023-08-12 |
rat |
| Anjali Rao, Diana Simmons, Alexander Sorki. Differential subcellular distribution of endosomal compartments and the dopamine transporter in dopaminergic neurons. Molecular and cellular neurosciences. vol 46. issue 1. 2011-07-05. PMID:20816972. |
dopamine (da) transporter (dat) functions at the surface of dopaminergic neurons to clear extracellular da. |
2011-07-05 |
2023-08-12 |
rat |
| Yu Luo, Yun Wang, Serena Y Kuang, Yung-Hsiao Chiang, Barry Hoffe. Decreased level of Nurr1 in heterozygous young adult mice leads to exacerbated acute and long-term toxicity after repeated methamphetamine exposure. PloS one. vol 5. issue 12. 2011-07-05. PMID:21151937. |
compared to naïve mice that received meth binge treatment for the first time, mice pretreated with meth in adolescence showed a greater loss of tyrosine hydroxylase (th) immunoreactivity in striatum, loss of thir fibers in the substantia nigra reticulata (snr) as well as decreased dopamine transporter (dat) level and compromised da clearance in striatum. |
2011-07-05 |
2023-08-12 |
mouse |
| Bhaskar Gopishetty, Stuart Hazeldine, Soumava Santra, Mark Johnson, Gyan Modi, Solav Ali, Juan Zhen, Maarten Reith, Aloke Dutt. Further structure-activity relationship studies on 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: identification of compounds with triple uptake inhibitory activity as potential antidepressant agents. Journal of medicinal chemistry. vol 54. issue 8. 2011-07-04. PMID:21446715. |
the novel compounds were tested for their affinities for the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) in the brain by measuring their potency in inhibiting the uptake of [(3)h]da, [(3)h]5-ht, and [(3)h]ne, respectively. |
2011-07-04 |
2023-08-12 |
rat |
| Xiongzhao Zhu, Sufang Peng, Xiuling Ma, Ting L. [Effect of maternal deprivation on emotion and expression of dopamine transporter in adult rats]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 35. issue 1. 2011-06-30. PMID:20130362. |
to investigate the change of emotion and striatum dopamine transporter(dat) expression in adult male rats experiencing maternal deprivation, and to explore whether dna methylation is involved in the regulatory mechanism of dat expression. |
2011-06-30 |
2023-08-12 |
rat |
| Lee E Eiden, Eberhard Weih. VMAT2: a dynamic regulator of brain monoaminergic neuronal function interacting with drugs of abuse. Annals of the New York Academy of Sciences. vol 1216. 2011-06-21. PMID:21272013. |
the effects of amphetamine (amph) and cocaine (coc), for example, depend on the ability to increase dopamine in the synapse, by effects on either the plasma membrane transporter dat or the vesicular transporter for monoamine storage, vmat2. |
2011-06-21 |
2023-08-12 |
Not clear |
| John A Gruner, Joanne R Mathiasen, Dorothy G Flood, Maciej Gasio. Characterization of pharmacological and wake-promoting properties of the dopaminergic stimulant sydnocarb in rats. The Journal of pharmacology and experimental therapeutics. vol 337. issue 2. 2011-06-21. PMID:21300706. |
the nature of sydnocarb-induced facilitation of dopamine (da) neurotransmission [da release versus da transporter (dat) inhibition] is not clear. |
2011-06-21 |
2023-08-12 |
human |
| H A Boger, P Mannangatti, D J Samuvel, A J Saylor, T S Bender, J F McGinty, A M Fortress, V Zaman, P Huang, L D Middaugh, P K Randall, L D Jayanthi, B Rohrer, K L Helke, A-C Granholm, S Ramamoorth. Effects of brain-derived neurotrophic factor on dopaminergic function and motor behavior during aging. Genes, brain, and behavior. vol 10. issue 2. 2011-06-15. PMID:20860702. |
dopamine neurotransmitter markers indicated no genotypic difference in striatal tyrosine hydroxylase, da transporter (dat) or vesicular monoamine transporter 2 (vmat2) immunoreactivity at any age. |
2011-06-15 |
2023-08-12 |
mouse |
| Akiko Muroyama, Shota Kobayashi, Yasuhide Mitsumot. Loss of striatal dopaminergic terminals during the early stage in response to MPTP injection in C57BL/6 mice. Neuroscience research. vol 69. issue 4. 2011-06-15. PMID:21185886. |
to investigate the selective daergic neurotoxicity, we have developed an immunological technique to isolate daergic synaptosomes from mouse striatal tissues using an antibody against 20 amino acid residues in the extracellular second loop of dopamine transporter (dat). |
2011-06-15 |
2023-08-12 |
mouse |
| Akiko Muroyama, Shota Kobayashi, Yasuhide Mitsumot. Loss of striatal dopaminergic terminals during the early stage in response to MPTP injection in C57BL/6 mice. Neuroscience research. vol 69. issue 4. 2011-06-15. PMID:21185886. |
gbr-12909, a dopamine uptake inhibitor, completely reversed the mptp-induced decrease of dat protein in the daergic synaptosomes. |
2011-06-15 |
2023-08-12 |
mouse |
| Teodora-Adriana Perles-Barbacaru, Daniel Procissi, Andrey V Demyanenko, F Scott Hall, George R Uhl, Russell E Jacob. Quantitative pharmacologic MRI: mapping the cerebral blood volume response to cocaine in dopamine transporter knockout mice. NeuroImage. vol 55. issue 2. 2011-06-10. PMID:21185387. |
in this report, we employed cbv-weighted phmri to compare cocaine-modulated neuronal activity in dopamine transporter (dat) knockout (ko) and wild-type mice. |
2011-06-10 |
2023-08-12 |
mouse |
| Teodora-Adriana Perles-Barbacaru, Daniel Procissi, Andrey V Demyanenko, F Scott Hall, George R Uhl, Russell E Jacob. Quantitative pharmacologic MRI: mapping the cerebral blood volume response to cocaine in dopamine transporter knockout mice. NeuroImage. vol 55. issue 2. 2011-06-10. PMID:21185387. |
cocaine acts to block the dopamine, norepinephrine, and serotonin transporters (dat, net, and sert) that clear their respective neurotransmitters from the synapses, helping to terminate cognate neurotransmission. |
2011-06-10 |
2023-08-12 |
mouse |
| Esther Cubo, Mateo Diez López, Jon Infante Ceberio, Isabel Lanchas Alfonso, Begoña Miguel Martinez, José Berciano, Fernando Iglesias, José A Obes. Striatal dopamine function in a family with multiple SCA-3 phenotypes. Journal of neurology. vol 258. issue 2. 2011-06-08. PMID:20809346. |
sca-3 can present with a levodopa responsive parkinsonism phenotype, and an abnormal dat scan showing predominant impairment of presynaptic dopamine function. |
2011-06-08 |
2023-08-12 |
Not clear |
| Susanna Nencetti, Maria R Mazzoni, Gabriella Ortore, Annalina Lapucci, Janette Giuntini, Elisabetta Orlandini, Irene Banti, Elisa Nuti, Antonio Lucacchini, Gino Giannaccini, Armando Rossell. Synthesis, molecular docking and binding studies of selective serotonin transporter inhibitors. European journal of medicinal chemistry. vol 46. issue 3. 2011-06-02. PMID:21272963. |
with the aim of obtaining compounds possessing high sert selectivity, in the present work we synthesized and studied the inhibition of serotonin (sert), dopamine (dat) and norepinephrine (net) transporters by docking studies and experimental binding measurements of a series of 4-(aryl)piperidin-3-one o-4-benzyl oxime hydrochlorides (1-10) of both e and z configuration. |
2011-06-02 |
2023-08-12 |
Not clear |
| B A Sorg, G Stark, A Sergeeva, H T Janse. Photoperiodic suppression of drug reinstatement. Neuroscience. vol 176. 2011-06-01. PMID:21185915. |
in an additional experiment, we examined the photoperiodic regulation of tyrosine hydroxylase (th) and dopamine transporter (dat) proteins in drug-naive rats. |
2011-06-01 |
2023-08-12 |
rat |
| Britta Haenisch, Heinz Bönisc. Depression and antidepressants: insights from knockout of dopamine, serotonin or noradrenaline re-uptake transporters. Pharmacology & therapeutics. vol 129. issue 3. 2011-05-19. PMID:21147164. |
major targets of ads are the serotonin transporter (sert), the noradrenaline transporter (nat) and also the dopamine transporter (dat) located in the plasma membrane of corresponding neurons. |
2011-05-19 |
2023-08-12 |
mouse |
| Alejandro Reynoso Palomar, Berenice Navarrete Larios, Victoria Chagoya De Sánchez, Lidia Martínez Pérez, Fidel De La Cruz López, Gonzalo Flores, Maria de Jesús Gómez-Villalobo. Expression and distribution of dopamine transporter in cardiac tissues of the guinea pig. Neurochemical research. vol 36. issue 3. 2011-05-19. PMID:21170736. |
dopamine transporter (dat) is a membrane protein that it is a marker for dopaminergic neurons. |
2011-05-19 |
2023-08-12 |
Not clear |
| Melanie Bousquet, Karl Gue, Vincent Emond, Pierre Julien, Jing X Kang, Francesca Cicchetti, Frederic Calo. Transgenic conversion of omega-6 into omega-3 fatty acids in a mouse model of Parkinson's disease. Journal of lipid research. vol 52. issue 2. 2011-05-05. PMID:21115966. |
such a limited endogenous production of n-3 pufas in the fat-1 mouse was insufficient to confer neuroprotection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity as assessed by dopamine levels, tyrosine hydroxylase (th)-positive neurons and fibers, as well as nigral nurr1 and dopamine transporter (dat) mrna expression. |
2011-05-05 |
2023-08-12 |
mouse |
| David J Lapinsky, Ranganadh Velagaleti, Nageswari Yarravarapu, Yi Liu, Yurong Huang, Christopher K Surratt, John R Lever, James D Foster, Rejwi Acharya, Roxanne A Vaughan, Howard M Deutsc. Azido-iodo-N-benzyl derivatives of threo-methylphenidate (Ritalin, Concerta): Rational design, synthesis, pharmacological evaluation, and dopamine transporter photoaffinity labeling. Bioorganic & medicinal chemistry. vol 19. issue 1. 2011-05-05. PMID:21129986. |
in contrast to tropane-based compounds such as benztropine and cocaine, non-tropane-based photoaffinity ligands for the dopamine transporter (dat) are relatively unexplored. |
2011-05-05 |
2023-08-12 |
rat |